Abstract: The lack of Information and Communication Technologies (ICT) infrastructure in African countries is hampering the successful adoption, development and implementation of e-government in Africa. Electronic government is the use of ICTs to modernize government public administration processes and to provide government services to citizens with a purpose to enhance efficiency, accountability, and transparency in government’s interaction with the citizenry. ICT application in public administration has the potential to modernize and create smarter government and improvement in public service delivery. China’s Internet Plus policy and One Belt One Road strategy present a golden opportunity for countries in Africa to attract the huge financial investment through Chinese IT companies to develop and close Africa’s ICT infrastructure gap. This study recommends the establishment of One Belt One Road ICT Infrastructure Fund for Africa (OBOR ICT Fund for Africa) to enable countries in Africa to source solely for the purpose of ICT infrastructure development in the public sector/government machinery which would in turn promote the adoption and development of e-government in the public sectors of respective countries in Africa.
Abstract: A torsional piezoelectric ultrasonic transducer design
is proposed to measure shear moduli in soft tissue with direct
access availability, using shear wave elastography technique. The
measurement of shear moduli of tissues is a challenging problem,
mainly derived from a) the difficulty of isolating a pure shear wave,
given the interference of multiple waves of different types (P, S,
even guided) emitted by the transducers and reflected in geometric
boundaries, and b) the highly attenuating nature of soft tissular
materials. An immediate application, overcoming these drawbacks,
is the measurement of changes in cervix stiffness to estimate the
gestational age at delivery. The design has been optimized using
a finite element model (FEM) and a semi-analytical estimator of
the probability of detection (POD) to determine a suitable geometry,
materials and generated waves. The technique is based on the time
of flight measurement between emitter and receiver, to infer shear
wave velocity. Current research is centered in prototype testing and
validation. The geometric optimization of the transducer was able
to annihilate the compressional wave emission, generating a quite
pure shear torsional wave. Currently, mechanical and electromagnetic
coupling between emitter and receiver signals are being the research
focus. Conclusions: the design overcomes the main described
problems. The almost pure shear torsional wave along with the short
time of flight avoids the possibility of multiple wave interference.
This short propagation distance reduce the effect of attenuation, and
allow the emission of very low energies assuring a good biological
security for human use.
Abstract: This study aimed to analyse the pregnancy outcomes in patients with TPO positivity after appropriate L-Thyroxin supplementation with close surveillance. All pregnant women attending the antenatal clinic at Milann-The Fertility Center, Bangalore, India- from Aug 2013 to Oct 2014 whose booking TSH was more than 2.5 mIU/L were included along with those pregnant women with prior hypothyroidism who were TPO positive. Those with TPO positive status were vigorously managed with appropriate thyroxin supplementation and the doses were readjusted every 3 to 4 weeks until delivery. Women with recurrent pregnancy loss were also tested for TPO positivity and if tested positive, were monitored serially with TSH and fT4 levels every 3 to 4 weeks and appropriately supplemented with thyroxin when the levels fluctuated. The testing was done after an informed consent in all these women. The statistical software namely SAS 9.2, SPSS 15.0, Stata 10.1, MedCalc 9.0.1, Systat 12.0 and R environment ver.2.11.1 were used for the analysis of the data. 460 pregnant women were screened for thyroid dysfunction at booking of which 52% were hypothyroid. Majority of them (31.08%) were subclinically hypothyroid and the remaining were overt. 25% of the total no. of patients screened were TPO positive. The various pregnancy complications that were observed in the TPO positive women were gestational glucose intolerance [60%], threatened abortion [21%], midtrimester abortion [4.3%], premature rupture of membranes [4.3%], cervical funneling [4.3%] and fetal growth restriction [3.5%]. 95.6% of the patients who followed up till the end delivered beyond 30 weeks. 42.6% of these patients had previous history of recurrent abortions or adverse obstetric outcome and 21.7% of the delivered babies required NICU admission. Obstetric outcomes in our study in terms of midtrimester abortions, placental abruption, and preterm delivery improved for the better after close monitoring of the thyroid hormone [TSH and fT4] levels every 3 to 4 weeks with appropriate dose adjustment throughout pregnancy. Euthyroid women with TPO positive status enrolled in the study incidentally were those with recurrent abortions/infertility and required thyroxin supplements due to elevated Thyroid hormone (TSH, fT4) levels during the course of their pregnancy. Significant associations were found with age>30 years and Hyperhomocysteinemia [p=0.017], recurrent pregnancy loss or previous adverse obstetric outcomes [p=0.067] and APLA [p=0.029]. TPO antibody levels >600 I U/ml were significantly associated with development of gestational hypertension [p=0.041] and fetal growth restriction [p=0.082]. Euthyroid women with TPO positivity were also screened periodically to counter fluctuations of the thyroid hormone levels with appropriate thyroxin supplementation. Thus, early identification along with aggressive management of thyroid dysfunction and stratification of these patients based on their TPO status with appropriate thyroxin supplementation beginning in the first trimester will aid risk modulation and also help avert complications.
