Abstract: The concept of myocardial injury, although first recognized from animal studies, is now recognized as a clinical phenomenon that may result in microvascular damage, no-reflow phenomenon, myocardial stunning, myocardial hibernation and ischemic preconditioning. The final consequence of this event is left ventricular (LV) systolic dysfunction leading to increased morbidity and mortality. The typical clinical case of reperfusion injury occurs in acute myocardial infarction (MI) with ST segment elevation in which an occlusion of a major epicardial coronary artery is followed by recanalization of the artery. This may occur spontaneously or by means of thrombolysis and/or by primary percutaneous coronary intervention (PCI) with efficient platelet inhibition by aspirin (acetylsalicylic acid), clopidogrel and glycoprotein IIb/IIIa inhibitors. In recent years, percutaneous coronary intervention (PCI) has become a well-established technique for the treatment of coronary artery disease. PCI improves symptoms in patients with coronary artery disease and it has been increasing safety of procedures. However, peri- and post-procedural myocardial injury, including angiographical slow coronary flow, microvascular embolization, and elevated levels of cardiac enzyme, such as creatine kinase and troponin-T and -I, has also been reported even in elective cases. Furthermore, myocardial reperfusion injury at the beginning of myocardial reperfusion, which causes tissue damage and cardiac dysfunction, may occur in cases of acute coronary syndrome. Because patients with myocardial injury is related to larger myocardial infarction and have a worse long-term prognosis than those without myocardial injury, it is important to prevent myocardial injury during and/or after PCI in patients with coronary artery disease. To date, many studies have demonstrated that adjunctive pharmacological treatment suppresses myocardial injury and increases coronary blood flow during PCI procedures. In this review, we highlight the usefulness of pharmacological treatment in combination with PCI in attenuating myocardial injury in patients with coronary artery disease.
Abstract: Full search block matching algorithm is widely used for hardware implementation of motion estimators in video compression algorithms. In this paper we are proposing a new architecture, which consists of a 2D parallel processing unit and a 1D unit both working in parallel. The proposed architecture reduces both data access power and computational power which are the main causes of power consumption in integer motion estimation. It also completes the operations with nearly the same number of clock cycles as compared to a 2D systolic array architecture. In this work sum of absolute difference (SAD)-the most repeated operation in block matching, is calculated in two steps. The first step is to calculate the SAD for alternate rows by a 2D parallel unit. If the SAD calculated by the parallel unit is less than the stored minimum SAD, the SAD of the remaining rows is calculated by the 1D unit. Early termination, which stops avoidable computations has been achieved with the help of alternate rows method proposed in this paper and by finding a low initial SAD value based on motion vector prediction. Data reuse has been applied to the reference blocks in the same search area which significantly reduced the memory access.
Abstract: This study was designed to investigate the role of serum nitric oxide and sialic acid in the development of diabetic nephropathy as disease marker. Total 210 diabetic patients (age and sex matched) were selected followed by informed consent and divided into four groups (70 each) as I: control; II: diabetic; III: diabetic hypertensive; IV: diabetic nephropathy. The blood samples of all subjects were collected and analyzed for serum nitric oxide, sialic acid, fasting blood glucose, serum urea, creatinine, HbA1c and GFR. The BMI, systolic and diastolic blood pressures, blood glucose, HbA1c and serum sialic acid levels were high (p
Abstract: In this paper, algorithm estimating the blood pressure
was proposed using the pulse transit time (PTT) as a more convenient
method of measuring the blood pressure. After measuring ECG and
pressure pulse, and photoplethysmography, the PTT was calculated
from the acquired signals. Thereafter, the system to indirectly measure
the systolic pressure and the diastolic pressure was composed using
the statistic method. In comparison between the blood pressure
indirectly measured by proposed algorithm estimating the blood
pressure and real blood pressure measured by conventional
sphygmomanometer, the systolic pressure indicates the mean error of
±3.24mmHg and the standard deviation of 2.53mmHg, while the
diastolic pressure indicates the satisfactory result, that is, the mean
error of ±1.80mmHg and the standard deviation of 1.39mmHg. These
results are satisfied with the regulation of ANSI/AAMI for
certification of sphygmomanometer that real measurement error value
should be within the mean error of ±5mmHg and the standard
deviation of 8mmHg. These results are suggest the possibility of
applying to portable and long time blood pressure monitoring system
hereafter.
