Abstract: Candida spp. are common and aggressive pathogens. Because of the growing resistance of Candida spp. to current antifungals, novel targets, found in Candida spp. but not in humans or other flora, have to be identified. The alternative oxidase (AOX) is one such possibility. This enzyme is insensitive to cyanide, but is sensitive to compounds such as salicylhydroxamic acid (SHAM), disulfiram and n-alkyl gallates. The growth each of six Candida spp. was inhibited significantly by ~13 mM SHAM or 2 mM cyanide, albeit to differing extents. In C. dubliniensis, C. krusei and C. tropicalis the rate of O2 uptake was inhibited by 18-36% by 25 mM SHAM, but this had little or no effect on C. glabrata, C. guilliermondii or C. parapsilosis. Although SHAM substantially inhibited the growth of Candida spp., it is unlikely that the inhibition of AOX was the cause. Salicylhydroxamic acid is used therapeutically in the treatment of urinary tract infections and urolithiasis, but it also has some potential in the treatment of Candida spp. infection.
Abstract: Numerous facts evidence the increasing religiosity of
the population and the intensification of religious movements in
various countries in the last decade of the 20th century. The number
of international religious institutions and foundations; religious
movements; parties and sects operating worldwide is increasing as
well. Some ethnic and inter-state conflicts are obviously of a
religious origin. All of this make a number of analysts to conclude
that the religious factor is becoming an important part of international
life, including the formation and activities of terrorist organizations.
Most of all is said and written about Islam, the second, after
Christianity, world religions professed according to various estimates
by 1.5 bln. individuals in 127 countries.
Abstract: In this paper we consider a nonlinear control design for
nonlinear systems by using two-stage formal linearization and twotype
LQ controls. The ordinary LQ control is designed on almost
linear region around the steady state point. On the other region,
another control is derived as follows. This derivation is based on
coordinate transformation twice with respect to linearization functions
which are defined by polynomials. The linearized systems can be
made up by using Taylor expansion considered up to the higher order.
To the resulting formal linear system, the LQ control theory is applied
to obtain another LQ control. Finally these two-type LQ controls
are smoothly united to form a single nonlinear control. Numerical
experiments indicate that this control show remarkable performances
for a nonlinear system.
Abstract: Searching similar documents and document
management subjects have important place in text mining. One of the
most important parts of similar document research studies is the
process of classifying or clustering the documents. In this study, a
similar document search approach that includes discussion of out the
case of belonging to multiple categories (multiple categories
problem) has been carried. The proposed method that based on Fuzzy
Similarity Classification (FSC) has been compared with Rocchio
algorithm and naive Bayes method which are widely used in text
mining. Empirical results show that the proposed method is quite
successful and can be applied effectively. For the second stage,
multiple categories vector method based on information of categories
regarding to frequency of being seen together has been used.
Empirical results show that achievement is increased almost two
times, when proposed method is compared with classical approach.
Abstract: Nowadays, fluidized bed plays an important part in industry. The design of this kind of reactor requires knowing the interfacial area between two phases and this interfacial area leads to calculate the solid holdup in the bed. Consequently achieving interfacial area between gas and solid in the bed experimentally is so significant. On interfacial area measurement in fluidized bed with gas has been worked, but light transmission technique has been used less. Therefore, in the current research the possibility of using of this technique and its accuracy are investigated. Measuring, a fluidized bed was designed and the problems were averted as far as possible. By using fine solid with equal shape and diameter and installing an optical system, the absorption of light during the time of fluidization has been measured. Results indicate that this method that its validity has been proved in the gas-liquid system, by different reasons have less application in gas-solid system. One important reason could be non-uniformity in such systems.
Abstract: The renewable energy has been attracting attention as
a new alternative energy due to the problem of environmental
pollution and resource depletion. In particular, daylighting and PV
system are regarded as the solutions. In this paper, the hybrid
dimming control system supplied by solar cell and daylighting
system was designed. Daylighting system is main source and PV
system is spare source. PV system operates the LED lamp which
supports daylighting system because daylighting system is unstable
due to the variation of irradiance. In addition, PV system has a role
charging batteries. Battery charging has a benefit that PV system
operate LED lamp in the bad weather. However, LED lamp always
can`t turn on that-s why dimming control system was designed. In
particular, the solar charging robot was designed to check the
interior irradiance intensity. These systems and the application of
the solar charging robot are expected to contribute developing
alternative energy in the near future.
Abstract: Extensive rainfall disaggregation approaches have been developed and applied in climate change impact studies such as flood risk assessment and urban storm water management.In this study, five rainfall models that were capable ofdisaggregating daily rainfall data into hourly one were investigated for the rainfall record in theChangi Airport, Singapore. The objectives of this study were (i) to study the temporal characteristics of hourly rainfall in Singapore, and (ii) to evaluate the performance of variousdisaggregation models. The used models included: (i) Rectangular pulse Poisson model (RPPM), (ii) Bartlett-Lewis Rectangular pulse model (BLRPM), (iii) Bartlett-Lewis model with 2 cell types (BL2C), (iv) Bartlett-Lewis Rectangular with cell depth distribution dependent on duration (BLRD), and (v) Neyman-Scott Rectangular pulse model (NSRPM). All of these models werefitted using hourly rainfall data ranging from 1980 to 2005 (which was obtained from Changimeteorological station).The study results indicated that the weight scheme of inversely proportional variance could deliver more accurateoutputs for fitting rainfall patterns in tropical areas, and BLRPM performedrelatively better than other disaggregation models.
