Abstract: Recent years have seen a growing trend towards the
integration of multiple information sources to support large-scale
prediction of protein-protein interaction (PPI) networks in model
organisms. Despite advances in computational approaches, the
combination of multiple “omic" datasets representing the same type
of data, e.g. different gene expression datasets, has not been
rigorously studied. Furthermore, there is a need to further investigate
the inference capability of powerful approaches, such as fullyconnected
Bayesian networks, in the context of the prediction of PPI
networks. This paper addresses these limitations by proposing a
Bayesian approach to integrate multiple datasets, some of which
encode the same type of “omic" data to support the identification of
PPI networks. The case study reported involved the combination of
three gene expression datasets relevant to human heart failure (HF).
In comparison with two traditional methods, Naive Bayesian and
maximum likelihood ratio approaches, the proposed technique can
accurately identify known PPI and can be applied to infer potentially
novel interactions.
Abstract: Based on a non-linear single track model which
describes the dynamics of vehicle, an optimal path planning strategy
is developed. Real time optimization is used to generate reference
control values to allow leading the vehicle alongside a calculated lane
which is optimal for different objectives such as energy consumption,
run time, safety or comfort characteristics. Strict mathematic
formulation of the autonomous driving allows taking decision on
undefined situation such as lane change or obstacle avoidance. Based
on position of the vehicle, lane situation and obstacle position, the
optimization problem is reformulated in real-time to avoid the
obstacle and any car crash.
Abstract: An active RC filters with a 880 / 1760 MHz dual bandwidth tuning ability is present for 60 GHz unlicensed band applications. A third order Butterworth low-pass filter utilizes two Cherry-Hooper amplifiers to satisfy the very high bandwidth requirements of an amplifier. The low-pass filter is fabricated in 90nm standard CMOS process. Drawing 6.7 mW from 1.2 V power supply, the low frequency gains of the filter are -2.5 and -4.1 dB, and the output third order intercept points (OIP3) are +2.2 and +1.9 dBm for the single channel and channel bonding conditions, respectively.
Abstract: This paper presents a several diagnostic methods designed to electrical machinesespecially for permanent magnets (PM) machines. Those machines are commonly used in small wind and water systems and vehicles drives.Thosemethodsare preferred by the author in periodic diagnostic of electrical machines. The special attentionshould be paid to diagnostic method of turn-to-turn insulation and vibrations. Both of those methodswere createdinInstitute of Electrical Drives and MachinesKomel. The vibration diagnostic method is the main thesis of author’s doctoral dissertation. This is method of determination the technical condition of PM electrical machine basing on its own signals is the subject of patent application No P.405669. Specific structural properties of machines excited by permanent magnets are used in this method - electromotive force (EMF) generated due to vibrations. There was analysed number of publications which describe vibration diagnostic methods and tests of electrical machines with permanent magnets and there was no method found to determine the technical condition of such machine basing on their own signals.
Abstract: There are three distinct stages in the evolution of
economic thought, namely:
1. in the first stage, the major concern was to accelerate
economic growth with increased availability of material
goods, especially in developing economies with very low
living standards, because poverty eradication meant faster
economic growth.
2. in the second stage, economists made distinction between
growth and development. Development was seen as going
beyond economic growth, and bringing certain changes in
the structure of the economy with more equitable
distribution of the benefits of growth, with the growth
coming automatic and sustained.
3. the third stage is now reached. Our concern is now with
“sustainable development", that is, development not only
for the present but also of the future.
Thus the focus changed from “sustained growth" to “sustained
development". Sustained development brings to the fore the long
term relationship between the ecology and economic development.
Since the creation of UNEP in 1972 it has worked for
development without destruction for environmentally sound and
sustained development. It was realised that the environment cannot
be viewed in a vaccum, it is not separate from development, nor is it
competing. It suggested for the integration of the environment with
development whereby ecological factors enter development planning,
socio-economic policies, cost-benefit analysis, trade, technology
transfer, waste management, educational and other specific areas.
Industrialisation has contributed to the growth of economy of
several countries. It has improved the standards of living of its people
and provided benefits to the society. It has also created in the process
great environmental problems like climate change, forest destruction
and denudation, soil erosion and desertification etc.
