Abstract: Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.
Abstract: Plasmodium vivax malaria differs from P. falciparum malaria in that a person suffering from P. vivax infection can suffer relapses of the disease. This is due the parasite being able to remain dormant in the liver of the patients where it is able to re-infect the patient after a passage of time. During this stage, the patient is classified as being in the dormant class. The model to describe the transmission of P. vivax malaria consists of a human population divided into four classes, the susceptible, the infected, the dormant and the recovered. The effect of a time delay on the transmission of this disease is studied. The time delay is the period in which the P. vivax parasite develops inside the mosquito (vector) before the vector becomes infectious (i.e., pass on the infection). We analyze our model by using standard dynamic modeling method. Two stable equilibrium states, a disease free state E0 and an endemic state E1, are found to be possible. It is found that the E0 state is stable when a newly defined basic reproduction number G is less than one. If G is greater than one the endemic state E1 is stable. The conditions for the endemic equilibrium state E1 to be a stable spiral node are established. For realistic values of the parameters in the model, it is found that solutions in phase space are trajectories spiraling into the endemic state. It is shown that the limit cycle and chaotic behaviors can only be achieved with unrealistic parameter values.
Abstract: We propose a fast and robust hierarchical face detection system which finds and localizes face images with a cascade of classifiers. Three modules contribute to the efficiency of our detector. First, heterogeneous feature descriptors are exploited to enrich feature types and feature numbers for face representation. Second, a PSO-Adaboost algorithm is proposed to efficiently select discriminative features from a large pool of available features and reinforce them into the final ensemble classifier. Compared with the standard exhaustive Adaboost for feature selection, the new PSOAdaboost algorithm reduces the training time up to 20 times. Finally, a three-stage hierarchical classifier framework is developed for rapid background removal. In particular, candidate face regions are detected more quickly by using a large size window in the first stage. Nonlinear SVM classifiers are used instead of decision stump functions in the last stage to remove those remaining complex nonface patterns that can not be rejected in the previous two stages. Experimental results show our detector achieves superior performance on the CMU+MIT frontal face dataset.
Abstract: In this paper, we propose a new approach to query-by-humming, focusing on MP3 songs database. Since MP3 songs are much more difficult in melody representation than symbolic performance data, we adopt to extract feature descriptors from the vocal sounds part of the songs. Our approach is based on signal filtering, sub-band spectral processing, MDCT coefficients analysis and peak energy detection by ignorance of the background music as much as possible. Finally, we apply dual dynamic programming algorithm for feature similarity matching. Experiments will show us its online performance in precision and efficiency.
Abstract: A bond graph model of a hydroelectric plant is
proposed. In order to analyze the system some structural properties
of a bond graph are used. The structural controllability of
the hydroelctric plant is described. Also, the steady state of the
state variables applying the bond graph in a derivative causality
assignment is obtained. Finally, simulation results of the system
are shown.
Abstract: The present study has been carried out with a view to calculate the coastal vulnerability index (CVI) to know the high and low sensitive areas and area of inundation due to future SLR. Both conventional and remotely sensed data were used and analyzed through the modelling technique. Out of the total study area, 8.26% is very high risk, 14.21% high, 9.36% medium, 22.46% low and 7.35% in the very low vulnerable category, due to costal components. Results of the inundation analysis indicate that 225.2 km² and 397 km² of the land area will be submerged by flooding at 1m and 10m inundation levels. The most severely affected sectors are expected to be the residential, industrial and recreational areas. As this coast is planned for future coastal developmental activities, measures such as industrializations, building regulation, urban growth planning and agriculture, development of an integrated coastal zone management, strict enforcement of the Coastal Regulation Zone (CRZ) Act, monitoring of impacts and further research in this regard are recommended for the study area.
Abstract: Undoubtedly, chassis is one of the most important
parts of a vehicle. Chassis that today are produced for vehicles are
made up of four parts. These parts are jointed together by screwing.
Transverse parts are called cross member.
This study reviews the stress generated by cyclic laboratory loads
in front cross member of Peugeot 405. In this paper the finite element
method is used to simulate the welding process and to determine the
physical response of the spot-welded joints. Analysis is done by the
Abaqus software.
The Stresses generated in cross member structure are generally
classified into two groups: The stresses remained in form of residual
stresses after welding process and the mechanical stress generated by
cyclic load. Accordingly the total stress must be obtained by
determining residual stress and mechanical stress separately and then
sum them according to the superposition principle.
In order to improve accuracy, material properties including
physical, thermal and mechanical properties were supposed to be
temperature-dependent. Simulation shows that maximum Von Misses
stresses are located at special points. The model results are then
compared to the experimental results which are reported by
producing factory and good agreement is observed.