Abstract: The problems associated with wind predictions of
WAsP model in complex terrain are already the target of several
studies in the last decade. In this paper, the influence of surrounding
orography on accuracy of wind data analysis of a train is
investigated. For the case study, a site with complex surrounding
orography is considered. This site is located in Manjil, one of the
windiest cities of Iran. For having precise evaluation of wind regime
in the site, one-year wind data measurements from two metrological
masts are used. To validate the obtained results from WAsP, the
cross prediction between each mast is performed. The analysis
reveals that WAsP model can estimate the wind speed behavior
accurately. In addition, results show that this software can be used
for predicting the wind regime in flat sites with complex surrounding
orography.
Abstract: The study examined the influence of pay differentials on employee retention in the State Colleges of Education in the South-South Region of Nigeria. 275 subjects drawn from members of the wage negotiating teams in the Colleges were administered questionnaires constructed for study. Analysis of Variance revealed that the observed pay differentials significantly influenced retainership, f(5,269 = 6.223, P< 0.05). However, the Multiple Classification Analysis and Post-Hoc test indicated that employees in two of the Colleges with slightly lower and higher pay levels may probably remain with their employers while employees in other Colleges with the least and highest pay levels suggested quitting. Based on these observations, the influence of pay on employee retention seems inconclusive. Generally, employees in the colleges studied are dissatisfied with current pay levels. Management should confront these challenges by improving pay packages to encourage employees to remain and be dedicated to duty.
Abstract: The chemistry of sulphone hydrazide has gained increase interest in both synthetic organic chemistry and biological fields and has considerable value. The therapeutic importance of these compounds is the attractive force to continue research in such a point. The present review covers the literature up to date for the synthesis, reactions and applications of such compounds.
Abstract: The menace of counterfeiting pharmaceuticals/drugs has become a major threat to consumers, healthcare providers, drug manufacturers and governments. It is a source of public health concern both in the developed and developing nations. Several solutions for detecting and authenticating counterfeit drugs have been adopted by different nations of the world. In this article, a dialogue system-based drug counterfeiting detection system was developed and the results of the user satisfaction and acceptability of the system are presented. The results show that the users were satisfied with the system and the system was widely accepted as a means of fighting counterfeited drugs.
Abstract: Learning programming is difficult for many learners. Some researches have found that the main difficulty relates to cognitive load. Cognitive overload happens in programming due to the nature of the subject which is intrinisicly over-bearing on the working memory. It happens due to the complexity of the subject itself. The problem is made worse by the poor instructional design methodology used in the teaching and learning process. Various efforts have been proposed to reduce the cognitive load, e.g. visualization softwares, part-program method etc. Use of many computer based systems have also been tried to tackle the problem. However, little success has been made to alleviate the problem. More has to be done to overcome this hurdle. This research attempts at understanding how cognitive load can be managed so as to reduce the problem of overloading. We propose a mechanism to measure the cognitive load during pre instruction, post instruction and in instructional stages of learning. This mechanism is used to help the instruction. As the load changes the instruction is made to adapt itself to ensure cognitive viability. This mechanism could be incorporated as a sub domain in the student model of various computer based instructional systems to facilitate the learning of programming.
Abstract: A synchronous network-on-chip using wormhole packet switching
and supporting guaranteed-completion best-effort with low-priority (LP)
and high-priority (HP) wormhole packet delivery service is presented in
this paper. Both our proposed LP and HP message services deliver a good
quality of service in term of lossless packet completion and in-order message
data delivery. However, the LP message service does not guarantee minimal
completion bound. The HP packets will absolutely use 100% bandwidth of
their reserved links if the HP packets are injected from the source node with
maximum injection. Hence, the service are suitable for small size messages
(less than hundred bytes). Otherwise the other HP and LP messages, which
require also the links, will experience relatively high latency depending on the
size of the HP message. The LP packets are routed using a minimal adaptive
routing, while the HP packets are routed using a non-minimal adaptive routing
algorithm. Therefore, an additional 3-bit field, identifying the packet type,
is introduced in their packet headers to classify and to determine the type
of service committed to the packet. Our NoC prototypes have been also
synthesized using a 180-nm CMOS standard-cell technology to evaluate the
cost of implementing the combination of both services.
Abstract: Linear stability analysis of wake-shear layers in twophase
shallow flows is performed in the present paper. Twodimensional
shallow water equations are used in the analysis. It is
assumed that the fluid contains uniformly distributed solid particles.