On the other hand, industry has provided jobs and improved the
prospects of wealth for the industrialists. The working class
communities had to simply put up with the high levels of pollution in
order to keep up their jobs and also to save their income.
There are many roots of the environmental problem. They may be
political, economic, cultural and technological conditions of the
modern society. The experts concede that industrial growth lies
somewhere close to the heart of the matter. Therefore, the objective
of this paper is not to document all roots of an environmental crisis
but rather to discuss the effects of industrial growth and
development.
We have come to the conclusion that although public intervention
is often unnecessary to ensure that perfectly competitive markets will
function in society-s best interests, such intervention is necessary
when firms or consumers pollute.
Abstract: The multidelays linear control systems described by
difference differential equations are often studied in modern control
theory. In this paper, the delay-independent stabilization algebraic
criteria and the theorem of delay-independent stabilization for linear
systems with multiple time-delays are established by using the
Lyapunov functional and the Riccati algebra matrix equation in the
matrix theory. An illustrative example and the simulation result, show
that the approach to linear systems with multiple time-delays is
effective.
Abstract: Grid computing provides an effective infrastructure for massive computation among flexible and dynamic collection of individual system for resource discovery. The major challenge for grid computing is to prevent breaches and secure the data from trespassers. To overcome such conflicts a semantic approach can be designed which will filter the access requests of peers by checking the resource description specifying the data and the metadata as factual statements. Between every node in the grid a semantic firewall as a middleware will be present The intruder will be required to present an application specifying there needs to the firewall and hence accordingly the system will grant or deny the application request.
Abstract: Identifying the nature of protein-nanoparticle
interactions and favored binding sites is an important issue in
functional characterization of biomolecules and their physiological
responses. Herein, interaction of silver nanoparticles with lysozyme
as a model protein has been monitored via fluorescence spectroscopy.
Formation of complex between the biomolecule and silver
nanoparticles (AgNPs) induced a steady state reduction in the
fluorescence intensity of protein at different concentrations of
nanoparticles. Tryptophan fluorescence quenching spectra suggested
that silver nanoparticles act as a foreign quencher, approaching the
protein via this residue. Analysis of the Stern-Volmer plot showed
quenching constant of 3.73 μM−1. Moreover, a single binding site in
lysozyme is suggested to play role during interaction with AgNPs,
having low affinity of binding compared to gold nanoparticles.
Unfolding studies of lysozyme showed that complex of lysozyme-
AgNPs has not undergone structural perturbations compared to the
bare protein. Results of this effort will pave the way for utilization of
sensitive spectroscopic techniques for rational design of
nanobiomaterials in biomedical applications.
Abstract: In a nuclear reactor Loss of Coolant accident (LOCA)
considers wide range of postulated damage or rupture of pipe in the
heat transport piping system. In the case of LOCA with/without
failure of emergency core cooling system in a Pressurised Heavy
water Reactor, the Pressure Tube (PT) temperature could rise
significantly due to fuel heat up and gross mismatch of the heat
generation and heat removal in the affected channel. The extent and
nature of deformation is important from reactor safety point of view.
Experimental set-ups have been designed and fabricated to simulate
ballooning (radial deformation) of PT for 220 MWe IPHWRs.
Experiments have been conducted by covering the CT by ceramic
fibers and then by submerging CT in water of voided PTs. In both
the experiments, it is observed that ballooning initiates at a
temperature around 665´┐¢C and complete contact between PT and
Caldaria Tube (CT) occurs at around 700´┐¢C approximately. The
strain rate is found to be 0.116% per second. The structural integrity
of PT is retained (no breach) for all the experiments. The PT heatup
is found to be arrested after the contact between PT and CT, thus
establishing moderator acting as an efficient heat sink for IPHWRs.
Abstract: Nowadays, Gene Ontology has been used widely by many researchers for biological data mining and information retrieval, integration of biological databases, finding genes, and incorporating knowledge in the Gene Ontology for gene clustering. However, the increase in size of the Gene Ontology has caused problems in maintaining and processing them. One way to obtain their accessibility is by clustering them into fragmented groups. Clustering the Gene Ontology is a difficult combinatorial problem and can be modeled as a graph partitioning problem. Additionally, deciding the number k of clusters to use is not easily perceived and is a hard algorithmic problem. Therefore, an approach for solving the automatic clustering of the Gene Ontology is proposed by incorporating cohesion-and-coupling metric into a hybrid algorithm consisting of a genetic algorithm and a split-and-merge algorithm. Experimental results and an example of modularized Gene Ontology in RDF/XML format are given to illustrate the effectiveness of the algorithm.