Abstract: A retrospective study conducted at Christian Medical
College (CMC) Teaching Hospital, Vellore, India on 14th August
2014 to assess the accuracy of clinically estimated foetal weight upon
labour admission. Estimating foetal weight is a crucial factor in
assessing maternal and foetal complications during and after labour.
Medical notes of ninety-eight postnatal women who fulfilled the
inclusion criteria were studied to evaluate the correlation between
their recorded Estimated Foetal Weight (EFW) on admission and
actual birth weight (ABW) of the newborn after delivery. Data
concerning maternal and foetal demographics was also noted.
Accuracy was determined by absolute percentage error and
proportion of estimates within 10% of ABW. Actual birth weights
ranged from 950-4080g. A strong positive correlation between EFW
and ABW (r=0.904) was noted. Term deliveries (≥40 weeks) in the
normal weight range (2500-4000g) had a 59.5% estimation accuracy
(n=74) compared to pre-term (4000g) were underestimated by 25% (n=3) and low birthweight
(LBW) babies were overestimated by 12.7% (n=9). Registrars who
estimated foetal weight were accurate in babies within normal weight
ranges. However, there needs to be an improvement in predicting
weight of macrosomic and LBW foetuses. We have suggested the use
of an amended version of the Johnson’s formula for the Indian
population for improvement and a need to re-audit once
implemented.
Abstract: Background: To improve the delivery of paediatric
healthcare in low resource settings, Community Health Workers
(CHW) have been provided with a paper-based set of protocols
known as Community Case Management (CCM). Yet research has
shown that CHW adherence to CCM guidelines is poor, ultimately
impacting health service delivery. Digitising the CCM guidelines via
mobile technology is argued in extant literature to improve CHW
adherence. However, little research exist which outlines how (a) this
process can be digitised and (b) adherence could be improved as a
result. Aim: To explore how an electronic mobile version of CCM
(eCCM) can overcome issues associated with the paper-based CCM
protocol (inadequate adherence to guidelines) vis-à-vis service
blueprinting. This service blueprint will outline how (a) the CCM
process can be digitised using mobile Clinical Decision Support
Systems software to support clinical decision-making and (b)
adherence can be improved as a result. Method: Development of a
single service blueprint for a standalone application which visually
depicts the service processes (eCCM) when supporting the CHWs,
using an application known as Supporting LIFE (SL eCCM app) as
an exemplar. Results: A service blueprint is developed which
illustrates how the SL eCCM app can be utilised by CHWs to assist
with the delivery of healthcare services to children. Leveraging
smartphone technologies can (a) provide CHWs with just-in-time
data to assist with their decision making at the point-of-care and (b)
improve CHW adherence to CCM guidelines. Conclusions: The
development of the eCCM opens up opportunities for the CHWs to
leverage the inherent benefit of mobile devices to assist them with
health service delivery in rural settings. To ensure that benefits are
achieved, it is imperative to comprehend the functionality and form
of the eCCM service process. By creating such a service blueprint for
an eCCM approach, CHWs are provided with a clear picture
regarding the role of the eCCM solution, often resulting in buy-in
from the end-users.