Abstract: Color constancy algorithms are generally based on the
simplified assumption about the spectral distribution or the reflection
attributes of the scene surface. However, in reality, these assumptions
are too restrictive. The methodology is proposed to extend existing
algorithm to applying color constancy locally to image patches rather
than globally to the entire images.
In this paper, a method based on low-level image features using
superpixels is proposed. Superpixel segmentation partition an image
into regions that are approximately uniform in size and shape. Instead
of using entire pixel set for estimating the illuminant, only superpixels
with the most valuable information are used. Based on large scale
experiments on real-world scenes, it can be derived that the estimation
is more accurate using superpixels than when using the entire image.
Abstract: Dr Eliyahu Goldratt has done the pioneering work in
the development of Theory of Constraints. Since then, many more
researchers around the globe are working to enhance this body of
knowledge. In this paper, an attempt has been made to compile the
salient features of this theory from the work done by Goldratt and
other researchers. This paper will provide a good starting point to the
potential researchers interested to work in Theory of Constraints. The
paper will also help the practicing managers by clarifying their
concepts on the theory and will facilitate its successful
implementation in their working areas.
Abstract: As the trend of manufacturing is being dominated depending on services, products and processes are more and more related with sophisticated services. Thus, this research starts with the discussion about integration of the product, process, and service in the innovation process. In particular, this paper sets out some foundations for a theory of service innovation in the field of manufacturing, and proposes the dynamic model of service innovation related to product and process. Two dynamic models of service innovation are suggested to investigate major tendencies and dynamic variations during the innovation cycle: co-innovation and sequential innovation. To structure dynamic models of product, process, and service innovation, the innovation stages in which two models are mainly achieved are identified. The research would encourage manufacturers to formulate strategy and planning for service development with product and process.
Abstract: Bone remodeling occurs by the balanced action of
bone resorbing osteoclasts (OC) and bone-building osteoblasts.
Increased bone resorption by excessive OC activity contributes
to malignant and non-malignant diseases including osteoporosis.
To study OC differentiation and function, OC formed in
in vitro cultures are currently counted manually, a tedious
procedure which is prone to inter-observer differences. Aiming
for an automated OC-quantification system, classification of
OC and precursor cells was done on fluorescence microscope
images based on the distinct appearance of fluorescent nuclei.
Following ellipse fitting to nuclei, a combination of eight
features enabled clustering of OC and precursor cell nuclei.
After evaluating different machine-learning techniques, LOGREG
achieved 74% correctly classified OC and precursor cell
nuclei, outperforming human experts (best expert: 55%). In
combination with the automated detection of total cell areas,
this system allows to measure various cell parameters and most
importantly to quantify proteins involved in osteoclastogenesis.
Abstract: In this paper, we propose a novel improvement for the generalized Lloyd Algorithm (GLA). Our algorithm makes use of an M-tree index built on the codebook which makes it possible to reduce the number of distance computations when the nearest code words are searched. Our method does not impose the use of any specific distance function, but works with any metric distance, making it more general than many other fast GLA variants. Finally, we present the positive results of our performance experiments.
Abstract: In this paper, a new technique for fast painting with
different colors is presented. The idea of painting relies on applying
masks with different colors to the background. Fast painting is
achieved by applying these masks in the frequency domain instead of
spatial (time) domain. New colors can be generated automatically as a
result from the cross correlation operation. This idea was applied
successfully for faster specific data (face, object, pattern, and code)
detection using neural algorithms. Here, instead of performing cross
correlation between the input input data (e.g., image, or a stream of
sequential data) and the weights of neural networks, the cross
correlation is performed between the colored masks and the
background. Furthermore, this approach is developed to reduce the
computation steps required by the painting operation. The principle of
divide and conquer strategy is applied through background
decomposition. Each background is divided into small in size subbackgrounds
and then each sub-background is processed separately by
using a single faster painting algorithm. Moreover, the fastest painting
is achieved by using parallel processing techniques to paint the
resulting sub-backgrounds using the same number of faster painting
algorithms. In contrast to using only faster painting algorithm, the
speed up ratio is increased with the size of the background when using
faster painting algorithm and background decomposition. Simulation
results show that painting in the frequency domain is faster than that in
the spatial domain.
Abstract: The present paper proposes high performance nonlinear
force controllers for a servopneumatic real-time fatigue test
machine. A CompactRIO® controller was used, being fully
programmed using LabVIEW language. Fuzzy logic control
algorithms were evaluated to tune the integral and derivative
components in the development of hybrid controllers, namely a FLC
P and a hybrid FLC PID real-time-based controllers. Their
behaviours were described by using state diagrams. The main
contribution is to ensure a smooth transition between control states,
avoiding discrete transitions in controller outputs. Steady-state errors
lower than 1.5 N were reached, without retuning the controllers.
