Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.
Abstract: The aim of this study was to compare the effects
of an altitude training camp on heart rate variability and
performance in elite triathletes. Ten athletes completed 20 days of live-high, train-low training at 1650m. Athletes
underwent pre and post 800-m swim time trials at sea-level, and two heart rate variability tests at 1650m on the first and
last day of the training camp. Based on their time trial results,
athletes were divided into responders and non-responders. Relative to the non-responders, the responders sympathetic-toparasympathetic
ratio decreased substantially after 20 days of altitude training (-0.68 ± 1.08 and -1.2 ± 0.96, mean ± 90%
confidence interval for supine and standing respectively). In
addition, sympathetic activity while standing was also
substantially lower post-altitude in the responders compared to the non-responders (-1869 ± 4764 ms2). Results indicate that
responders demonstrated a change to more vagal
predominance compared to non-responders.
Abstract: Biclustering aims at identifying several biclusters that
reveal potential local patterns from a microarray matrix. A bicluster is
a sub-matrix of the microarray consisting of only a subset of genes
co-regulates in a subset of conditions. In this study, we extend the
motif of subspace clustering to present a K-biclusters clustering (KBC)
algorithm for the microarray biclustering issue. Besides minimizing
the dissimilarities between genes and bicluster centers within all
biclusters, the objective function of the KBC algorithm additionally
takes into account how to minimize the residues within all biclusters
based on the mean square residue model. In addition, the objective
function also maximizes the entropy of conditions to stimulate more
conditions to contribute the identification of biclusters. The KBC
algorithm adopts the K-means type clustering process to efficiently
make the partition of K biclusters be optimized. A set of experiments
on a practical microarray dataset are demonstrated to show the
performance of the proposed KBC algorithm.
Abstract: Battery storage system is emerging as an essential component of hybrid power system based on renewable energy resources such as solar and wind in order to make these sources dispatchable. Accurate modeling of battery storage system is ssential in order to ensure optimal planning of hybrid power systems incorporating battery storage. Majority of the system planning studies involving battery storage assume battery charging efficiency to be constant. However a strong correlation exists between battery charging efficiency and battery state of charge. In this work a Fuzzy logic based model has been presented for determining battery charging efficiency relative to a particular SOC. In order to demonstrate the efficacy of proposed approach, reliability evaluation studies are carried out for a hypothetical autonomous hybrid power system located in Jaisalmer, Rajasthan, India. The impact of considering battery charging efficiency as a function of state of charge is compared against the assumption of fixed battery charging efficiency for three different configurations comprising of wind-storage, solar-storage and wind-solar-storage.
Abstract: We propose an enhanced collaborative filtering
method using Hofstede-s cultural dimensions, calculated for 111
countries. We employ 4 of these dimensions, which are correlated to
the costumers- buying behavior, in order to detect users- preferences
for items. In addition, several advantages of this method
demonstrated for data sparseness and cold-start users, which are
important challenges in collaborative filtering. We present
experiments using a real dataset, Book Crossing Dataset.
Experimental results shows that the proposed algorithm provide
significant advantages in terms of improving recommendation
quality.
Abstract: Automatic segmentation of skin lesions is the first step
towards the automated analysis of malignant melanoma. Although
numerous segmentation methods have been developed, few studies
have focused on determining the most effective color space for
melanoma application. This paper proposes an automatic segmentation
algorithm based on color space analysis and clustering-based histogram
thresholding, a process which is able to determine the optimal
color channel for detecting the borders in dermoscopy images. The
algorithm is tested on a set of 30 high resolution dermoscopy images.
A comprehensive evaluation of the results is provided, where borders
manually drawn by four dermatologists, are compared to automated
borders detected by the proposed algorithm, applying three previously
used metrics of accuracy, sensitivity, and specificity and a new metric
of similarity. By performing ROC analysis and ranking the metrics,
it is demonstrated that the best results are obtained with the X and
XoYoR color channels, resulting in an accuracy of approximately
97%. The proposed method is also compared with two state-of-theart
skin lesion segmentation methods.