Abstract: A analysis on the conventional the blood pressure estimation method using an oscillometric sphygmomanometer was
performed through a computer simulation using an arterial pressure-volume (APV) model. Traditionally, the maximum amplitude algorithm (MAP) was applied on the oscillation waveforms of the APV model to obtain the mean arterial pressure and the characteristic ratio. The estimation of mean arterial pressure and
characteristic ratio was significantly affected with the shape of the blood pressure waveforms and the cutoff frequency of high-pass filter
(HPL) circuitry. Experimental errors are due to these effects when estimating blood pressure. To find out an algorithm independent from
the influence of waveform shapes and parameters of HPL, the volume
oscillation of the APV model and the phase shift of the oscillation with fast fourier transform (FFT) were testified while increasing the cuff
pressure from 1 mmHg to 200 mmHg (1 mmHg per second). The phase shift between the ranges of volume oscillation was then only observed between the systolic and the diastolic blood pressures. The same results were also obtained from the simulations performed on two different the arterial blood pressure waveforms and one
hyperthermia waveform.
Abstract: In this paper, we propose a new architecture for the implementation of the N-point Fast Fourier Transform (FFT), based on the Radix-2 Decimation in Frequency algorithm. This architecture is based on a pipeline circuit that can process a stream of samples and produce two FFT transform samples every clock cycle. Compared to existing implementations the architecture proposed achieves double processing speed using the same circuit complexity.
Abstract: Recently, the health of retired National Football
League players, particularly lineman has been investigated. A
number of studies have reported increased cardiometabolic risk,
premature cardiovascular disease and incidence of type 2 diabetes.
Rugby union players have somatotypes very similar to National
Football League players which suggests that rugby players may have
similar health risks. The International Golden Oldies World Rugby
Festival (GORF) provided a unique opportunity to investigate the
demographics of veteran rugby players. METHODOLOGIES: A
cross-sectional, observational study was completed using an online
web-based questionnaire that consisted of medical history and
physiological measures. Data analysis was completed using a one
sample t-test (50yrs) and Chi-square test. RESULTS:
A total of 216 veteran rugby competitors (response rate = 6.8%)
representing 10 countries, aged 35-72 yrs (mean 51.2, S.D. ±8.0),
participated in the online survey. As a group, the incidence of current
smokers was low at 8.8% (avg 72.4 cigs/wk) whilst the percentage
consuming alcohol was high (93.1% (avg 11.2 drinks/wk).
Competitors reported the following top six chronic
diseases/disorders; hypertension (18.6%), arthritis (OA/RA, 11.5%),
asthma (9.3%), hyperlipidemia (8.2%), diabetes (all types, 7.5%) and
gout (6%), there were significant differences between groups with
regard to cancer (all types) and migraines. When compared to the
Australian general population (Australian Bureau of Statistics data,
n=18,000), GORF competitors had a significantly lower incidence of
anxiety (p
Abstract: En bloc assumes modeling all phases of the orthostatic test with the only one mathematical model, which allows the complex parametric view of orthostatic response. The work presents the implementation of a mathematical model for processing of the measurements of systolic, diastolic blood pressure and heart rate performed on volunteers during orthostatic test. The original assumption of model hypothesis that every postural change means only one Stressor, did not complying with the measurements of physiological circulation factor-time profiles. Results of the identification support the hypothesis that second postural change of orthostatic test causes induced Stressors, with the observation of a physiological regulation mechanism. Maximal demonstrations are on the heart rate and diastolic blood pressure-time profile, minimal are for the measurements of the systolic blood pressure. Presented study gives a new view on orthostatic test with impact on clinical practice.
