Abstract: Freeze concentration freezes or crystallises the water
molecules out as ice crystals and leaves behind a highly concentrated
solution. In conventional suspension freeze concentration where ice
crystals formed as a suspension in the mother liquor, separation of
ice is difficult. The size of the ice crystals is still very limited which
will require usage of scraped surface heat exchangers, which is very
expensive and accounted for approximately 30% of the capital cost.
This research is conducted using a newer method of freeze
concentration, which is progressive freeze concentration. Ice crystals
were formed as a layer on the designed heat exchanger surface. In
this particular research, a helical structured copper crystallisation
chamber was designed and fabricated. The effect of two operating
conditions on the performance of the newly designed crystallisation
chamber was investigated, which are circulation flowrate and coolant
temperature. The performance of the design was evaluated by the
effective partition constant, K, calculated from the volume and
concentration of the solid and liquid phase. The system was also
monitored by a data acquisition tool in order to see the temperature
profile throughout the process. On completing the experimental
work, it was found that higher flowrate resulted in a lower K, which
translated into high efficiency. The efficiency is the highest at 1000
ml/min. It was also found that the process gives the highest
efficiency at a coolant temperature of -6 °C.
Abstract: This paper presents a new study on the applications of
optimization and regression analysis techniques for optimal
calculation of partial ratios of four-step helical gearboxes for getting
minimal gearbox length. In the paper, basing on the moment
equilibrium condition of a mechanic system including four gear units
and their regular resistance condition, models for determination of the
partial ratios of the gearboxes are proposed. In particular, explicit
models for calculation of the partial ratios are proposed by using
regression analysis. Using these models, the determination of the
partial ratios is accurate and simple.
Abstract: The prediction of transmembrane helical segments
(TMHs) in membrane proteins is an important field in the
bioinformatics research. In this paper, a method based on discrete
wavelet transform (DWT) has been developed to predict the number
and location of TMHs in membrane proteins. PDB coded as 1F88 was
chosen as an example to describe the prediction of the number and
location of TMHs in membrane proteins by using this method. One
group of test data sets that contain total 19 protein sequences was
utilized to access the effect of this method. Compared with the
prediction results of DAS, PRED-TMR2, SOSUI, HMMTOP2.0 and
TMHMM2.0, the obtained results indicate that the presented method
has higher prediction accuracy.
Abstract: Numerical study is performed to investigate the
temperature distribution in an annular diffuser fitted with helical tape
hub. Different pitches (Y = 20 mm, and Y = 30 mm) for the helical
tape are studied with different heights (H = 20 mm, 22 mm, and 24
mm) to be compared. The geometry of the annular diffuser and the
inlet condition for both hub arrangements are kept constant. The
result obtains that using helical tape insert with different pitches and
different heights will force the temperature to distribute in a helical
direction; however the use of helical tape hub with height (H = 22
mm) for both pitches enhance the temperature distribution in a good
manner.
Abstract: The prediction of transmembrane helical segments
(TMHs) in membrane proteins is an important field in the
bioinformatics research. In this paper, a new method based on discrete
wavelet transform (DWT) has been developed to predict the number
and location of TMHs in membrane proteins. PDB coded as 1KQG
was chosen as an example to describe the prediction of the number and
location of TMHs in membrane proteins by using this method. To
access the effect of the method, 80 proteins with known 3D-structure
from Mptopo database are chosen at random as the test objects
(including 325 TMHs), 308 of which can be predicted accurately, the
average predicted accuracy is 96.3%. In addition, the above 80
membrane proteins are divided into 13 groups according to their
function and type. In particular, the results of the prediction of TMHs
of the 13 groups are satisfying.
Abstract: In this study the mixed convection heat transfer in a
coil-in-shell heat exchanger for various Reynolds numbers and
various dimensionless coil pitch was experimentally investigated.
The experiments were conducted for both laminar and turbulent flow
inside coil and the effects of coil pitch on shell-side heat transfer
coefficient of the heat exchanger were studied. The particular
difference in this study in comparison with the other similar studies
was the boundary conditions for the helical coils. The results indicate
that with the increase of coil pitch, shell-side heat transfer coefficient
is increased.
Abstract: In this paper, a study on the applications of the
optimization and regression techniques for optimal calculation of
partial ratios of helical gearboxes with second-step double gear-sets
for minimal cross section dimension is introduced. From the condition
of the moment equilibrium of a mechanic system including three gear
units and their regular resistance condition, models for calculation of
the partial ratios of helical gearboxes with second-step double
gear-sets were given. Especially, by regression analysis, explicit
models for calculation of the partial ratios are introduced. These
models allow determining the partial ratios accurately and simply.