Abstract: Education, as the most important resource in any country, has multiplying effects on all facets of development in a society. The new social realities, particularly the interplay between democratization of education; unprecedented developments in IT sector; emergence of knowledge society, liberalization of economy and globalization have greatly influenced the educational process of all nations. This turbulence entails upon education to undergo dramatic changes to keep up with the new expectations. Growth of entrepreneurship among Indian women is highly important for empowering them and this is highly essential for socio-economic development of a society. Unfortunately in India there is poor acceptance of entrepreneurship among women as unfounded myths and fears restrain them to be enterprising. To remove these inhibitions, education system needs to be re-engineered to make entrepreneurship more acceptable. This paper empirically analyses the results of a survey done on around 500 female graduates in North India to measure and evaluate various entrepreneurial traits present in them. A formative model has been devised in this context, which should improve the teaching-learning process in our education system, which can lead to sustainable growth of women entrepreneurship in India.
Abstract: The present paper deals with the analysis and development of noise-reduction transformer that has a filter function for conductive noise transmission. Two types of prototype noise-reduction transformers with two different output voltages are proposed. To determine an optimum design for the noise-reduction transformer, noise attenuation characteristics are discussed based on the experiments and the equivalent circuit analysis. The analysis gives a relation between the circuit parameters and the noise attenuation. High performance step-down noise-reduction transformer for direct power supply to electronics equipment is developed. The input voltage of the transformer is 100 V and the output voltage is 5 V. Frequency characteristics of noise attenuation are discussed, and prevention of pulse noise transmission is demonstrated. Normal mode noise attenuation of this transformer is –80 dB, and common mode exceeds –90 dB. The step-down noise-reduction transformer eliminates pulse noise efficiently.
Abstract: We demonstrate a nonfaradaic electrochemical impedance spectroscopy measurement of biochemically modified gold plated electrodes using a two-electrode system. The absence of any redox indicator in the impedance measurements provide more precise and accurate characterization of the measured bioanalyte at molecular resolution. An equivalent electrical circuit of the electrodeelectrolyte interface was deduced from the observed impedance data of saline solution at low and high concentrations. The detection of biomolecular interactions was fundamentally correlated to electrical double-layer variation at modified interface. The investigations were done using 20mer deoxyribonucleic acid (DNA) strands without any label. Surface modification was performed by creating mixed monolayer of the thiol-modified single-stranded DNA and a spacer thiol (mercaptohexanol) by a two-step self-assembly method. The results clearly distinguish between the noncomplementary and complementary hybridization of DNA, at low frequency region below several hundreds Hertz.
Abstract: Numerical analysis naturally finds applications in all
fields of engineering and the physical sciences, but in the
21st century, the life sciences and even the arts have adopted
elements of scientific computations. The numerical data analysis
became key process in research and development of all the fields [6].
In this paper we have made an attempt to analyze the specified
numerical patterns with reference to the association rule mining
techniques with minimum confidence and minimum support mining
criteria. The extracted rules and analyzed results are graphically
demonstrated. Association rules are a simple but very useful form of
data mining that describe the probabilistic co-occurrence of certain
events within a database [7]. They were originally designed to
analyze market-basket data, in which the likelihood of items being
purchased together within the same transactions are analyzed.
Abstract: Well-being has been given special emphasis in quality
of life. It involves living a meaningful, life satisfaction, stability and
happiness in life. Well-being also concerns the satisfaction of
physical, psychological, social needs and demands of an individual.
The purpose of this study was to validate three-factor measurement
model of well-being using structural equation modeling (SEM). The
conceptions of well-being measured such dimensions as physical,
psychological and social well-being. This study was done based on a
total sample of 650 adolescents from east-coast of peninsular
Malaysia. The Well-Being Scales which was adapted from [1] was
used in this study. The items were hypothesized a priori to have nonzero
loadings on all dimensions in the model. The findings of the
SEM demonstrated that it is a good fitting model which the proposed
model fits the driving theory; (x2df = 1.268; GFI = .994; CFI = .998;
TLI= .996; p = .255; RMSEA = .021). Composite reliability (CR)
was .93 and average variance extracted (AVE) was 58%. The model
in this study fits with the sample of data and well-being is important
to bring sustainable development to the mainstream.
