Abstract: Predicting protein-protein interactions represent a key step in understanding proteins functions. This is due to the fact that proteins usually work in context of other proteins and rarely function alone. Machine learning techniques have been applied to predict protein-protein interactions. However, most of these techniques address this problem as a binary classification problem. Although it is easy to get a dataset of interacting proteins as positive examples, there are no experimentally confirmed non-interacting proteins to be considered as negative examples. Therefore, in this paper we solve this problem as a one-class classification problem using one-class support vector machines (SVM). Using only positive examples (interacting protein pairs) in training phase, the one-class SVM achieves accuracy of about 80%. These results imply that protein-protein interaction can be predicted using one-class classifier with comparable accuracy to the binary classifiers that use artificially constructed negative examples.
Abstract: Interpretation of aerial images is an important task in
various applications. Image segmentation can be viewed as the essential
step for extracting information from aerial images. Among many
developed segmentation methods, the technique of clustering has been
extensively investigated and used. However, determining the number
of clusters in an image is inherently a difficult problem, especially
when a priori information on the aerial image is unavailable. This
study proposes a support vector machine approach for clustering
aerial images. Three cluster validity indices, distance-based index,
Davies-Bouldin index, and Xie-Beni index, are utilized as quantitative
measures of the quality of clustering results. Comparisons on the
effectiveness of these indices and various parameters settings on the
proposed methods are conducted. Experimental results are provided
to illustrate the feasibility of the proposed approach.