Abstract: It is well known that Logistic Regression is the gold
standard method for predicting clinical outcome, especially
predicting risk of mortality. In this paper, the Decision Tree method
has been proposed to solve specific problems that commonly use
Logistic Regression as a solution. The Biochemistry and
Haematology Outcome Model (BHOM) dataset obtained from
Portsmouth NHS Hospital from 1 January to 31 December 2001 was
divided into four subsets. One subset of training data was used to
generate a model, and the model obtained was then applied to three
testing datasets. The performance of each model from both methods
was then compared using calibration (the χ2 test or chi-test) and
discrimination (area under ROC curve or c-index). The experiment
presented that both methods have reasonable results in the case of the
c-index. However, in some cases the calibration value (χ2) obtained
quite a high result. After conducting experiments and investigating
the advantages and disadvantages of each method, we can conclude
that Decision Trees can be seen as a worthy alternative to Logistic
Regression in the area of Data Mining.
Abstract: Availability of high dimensional biological datasets such as from gene expression, proteomic, and metabolic experiments can be leveraged for the diagnosis and prognosis of diseases. Many classification methods in this area have been studied to predict disease states and separate between predefined classes such as patients with a special disease versus healthy controls. However, most of the existing research only focuses on a specific dataset. There is a lack of generic comparison between classifiers, which might provide a guideline for biologists or bioinformaticians to select the proper algorithm for new datasets. In this study, we compare the performance of popular classifiers, which are Support Vector Machine (SVM), Logistic Regression, k-Nearest Neighbor (k-NN), Naive Bayes, Decision Tree, and Random Forest based on mock datasets. We mimic common biological scenarios simulating various proportions of real discriminating biomarkers and different effect sizes thereof. The result shows that SVM performs quite stable and reaches a higher AUC compared to other methods. This may be explained due to the ability of SVM to minimize the probability of error. Moreover, Decision Tree with its good applicability for diagnosis and prognosis shows good performance in our experimental setup. Logistic Regression and Random Forest, however, strongly depend on the ratio of discriminators and perform better when having a higher number of discriminators.
Abstract: In today-s turbulent environment, companies are faced with two principal challenges. On the one hand, it is necessary to produce ever more cost-effectively to remain competitive. On the other hand, factories need to be transformable in order to manage unpredictable changes in the corporate environment. To deal with these different challenges, companies use the philosophy of lean production in the first case, in the second case the philosophy of transformability. To a certain extent these two approaches follow different directions. This can cause conflicts when designing factories. Therefore, the Institute of Production Systems and Logistics (IFA) of the Leibniz University of Hanover has developed a procedure to allow companies to evaluate and design their factories with respect to the requirements of both philosophies.