Abstract: Mutations of the telomeric copy of the survival motor neuron 1 (SMN1) gene cause spinal muscular atrophy. A deletion of the Eef1a2 gene leads to lower motor neuron degeneration in wasted mice. Indirect evidences have been shown that the eEF1A protein family may interact with SMN, and our previous study showed that abnormalities of neuromuscular junctions in wasted mice were similar to those of Smn mutant mice. To determine potential colocalization between SMN and tissue-specific translation elongation factor 1A2 (eEF1A2), an immunochemical analysis of HeLa cells transfected with the plasmid pcDNA3.1(+)C-hEEF1A2- myc and a new quantitative test of colocalization by intensity correlation analysis (ICA) was used to explore the association of SMN and eEF1A2. Here the results showed that eEF1A2 redistributed from the cytoplasm to the nucleus in response to serum and epidermal growth factor. In the cytoplasm, compelling evidence showed that staining for myc-tagged eEF1A2 varied in synchrony with that for SMN, consistent with the formation of a SMN-eEF1A2 complex in the cytoplasm of HeLa cells. These findings suggest that eEF1A2 may colocalize with SMN in the cytoplasm and may be a component of the SMN complex. However, the limitation of the ICA method is an inability to resolve colocalization in components of small organelles such as the nucleus.
Abstract: We study different types of aggregation operators and
the decision making process with minimization of regret. We analyze
the original work developed by Savage and the recent work
developed by Yager that generalizes the MMR method creating a
parameterized family of minimal regret methods by using the ordered
weighted averaging (OWA) operator. We suggest a new method that
uses different types of geometric operators such as the weighted
geometric mean or the ordered weighted geometric operator (OWG)
to generalize the MMR method obtaining a new parameterized family
of minimal regret methods. The main result obtained in this method
is that it allows to aggregate negative numbers in the OWG operator.
Finally, we give an illustrative example.
Abstract: This paper presents a new and efficient approach for capacitor placement in radial distribution systems that determine the optimal locations and size of capacitor with an objective of improving the voltage profile and reduction of power loss. The solution methodology has two parts: in part one the loss sensitivity factors are used to select the candidate locations for the capacitor placement and in part two a new algorithm that employs Plant growth Simulation Algorithm (PGSA) is used to estimate the optimal size of capacitors at the optimal buses determined in part one. The main advantage of the proposed method is that it does not require any external control parameters. The other advantage is that it handles the objective function and the constraints separately, avoiding the trouble to determine the barrier factors. The proposed method is applied to 9, 34, and 85-bus radial distribution systems. The solutions obtained by the proposed method are compared with other methods. The proposed method has outperformed the other methods in terms of the quality of solution.
Abstract: The main emphasis of metallurgists has been to process the materials to obtain the balanced mechanical properties for the given application. One of the processing routes to alter the properties is heat treatment. Nearly 90% of the structural applications are related to the medium carbon an alloyed steels and hence are regarded as structural steels. The major requirement in the conventional steel is to improve workability, toughness, hardness and grain refinement. In this view, it is proposed to study the mechanical and tribological properties of unalloyed structural (AISI 1140) steel with different thermal (heat) treatments like annealing, normalizing, tempering and hardening and compared with as brought (cold worked) specimen. All heat treatments are carried out in atmospheric condition. Hardening treatment improves hardness of the material, a marginal decrease in hardness value with improved ductility is observed in tempering. Annealing and normalizing improve ductility of the specimen. Normalized specimen shows ultimate ductility. Hardened specimen shows highest wear resistance in the initial period of slide wear where as above 25KM of sliding distance, as brought steel dominates the hardened specimen. Both mild and severe wear regions are observed. Microstructural analysis shows the existence of pearlitic structure in normalized specimen, lath martensitic structure in hardened, pearlitic, ferritic structure in annealed specimen.
Abstract: In this paper, the energy performance of a selected
UHDE Ammonia plant is optimized by conducting heat integration through waste heat recovery and the synthesis of a heat exchange
network (HEN). Minimum hot and cold utility requirements were estimated through IChemE spreadsheet. Supporting simulation was
carried out using HYSYS software. The results showed that there is
no need for heating utility while the required cold utility was found to
be around 268,714 kW. Hence a threshold pinch case was faced. Then, the hot and cold streams were matched appropriately. Also,
waste heat recovered resulted with savings in HP and LP steams of
approximately 51.0% and 99.6%, respectively. An economic analysis
on proposed HEN showed very attractive overall payback period not
exceeding 3 years. In general, a net saving approaching 35% was
achieved in implementing heat optimization of current studied UHDE Ammonia process.
