Abstract: Rarefied gas flows are often occurred in micro electro
mechanical systems and classical CFD could not precisely anticipate
the flow and thermal behavior due to the high Knudsen number.
Therefore, the heat transfer and the fluid dynamics characteristics of
rarefied gas flows in both a two-dimensional simple microchannel
and geometry similar to single Knudsen compressor have been
investigated with a goal of increasing performance of a actual
Knudsen compressor by using a particle simulation method. Thermal
transpiration and thermal creep, which are rarefied gas dynamic
phenomena, that cause movement of the flow from less to higher
temperature is generated by using two different longitude temperature
gradients (Linear, Step) along the walls of the flow microchannel. In
this study the influence of amount of temperature gradient and
governing pressure in various Knudsen numbers and length-to-height
ratios have been examined.
Abstract: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor.
Abstract: An advanced Monte Carlo simulation method, called Subset Simulation (SS) for the time-dependent reliability prediction for underground pipelines has been presented in this paper. The SS can provide better resolution for low failure probability level with efficient investigating of rare failure events which are commonly encountered in pipeline engineering applications. In SS method, random samples leading to progressive failure are generated efficiently and used for computing probabilistic performance by statistical variables. SS gains its efficiency as small probability event as a product of a sequence of intermediate events with larger conditional probabilities. The efficiency of SS has been demonstrated by numerical studies and attention in this work is devoted to scrutinise the robustness of the SS application in pipe reliability assessment. It is hoped that the development work can promote the use of SS tools for uncertainty propagation in the decision-making process of underground pipelines network reliability prediction.
Abstract: This paper presents a new high speed simulation methodology to solve the long simulation time problem of CMOS image sensor matrix. Generally, for integrating the pixel matrix in SOC and simulating the system performance, designers try to model the pixel in various modeling languages such as VHDL-AMS, SystemC or Matlab. We introduce a new alternative method based on spice model in cadence design platform to achieve accuracy and reduce simulation time. The simulation results indicate that the pixel output voltage maximum error is at 0.7812% and time consumption reduces from 2.2 days to 13 minutes achieving about 240X speed-up for the 256x256 pixel matrix.
Abstract: Historic religious buildings located in seismic areas
have developed different failure mechanisms. Simulation of failure
modes is done with computer programs through a nonlinear dynamic
analysis or simplified using the method of failure blocks. Currently
there are simulation methodologies of failure modes based on the
failure rigid blocks method only for Roman Catholic churches type.
Due to differences of shape in plan, elevation and construction
systems between Orthodox churches and Catholic churches, for the
first time there were initiated researches in the development of this
simulation methodology for Orthodox churches. In this article are
presented the first results from the researches. The theoretical results
were compared with real failure modes recorded at an Orthodox
church from Banat region, severely damaged by earthquakes in
1991. Simulated seismic response, using a computer program based
on finite element method was confirmed by cracks after earthquakes.
The consolidation of the church was made according to these
theoretical results, realizing a rigid floor connecting all the failure
blocks.
Abstract: Nowadays, power systems, energy generation by wind
has been very important. Noting that the production of electrical
energy by wind turbines on site to several factors (such as wind speed
and profile site for the turbines, especially off the wind input speed,
wind rated speed and wind output speed disconnect) is dependent. On
the other hand, several different types of turbines in the market there.
Therefore, selecting a turbine that its capacity could also answer the
need for electric consumers the efficiency is high something is
important and necessary. In this context, calculating the amount of
wind power to help optimize overall network, system operation, in
determining the parameters of wind power is very important.
In this article, to help calculate the amount of wind power plant,
connected to the national network in the region Manjil wind,
selecting the best type of turbine and power delivery profile
appropriate to the network using Monte Carlo method has been.
In this paper, wind speed data from the wind site in Manjil, as minute
and during the year has been. Necessary simulations based on
Random Numbers Simulation method and repeat, using the software
MATLAB and Excel has been done.
Abstract: One of the difficulties of the vibration-based damage identification methods is the nonuniqueness of the results of damage identification. The different damage locations and severity may cause the identical response signal, which is even more severe for detection of the multiple damage. This paper proposes a new strategy for damage detection to avoid this nonuniqueness. This strategy firstly determines the approximates damage area based on the statistical pattern recognition method using the dynamic strain signal measured by the distributed fiber Bragg grating, and then accurately evaluates the damage information based on the Bayesian model updating method using the experimental modal data. The stochastic simulation method is then used to compute the high-dimensional integral in the Bayesian problem. Finally, an experiment of the plate structure, simulating one part of mechanical structure, is used to verify the effectiveness of this approach.
Abstract: CFlow is a flow chart software, it contains facilities to
draw and evaluate a flow chart. A flow chart evaluation applies a
simulation method to enable presentation of work flow in a flow
chart solution. Flow chart simulation of CFlow is executed by
manipulating the CFlow data file which is saved in a graphical vector
format. These text-based data are organised by using a data
classification technic based on a Library classification-scheme. This
paper describes the file format for flow chart simulation software of
CFlow.
Abstract: As business environments are rapidly changing,
the manufacturing system must be reconfigured to adapt to
various customer needs. In order to cope with this challenge, it
is quintessential to test industrial control logic rapidly and
easily in the design time, and monitor operational behavior in
the run time of automated manufacturing system. Proposed
integrated model for virtual prototyping and operational
monitoring of industrial control logic is to improve limitations
of current ladder programming practices and general discrete
event simulation method. Each plant layout model using HMI
package and object-oriented control logic model is designed
independently and is executed simultaneously in integrated
manner to reflect design practices of automation system in the
design time. Control logic is designed and executed using UML
activity diagram without considering complicated control
behavior to deal with current trend of reconfigurable
manufacturing. After the physical installation, layout model of
virtual prototype constructed in the design time is reused for
operational monitoring of system behavior during run time.
Abstract: Actual load, material characteristics and other
quantities often differ from the design values. This can cause worse
function, shorter life or failure of a civil engineering structure, a
machine, vehicle or another appliance. The paper shows main causes
of the uncertainties and deviations and presents a systematic
approach and efficient tools for their elimination or mitigation of
consequences. Emphasis is put on the design stage, which is most
important for reliability ensuring. Principles of robust design and
important tools are explained, including FMEA, sensitivity analysis
and probabilistic simulation methods. The lifetime prediction of
long-life objects can be improved by long-term monitoring of the
load response and damage accumulation in operation. The condition
evaluation of engineering structures, such as bridges, is often based
on visual inspection and verbal description. Here, methods based on
fuzzy logic can reduce the subjective influences.