Abstract: The concept of economic policy and the practical
economic policy diverge from each other at a certain stage of
development. This is related to the concept of realization of the
underlying problems. It comes with all the problems emerged in the
market oriented economic order due to the political processes based
on social welfare policy. The realization of the concept of economic
policy is impeded by economic and political obstacles. If you want to
fill the appeared between the concept and reality, it is necessary to
identify and avoid these obstacles. It requires the following: increase
of the level of the knowledge of prevention technology in
understanding of economic relations, as well as political aspects of
the formation of ideas; perfection of economic policy toolkit, and
political methods.
It is necessary to realize what is the main precondition of
implementation and further development of the concept of economic
policy, as well as the formation of opinions about economic and
public safety. This is a broad consensus on the basic values of the
content and the scale of action, which the general public wants to be
realized.
Abstract: Theory of Mind (ToM) refers to the ability to infer
another’s mental state. With appropriate ToM, one can behave well in
social interactions. A growing body of evidence has demonstrated that
patients with temporal lobe epilepsy (TLE) may damage ToM by
affecting on regions of the underlying neural network of ToM.
However, the question of whether there is cerebral laterality for ToM
functions remains open. This study aimed to examine whether there is
cerebral lateralization for ToM abilities in TLE patients. Sixty-seven
adult TLE patients and 30 matched healthy controls (HC) were
recruited. Patients were classified into right (RTLE), left (LTLE), and
bilateral (BTLE) TLE groups on the basis of a consensus panel review
of their seizure semiology, EEG findings, and brain imaging results.
All participants completed an intellectual test and four tasks measuring
basic and advanced ToM. The results showed that, on all ToM tasks,
(1) each patient group performed worse than HC; (2) there were no
significant differences between LTLE and RTLE groups; and (3) the
BTLE group performed the worst. It appears that the neural network
responsible for ToM is distributed evenly between the cerebral
hemispheres.
Abstract: International and domestic environmental law has
evolved quite rapidly in the last few decades. At the international
level the Stockholm and Rio Declarations paved the way for a broad
based consensus of the international community on environmental
issues and principles. At the Domestic level also many states have
incorporated environmental protection in their constitutions and even
more states are doing the same at least in their domestic legislations.
In this process of evolution environmental law has unleashed a
number of novel principles such as; the participatory principle, the
polluter pays principle, the precautionary principle, the intergenerational
and intra-generational principles, the prevention
principle, the sustainable development principle and so on.
Abstract: In this paper, reliable consensus of multi-agent systems
with sampled-data is investigated. By using a suitable
Lyapunov-Krasovskii functional and some techniques such as
Wirtinger Inequality, Schur Complement and Kronecker Product, the
results of such system are obtained by solving a set of Linear Matrix
Inequalities (LMIs). One numerical example is included to show the
effectiveness of the proposed criteria.
Abstract: Many studies have revealed the fact of the complexity
of ontology building process. Therefore there is a need for a new
approach which one of that addresses the socio-technical aspects in the
collaboration to reach a consensus. Meta-design approach is
considered applicable as a method in the methodological model of
socio-technical ontology engineering. Principles in the meta-design
framework are applied in the construction phases of the ontology. A
web portal is developed to support the meta-design principles
requirements. To validate the methodological model semantic web
applications were developed and integrated in the portal and also used
as a way to show the usefulness of the ontology. The knowledge based
system will be filled with data of Indonesian medicinal plants. By
showing the usefulness of the developed ontology in a semantic web
application, we motivate all stakeholders to participate in the
development of knowledge based system of medicinal plants in
Indonesia.
Abstract: Many quality models have been used to measure egovernment
portals quality. However, the absence of an international
consensus for e-government portals quality models results in many
differences in terms of quality attributes and measures. The aim of
this paper is to compare and analyze the existing e-government
quality models proposed in literature (those that are based on ISO
standards and those that are not) in order to propose guidelines to
build a good and useful e-government portals quality model. Our
findings show that, there is no e-government portal quality model
based on the new international standard ISO 25010. Besides that, the
quality models are not based on a best practice model to allow
agencies to both; measure e-government portals quality and identify
missing best practices for those portals.
Abstract: This study is an attempt to raise the awareness of the
stakeholders and the authorities on the sensitivity of Algerian
secondary school teachers of English as a Foreign Language about
the students’ loss of English language skills learned during formal
schooling with effort and at expense and the supposed measures to
arrest that loss. Data was collected from secondary school teachers of
EFL and analyzed quantitatively using a questionnaire containing
open-ended and close-ended questions. The results advocate a
consensus about the need for actions to be adopted to make
assessment techniques outcome-oriented. Most of the participants
were in favor of including curricular activities involving
contextualized learning, problem-solving learning critical selfawareness,
self and peer-assisted learning, use of computers and
internet so as to make learners autonomous.