Abstract: In this paper the features of multiple material gate
silicon-on-insulator MOSFETs are presented and compared with
single material gate silicon-on-insulator MOSFET structures. The
results indicate that the multiple material gate structures reduce short
channel effects such as drain induce barrier lowering, hot electron
effect and better current characteristics in comparison with single
material structures
Abstract: This study was carried out to develop a flotation
procedure for an oxide copper ore from a Region in Central Africa
for producing an 18% copper concentrate for downstream processing
at maximum recovery from a 4% copper feed grade. The copper
recoveries achieved from the test work were less than 50% despite
changes in reagent conditions (multistage sulphidisation, use of RCA
emulsion and mixture, use of AM 2, etc). The poor recoveries were
attributed to the mineralogy of the ore from which copper silicates
accounted for approximately 70% (mass) of the copper minerals in
the ore. These can be complex and difficult to float using
conventional flotation methods. Best results were obtained using
basic sulphidisation procedures, a high flotation temperature and
extended flotation residence time.
Abstract: A new, combinatorial model for analyzing and inter-
preting an electrocardiogram (ECG) is presented. An application of
the model is QRS peak detection. This is demonstrated with an
online algorithm, which is shown to be space as well as time efficient.
Experimental results on the MIT-BIH Arrhythmia database show that
this novel approach is promising. Further uses for this approach are
discussed, such as taking advantage of its small memory requirements
and interpreting large amounts of pre-recorded ECG data.
Abstract: Fishbone of Nile Tilapia (Tilapia nilotica), waste from the frozen Nile Tilapia fillet factory, is one of calcium sources. In order to increase fish bone powder value, this study aimed to investigate the effect of Tilapia bone flour (TBF) addition (5, 10, 15% by flour weight) on cooking quality, texture and sensory attributes of noodles. The results indicated that tensile strength, color value (a*) and water absorption of noodles significantly decreased (p£0.05) as the levels of TBF increased from 0-15%. While cooking loss, cooking time and color values (L* and b*) of noodles significantly increased (p£0.05). Sensory evaluation indicated that noodles with 5% TBF received the highest overall acceptability score.
Abstract: The present study examines the mediating effect of
online flow experience on the relationship between extraversionintroversion,
locus of control and loneliness, and depression and
satisfaction with life. The data was obtained using a structured
questionnaire prepared by adapting standardized scales available from
a sample of 102 engineering students from different technical
institutions at Bhubaneswar, India. The results indicate that there is a
positive significant relationship between introversion, external locus
of control, loneliness, depression and online flow experience, and
extraversion, internal locus of control and satisfaction with life. The
results also suggest that online flow experience mediates the
relationship between the aforementioned variables.
Abstract: Promoting critical thinking (CT) in an educational
setting has been appraised in order to enhance learning and
intellectual skills. In this study, a pedagogical course in a vocational
teacher education program in Turkey was designed by integrating CT
skill-based strategies/activities into the course content and CT skills
were means leading to intended course objectives. The purpose of the
study was to evaluate the importance of the course objectives, the
attainment of the objectives, and the effectiveness of teachinglearning
strategies/activities from prospective teachers- points of
view. The results revealed that although the students mostly
considered the course objectives important, they did not feel
competent in the attainment of all objectives especially in those
related to the main topic of Learning and those requiring higher order
thinking skills. On the other hand, the students considered the course
activities effective for learning and for the development of thinking
skills, especially, in interpreting, comparing, questioning,
contrasting, and forming relationships.
Abstract: The demand of hydrocarbons has increased the
construction of pipelines and the protection of the physical and
mechanical integrity of the already existing infrastructure. Corrosion
is the main reason of failures in the pipeline and it is mostly produced
by acid (HCOOCH3). In this basis, a CFD code was used, in order to
study the corrosion of internal wall of hydrocarbons pipeline. In this
situation, the corrosion phenomenon shows a growing deposit, which
causes defect damages (welding or fabrication) at diverse positions
along the pipeline. The solution of the pipeline corrosion is based on
the diminution of the Naphthenic acid.