Abstract: Dilated cardiomyopathy (DCM) is a severe
cardiovascular disorder characterized by progressive systolic
dysfunction due to cardiac chamber dilatation and inefficient
myocardial contractility often leading to chronic heart failure.
Recently, a genome-wide association studies (GWASs) on DCM
indicate that the ZBTB17 gene rs10927875 single nucleotide
polymorphism is associated with DCM. The aim of the study was to
identify the distribution of ZBTB17 gene rs10927875 polymorphism
in 50 Slovak patients with DCM and 80 healthy control subjects
using the Custom Taqman®SNP Genotyping assays. Risk factors
detected at baseline in each group included age, sex, body mass
index, smoking status, diabetes and blood pressure. The mean age of
patients with DCM was 52.9±6.3 years; the mean age of individuals
in control group was 50.3±8.9 years. The distribution of investigated
genotypes of rs10927875 polymorphism within ZBTB17 gene in the
cohort of Slovak patients with DCM was as follows: CC (38.8%), CT
(55.1%), TT (6.1%), in controls: CC (43.8%), CT (51.2%), TT
(5.0%). The risk allele T was more common among the patients with
dilated cardiomyopathy than in normal controls (33.7% versus
30.6%). The differences in genotype or allele frequencies of ZBTB17
gene rs10927875 polymorphism were not statistically significant
(p=0.6908; p=0.6098). The results of this study suggest that ZBTB17
gene rs10927875 polymorphism may be a risk factor for
susceptibility to DCM in Slovak patients with DCM. Studies of
numerous files and additional functional investigations are needed to
fully understand the roles of genetic associations.
Abstract: Human immunodeficiency virus infection and
acquired immunodeficiency syndrome is a global pandemic with
cases reporting from virtually every country and continues to be a
common infection in developing country like India.
Microalbuminuria is a manifestation of human immunodeficiency
virus associated nephropathy. Therefore, microalbuminuria may be
an early marker of human immunodeficiency virus associated
nephropathy, and screening for its presence may be beneficial. A
strikingly high prevalence of microalbuminuria among human
immunodeficiency virus infected patients has been described in
various studies. Risk factors for clinically significant proteinuria
include African - American race, higher human immunodeficiency
virus ribonucleic acid level and lower CD4 lymphocyte count. The
cardiovascular risk factors of increased systolic blood pressure and
increase fasting blood sugar level are strongly associated with
microalbuminuria in human immunodeficiency virus patient. These
results suggest that microalbuminuria may be a sign of current
endothelial dysfunction and micro-vascular disease and there is
substantial risk of future cardiovascular disease events. Positive
contributing factors include early kidney disease such as human
immunodeficiency virus associated nephropathy, a marker of end
organ damage related to co morbidities of diabetes or hypertension,
or more diffuse endothelial cells dysfunction. Nevertheless after
adjustment for non human immunodeficiency virus factors, human
immunodeficiency virus itself is a major risk factor. The presence of
human immunodeficiency virus infection is independent risk to
develop microalbuminuria in human immunodeficiency virus patient.
Cardiovascular risk factors appeared to be stronger predictors of
microalbuminuria than markers of human immunodeficiency virus
severity person with human immunodeficiency virus infection and
microalbuminuria therefore appear to potentially bear the burden of
two separate damage related to known vascular end organ damage
related to know vascular risk factors, and human immunodeficiency
virus specific processes such as the direct viral infection of kidney
cells.The higher prevalence of microalbuminuria among the human
immunodeficiency virus infected could be harbinger of future
increased risks of both kidney and cardiovascular disease. Further
study defining the prognostic significance of microalbuminuria
among human immunodeficiency virus infected persons will be
essential. Microalbuminuria seems to be a predictor of cardiovascular
disease in diabetic and non diabetic subjects, hence it can also be
used for early detection of micro vascular disease in human
immunodeficiency virus positive patients, thus can help to diagnose
the disease at the earliest.