Abstract: An extensive amount of work has been done in data
clustering research under the unsupervised learning technique in Data
Mining during the past two decades. Moreover, several approaches
and methods have been emerged focusing on clustering diverse data
types, features of cluster models and similarity rates of clusters.
However, none of the single clustering algorithm exemplifies its best
nature in extracting efficient clusters. Consequently, in order to
rectify this issue, a new challenging technique called Cluster
Ensemble method was bloomed. This new approach tends to be the
alternative method for the cluster analysis problem. The main
objective of the Cluster Ensemble is to aggregate the diverse
clustering solutions in such a way to attain accuracy and also to
improve the eminence the individual clustering algorithms. Due to
the massive and rapid development of new methods in the globe of
data mining, it is highly mandatory to scrutinize a vital analysis of
existing techniques and the future novelty. This paper shows the
comparative analysis of different cluster ensemble methods along
with their methodologies and salient features. Henceforth this
unambiguous analysis will be very useful for the society of clustering
experts and also helps in deciding the most appropriate one to resolve
the problem in hand.
Abstract: Although several factors that affect learning to
program have been identified over the years, there continues to be no
indication of any consensus in understanding why some students learn
to program easily and quickly while others have difficulty. Seldom
have researchers considered the problem of how to help the students
enhance the programming learning outcome. The research had been
conducted at a high school in Taiwan. Students participating in the
study consist of 330 tenth grade students enrolled in the Basic
Computer Concepts course with the same instructor. Two types of
training methods-instruction-oriented and exploration-oriented were
conducted. The result of this research shows that the
instruction-oriented training method has better learning performance
than exploration-oriented training method.
Abstract: This paper studies a robust stabilization problem of a
single agent in a multi-agent consensus system composed of identical
agents, when the network topology of the system is completely
unknown. It is shown that the transfer function of an agent in a
consensus system can be described as a multiplicative perturbation
of the isolated agent transfer function in frequency domain. From an
existing robust stabilization result, we present sufficient conditions for
a robust stabilization of an agent against unknown network topology.
Abstract: The MyD88 is an evolutionarily conserved host-expressed adaptor protein that is essential for proper TLR/ IL1R immune-response signaling. A previously identified complete cDNA (1626 bp) of OfMyD88 comprised an ORF of 867 bp encoding a protein of 288 amino acids (32.9 kDa). The gDNA (3761 bp) of OfMyD88 revealed a quinquepartite genome organization composed of 5 exons (with the sizes of 310, 132, 178, 92 and 155 bp) separated by 4 introns. All the introns displayed splice signals consistent with the consensus GT/AG rule. A bipartite domain structure with two domains namely death domain (24-103) coded by 1st exon, and TIR domain (151-288) coded by last 3 exons were identified through in silico analysis. Moreover, homology modeling of these two domains revealed a similar quaternary folding nature between human and rock bream homologs. A comprehensive comparison of vertebrate MyD88 genes showed that they possess a 5-exonic structure.In this structure, the last three exons were strongly conserved, and this suggests that a rigid structure has been maintained during vertebrate evolution.A cluster of TATA box-like sequences were found 0.25 kb upstream of cDNA starting position. In addition, putative 5'-flanking region of OfMyD88 was predicted to have TFBS implicated with TLR signaling, including copies of NFkB1, APRF/ STAT3, Sp1, IRF1 and 2 and Stat1/2. Using qPCR technique, a ubiquitous mRNA expression was detected in liver and blood. Furthermore, a significantly up-regulated transcriptional expression of OfMyD88 was detected in head kidney (12-24 h; >2-fold), spleen (6 h; 1.5-fold), liver (3 h; 1.9-fold) and intestine (24 h; ~2-fold) post-Fla challenge. These data suggest a crucial role for MyD88 in antibacterial immunity of teleosts.
Abstract: The objectives of this research was to design and develop a quality management of the school buildings and environment. A quantitative and qualitative mixed research methodology was used. The population sample included 14 directors of primary schools. Two research tools were used. The first research tool included an in-depth interview and questionnaire. The second research tool included the Quality Business Process and Quality Work Procedure, and a Key Performance Indicator of each activity. The statistics included mean and standard deviation. The findings for the development of a quality management process of buildings and environment administration of the basic schools consisted of one quality business process (QBP) and seven quality work processes (QWP). The result from the experts’ evaluation revealed that the process and implementation of quality management of the school buildings and environment has passed the inspection process with consensus. This implies that the process of quality management of the school buildings and environment is suitable for implementation. Moreover, the level of agreement in the feasibility of the implementation of this plan had the mean in the range of 0.64-1.00 which suggests the design of the new plan is acceptable.