Abstract: This research was conducted in an automotive company in Indonesia to overcome the problem of high logistics cost. The problem causes high of additional truck delivery. From the breakdown of the problem, chosen one route, which has the highest gap value, namely for RE-04. Research methodology will be started from calculating the ideal condition, making simulation, calculating the ideal logistic cost, and proposing an improvement. From the calculation of the ideal condition, box arrangement was done on the truck has efficiency with three trucks delivery per day. Route simulation making uses Tecnomatix Plant Simulation software as a visualization for the company about how the system is occurred on route RE-04 in ideal condition. The last step is proposing improvements on the area of route RE-04. The route arrangement is done by Saving Method and sequence of each supplier with the Nearest Neighbor. The results of the proposed improvements are three new route groups, where was expected to decrease logistics cost and increase the average of the truck efficiency per day.
Abstract: In many countries, governments have been promoting the involvement of private sector entities to enter into long-term agreements for the development and delivery of large infrastructure projects, with a focus on overcoming the limitations upon public fund of the traditional approach. The involvement of private sector through public private partnerships (PPP) brings in new capital investments, value for money and additional risks to handle. Worldwide research studies have shown that an objective, systematic, reliable and useroriented risk assessment process and an optimal allocation mechanism among different stakeholders is crucial to the successful completion. In this framework, this paper, which is the first stage of a research study, aims to identify the main risks for the delivery of PPP projects. A review of cross-countries research projects and case studies was performed to map the key risks affecting PPP infrastructure delivery. The matrix of mapping offers a summary of the frequency of factors, clustered in eleven categories: construction, design, economic, legal, market, natural, operation, political, project finance, project selection and relationship. Results will highlight the most critical risk factors, and will hopefully assist the project managers in directing the managerial attention in the further stages of risk allocation.
Abstract: Lead time is a critical measure of a supply chain's
performance. It impacts both the customer satisfactions as well as the
total cost of inventory. This paper presents the result of a study on the
analysis of the customer order lead-time for a multinational company.
In the study, the lead time was divided into three stages respectively:
order entry, order fulfillment, and order delivery. A sample of size 2,425 order lines was extracted from the
company's records to use for this study. The sample data entails
information regarding customer orders from the time of order entry
until order delivery. Data regarding the lead time of each stage for
different orders were also provided. Summary statistics on lead time
data reveals that about 30% of the orders were delivered later than the
scheduled due date. The result of the multiple linear regression
analysis technique revealed that component type, logistics parameter,
order size and the customer type have significant impacts on lead
time. Data analysis on the stages of lead time indicates that stage 2
consumed over 50% of the lead time. Pareto analysis was made to
study the reasons for the customer order delay in each stage.
Recommendation was given to resolve the problem.
Abstract: There have been rigorous research and development
of unmanned aerial vehicles in the field of search and rescue (SAR)
operation recently. UAVs reduce unnecessary human risks while
assisting rescue efforts through aerial imagery, topographic mapping
and emergency delivery. The application of UAVs in offshore and
nearshore marine SAR missions is discussed in this paper. Projects
that integrate UAV technology into their systems are introduced to
highlight the great advantages and capabilities of UAVs. Scenarios
where UAVs could provide invaluable assistance are also suggested.
Abstract: Due to today’s globalization as well as outsourcing
practices of the companies, the Supply Chain (SC) performances
have become more dependent on the efficient movement of material
among places that are geographically dispersed, where there is more
chance for disruptions. One such disruption is the quality and
delivery uncertainties of outsourcing. These uncertainties could lead
the products to be unsafe and, as is the case in a number of recent
examples, companies may have to end up in recalling their products.