Abstract: Recently, the health of retired National Football
League players, particularly lineman has been investigated. A number of studies have reported increased cardiometabolic risk, premature ardiovascular disease and incidence of type 2 diabetes. Rugby union players have somatotypes very similar
to National Football league players which suggest that rugby players may have similar health risks. The International Golden Oldies World Rugby Festival (GORF) provided a
unique opportunity to investigate the demographics of veteran rugby players. METHODOLOGIES: A cross-sectional, observational study was completed using an online web-based
questionnaire that consisted of medical history and
physiological measures. Data analysis was completed using a one sample t-test (50yrs) and Chi-square test. RESULTS: A total of 216 veteran rugby competitors
(response rate = 6.8%) representing 10 countries, aged 35-72 yrs (mean 51.2, S.D. ±8.0), participated in the online survey. As a group, the incidence of current smokers was low at 8.8%
(avg 72.4 cigs/wk) whilst the percentage consuming alcohol
was high (93.1% (avg 11.2 drinks/wk). Competitors reported
the following top six chronic diseases/disorders; hypertension
(18.6%), arthritis (OA/RA, 11.5%), asthma (9.3%),
hyperlipidemia (8.2%), diabetes (all types, 7.5%) and gout (6%), there were significant differences between groups with
regard to cancer (all types) and migraines. When compared to
the Australian general population (Australian Bureau of Statistics data, n=18,000), GORF competitors had a
Climstein Mike, Walsh Joe (corresponding author) and Burke Stephen
School of Exercise Science, Australian Catholic University, 25A Barker Road,
Strathfield, Sydney, NSW, 2016, Australia (e-mail:
[email protected], [email protected],
[email protected]).
John Best is with Orthosports, 160 Belmore Rd., Randwick, Sydney,NSW
2031, Australia (e-mail: [email protected]).
Heazlewood, Ian Timothy is with School of Environmental and Life
Sciences, Faculty Education, Health and Science, Charles Darwin University,
Precinct Yellow Building 2, Charles Darwin University, NT 0909, Australia
(e-mail: [email protected]).
Kettunen Jyrki Arcada University of Applied Sciences, Jan-Magnus
Janssonin aukio 1, FI-00550, Helsinki, Finland (e-mail:
[email protected]).
Adams Kent is with California State University Monterey Bay, Kinesiology Department, 100 Campus Center, Seaside, CA., 93955, USA (email: [email protected]).
DeBeliso Mark is with Department of Physical Education and Human
Performance, Southern Utah University, 351 West University Blvd, Cedar
City, Utah, USA (e-mail: [email protected]).
significantly lower incidence of anxiety (p
Abstract: Noise has adverse effect on human health and
comfort. Noise not only cause hearing impairment, but it also acts as
a causal factor for stress and raising systolic pressure. Additionally it
can be a causal factor in work accidents, both by marking hazards
and warning signals and by impeding concentration. Industry
workers also suffer psychological and physical stress as well as
hearing loss due to industrial noise. This paper proposes an approach
to enable engineers to point out quantitatively the noisiest source for
modification, while multiple machines are operating simultaneously.
The model with the point source and spherical radiation in a free field
was adopted to formulate the problem. The procedure works very
well in ideal cases (point source and free field). However, most of the
industrial noise problems are complicated by the fact that the noise is
confined in a room. Reflections from the walls, floor, ceiling, and
equipment in a room create a reverberant sound field that alters the
sound wave characteristics from those for the free field. So the model
was validated for relatively low absorption room at NIT Kurukshetra
Central Workshop. The results of validation pointed out that the
estimated sound power of noise sources under simultaneous
conditions were on lower side, within the error limits 3.56 - 6.35 %.