Abstract: Aurein 1.2 is a 13-residue amphipathic peptide with antibacterial and anticancer activity. Aurein1.2 and its retro analog were synthesized to study the activity of the peptides in relation to their structure. The antibacterial test result showed the retro-analog is inactive. The secondary structural analysis by CD spectra indicated that both of the peptides at TFE/Water adopt alpha-helical conformation. MD simulation was performed on aurein 1.2 and retro-analog in water and TFE in order to analyse the factors that are involved in the activity difference between retro and the native peptide. The simulation results are discussed and validated in the light of experimental data from the CD experiment. Both of the peptides showed a relatively similar pattern for their hydrophobicity, hydrophilicity, solvent accessible surfaces, and solvent accessible hydrophobic surfaces. However, they showed different in directions of dipole moment of peptides. Also, Our results further indicate that the reversion of the amino acid sequence affects flexibility .The data also showed that factors causing structural rigidity may decrease the activity. Consequently, our finding suggests that in the case of sequence-reversed peptide strategy, one has to pay attention to the role of amino acid sequence order in making flexibility and role of dipole moment direction in peptide activity. KeywordsAntimicrobial peptides, retro, molecular dynamic, circular dichroism.
Abstract: In this work, we perform numerical simulation of fluid
mixing in a floor-grooved micro-channel with wavy sidewalls which
may impose perturbation on the helical flow induced by the slanted
grooves on the channel floor. The perturbation is caused by separation
vortices in the recesses of the wavy-walled channel as the Reynolds
number is large enough. The results show that the effects of the wavy
sidewalls of the present micromixer on the enhancement of fluid
mixing increase with the increase of Reynolds number. The degree of
mixing increases with the increase of the corrugation angle, until the
angle is greater than 45 degrees. Besides, the pumping pressure of the
micromixer increases with the increase of the corrugation angle
monotonically. Therefore, we would suggest setting the corrugation
angle of the wavy sidewalls to be 45 degrees.
Abstract: Coronary artery bypass grafts (CABG) are widely
studied with respect to hemodynamic conditions which play
important role in presence of a restenosis. However, papers which
concern with constitutive modeling of CABG are lacking in the
literature. The purpose of this study is to find a constitutive model for
CABG tissue. A sample of the CABG obtained within an autopsy
underwent an inflation–extension test. Displacements were
recoredered by CCD cameras and subsequently evaluated by digital
image correlation. Pressure – radius and axial force – elongation
data were used to fit material model. The tissue was modeled as onelayered
composite reinforced by two families of helical fibers. The
material is assumed to be locally orthotropic, nonlinear,
incompressible and hyperelastic. Material parameters are estimated
for two strain energy functions (SEF). The first is classical
exponential. The second SEF is logarithmic which allows
interpretation by means of limiting (finite) strain extensibility.
Presented material parameters are estimated by optimization based
on radial and axial equilibrium equation in a thick-walled tube. Both
material models fit experimental data successfully. The exponential
model fits significantly better relationship between axial force and
axial strain than logarithmic one.
Abstract: This paper deals with the helical flow of a Newtonian
fluid in an infinite circular cylinder, due to both longitudinal and
rotational shear stress. The velocity field and the resulting shear
stress are determined by means of the Laplace and finite Hankel
transforms and satisfy all imposed initial and boundary conditions.
For large times, these solutions reduce to the well-known steady-state
solutions.
Abstract: To unveil the mechanism of fast autooxidation of fish
myoglobins, the effect of temperature on the structural change of tuna
myoglobin was investigated. Purified myoglobin was subjected to
preincubation at 5, 20, 50 and 40oC. Overall helical structural decay
through thermal treatment up to 95oC was monitored by circular
dichroism spectrometry, while the structural changes around the heme
pocket was measured by ultraviolet/visible absorption spectrophotometry.
As a result, no essential structural change of myoglobin
was observed under 30oC, roughly equivalent to their body
temperature, but the structure was clearly damaged at 40oC. The Soret
band absorption hardly differed irrespective of preincubation
temperature, suggesting that the structure around the heme pocket was
not perturbed even after thermal treatment.
Abstract: This paper demonstrates the feasibility of replacing
the metal coil spring with the composite coil spring. Three different
types of springs were made using glass fiber, carbon fiber and
combination of glass fiber and carbon fiber. The objective of the
study is to reduce the weight of the spring. According to the
experimental results the spring rate of the carbon fiber spring is
34% more than the glass fiber spring and 45% more than the glass
fiber/carbon fiber spring. The weight of the carbon fiber spring is
18% less than the glass fiber spring, 15% less than the Glass
fiber/carbon fiber spring and 80% less than the steel spring.
Abstract: Helical milling operations are used to generate or
enlarge boreholes by means of a milling tool. The bore diameter can be
adjusted through the diameter of the helical path. The kinematics of
helical milling on a three axis machine tool is analysed firstly. The
relationships between processing parameters, cutting tool geometry
characters with machined hole feature are formulated. The feed motion
of the cutting tool has been decomposed to plane circular feed and
axial linear motion. In this paper, the time varying cutting forces acted
on the side cutting edges and end cutting edges of the flat end cylinder
miller is analysed using a discrete method separately. These two
components then are combined to produce the cutting force model
considering the complicated interaction between the cutters and
workpiece. The time varying cutting force model describes the
instantaneous cutting force during processing. This model could be
used to predict cutting force, calculate statics deflection of cutter and
workpiece, and also could be the foundation of dynamics model and
predicting chatter limitation of the helical milling operations.