Abstract: This article discusses superordinate national identity as a means for immigrants integration into democratic polities. It is suggested that a superordinate national identity perceived as inclusive, by immigrants and by the native population, would be conducive to such integration. Command of the dominant language of society is seen as most important of the inclusive criteria. Other such criteria are respect of the country's political institutions and feelings of belonging to the country where you live. The argument is supported by data, showing a majority in favour of inclusive criteria for 'Swedishness', from a recent study among 1000 secondary school students of 'Swedish' and non-'Swedish' backgrounds.
Abstract: Preliminary results for a new flat plate test
facility are presented here in the form of Computational Fluid Dynamics (CFD), flow visualisation, pressure measurements and thermal anemometry. The results from the CFD and flow
visualisation show the effectiveness of the plate design, with the trailing edge flap anchoring the stagnation point on the working surface and reducing the extent of the leading edge separation. The flow visualization technique demonstrates the
two-dimensionality of the flow in the location where the
thermal anemometry measurements are obtained.
Measurements of the boundary layer mean velocity profiles compare favourably with the Blasius solution, thereby allowing for comparison of future measurements with the
wealth of data available on zero pressure gradient Blasius
flows. Results for the skin friction, boundary layer thickness,
frictional velocity and wall shear stress are shown to agree well with the Blasius theory, with a maximum experimental deviation from theory of 5%. Two turbulence generating grids
have been designed and characterized and it is shown that the turbulence decay downstream of both grids agrees with established correlations. It is also demonstrated that there is
little dependence of turbulence on the freestream velocity.
Abstract: A new analytical method to predict the torsional
capacity and behavior of R.C multi-cell box girders strengthened with
carbon fiber reinforced polymer (CFRP) sheets is presented.
Modification was done on the Softened Truss Model (STM) in the
proposed method; the concrete torsional problem is solved by
combining the equilibrium conditions, compatibility conditions and
constitutive laws of materials by taking into account the confinement
of concrete with CFRP sheets. A specific algorithm is developed to
predict the torsional behavior of reinforced concrete multi-cell box
girders with or without strengthening by CFRP sheets. Applications
of the developed method as an assessment tool to strengthened multicell
box girders with CFRP and first analytical example that
demonstrate the contribution of the CFRP materials on the torsional
response is also included.
Abstract: This paper describes the evolution of language
politics and the part played by political leaders with reference to
the Dravidian parties in Tamil Nadu. It explores the interesting
evolution from separatism to coalition in sustaining the values of
parliamentary democracy and federalism. It seems that the
appropriation of language politics is fully ascribed to the DMK
leadership under Annadurai and Karunanidhi. For them, the Tamil
language is a self-determining power, a terrain of nationhood, and
a perennial source of social and political powers. The DMK
remains a symbol of Tamil nationalist party playing language
politics in the interest of the Tamils. Though electoral alliances
largely determine the success, the language politics still has
significant space in the politics of Tamil Nadu. Ironically, DMK
moves from the periphery to centre for getting national recognition
for the Tamils as well as for its own maximization of power. The
evolution can be seen in two major phases as: language politics for
party building; and language politics for state building with three
successive political processes, namely, language politics in the
process of separatism, representative politics and coalition. The
much pronounced Dravidian Movement is radical enough to
democratize the party ideology to survive the spirit of
parliamentary democracy. This has secured its own rewards in
terms of political power. The political power provides the means to
achieve the social and political goal of the political party.
Language politics and leadership pattern actualized this trend
though the movement is shifted from separatism to coalition.