Good results were also obtained for sinusoidal tracking tasks from
1/¤Ç to 8/¤Ç Hz.
Abstract: The resident registration number was adopted for the purposes of enhanced services for resident convenience and effective performance of governmental administrative affairs. However, it has been used for identification purposes customarily and irrationally in line with the development and spread of the Internet. In response to the growing concern about the leakage of collected RRNs and possible abuses of stolen RRNs, e.g. identity theft, for crimes, the Korean Communications Commission began to take legal/regulatory actions in 2011 to minimize the online collection and use of resident registration numbers. As the use of the RRN was limited after the revision of the Act on Promotion of Information and Communications Network Utilization and Information Protection, etc., online business providers were required to have alternatives to the RRN for the purpose of identifying the user's identity and age, in compliance with the law, and settling disputes with customers. This paper presents means of verifying the personal identity by taking advantage of the commonly used infrastructure and simply replacing personal information entered and stored, without requiring users to enter their RRNs.
Abstract: Artificial Neural Network (ANN) has been
extensively used for classification of heart sounds for its
discriminative training ability and easy implementation. However, it
suffers from overparameterization if the number of nodes is not
chosen properly. In such cases, when the dataset has redundancy
within it, ANN is trained along with this redundant information that
results in poor validation. Also a larger network means more
computational expense resulting more hardware and time related
cost. Therefore, an optimum design of neural network is needed
towards real-time detection of pathological patterns, if any from heart
sound signal. The aims of this work are to (i) select a set of input
features that are effective for identification of heart sound signals and
(ii) make certain optimum selection of nodes in the hidden layer for a
more effective ANN structure. Here, we present an optimization
technique that involves Singular Value Decomposition (SVD) and
QR factorization with column pivoting (QRcp) methodology to
optimize empirically chosen over-parameterized ANN structure.
Input nodes present in ANN structure is optimized by SVD followed
by QRcp while only SVD is required to prune undesirable hidden
nodes. The result is presented for classifying 12 common
pathological cases and normal heart sound.
Abstract: A finite element analysis (FEA) computer software HyperWorks is utilized in re-designing an automotive component to reduce its mass. Reduction of components mass contributes towards environmental sustainability by saving world-s valuable metal resources and by reducing carbon emission through improved overall vehicle fuel efficiency. A shape optimization analysis was performed on a rear spindle component. Pre-processing and solving procedures were performed using HyperMesh and RADIOSS respectively. Shape variables were defined using HyperMorph. Then optimization solver OptiStruct was utilized with fatigue life set as a design constraint. Since Stress-Number of Cycle (S-N) theory deals with uni-axial stress, the Signed von Misses stress on the component was used for looking up damage on S-N curve, and Gerber criterion for mean stress corrections. The optimization analysis resulted in mass reduction of 24% of the original mass. The study proved that the adopted approach has high potential use for environmental sustainability.
Abstract: Glaucoma diagnosis involves extracting three features
of the fundus image; optic cup, optic disc and vernacular. Present
manual diagnosis is expensive, tedious and time consuming. A
number of researches have been conducted to automate this process.
However, the variability between the diagnostic capability of an
automated system and ophthalmologist has yet to be established. This
paper discusses the efficiency and variability between
ophthalmologist opinion and digital technique; threshold. The
efficiency and variability measures are based on image quality
grading; poor, satisfactory or good. The images are separated into
four channels; gray, red, green and blue. A scientific investigation
was conducted on three ophthalmologists who graded the images
based on the image quality. The images are threshold using multithresholding
and graded as done by the ophthalmologist. A
comparison of grade from the ophthalmologist and threshold is made.
The results show there is a small variability between result of
ophthalmologists and digital threshold.
Abstract: In this paper, we propose a chaotic cipher system consisting of Improved Volterra Filters and the mapping that is created from the actual voice by using Radial Basis Function Network. In order to achieve a practical system, the system supposes to use the digital communication line, such as the Internet, to maintain the parameter matching between the transmitter and receiver sides. Therefore, in order to withstand the attack from outside, it is necessary that complicate the internal state and improve the sensitivity coefficient. In this paper, we validate the robustness of proposed method from three perspectives of "Chaotic properties", "Randomness", "Coefficient sensitivity".
Abstract: This paper introduced the status quo of laws and
regulations of sustainable construction in China and investigated the
existing problems of current laws and regulations through
person-interviews in Beijing, Shanghai, Chongqing and Shenzhen in
China. The problems include incomplete legal system, lack of
guidance of higher-level laws, backward in some laws and regulations,
unclear legal liability and poor law enforcement. Aimed at these
problems, this paper also put forward some improvement approaches,
such as filling the legal gap, revising laws and regulations, establishing
incentive system and keeping pace with level of development.