Abstract: Impaired fertility may be the result of indirect
consumption of anti-fertility agents through food. Monosodium
glutamate (MSG) has been widely used as food additive, flavour
enhancer and included in vaccines. This study focuses in determining
the gonadotoxic and cytotoxic effect of MSG on selected sperm
parameters such as sperm viability, sperm membrane integrity and
testes cytoarchitecture of male mice via histological examination to
determine its effect on spermatogenesis. Twenty-four Mus musculus
were randomly divided into 4 groups and given intraperitoneal
injections (IP) daily for 14 days of different MSG concentrations at
250, 500 and 1000mg/kg MSG to body weight to induce obesity.
Saline was given to control group. Mice were sacrificed and analysis
revealed abnormalities in values for sperm parameters and damages
to testes cytoarchitecture of male mice. The results recorded
decreased viability (p0.05) with degenerative structures in seminiferous tubule of
testes. The results indicated various implications of MSG on male
mice reproductive system which has consequences in fertility
potential.
Abstract: In this study, we investigated the effects of ginger and
L-carnitine on the reproductive performance of male rats with respect
to semen parameters, male sex hormones and the testicular
antioxidant system. A total of sixty mature male albino rats were
divided into four groups of fifteen rats. The control group received
saline, whereas the other three groups received ginger (100 mg kg-1 d-
1.), L-carnitine (150 mg kg-1 d-1.) or a combination of both ginger
(100 mg kg-1 d-1.) and L-carnitine (150 mg kg-1 d-1.) via a stomach
tube daily for one month. At the end of the treatment period, the rats
were sacrificed, and their sperm characteristics (count, motility and
viability), antioxidant enzyme factors levels (reduced glutathione,
catalase, superoxide dismutase and total antioxidant capacity) and sex
hormone levels (testosterone, Follicle stimulating hormone(FSH) and
luteinizing hormone (LH) were analysed. Our results showed that the
three experimental treatments improved sperm parameters,
antioxidant enzyme activity and testosterone hormone levels; the
most pronounced positive effects were observed in the group that
received a combination of both ginger and L-carnitine. Therefore, the
administration of a combination of ginger and L-carnitine may be
beneficial for improving male sexual performance.