As a result of these problems, there is a need to develop a
methodology for selecting suppliers globally in view of risks
associated with low quality and late delivery. Accordingly, we
developed a two-stage stochastic model that captures the risks
associated with uncertainty in quality and delivery as well as a
solution procedure for the model. The stochastic model developed
simultaneously optimizes supplier selection and purchase quantities
under price discounts over a time horizon. In particular, our target is
the study of global organizations with multiple sites and multiple
overseas suppliers, where the pricing is offered in suppliers’ local
currencies. Our proposed methodology is applied to a case study for a
US automotive company having two assembly plants and four
potential global suppliers to illustrate how the proposed model works
in practice.
Abstract: A sensory network consists of multiple detection
locations called sensor nodes, each of which is tiny, featherweight
and portable. A single path routing protocols in wireless sensor
network can lead to holes in the network, since only the nodes
present in the single path is used for the data transmission. Apart
from the advantages like reduced computation, complexity and
resource utilization, there are some drawbacks like throughput,
increased traffic load and delay in data delivery. Therefore, multipath
routing protocols are preferred for WSN. Distributing the traffic
among multiple paths increases the network lifetime. We propose a
scheme, for the data to be transmitted through a dominant path to
save energy. In order to obtain a high delivery ratio, a basic route
reconstruction protocol is utilized to reconstruct the path whenever a
failure is detected. A basic reconstruction routing (BRR) algorithm is
proposed, in which a node can leap over path failure by using the
already existing routing information from its neighbourhood while
the composed data is transmitted from the source to the sink. In order
to save the energy and attain high data delivery ratio, data is
transmitted along a multiple path, which is achieved by BRR
algorithm whenever a failure is detected. Further, the analysis of
how the proposed protocol overcomes the drawback of the existing
protocols is presented. The performance of our protocol is compared
to AOMDV and energy efficient node-disjoint multipath routing
protocol (EENDMRP). The system is implemented using NS-2.34.
The simulation results show that the proposed protocol has high
delivery ratio with low energy consumption.
Abstract: The paper tackles the topic of determining the cost of
innovation in software development projects. Innovation can be
achieved either in a planned or unplanned manner. The paper
approaches the scenarios were innovation is planned for. As a starting
point an innovative software development project is analyzed. The
project is depicted step by step as it was implemented, from inception
to delivery. Costs that are proprietary to innovation in software
development are isolated based on the author’s personal experience
in managing the above mentioned project. Innovation costs
components identified by the author are then validated using open
discussions with software development professionals and projects
managers on LinkedIn groups. In order to receive relevant feedback
only groups that focus on software development and innovation
management are targeted. Additional innovation cost components
suggested by software development professionals and projects
managers are also considered. Based on the identified cost
components an indicator is built. The indicator is meant to formalize
the process of determining the cost of innovation in a software
development project. The indicator aggregates all the innovation cost
components that are identified in the research process. The process of
calculating each cost component is also described. Conclusions are
formulated and new related research topics are submitted for debate.
Abstract: In this investigation, we have evaluated the effects of
arsenic trioxide on hepatic function in pregnant and lactating Swiss
albino mice and their suckling pups. Experiments were carried out on
female mice given 175 ppm As2O3 in their drinking water from the
14th day of pregnancy until day 14 after delivery. Our results showed
a significant decrease in plasma levels of total protein and albumin,
cholesterol and triglyceride in As2O3 treated mice and their pups. The
hyperbilirubinemia and the increased plasma total alkaline
phosphatase activity suggested the presence of cholestasis.
Transaminase activities as well as lactate deshydrogenase activity in
plasma, known as biomarkers of hepatocellular injury, were elevated
indicating hepatic cells’ damage after treatment with As2O3.
Exposure to arsenic led to an increase of liver thiobarbituric acid
reactive substances level along with a concomitant decrease in the
activities of superoxide dismutase, catalase and glutathione
peroxidase and in glutathione.
Abstract: Liposome plays an important role in medical and
pharmaceutical science as e.g. nano scale drug carriers. Liposomes
are vesicles of varying size consisting of a spherical lipid bilayer and
an aqueous inner compartment. Magnet-driven liposome used for the
targeted delivery of drugs to organs and tissues. These liposome
preparations contain encapsulated drug components and finely
dispersed magnetic particles.
