Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: Gas turbine air inlet cooling is a useful method for
increasing output for regions where significant power demand and
highest electricity prices occur during the warm months. Inlet air
cooling increases the power output by taking advantage of the gas
turbine-s feature of higher mass flow rate when the compressor inlet
temperature decreases. Different methods are available for reducing
gas turbine inlet temperature. There are two basic systems currently
available for inlet cooling. The first and most cost-effective system is
evaporative cooling. Evaporative coolers make use of the evaporation
of water to reduce the gas turbine-s inlet air temperature. The second
system employs various ways to chill the inlet air. In this method, the
cooling medium flows through a heat exchanger located in the inlet
duct to remove heat from the inlet air. However, the evaporative
cooling is limited by wet-bulb temperature while the chilling can cool
the inlet air to temperatures that are lower than the wet bulb
temperature. In the present work, a thermodynamic model of a gas
turbine is built to calculate heat rate, power output and thermal
efficiency at different inlet air temperature conditions. Computational
results are compared with ISO conditions herein called "base-case".
Therefore, the two cooling methods are implemented and solved for
different inlet conditions (inlet temperature and relative humidity).
Evaporative cooler and absorption chiller systems results show that
when the ambient temperature is extremely high with low relative
humidity (requiring a large temperature reduction) the chiller is the
more suitable cooling solution. The net increment in the power output
as a function of the temperature decrease for each cooling method is
also obtained.
Abstract: In recent years, tuned mass damper (TMD) control systems for civil engineering structures have attracted considerable attention. This paper emphasizes on the application of particle swarm application (PSO) to design and optimize the parameters of the TMD control scheme for achieving the best results in the reduction of the building response under earthquake excitations. The Integral of the Time multiplied Absolute value of the Error (ITAE) based on relative displacement of all floors in the building is taken as a performance index of the optimization criterion. The problem of robustly TMD controller design is formatted as an optimization problem based on the ITAE performance index to be solved using the PSO technique which has a story ability to find the most optimistic results. An 11- story realistic building, located in the city of Rasht, Iran is considered as a test system to demonstrate effectiveness of the proposed method. The results analysis through the time-domain simulation and some performance indices reveals that the designed PSO based TMD controller has an excellent capability in reduction of the seismically excited example building.
Abstract: Chemical industry project management involves
complex decision making situations that require discerning abilities
and methods to make sound decisions. Project managers are faced
with decision environments and problems in projects that are
complex. In this work, case study is Research and Development
(R&D) project selection. R&D is an ongoing process for forward
thinking technology-based chemical industries. R&D project
selection is an important task for organizations with R&D project
management. It is a multi-criteria problem which includes both
tangible and intangible factors. The ability to make sound decisions
is very important to success of R&D projects. Multiple-criteria
decision making (MCDM) approaches are major parts of decision
theory and analysis. This paper presents all of MCDM approaches
for use in R&D project selection. It is hoped that this work will
provide a ready reference on MCDM and this will encourage the
application of the MCDM by chemical engineering management.
Abstract: Natural disasters, including earthquake, kill many people around the world every year. Society rescue actions, which start after the earthquake and are called LAST in abbreviation, include locating, access, stabilization and transportation. In the present article, we have studied the process of local accessibility to the injured and transporting them to health care centers. With regard the heavy traffic load due to earthquake, the destruction of connecting roads and bridges and the heavy debris in alleys and street, which put the lives of the injured and the people buried under the debris in danger, accelerating the rescue actions and facilitating the accessibilities are of great importance, obviously. Tehran, the capital of Iran, is among the crowded cities in the world and is the center of extensive economic, political, cultural and social activities. Tehran has a population of about 9.5 millions and because of the immigration of people from the surrounding cities. Furthermore, considering the fact that Tehran is located on two important and large faults, a 6 Richter magnitude earthquake in this city could lead to the greatest catastrophe during the entire human history. The present study is a kind of review and a major part of the required information for it, has been obtained from libraries all of the rescue vehicles around the world, including rescue helicopters, ambulances, fire fighting vehicles and rescue boats, and their applied technology, and also the robots specifically designed for the rescue system and the advantages and disadvantages of them, have been investigated. The studies show that there is a significant relationship between the rescue team-s arrival time at the incident zone and the number of saved people; so that, if the duration of burial under debris 30 minutes, the probability of survival is %99.3, after a day is %81, after 2days is %19 and after 5days is %7.4. The exiting transport systems all have some defects. If these defects are removed, more people could be saved each hour and the preparedness against natural disasters is increased. In this study, transport system has been designed for the rescue team and the injured; which could carry the rescue team to the incident zone and the injured to the health care centers. In addition, this system is able to fly in the air and move on the earth as well; so that the destruction of roads and the heavy traffic load could not prevent the rescue team from arriving early at the incident zone. The system also has the equipment required firebird for debris removing, optimum transport of the injured and first aid.
