Abstract: Global Competitiveness Index (GCI) prepared by World Economic Forum has become a benchmark in studying the competitiveness of countries and for understanding the factors that enable competitiveness. Innovation is a key pillar in competitiveness and has the unique property of enabling exponential economic growth. This paper attempts to analyze how the pillars comprising the Global Competitiveness Index affect innovation and whether GDP growth can directly affect innovation outcomes for a country. The key objective of the study is to identify areas on which governments of developing countries can focus policies and programs to improve their country’s innovativeness. We have compiled a panel data set for top innovating countries and large emerging economies called BRICS from 2007-08 to 2014-15 in order to find the significant factors that affect innovation. The results of the regression analysis suggest that government should make policies to improve labor market efficiency, establish sophisticated business networks, provide basic health and primary education to its people and strengthen the quality of higher education and training services in the economy. The achievements of smaller economies on innovation suggest that concerted efforts by governments can counter any size related disadvantage, and in fact can provide greater flexibility and speed in encouraging innovation.
Abstract: This paper presents the effect of actuation schemes on the performance of parallel manipulators and also how the singularity loci have been changed in the reachable workspace of the manipulator with the choice of actuation scheme to drive the manipulator. The performance of the eight possible actuation schemes of 3RRR planar parallel manipulator is compared with each other. The optimal design problem is formulated to find the manipulator geometry that maximizes the singularity free conditioned workspace for all the eight actuation cases, the optimization problem is solved by using genetic algorithms.
Abstract: In this study, spatial differences of Power Transmission Line (PTL) and effects of the situation before and after the urban regeneration are studied by using Geographical Information System (GIS). In addition, a questionable and analyzable structure is acquired by developed system. In the study area many parcels on the PTL were analyzed. The amount of the parcels, which are affected by the negativity of PTL is clearly seen with the aid of generated maps. Some kind of changes are exhibited in the system, which are created by GIS, for instance before urban regeneration PTL was very close to people’s private properties and huge parts of PTL were among the buildings, however; after urban regeneration electricity lines were changed their locations to the underground. According to the results, GIS can be used as a device in planning and managing of PTL in urban regeneration projects and can be used for analyses. By the help of GIS technology, necessary investigations should be carried out in urban regeneration applications for creating sustainable cities.
Abstract: Gastric Cancer (GC) has high morbidity and fatality
rate in various countries. It is still one of the most frequent and
deadly diseases. Gastrokine1 (GKN1) and gastrokine2 (GKN2) genes
are highly expressed in the normal stomach epithelium and play
important roles in maintaining the integrity and homeostasis of
stomach mucosal epithelial cells. In this study, 47 paired samples that
were grouped according to the types of gastric cancer and the clinical
characteristics of the patients, including gender and average of age.
They were investigated with gene expression analysis and mutation
screening by monitoring RT-PCR, SSCP and nucleotide sequencing
techniques. Both GKN1 and GKN2 genes were observed significantly
reduced found by (Wilcoxon signed rank test; p
Abstract: Background: To compare the thinning patterns of the
ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal
nerve fiber layer (pRNFL) as measured using Cirrus high-definition
optical coherence tomography (HD-OCT) in patients with visual field
(VF) defects that respect the vertical meridian. Methods: Twenty eyes of eleven patients with VF defects that
respect the vertical meridian were enrolled retrospectively. The
thicknesses of the macular GCIPL and pRNFL were measured using
Cirrus HD-OCT. The 5% and 1% thinning area index (TAI) was
calculated as the proportion of abnormally thin sectors at the 5% and
1% probability level within the area corresponding to the affected VF.
The 5% and 1% TAI were compared between the GCIPL and pRNFL
measurements. Results: The color-coded GCIPL deviation map showed a
characteristic vertical thinning pattern of the GCIPL, which is also
seen in the VF of patients with brain lesions. The 5% and 1% TAI
were significantly higher in the GCIPL measurements than in the
pRNFL measurements (all P < 0.01). Conclusions: Macular GCIPL analysis clearly visualized a
characteristic topographic pattern of retinal ganglion cell (RGC) loss
in patients with VF defects that respect the vertical meridian, unlike
pRNFL measurements. Macular GCIPL measurements provide more
valuable information than pRNFL measurements for detecting the
loss of RGCs in patients with retrograde degeneration of the optic
nerve fibers.
Abstract: Rapid population growth, urbanization and
industrialization are known as the most important factors of
environment problems. Elimination and management of solid wastes
are also within the most important environment problems. One of the
main problems in solid waste management is the selection of the best
site for elimination of solid wastes. Lately, Geographical Information
System (GIS) has been used for easing selection of landfill area. GIS
has the ability of imitating necessary economic, environmental and
political limitations. They play an important role for the site selection
of landfill area as a decision support tool. In this study; map layers will be studied for minimum effect of
environmental, social and cultural factors and maximum effect for
engineering/economic factors for site selection of landfill areas and
using GIS for a decision support mechanism in solid waste landfill
areas site selection will be presented in Aksaray/Turkey city,
Güzelyurt district practice.
Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: This study presented to reduce earthquake damage and
emergency rehabilitation of critical structures such as schools, hightech
factories, and hospitals due to strong ground motions associated
with climate changes. Regarding recent trend, a strong earthquake
causes serious damage to critical structures and then the critical
structure might be influenced by sequence aftershocks (or tsunami)
due to fault plane adjustments. Therefore, in order to improve seismic
performance of critical structures, retrofitted or strengthening study
of the structures under aftershocks sequence after emergency
rehabilitation of the structures subjected to strong earthquakes is
widely carried out. Consequently, this study used composite material
for emergency rehabilitation of the structure rather than concrete and
steel materials because of high strength and stiffness, lightweight,
rapid manufacturing, and dynamic performance. Also, this study was
to develop or improve the seismic performance or seismic retrofit of
critical structures subjected to strong ground motions and earthquake
aftershocks, by utilizing GFRP-Corrugated Infill Panels (GCIP).
Abstract: Materials added to the matrix help improving operating properties of a composite. This experimental study has targeted to investigate this aim where Silicon Oxide particles were added to glass fibre and epoxy resin at an amount of 15% to the main material to obtain a sort of new composite material. Erosive wear behavior of epoxy-resin dipped composite materials reinforced with glass fibre and Silicon Oxide under three different impingement angles (30°, 60° and 90°), three different impact velocities (23, 34 and 53 m/s), two different angular Aluminum abrasive particle sizes (approximately 200 and 400 μm) and the fibre orientation of 45° (45/-45) were investigated. In the test results, erosion rates were obtained as functions of impingement angles, impact velocities, particle sizes and fibre orientation. Moreover, materials with addition of Silicon Oxide filler material exhibited lower wear as compared to neat materials with no added filler material. In addition, SEM views showing worn out surfaces of the test specimens were scrutinized.
Abstract: Understanding how airborne pathogens are
transported through hospital wards is essential for determining the
infection risk to patients and healthcare workers. This study utilizes
Computational Fluid Dynamics (CFD) simulations to explore
possible pathogen transport within a six-bed partitioned Nightingalestyle
hospital ward.
Grid independence of a ward model was addressed using the Grid
Convergence Index (GCI) from solutions obtained using three fullystructured
grids. Pathogens were simulated using source terms in
conjunction with a scalar transport equation and a RANS turbulence
model. Errors were found to be less than 4% in the calculation of air
velocities but an average of 13% was seen in the scalar field.
A parametric study of variations in the pathogen release point
illustrated that its distribution is strongly influenced by the local
velocity field and the degree of air mixing present.