Liposomes are vesicles of varying size consisting of a spherical
lipid bilayer and an aqueous inner compartment that are generated in
vitro. These are useful in terms of biocompatibility, biodegradability,
and low toxicity, and can control biodistribution by changing the size,
lipid composition, and physical characteristics. Furthermore,
liposomes can entrap both hydrophobic and hydrophilic drugs and are
able to continuously release the entrapped substrate, thus being useful
drug carriers. Magnetic liposomes (MLs) are phospholipid vesicles
that encapsulate magneticor paramagnetic nanoparticles. They are
applied as contrast agents for magnetic resonance imaging (MRI).
The biological synthesis of nanoparticles using plant extracts plays
an important role in the field of nanotechnology. Green-synthesized
magnetite nanoparticles-protein hybrid has been produced by treating
Iron (III) / Iron (II) chloride with the leaf extract of Datura inoxia.
The phytochemicals present in the leaf extracts act as a reducing as
well stabilizing agents preventing agglomeration, which include
flavonoids, phenolic compounds, cardiac glycosides, proteins and
sugars.
The magnetite nanoparticles-protein hybrid has been trapped
inside the aqueous core of the liposome prepared by reversed phase
evaporation (REV) method using oleic and linoleic acid which has
been shown to be driven under magnetic field confirming the
formation magnetic liposome (ML). Chemical characterization of
stealth magnetic liposome has been performed by breaking the
liposome and release of magnetic nanoparticles. The presence iron
has been confirmed by colour complex formation with KSCN and
UV-Vis study using spectrophotometer Cary 60, Agilent.
This magnet driven liposome using nanoparticles-protein hybrid
can be a smart vesicles for the targeted drug delivery.
Abstract: The focal aspire of e-Government (eGovt) is to offer
citizen-centered service delivery. Accordingly, the citizenry
consumes services from multiple government agencies through
national portal. Thus, eGovt is an enterprise with the primary
business motive of transparent, efficient and effective public services
to its citizenry and its logical structure is the eGovernment Enterprise
Architecture (eGEA). Since eGovt is IT oriented multifaceted
service-centric system, EA doesn’t do much on an automated
enterprise other than the business artifacts. Service-Oriented
Architecture (SOA) manifestation led some governments to pertain
this in their eGovts, but it limits the source of business artifacts. The
concurrent use of EA and SOA in eGovt executes interoperability and
integration and leads to Service-Oriented e-Government Enterprise
(SOeGE). Consequently, agile eGovt system becomes a reality. As an
IT perspective eGovt comprises of centralized public service artifacts
with the existing application logics belong to various departments at
central, state and local level. The eGovt is renovating to SOeGE by
apply the Service-Orientation (SO) principles in the entire system.
This paper explores IT perspective of SOeGE in India which
encompasses the public service models and illustrated with a case
study the Passport service of India.
Abstract: Solid lipid nanoparticles (SLNs) have gained great attention for the topical treatment of skin associated fungal infection as they facilitate the skin penetration of loaded drugs. Our work deals with the preparation of nystatin loaded solid lipid nanoparticles (NystSLNs) using the hot homogenization and ultrasonication method. The prepared NystSLNs were characterized in terms of entrapment efficiency, particle size, zeta potential, transmission electron microscopy, differential scanning calorimetry, rheological behavior and in vitro drug release. A stability study for 6 months was performed. A microbiological study was conducted in male rats infected with Candida albicans, by counting the colonies and examining the histopathological changes induced on the skin of infected rats. The results showed that SLNs dispersions are spherical in shape with particle size ranging from 83.26±11.33 to 955.04±1.09 nm. The entrapment efficiencies are ranging from 19.73±1.21 to 72.46±0.66% with zeta potential ranging from -18.9 to -38.8 mV and shear-thinning rheological Behavior. The stability studies done for 6 months showed that nystatin (Nyst) is a good candidate for topical SLN formulations. A least number of colony forming unit/ ml (cfu/ml) was recorded for the selected NystSLN compared to the drug solution and the commercial Nystatin® cream present in the market. It can be fulfilled from this work that SLNs provide a good skin targeting effect and may represent promising carrier for topical delivery of Nyst offering the sustained release and maintaining the localized effect, resulting in an effective treatment of cutaneous fungal infection.