Abstract: Physical education (PE) is still neglected in schools
despite its academic, social, psychological, and health benefits.
Based on the assumption that Information and Communication
Technologies (ICTs) can contribute to the development of PE in
schools, this study aims to design a model of the factors affecting the
adoption of ICTs for PE in schools. The proposed model is based on
a sound theoretical framework. It was designed following a literature
review of technology adoption theories and of ICT adoption factors
for physical education. The technology adoption model that fitted to
the best all ICT adoption factors was then chosen as the basis for the
proposed model. It was found that the Unified Theory of Acceptance
and Use of Technology (UTAUT) is the most adequate theoretical
framework for the modeling of ICT adoption factors for physical
education.
Abstract: Chlorine is one of the most abundant elements in
nature, which undergoes a complex biogeochemical cycle. Chlorine
bound in some substances is partly responsible for atmospheric ozone
depletion and contamination of some ecosystems. As due to
international regulations anthropogenic burden of volatile
organochlorines (VOCls) in atmosphere decreases, natural sources
(plants, soil, abiotic formation) are expected to dominate VOCl
production in the near future. Examples of plant VOCl production are
methyl chloride, and bromide emission from (sub)tropical ferns,
chloroform, 1,1,1-trichloroethane and tetrachloromethane emission
from temperate forest fern and moss. Temperate forests are found to
emit in addition to the previous compounds tetrachloroethene, and
brominated volatile compounds. VOCls can be taken up and further
metabolized in plants. The aim of this work is to identify and
quantitatively analyze the formed VOCls in temperate forest
ecosystems by a cryofocusing/GC-ECD detection method, hence
filling a gap of knowledge in the biogeochemical cycle of chlorine.
Abstract: Mobile IP has been developed to provide the
continuous information network access to mobile users. In IP-based
mobile networks, location management is an important component of
mobility management. This management enables the system to track
the location of mobile node between consecutive communications. It
includes two important tasks- location update and call delivery.
Location update is associated with signaling load. Frequent updates
lead to degradation in the overall performance of the network and the
underutilization of the resources. It is, therefore, required to devise
the mechanism to minimize the update rate. Mobile IPv6 (MIPv6)
and Hierarchical MIPv6 (HMIPv6) have been the potential
candidates for deployments in mobile IP networks for mobility
management. HMIPv6 through studies has been shown with better
performance as compared to MIPv6. It reduces the signaling
overhead traffic by making registration process local. In this paper,
we present performance analysis of MIPv6 and HMIPv6 using an
analytical model. Location update cost function is formulated based
on fluid flow mobility model. The impact of cell residence time, cell
residence probability and user-s mobility is investigated. Numerical
results are obtained and presented in graphical form. It is shown that
HMIPv6 outperforms MIPv6 for high mobility users only and for low
mobility users; performance of both the schemes is almost equivalent
to each other.
Abstract: The one-class support vector machine “support vector
data description” (SVDD) is an ideal approach for anomaly or outlier
detection. However, for the applicability of SVDD in real-world
applications, the ease of use is crucial. The results of SVDD are
massively determined by the choice of the regularisation parameter C
and the kernel parameter of the widely used RBF kernel. While for
two-class SVMs the parameters can be tuned using cross-validation
based on the confusion matrix, for a one-class SVM this is not
possible, because only true positives and false negatives can occur
during training. This paper proposes an approach to find the optimal
set of parameters for SVDD solely based on a training set from
one class and without any user parameterisation. Results on artificial
and real data sets are presented, underpinning the usefulness of the
approach.
Abstract: Injection molding is a very complicated process to
monitor and control. With its high complexity and many process
parameters, the optimization of these systems is a very challenging
problem. To meet the requirements and costs demanded by the
market, there has been an intense development and research with the
aim to maintain the process under control. This paper outlines the
latest advances in necessary algorithms for plastic injection process
and monitoring, and also a flexible data acquisition system that
allows rapid implementation of complex algorithms to assess their
correct performance and can be integrated in the quality control
process. This is the main topic of this paper. Finally, to demonstrate
the performance achieved by this combination, a real case of use is
presented.