Abstract: Electronic Government is one of the special concepts
which has been performed successfully within recent decades.
Electronic government is a digital, wall-free government with a
virtual organization for presenting of online governmental services
and further cooperation in different political/social activities. In order
to have a successful implementation of electronic government
strategy and benefiting from its complete potential and benefits and
generally for establishment and applying of electronic government, it
is necessary to have different infrastructures as the basics of
electronic government with lack of which it is impossible to benefit
from mentioned services. For this purpose, in this paper we have
managed to recognize relevant obstacles for establishment of
electronic government in Iran. All required data for recognition of
obstacles were collected from statistical society of involved
specialists of Ministry of Communications & Information
Technology of Iran and Information Technology Organization of
Tehran Municipality through questionnaire. Then by considering of
five-point Likert scope and μ =3 as the index of relevant factors of
proposed model, we could specify current obstacles against
electronic government in Iran along with some guidelines and
proposal in this regard. According to the results, mentioned obstacles
for applying of electronic government in Iran are as follows:
Technical & technological problems, Legal, judicial & safety
problems, Economic problems and Humanistic Problems.
Abstract: In this paper we proposed a method for finding video
frames representing one sign in the finger alphabet. The method is
based on determining hands location, segmentation and the use of
standard video quality evaluation metrics. Metric calculation is
performed only in regions of interest. Sliding mechanism for finding
local extrema and adaptive threshold based on local averaging is used
for key frames selection. The success rate is evaluated by recall,
precision and F1 measure. The method effectiveness is compared
with metrics applied to all frames. Proposed method is fast, effective
and relatively easy to realize by simple input video preprocessing
and subsequent use of tools designed for video quality measuring.
Abstract: The literature reports a large number of approaches for
measuring the similarity between protein sequences. Most of these
approaches estimate this similarity using alignment-based techniques
that do not necessarily yield biologically plausible results, for two
reasons.
First, for the case of non-alignable (i.e., not yet definitively aligned
and biologically approved) sequences such as multi-domain, circular
permutation and tandem repeat protein sequences, alignment-based
approaches do not succeed in producing biologically plausible results.
This is due to the nature of the alignment, which is based on the
matching of subsequences in equivalent positions, while non-alignable
proteins often have similar and conserved domains in non-equivalent
positions.
Second, the alignment-based approaches lead to similarity measures
that depend heavily on the parameters set by the user for the alignment
(e.g., gap penalties and substitution matrices). For easily alignable
protein sequences, it's possible to supply a suitable combination of
input parameters that allows such an approach to yield biologically
plausible results. However, for difficult-to-align protein sequences,
supplying different combinations of input parameters yields different
results. Such variable results create ambiguities and complicate the
similarity measurement task.
To overcome these drawbacks, this paper describes a novel and
effective approach for measuring the similarity between protein
sequences, called SAF for Substitution and Alignment Free. Without
resorting either to the alignment of protein sequences or to substitution
relations between amino acids, SAF is able to efficiently detect the
significant subsequences that best represent the intrinsic properties of
protein sequences, those underlying the chronological dependencies of
structural features and biochemical activities of protein sequences.
Moreover, by using a new efficient subsequence matching scheme,
SAF more efficiently handles protein sequences that contain similar
structural features with significant meaning in chronologically
non-equivalent positions. To show the effectiveness of SAF, extensive
experiments were performed on protein datasets from different
databases, and the results were compared with those obtained by
several mainstream algorithms.