Abstract: Although urbanization in Africa has been characterized by fragile socio-economic successes, the sustainability of city infrastructure is now central to planning processes as a pathway to closing the deficit in terms of coverage and access. This paper builds on survey and interview data from Kampala city, to demonstrate how the principle gender responsiveness can inform improvements in urban infrastructure and service delivery. We discovered that women prefer infrastructure that combines living and working spaces for reduced labour and travel burdens between homes, markets, schools, and other urban spaces. Men’s conception of infrastructure needs on the other hand, mirrored public security and connectivity concerns along city streets and work places. However, the urban planning approach at city-level is guided by mainstream engineering and architectural designs that do not necessarily reflect the social context within which urban infrastructure influences gender roles and the attendant mobility needs. To address the challenge across cities of similar context, the paper concludes with a set of analytic steps on how the gendered influences on infrastructure-use can be considered in urban planning cycles.
Abstract: Disaster preparedness is a key success factor for any effective disaster management practices. This paper evaluates the disaster preparedness and management in Saudi Arabia using an empirical investigation approach. It presents the results of the survey conducted by interviewing representatives of the Saudi decision-makers and administrators responsible for disaster control in Jeddah before, during and after flooding in 2009 and 2010. First, demographics of the respondents are presented, followed by quantitative analysis of their views and experiences regarding the Kingdom’s readiness before and after each flood. This is shown as a series of dependent and independent variables. Following this is a list of respondents’ priorities for disaster preparation in the Kingdom.
Abstract: The purpose of this study was to prepare time and pH dependent release tablets of Ayurvedic Churna formulation and evaluate their advantages as colon targeted drug delivery system. The Vidangadi Churna was selected for this study which contains Embelin and Gallic acid. Embelin is used in Helminthiasis as therapeutic agent. Embelin is insoluble in water and unstable in gastric environment so it was formulated in time and pH dependent tablets coated with combination of two polymers Eudragit L100 and ethyl cellulose. The 150mg of core tablet of dried extract and lactose were prepared by wet granulation method. The compression coating was used in the polymer concentration of 150mg for both the layer as upper and lower coating tablet was investigated. The results showed that no release was found in 0.1 N HCl and pH 6.8 phosphate buffers for initial 5 hours and about 98.97% of the drug was released in pH 7.4 phosphate buffer in total 17 Hours. The in vitro release profiles of drug from the formulation could be best expressed first order kinetics as highest linearity (r2= 0.9943). The results of the present study have demonstrated that the time and pH dependent tablets system is a promising vehicle for preventing rapid hydrolysis in gastric environment and improving oral bioavailability of Embelin and Gallic acid for treatment of Helminthiasis.
Abstract: Novel solid lipid nanoparticles (SLNs) were developed to improve oral bioavailability of oxyresveratrol (OXY). The SLNs were prepared by a high speed homogenization technique, at an effective speed and time, using Compritol® 888 ATO (5% w/w) as the solid lipid. The appropriate weight proportions (0.3% w/w) of OXY affected the physicochemical properties of blank SLNs. The effects of surfactant types on the properties of the formulations such as particle size and entrapment efficacy were also investigated. Conclusively, Tween 80 combined with soy lecithin was the most appropriate surfactant to stabilize OXY-loaded SLNs. The mean particle size of the optimized formulation was 134.40 ± 0.57 nm. In vitro drug release study, the selected S2 formulation showed a retarded release profile for OXY with no initial burst release compared to OXY suspension in the simulated gastrointestinal fluids. Therefore, these SLNs could provide a suitable system to develop for the oral OXY delivery.