Abstract: Recently, X. Ge and J. Qian investigated some relations between higher mathematics scores and calculus scores (resp. linear algebra scores, probability statistics scores) for Chinese university students. Based on rough-set theory, they established an information system S = (U,CuD,V, f). In this information system, higher mathematics score was taken as a decision attribute and calculus score, linear algebra score, probability statistics score were taken as condition attributes. They investigated importance of each condition attribute with respective to decision attribute and strength of each condition attribute supporting decision attribute. In this paper, we give further investigations for this issue. Based on the above information system S = (U, CU D, V, f), we analyze the decision rules between condition and decision granules. For each x E U, we obtain support (resp. strength, certainty factor, coverage factor) of the decision rule C —>x D, where C —>x D is the decision rule induced by x in S = (U, CU D, V, f). Results of this paper gives new analysis of on higher mathematics scores for Chinese university students, which can further lead Chinese university students to raise higher mathematics scores in Chinese graduate student entrance examination.
Abstract: Due to today-s fierce competition, companies have to
be proactive creators of the future by effectively developing
innovations. Especially radical innovations allow high profit margins
– but they also entail high risks. One possibility to realize radical
innovations and reduce the risk of failure is cross-industry innovation
(CII). CII brings together problems and solution ideas from different
industries. However, there is a lack of systematic ways towards CII.
Bridging this gap, the present paper provides a systematic approach
towards planned CII. Starting with the analysis of potentials, the
definition of promising search strategies is crucial. Subsequently,
identified solution ideas need to be assessed. For the most promising
ones, the adaption process has to be systematically planned –
regarding the risk affinity of a company. The introduced method is
explained on a project from the furniture industry.
Abstract: In this paper, the details of an experimental method to measure the clamping force value at bolted connections due to application of wrenching torque to tighten the nut have been presented. A simplified bolted joint including a holed plate with a single bolt was considered to carry out the experiments. This method was designed based on Hooke-s law by measuring compressive axial strain of a steel bush placed between the nut and the plate. In the experimental procedure, the values of clamping force were calculated for seven different levels of applied torque, and this process was repeated three times for each level of the torque. Moreover, the effect of lubrication of threads on the clamping value was studied using the same method. In both conditions (dry and lubricated threads), relation between the torque and the clamping force have been displayed in graphs.
Abstract: The aim of this in vitro study was to evaluate the possible interference of a Nectandra membranacea extract (i) on the labeling of blood cells (BC), (ii) on the labeling process of BC and plasma (P) proteins with technetium-99m (Tc-99m) and (iii) on the morphology of red blood cells (RBC). Blood samples were incubated with a Nectandra membranacea crude extract, stannous chloride, Tc- 99m (sodium pertechnetate) was added, and soluble (SF) and insoluble (IF) fractions were isolated. Morphometry studies were performed with blood samples incubated with Nectandra membranacea extract. The results show that the Nectandra membranacea extract does not promote significant alteration of the labeling of BC, IF-P and IF-BC. The Nectandra membranacea extract was able to alter the erythrocyte membrane morphology, but these morphological changes were not capable to interfere on the labeling of blood constituents with Tc-99m.
Abstract: Bovine viral diarrhea virus (BVDV) can cause lifelong
persistent infection. One reason for the phenomena is attributed to
BVDV infection to placenta tissue. However the mechanisms that
BVDV invades into placenta tissue remain unclear. To clarify the
molecular mechanisms, we investigated the possible means that
BVDV entered into bovine trophoblast cells (TPC). Yeast two-hybrid
system was used to identify proteins extracted from TPC, which
interact with BVDV envelope glycoprotein E2. A PGbkt7-E2 yeast
expression vector and TPC cDNA library were constructed. Through
two rounds of screening, three positive clones were identified.
Sequencing analysis indicated that all the three positive clones
encoded the same protein clathrin. Physical interaction between
clathrin and BVDV E2 protein was further confirmed by
coimmunoprecipitation experiments. This result suggested that the
clathrin might play a critical role in the process of BVDV entry into
placenta tissue and might be a novel antiviral target for preventing
BVDV infection.