Abstract: A reliable, real-time, and non-invasive system that can identify patients at risk for hemodynamic instability is needed to aid clinicians in their efforts to anticipate patient deterioration and initiate early interventions. The purpose of this pilot study was to explore the clinical capabilities of a real-time analytic from a single lead of an electrocardiograph to correctly distinguish between rapid response team (RRT) activations due to hemodynamic (H-RRT) and non-hemodynamic (NH-RRT) causes, as well as predict H-RRT cases with actionable lead times. The study consisted of a single center, retrospective cohort of 21 patients with RRT activations from step-down and telemetry units. Through electronic health record review and blinded to the analytic’s output, each patient was categorized by clinicians into H-RRT and NH-RRT cases. The analytic output and the categorization were compared. The prediction lead time prior to the RRT call was calculated. The analytic correctly distinguished between H-RRT and NH-RRT cases with 100% accuracy, demonstrating 100% positive and negative predictive values, and 100% sensitivity and specificity. In H-RRT cases, the analytic detected hemodynamic deterioration with a median lead time of 9.5 hours prior to the RRT call (range 14 minutes to 52 hours). The study demonstrates that an electrocardiogram (ECG) based analytic has the potential for providing clinical decision and monitoring support for caregivers to identify at risk patients within a clinically relevant timeframe allowing for increased vigilance and early interventional support to reduce the chances of continued patient deterioration.
Abstract: The problem of nonlinear oscillations of a two-layer liquid completely filling a limited volume is considered. Using two basic asymmetric harmonics excited in two mutually perpendicular planes, ordinary differential equations of nonlinear oscillations of the interface of a two-layer liquid are investigated. In this paper, hydrodynamic coefficients of linear and nonlinear problems in integral relations were determined. As a result, the instability regions of forced oscillations of a two-layered liquid in a cylindrical tank occurring in the plane of action of the disturbing force are constructed, as well as the dynamic instability regions of the parametric resonance for different ratios of densities of the upper and lower liquids depending on the amplitudes of liquids from the excitations frequencies. Steady-state regimes of fluid motion were found in the regions of dynamic instability of the initial oscillation form. The Bubnov-Galerkin method is used to construct instability regions for approximate solution of nonlinear differential equations.
Abstract: Predicting the collapse potential of a structure during
earthquakes is an important issue in earthquake engineering. Many
researchers proposed different methods to assess the collapse
potential of structures under the effect of strong ground motions.
However most of them did not consider degradation and softening
effect in hysteretic behavior. In this study, collapse potential of
SDOF systems caused by dynamic instability with stiffness and
strength degradation has been investigated. An equation was
proposed for the estimation of collapse period of SDOF system which
is a limit value of period for dynamic instability. If period of the
considered SDOF system is shorter than the collapse period then the
relevant system exhibits dynamic instability and collapse occurs.
Abstract: In this study the instability problem of a modified
Taylor-Couette flow between two vertical coaxial cylinders of radius
R1, R2 is considered. The modification is based on the wavy shape of
the inner cylinder surface, where inner cylinders with different
surface amplitude and wavelength are used. The study aims to
discover the effect of the inner surface geometry on the instability
phenomenon that undergoes Taylor-Couette flow. The study reveals
that the transition processes depends strongly on the amplitude and
wavelength of the inner cylinder surface and resulting in flow
instabilities that are strongly different from that encountered in the
case of the classical Taylor-Couette flow.
Abstract: The three-dimensional incompressible flow past a
rectangular open cavity is investigated, where the aspect ratio of the
cavity is considered as 4. The principle objective is to use large-eddy
simulation to resolve and control the large-scale structures, which are
largely responsible for flow oscillations in a cavity. The flow past an
open cavity is very common in aerospace applications and can be a
cause of acoustic source due to hydrodynamic instability of the shear
layer and its interactions with the downstream edge. The unsteady
Navier-stokes equations have been solved on a staggered mesh using
a symmetry-preserving central difference scheme. Synthetic jet has
been used as an active control to suppress the cavity oscillations in
wake mode for a Reynolds number of ReD = 3360. The effect of
synthetic jet has been studied by varying the jet amplitude and
frequency, which is placed at the upstream wall of the cavity. The
study indicates that there exits a frequency band, which is larger than
a critical value, is effective in attenuating cavity oscillations when
blowing ratio is more than 1.0.
Abstract: The integral form of equations of motion of composite
beams subjected to varying time loads are discretized using a
developed finite element model. The model consists of a straight five
node twenty-two degrees of freedom beam element. The stability
analysis of the beams is studied by solving the matrix form
characteristic equations of the system. The principle of virtual work
and the first order shear deformation theory are employed to analyze
the beams with large deformation and small strains. The regions of
dynamic instability of the beam are determined by solving the
obtained Mathieu form of differential equations. The effects of nonconservative
loads, shear stiffness, and damping parameters on
stability and response of the beams are examined. Several numerical
calculations are presented to compare the results with data reported
by other researchers.
Abstract: We study dynamic instability in high-rise steel moment
resisting frames (SMRFs) subjected to synthetic long-period ground
motions caused by hypothetical huge subduction earthquakes. Since
long duration as well as long dominant periods is a characteristic of
long-period ground motions, interstory drifts may enter the negative
postyield stiffness range many times when high-rise buildings are
subjected to long-period ground motions. Through the case studies of
9 high-rise SMRFs designed in accordance with the Japanese design
practice in 1980s, we demonstrate that drifting, or accumulation of
interstory drifts in one direction, occurs at the lower stories of the
SMRFs, if their natural periods are close to the dominant periods of the
long-period ground motions. The drifting led to residual interstory
drift ratio over 0.01, or to collapse if the design base shear was small.