Abstract: Over the past epoch a rampant amount of work has been done in the data clustering research under the unsupervised learning technique in Data mining. Furthermore several algorithms and methods have been proposed focusing on clustering different data types, representation of cluster models, and accuracy rates of the clusters. However no single clustering algorithm proves to be the most efficient in providing best results. Accordingly in order to find the solution to this issue a new technique, called Cluster ensemble method was bloomed. This cluster ensemble is a good alternative approach for facing the cluster analysis problem. The main hope of the cluster ensemble is to merge different clustering solutions in such a way to achieve accuracy and to improve the quality of individual data clustering. Due to the substantial and unremitting development of new methods in the sphere of data mining and also the incessant interest in inventing new algorithms, makes obligatory to scrutinize a critical analysis of the existing techniques and the future novelty. This paper exposes the comparative study of different cluster ensemble methods along with their features, systematic working process and the average accuracy and error rates of each ensemble methods. Consequently this speculative and comprehensive analysis will be very useful for the community of clustering practitioners and also helps in deciding the most suitable one to rectify the problem in hand.
Abstract: The construction sector constitutes one of the most important sectors in the economy of any country. Contractor selection is a critical decision that is undertaken by client organizations and is central to the success of any construction project. Contractor selection (CS) is a process which involves investigating, screening and determining whether candidate contractors have the technical and financial capability to be accepted to formally tender for construction work. The process should be conducted prior to the award of contract, characterized by many factors such as: contactor’s skills, experience on similar projects, track- record in the industry, and financial stability. However, this paper evaluates the current state of knowledge in relation to contractor selection process and demonstrates the findings from the analysis of the data collected from the Delphi questionnaire survey. The survey was conducted with a group of 12 experts working in the Libyan construction industry (LCI). The paper starts by briefly explaining the general outline of the questionnaire including the survey participation rate, the different fields the experts came from, and the business titles of the participants. Then the paper describes the tests used to determine when the experts had reached consensus. The paper is based on research which aims to develop rank contractor selection criteria with specific application to make construction projects in the Libyan context. The findings of this study will be utilized to establish the scope of work that will be used as part of a PhD research.
Abstract: There is widespread emphasis on reform in the teaching of introductory statistics at the college level. Underpinning this reform is a consensus among educators and practitioners that traditional curricular materials and pedagogical strategies have not been effective in promoting statistical literacy, a competency that is becoming increasingly necessary for effective decision-making and evidence-based practice. This paper explains the historical context of, and rationale for reform-oriented teaching of introductory statistics (at the college level) in the health, social and behavioral sciences (evidence-based disciplines). A firm understanding and appreciation of the basis for change in pedagogical approach is important, in order to facilitate commitment to reform, consensus building on appropriate strategies, and adoption and maintenance of best practices. In essence, reform-oriented pedagogy, in this context, is a function of the interaction among content, pedagogy, technology, and assessment. The challenge is to create an appropriate balance among these domains.
Abstract: Mammalian genomes contain large number of
retroelements (SINEs, LINEs and LTRs) which could affect
expression of protein coding genes through associated transcription
factor binding sites (TFBS). Activity of the retroelement-associated
TFBS in many genes is confirmed experimentally but their global
functional impact remains unclear. Human SINEs (Alu repeats) and
mouse SINEs (B1 and B2 repeats) are known to be clustered in GCrich
gene rich genome segments consistent with the view that they
can contribute to regulation of gene expression. We have shown
earlier that Alu are involved in formation of cis-regulatory modules
(clusters of TFBS) in human promoters, and other authors reported
that Alu located near promoter CpG islands have an increased
frequency of CpG dinucleotides suggesting that these Alu are
undermethylated. Human Alu and mouse B1/B2 elements have an
internal bipartite promoter for RNA polymerase III containing
conserved sequence motif called B-box which can bind basal
transcription complex TFIIIC. It has been recently shown that TFIIIC
binding to B-box leads to formation of a boundary which limits
spread of repressive chromatin modifications in S. pombe. SINEassociated
B-boxes may have similar function but conservation of
TFIIIC binding sites in SINEs located near mammalian promoters
has not been studied earlier. Here we analysed abundance and
distribution of retroelements (SINEs, LINEs and LTRs) in annotated
sequences of the Database of mammalian transcription start sites
(DBTSS). Fractions of SINEs in human and mouse promoters are
slightly lower than in all genome but >40% of human and mouse
promoters contain Alu or B1/B2 elements within -1000 to +200 bp
interval relative to transcription start site (TSS). Most of these SINEs