Thus suggesting the use of this methodology for practical
implementation in industry. To demonstrate the application of the
above analytical procedure for estimating the sound power of noise
sources under simultaneous operating conditions, a manufacturing
facility (Railway Workshop at Yamunanagar, India) having five
sound sources (machines) on its workshop floor is considered in this
study. The findings of the case study had identified the two most
effective candidates (noise sources) for noise control in the Railway
Workshop Yamunanagar, India. The study suggests that the
modification in the design and/or replacement of these two identified
noisiest sources (machine) would be necessary so as to achieve an
effective reduction in noise levels. Further, the estimated data allows
engineers to better understand the noise situations of the workplace
and to revise the map when changes occur in noise level due to a
workplace re-layout.
Abstract: In this paper is investigated a possible
optimization of some linear algebra problems which can be
solved by parallel processing using the special arrays called
systolic arrays. In this paper are used some special types of
transformations for the designing of these arrays. We show
the characteristics of these arrays. The main focus is on
discussing the advantages of these arrays in parallel
computation of matrix product, with special approach to the
designing of systolic array for matrix multiplication.
Multiplication of large matrices requires a lot of
computational time and its complexity is O(n3 ). There are
developed many algorithms (both sequential and parallel) with
the purpose of minimizing the time of calculations. Systolic
arrays are good suited for this purpose. In this paper we show
that using an appropriate transformation implicates in finding
more optimal arrays for doing the calculations of this type.
Abstract: Introduction: Obesity is a major health risk issue in
the present day of life for one and all globally. Obesity is one of the
major concerns for public health according to recent increasing trends
in obesity-related diseases such as Type 2 diabetes. ( Kazuya,
1994).and hyperlipidemia, (Sakata,1990) .which are more prevalent
in Japanese adults with body mass index (BMI) values Z25 kg/m2.(
Japanese Ministry of Health and Welfare,1997). The purpose of the
study was to assess the effect of twelve weeks of brisk walking on
blood pressure and body mass index, anthropometric measurements
of obese males. Method: Thirty obese (BMI= above 30) males, aged
18 to 22 years, were selected from King Fahd University of
Petroleum & Minerals, Saudi Arabia. The subject-s height (cm) was
measured using a stadiometer and body mass (kg) was measured with
a electronic weighing machine. BMI was subsequently calculated
(kg/m2). The blood pressure was measured with standardized
sphygmomanometer in mm of Hg. All the measurements were taken
twice before and twice after the experimental period. The pre and
post anthropometric measurements of waist and hip circumference
were measured with the steel tape in cm. The subjects underwent
walking schedule two times in a week for 12 weeks. The 45 minute
sessions of brisk walking were undertaken at an average intensity of
65% to 85% of maximum HR (HRmax; calculated as 220-age).
Results & Discussion: Statistical findings revealed significant
changes from pre test to post test in case of both systolic blood
pressure and diastolic blood pressure in the walking group. Results
also showed significant decrease in their body mass index and
anthropometric measurements i.e. (waist & hip circumference).
Conclusion: It was concluded that twelve weeks brisk walking is
beneficial for lowering of blood pressure, body mass index, and
anthropometric circumference of obese males.
Abstract: Hospitals in southern Hualien teamed with the
Hypertension Joint Care Network. Working with the network, the
team provided a special designed health education to the individual
who had been identified as a hypertension patient in the outpatient
department. Some metabolism improvements achieved. This is a
retrospective study by purposively taking 106 patients from a hospital
between 2008 and 2010. Records of before and after education
intervention of the objects was collected and analyzed to see the how
the intervention affected the patients- hypertension control via clinical
parameter monitoring. The results showed that the clinical indicators,
the LDL-C, the cholesterol and the systolic blood pressure were
significantly improved. The study provides evidence for the
effectiveness of the network in controlling hypertension.