Abstract: With data centers, end-users can realize the pervasiveness of services that will be one day the cornerstone of our lives. However, data centers are often classified as computing systems that consume the most amounts of power. To circumvent such a problem, we propose a self-adaptive weighted sum methodology that jointly optimizes the performance and power consumption of any given data center. Compared to traditional methodologies for multi-objective optimization problems, the proposed self-adaptive weighted sum technique does not rely on a systematical change of weights during the optimization procedure. The proposed technique is compared with the greedy and LR heuristics for large-scale problems, and the optimal solution for small-scale problems implemented in LINDO. the experimental results revealed that the proposed selfadaptive weighted sum technique outperforms both of the heuristics and projects a competitive performance compared to the optimal solution.
Abstract: This work proposes a novel market-based air traffic flow control model considering competitive airlines in air traffic network. In the flow model, an agent based framework for resources (link/time pair) pricing is described. Resource agent and auctioneer for groups of resources are also introduced to simulate the flow management in Air Traffic Control (ATC). Secondly, the distributed group pricing algorithm is introduced, which efficiently reflect the competitive nature of the airline industry. Resources in the system are grouped according to the degree of interaction, and each auctioneer adjust s the price of one group of resources respectively until the excess demand of resources becomes zero when the demand and supply of resources of the system changes. Numerical simulation results show the feasibility of solving the air traffic flow control problem using market mechanism and pricing algorithms on the air traffic network.
Abstract: MATCH project [1] entitle the development of an
automatic diagnosis system that aims to support treatment of colon
cancer diseases by discovering mutations that occurs to tumour
suppressor genes (TSGs) and contributes to the development of
cancerous tumours. The constitution of the system is based on a)
colon cancer clinical data and b) biological information that will be
derived by data mining techniques from genomic and proteomic
sources The core mining module will consist of the popular, well
tested hybrid feature extraction methods, and new combined
algorithms, designed especially for the project. Elements of rough
sets, evolutionary computing, cluster analysis, self-organization maps
and association rules will be used to discover the annotations
between genes, and their influence on tumours [2]-[11].
The methods used to process the data have to address their high
complexity, potential inconsistency and problems of dealing with the
missing values. They must integrate all the useful information
necessary to solve the expert's question. For this purpose, the system
has to learn from data, or be able to interactively specify by a domain
specialist, the part of the knowledge structure it needs to answer a
given query. The program should also take into account the
importance/rank of the particular parts of data it analyses, and adjusts
the used algorithms accordingly.
Abstract: In this paper, we introduce GODYS-PC software
package for modeling, simulating and analyzing dynamic systems.
To illustrate the use of GODYS-PC we present a few examples
which concern modeling and simulating of engineering systems. In
order to compare GODYS-PC with widely used in academia and
industry Simulink®, the same examples are provided both in
GODYS-PC and Simulink®.
Abstract: The major part of light weight timber constructions
consists of insulation. Mineral wool is the most commonly used
insulation due to its cost efficiency and easy handling. The fiber
orientation and porosity of this insulation material enables flowthrough.
The air flow resistance is low. If leakage occurs in the
insulated bay section, the convective flow may cause energy losses
and infiltration of the exterior wall with moisture and particles. In
particular the infiltrated moisture may lead to thermal bridges and
growth of health endangering mould and mildew. In order to prevent
this problem, different numerical calculation models have been
developed. All models developed so far have a potential for
completion. The implementation of the flow-through properties of
mineral wool insulation may help to improve the existing models.
Assuming that the real pressure difference between interior and
exterior surface is larger than the prescribed pressure difference in the
standard test procedure for mineral wool ISO 9053 / EN 29053,
measurements were performed using the measurement setup for
research on convective moisture transfer “MSRCMT".
These measurements show, that structural inhomogeneities of
mineral wool effect the permeability only at higher pressure
differences, as applied in MSRCMT. Additional microscopic
investigations show, that the location of a leak within the
construction has a crucial influence on the air flow-through and the
infiltration rate. The results clearly indicate that the empirical values
for the acoustic resistance of mineral wool should not be used for the
calculation of convective transfer mechanisms.
Abstract: In today's day and age, one of the important topics in
information security is authentication. There are several alternatives
to text-based authentication of which includes Graphical Password
(GP) or Graphical User Authentication (GUA). These methods stems
from the fact that humans recognized and remembers images better
than alphanumerical text characters. This paper will focus on the
security aspect of GP algorithms and what most researchers have
been working on trying to define these security features and
attributes. The goal of this study is to develop a fuzzy decision model
that allows automatic selection of available GP algorithms by taking
into considerations the subjective judgments of the decision makers
who are more than 50 postgraduate students of computer science. The
approach that is being proposed is based on the Fuzzy Analytic
Hierarchy Process (FAHP) which determines the criteria weight as a
linear formula.