Abstract: We consider a typical problem in the assembly of
printed circuit boards (PCBs) in a two-machine flow shop system to
simultaneously minimize the weighted sum of weighted tardiness and
weighted flow time. The investigated problem is a group scheduling
problem in which PCBs are assembled in groups and the interest is to
find the best sequence of groups as well as the boards within each
group to minimize the objective function value. The type of setup
operation between any two board groups is characterized as carryover
sequence-dependent setup time, which exactly matches with the real
application of this problem. As a technical constraint, all of the
boards must be kitted before the assembly operation starts (kitting
operation) and by kitting staff. The main idea developed in this paper
is to completely eliminate the role of kitting staff by assigning the
task of kitting to the machine operator during the time he is idle
which is referred to as integration of internal (machine) and external
(kitting) setup times. Performing the kitting operation, which is a
preparation process of the next set of boards while the other boards
are currently being assembled, results in the boards to continuously
enter the system or have dynamic arrival times. Consequently, a
dynamic PCB assembly system is introduced for the first time in the
assembly of PCBs, which also has characteristics similar to that of
just-in-time manufacturing. The problem investigated is
computationally very complex, meaning that finding the optimal
solutions especially when the problem size gets larger is impossible.
Thus, a heuristic based on Genetic Algorithm (GA) is employed. An
example problem on the application of the GA developed is
demonstrated and also numerical results of applying the GA on
solving several instances are provided.
Abstract: Employing a recently introduced unified adaptive filter
theory, we show how the performance of a large number of important
adaptive filter algorithms can be predicted within a general framework
in nonstationary environment. This approach is based on energy conservation
arguments and does not need to assume a Gaussian or white
distribution for the regressors. This general performance analysis can
be used to evaluate the mean square performance of the Least Mean
Square (LMS) algorithm, its normalized version (NLMS), the family
of Affine Projection Algorithms (APA), the Recursive Least Squares
(RLS), the Data-Reusing LMS (DR-LMS), its normalized version
(NDR-LMS), the Block Least Mean Squares (BLMS), the Block
Normalized LMS (BNLMS), the Transform Domain Adaptive Filters
(TDAF) and the Subband Adaptive Filters (SAF) in nonstationary
environment. Also, we establish the general expressions for the
steady-state excess mean square in this environment for all these
adaptive algorithms. Finally, we demonstrate through simulations that
these results are useful in predicting the adaptive filter performance.
Abstract: Hearing impairment is the number one chronic
disability affecting many people in the world. Background noise is
particularly damaging to speech intelligibility for people with
hearing loss especially for sensorineural loss patients. Several
investigations on speech intelligibility have demonstrated
sensorineural loss patients need 5-15 dB higher SNR than the normal
hearing subjects. This paper describes Discrete Hartley Transform
Power Normalized Least Mean Square algorithm (DHT-LMS) to
improve the SNR and to reduce the convergence rate of the Least
Means Square (LMS) for sensorineural loss patients. The DHT
transforms n real numbers to n real numbers, and has the convenient
property of being its own inverse. It can be effectively used for noise
cancellation with less convergence time. The simulated result shows
the superior characteristics by improving the SNR at least 9 dB for
input SNR with zero dB and faster convergence rate (eigenvalue ratio
12) compare to time domain method and DFT-LMS.
Abstract: The surface water used in this study was collected from the Chao Praya River at the lower part at the Nonthaburi bridge. It was collected and used throughout the experiment. TOC (also known as DOC) in the range between 2.5 to 5.6 mg/l were investigated in this experiment. The use of conventional treatment methods such as FeCl3 and PAC showed that TOC removal was 65% using FeCl3 and 78% using PAC (powder activated carbon). The advanced oxidation process alone showed only 35% removal of TOC. Coupling advanced oxidation with a small amount of PAC (0.05g/L) increased efficiency by upto 55%. The combined BAC with advanced oxidation process and small amount of PAC demonstrated the highest efficiency of up to 95% of TOC removal and lower sludge production compared with other methods.
Abstract: This paper focuses on a critical component of the situational awareness (SA), the neural control of depth flight of an autonomous underwater vehicle (AUV). Constant depth flight is a challenging but important task for AUVs to achieve high level of autonomy under adverse conditions. With the SA strategy, we proposed a multirate neural control of an AUV trajectory for a nontrivial mid-small size AUV “r2D4" stochastic model. This control system has been demonstrated and evaluated by simulation of diving maneuvers using software package Simulink. From the simulation results it can be seen that the chosen AUV model is stable in the presence of noises, and also can be concluded that the proposed research technique will be useful for fast SA of similar AUV systems in real-time search-and-rescue operations.