Abstract: The Spalart and Allmaras turbulence model has been
implemented in a numerical code to study the compressible turbulent
flows, which the system of governing equations is solved with a
finite volume approach using a structured grid. The AUSM+ scheme
is used to calculate the inviscid fluxes. Different benchmark
problems have been computed to validate the implementation and
numerical results are shown. A special Attention is paid to wall jet
applications. In this study, the jet is submitted to various wall
boundary conditions (adiabatic or uniform heat flux) in forced
convection regime and both two-dimensional and axisymmetric wall
jets are considered. The comparison between the numerical results
and experimental data has given the validity of this turbulence model
to study the turbulent wall jets especially in engineering applications.
Abstract: In this paper, a novel corner detection method is
presented to stably extract geometrically important corners.
Intensity-based corner detectors such as the Harris corner can detect
corners in noisy environments but has inaccurate corner position and
misses the corners of obtuse angles. Edge-based corner detectors such
as Curvature Scale Space can detect structural corners but show
unstable corner detection due to incomplete edge detection in noisy
environments. The proposed image-based direct curvature estimation
can overcome limitations in both inaccurate structural corner detection
of the Harris corner detector (intensity-based) and the unstable corner
detection of Curvature Scale Space caused by incomplete edge
detection. Various experimental results validate the robustness of the
proposed method.
Abstract: In this paper, the techniques for estimating the
residual stress in high velocity oxy fuel thermal spray coatings have
been discussed and compared. The development trend and the last
investigation have been studied. It is seemed that the there is not
effective study on the effect of the peening action in HVOF
analytically and numerically.
Abstract: Optimal design of structure has a main role in reduction of material usage which leads to deduction in the final cost of construction projects. Evolutionary approaches are found to be more successful techniques for solving size and shape structural optimization problem since it uses a stochastic random search instead of a gradient search. By reviewing the recent literature works the problem found was the optimization of weight. A new meta-heuristic algorithm called as Cuckoo Search (CS) Algorithm has used for the optimization of the total weight of the truss structures. This paper has used set of 10 bars and 25 bars trusses for the testing purpose. The main objective of this work is to reduce the number of iterations, weight and the total time consumption. In order to demonstrate the effectiveness of the present method, minimum weight design of truss structures is performed and the results of the CS are compared with other algorithms.
Abstract: Using quantum hydrodynamical (QHD) model the linear dispersion relation for the electron plasma waves propagating in a cylindrical waveguide filled with a dense plasma containing streaming electron, hole and stationary charged dust particles has been derived. It is shown that the effect of finite boundary and stream velocity of electrons and holes make some of the possible modes of propagation linearly unstable. The growth rate of this instability is shown to depend significantly on different plasma parameters.
Abstract: Today, Hydroforming technology provides an
attractive alternative to conventional matched die forming, especially
for cost-sensitive, lower volume production, and for parts with
irregular contours. In this study the critical fluid pressures which lead
to rupture in the workpiece has been investigated by theoretical and
finite element methods. The axisymmetric analysis was developed to
investigate the tearing phenomenon in cylindrical Hydroforming
Deep Drawing (HDD). By use of obtained equations the effect of
anisotropy, drawing ratio, sheet thickness and strain hardening
exponent on tearing diagram were investigated.
Abstract: At the time where electronic books, or e-Books, offer
students a fun way of learning , teachers who are used to the paper
text books may find it as a new challenge to use it as a part of
learning process. Precisely, there are various types of e-Books
available to suit students- knowledge, characteristics, abilities, and
interests. The paper discusses teachers- perceptions on the use of ebooks
as a paper text book in the classroom. A survey was conducted
on 72 teachers who use e-books as textbooks. It was discovered that a
majority of these teachers had good perceptions on the use of ebooks.
However, they had little problems using the devices. It can be
overcome with some strategies and a suggested framework.
Abstract: A key aspect of the design of any software system is
its architecture. An architecture description provides a formal model
of the architecture in terms of components and connectors and how
they are composed together. COSA (Component-Object based
Software Structures), is based on object-oriented modeling and
component-based modeling. The model improves the reusability by
increasing extensibility, evolvability, and compositionality of the
software systems. This paper presents the COSA modelling tool
which help architects the possibility to verify the structural coherence
of a given system and to validate its semantics with COSA approach.