Abstract: A cancelable palmprint authentication system
proposed in this paper is specifically designed to overcome the
limitations of the contemporary biometric authentication system. In
this proposed system, Geometric and pseudo Zernike moments are
employed as feature extractors to transform palmprint image into a
lower dimensional compact feature representation. Before moment
computation, wavelet transform is adopted to decompose palmprint
image into lower resolution and dimensional frequency subbands.
This reduces the computational load of moment calculation
drastically. The generated wavelet-moment based feature
representation is used to generate cancelable verification key with a
set of random data. This private binary key can be canceled and
replaced. Besides that, this key also possesses high data capture
offset tolerance, with highly correlated bit strings for intra-class
population. This property allows a clear separation of the genuine
and imposter populations, as well as zero Equal Error Rate
achievement, which is hardly gained in the conventional biometric
based authentication system.
Abstract: The new concept of two–dimensional (2D) image
processing implementation for auto-guiding system is shown in this
paper. It is dedicated to astrophotography and operates with
astronomy CCD guide cameras or with self-guided dual-detector
CCD cameras and ST4 compatible equatorial mounts. This idea was
verified by MATLAB model, which was used to test all procedures
and data conversions. Next the circuit prototype was implemented at
Altera MAX II CPLD device and tested for real astronomical object
images. The digital processing speed of CPLD prototype board was
sufficient for correct equatorial mount guiding in real-time system.
Abstract: This paper deals with the problem of constructing
constraints in non safe Petri Nets and then reducing the number of the
constructed constraints. In a system, assigning some linear constraints
to forbidden states is possible. Enforcing these constraints on the
system prevents it from entering these states. But there is no a
systematic method for assigning constraints to forbidden states in non
safe Petri Nets. In this paper a useful method is proposed for
constructing constraints in non safe Petri Nets. But when the number of these constraints is large enforcing them on the system may complicate the Petri Net model. So, another method is proposed for reducing the number of constructed constraints.
Abstract: Palestinian cities face the challenges of land scarcity,
high population growth rates, rapid urbanization, uneven
development and territorial fragmentation. Due to geopolitical
constrains and the absence of an effective Palestinian planning
institution, urban development in Palestinian cities has not followed
any discernable planning scheme. This has led to a number of
internal contradictions in the structure of cities, and adversely
affected land use, the provision of urban services, and the quality of
the living environment.
This paper explores these challenges, and the potential that exists
for introducing a more sustainable urban development pattern in
Palestinian cities. It assesses alternative development approaches
with a particular focus on sustainable development, promoting ecodevelopment
imperatives, limiting random urbanization, and meeting
present and future challenges, including fulfilling the needs of the
people and conserving the scarce land and limited natural resources.
This paper concludes by offering conceptual proposals and guidelines
for promoting sustainable physical development in Palestinian cities.
Abstract: Data mining uses a variety of techniques each of which is useful for some particular task. It is important to have a deep understanding of each technique and be able to perform sophisticated analysis. In this article we describe a tool built to simulate a variation of the Kohonen network to perform unsupervised clustering and support the entire data mining process up to results visualization. A graphical representation helps the user to find out a strategy to optmize classification by adding, moving or delete a neuron in order to change the number of classes. The tool is also able to automatically suggest a strategy for number of classes optimization.The tool is used to classify macroeconomic data that report the most developed countries? import and export. It is possible to classify the countries based on their economic behaviour and use an ad hoc tool to characterize the commercial behaviour of a country in a selected class from the analysis of positive and negative features that contribute to classes formation.
Abstract: Catalytic converters are used for minimizing the release of pollutants to the atmosphere. It is during the warm-up period that hydrocarbons are seen to be released in appreciable quantities from these converters. In this paper the conversion of a fast oxidizing hydrocarbon propylene is analysed using two numerical methods. The quasi steady state method assumes the accumulation terms to be negligible in the gas phase mass and energy balance equations, however this term is present in the solid phase energy balance. The unsteady state model accounts for the accumulation term to be present in the gas phase mass and energy balance and in the solid phase energy balance. The results derived from the two models for gas concentration, gas temperature and solid temperature are compared.