is associated with distal segments of promoters (-1000 to -200 bp
relative to TSS) indicating that their insertion at distances >200 bp
upstream of TSS is tolerated during evolution. Distribution of SINEs
in promoters correlates negatively with the distribution of CpG
sequences. Using analysis of abundance of 12-mer motifs from the
B1 and Alu consensus sequences in genome and DBTSS it has been
confirmed that some subsegments of Alu and B1 elements are poorly
conserved which depends in part on the presence of CpG
dinucleotides. One of these CpG-containing subsegments in B1
elements overlaps with SINE-associated B-box and it shows better
conservation in DBTSS compared to genomic sequences. It has been
also studied conservation in DBTSS and genome of the B-box
containing segments of old (AluJ, AluS) and young (AluY) Alu
repeats and found that CpG sequence of the B-box of old Alu is
better conserved in DBTSS than in genome. This indicates that Bbox-
associated CpGs in promoters are better protected from
methylation and mutation than B-box-associated CpGs in genomic
SINEs. These results are consistent with the view that potential
TFIIIC binding motifs in SINEs associated with human and mouse
promoters may be functionally important. These motifs may protect
promoters from repressive histone modifications which spread from
adjacent sequences. This can potentially explain well known
clustering of SINEs in GC-rich gene rich genome compartments and
existence of unmethylated CpG islands.
Abstract: The management of the health-care wastes is one of
the most important problems in Istanbul, a city with more than 12
million inhabitants, as it is in most of the developing countries.
Negligence in appropriate treatment and final disposal of the healthcare
wastes can lead to adverse impacts to public health and to the
environment. This paper employs a fuzzy multi-criteria group
decision making approach, which is based on the principles of fusion
of fuzzy information, 2-tuple linguistic representation model, and
technique for order preference by similarity to ideal solution
(TOPSIS), to evaluate health-care waste (HCW) treatment
alternatives for Istanbul. The evaluation criteria are determined
employing nominal group technique (NGT), which is a method of
systematically developing a consensus of group opinion. The
employed method is apt to manage information assessed using multigranularity
linguistic information in a decision making problem with
multiple information sources. The decision making framework
employs ordered weighted averaging (OWA) operator that
encompasses several operators as the aggregation operator since it
can implement different aggregation rules by changing the order
weights. The aggregation process is based on the unification of
information by means of fuzzy sets on a basic linguistic term set
(BLTS). Then, the unified information is transformed into linguistic
2-tuples in a way to rectify the problem of loss information of other
fuzzy linguistic approaches.
Abstract: Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.
Abstract: Along with the progress of our information society,
various risks are becoming increasingly common, causing multiple social problems. For this reason, risk communications for
establishing consensus among stakeholders who have different
priorities have become important. However, it is not always easy for the decision makers to agree on measures to reduce risks based on
opposing concepts, such as security, privacy and cost. Therefore, we previously developed and proposed the “Multiple Risk Communicator" (MRC) with the following functions: (1) modeling
the support role of the risk specialist, (2) an optimization engine, and (3) displaying the computed results. In this paper, MRC program
version 1.0 is applied to the personal information leakage problem. The application process and validation of the results are discussed.
Abstract: Biodiversity crisis is one of the many crises that
started at the turn of the millennia. Concrete form of expression is
still disputed, but there is a relatively high consensus regarding the
high rate of degradation and the urgent need for action. The strategy
of action outlines a strong economic component, together with the
recognition of market mechanisms as the most effective policies to
protect biodiversity. In this context, biodiversity and ecosystem
services are natural assets that play a key role in economic strategies
and technological development to promote development and
prosperity. Developing and strengthening policies for transition to an
economy based on efficient use of resources is the way forward.
To emphasize the co-viability specific to the connection economyecosystem
services, scientific approach aimed on one hand how to
implement policies for nature conservation and on the other hand, the
concepts underlying the economic expression of ecosystem services-
value, in the context of current technology. Following the analysis of
business opportunities associated with changes in ecosystem services
was concluded that development of market mechanisms for nature
conservation is a trend that is increasingly stronger individualized
within recent years. Although there are still many controversial issues
that have already given rise to an obvious bias, international
organizations and national governments have initiated and
implemented in cooperation or independently such mechanisms.
Consequently, they created the conditions for convergence between
private interests and social interests of nature conservation, so there
are opportunities for ongoing business development which leads,
among other things, the positive effects on biodiversity. Finally,
points out that markets fail to quantify the value of most ecosystem
services. Existing price signals reflect at best, only a proportion of the
total amount corresponding provision of food, water or fuel.