No dynamic interaction between the carrier fluid and particles is
expected in the initial moment. The stability calculations are
performed for different values of the particle loading parameter and
two other parameters which characterize the velocity ratio and the
velocity deficit. The results show that the particle loading parameter
has a stabilizing effect on the flow while the increase in the velocity
ratio or in the velocity deficit destabilizes the flow.
Abstract: The spectral action balance equation is an equation that
used to simulate short-crested wind-generated waves in shallow water
areas such as coastal regions and inland waters. This equation consists
of two spatial dimensions, wave direction, and wave frequency which
can be solved by finite difference method. When this equation with
dominating convection term are discretized using central differences,
stability problems occur when the grid spacing is chosen too coarse.
In this paper, we introduce the splitting upwind schemes for avoiding
stability problems and prove that it is consistent to the upwind scheme
with same accuracy. The splitting upwind schemes was adopted
to split the wave spectral action balance equation into four onedimensional
problems, which for each small problem obtains the
independently tridiagonal linear systems. For each smaller system
can be solved by direct or iterative methods at the same time which
is very fast when performed by a multi-processor computer.
Abstract: In the last decade, energy based control theory has undergone a significant breakthrough in dealing with underactated mechanical systems with two successful and similar tools, controlled Lagrangians and controlled Hamiltanians (IDA-PBC). However, because of the complexity of these tools, successful case studies are lacking, in particular, MIMO cases. The seminal theoretical paper of controlled Lagrangians proposed by Bloch and his colleagues presented a benchmark example–a 4 d.o.f underactuated pendulum on a cart but a detailed and completed design is neglected. To compensate this ignorance, the note revisit their design idea by addressing explicit control functions for a similar device motivated by a vector thrust body hovering in the air. To the best of our knowledge, this system is the first MIMO, underactuated example that is stabilized by using energy based tools at the courtesy of the original design idea. Some observations are given based on computer simulation.
Abstract: Cloud Computing has recently emerged as a
compelling paradigm for managing and delivering services over the
internet. The rise of Cloud Computing is rapidly changing the
landscape of information technology, and ultimately turning the longheld
promise of utility computing into a reality. As the development
of Cloud Computing paradigm is speedily progressing, concepts, and
terminologies are becoming imprecise and ambiguous, as well as
different technologies are interfering. Thus, it becomes crucial to
clarify the key concepts and definitions. In this paper, we present the
anatomy of Cloud Computing, covering its essential concepts,
prominent characteristics, its affects, architectural design and key
technologies. We differentiate various service and deployment
models. Also, significant challenges and risks need are tackled in
order to guarantee the long-term success of Cloud Computing. The
aim of this paper is to provide a better understanding of the anatomy
of Cloud Computing and pave the way for further research in this
area.
Abstract: The line sleeves on power transmission line connects
two conductors while the transmission line is constructing. However,
the line sleeves sometimes cause transmission line break down,
because the line sleeves are deteriorated and decayed by acid rain.
When the transmission line is broken, the economical loss is huge.
Therefore the line sleeves on power transmission lines should be
inspected periodically to prevent power failure. In this paper, Korea
Electric Power Research Institute reviewed several robots to inspect
line status and proposes a robot to inspect line sleeve by measuring
magnetic field on line sleeve. The developed inspection tool can
reliable to move along transmission line and overcome several
obstacles on transmission line. The developed system is also applied
on power transmission line and verified the efficiency of the robot.
Abstract: Microarrays have become the effective, broadly used tools in biological and medical research to address a wide range of problems, including classification of disease subtypes and tumors. Many statistical methods are available for analyzing and systematizing these complex data into meaningful information, and one of the main goals in analyzing gene expression data is the detection of samples or genes with similar expression patterns. In this paper, we express and compare the performance of several clustering methods based on data preprocessing including strategies of normalization or noise clearness. We also evaluate each of these clustering methods with validation measures for both simulated data and real gene expression data. Consequently, clustering methods which are common used in microarray data analysis are affected by normalization and degree of noise and clearness for datasets.
Abstract: In this paper, a two-dimensional (2D) numerical
model for the tidal currents simulation in Persian Gulf is presented.
The model is based on the depth averaged equations of shallow water
which consider hydrostatic pressure distribution. The continuity
equation and two momentum equations including the effects of bed
friction, the Coriolis effects and wind stress have been solved. To
integrate the 2D equations, the Alternative Direction Implicit (ADI)
technique has been used. The base of equations discritization was
finite volume method applied on rectangular mesh. To evaluate the
model validation, a dam break case study including analytical
solution is selected and the comparison is done. After that, the
capability of the model in simulation of tidal current in a real field is
represented by modeling the current behavior in Persian Gulf. The
tidal fluctuations in Hormuz Strait have caused the tidal currents in
the area of study. Therefore, the water surface oscillations data at
Hengam Island on Hormoz Strait are used as the model input data.
The check point of the model is measured water surface elevations at
Assaluye port. The comparison between the results and the
acceptable agreement of them showed the model ability for modeling
marine hydrodynamic.