Abstract: Within the healthcare system, training and continued professional development although essential, can be effected by cost and logistical restraints due to the nature of healthcare provision e.g employee shift patterns, access to expertise, cost factors in releasing staff to attend training etc. The use of multimedia technology for the development of e-learning applications is also a major cost consideration for healthcare management staff, and this type of media whether optical or on line requires careful planning in order to remain inclusive of all staff with potentially varied access to multimedia computing. This paper discusses a project in which the use of DVD authoring technology has been successfully implemented to meet the needs of distance learning and user considerations, and is based on film production techniques and reduced product turnaround deadlines.
Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: An application framework provides a reusable design
and implementation for a family of software systems. If the
framework contains defects, the defects will be passed on to the
applications developed from the framework. Framework defects are
hard to discover at the time the framework is instantiated. Therefore,
it is important to remove all defects before instantiating the
framework. In this paper, two measures for the adequacy of an
object-oriented system-based testing technique are introduced. The
measures assess the usefulness and uniqueness of the testing
technique. The two measures are applied to experimentally compare
the adequacy of two testing techniques introduced to test objectoriented
frameworks at the system level. The two considered testing
techniques are the New Framework Test Approach and Testing
Frameworks Through Hooks (TFTH). The techniques are also
compared analytically in terms of their coverage power of objectoriented
aspects. The comparison study results show that the TFTH
technique is better than the New Framework Test Approach in terms
of usefulness degree, uniqueness degree, and coverage power.
Abstract: A hybrid feature based adaptive particle filter algorithm is presented for object tracking in real scenarios with static camera.
The hybrid feature is combined by two effective features: the Grayscale Arranging Pairs (GAP) feature and the color histogram feature. The GAP feature has high discriminative ability even under conditions of severe illumination variation and dynamic background
elements, while the color histogram feature has high reliability to identify the detected objects. The combination of two features covers the shortage of single feature. Furthermore, we adopt an updating
target model so that some external problems such as visual angles can be overcame well. An automatic initialization algorithm is introduced which provides precise initial positions of objects. The experimental
results show the good performance of the proposed method.
Abstract: While the form of crises may change, their essence
remains the same (such as a cycle of abundant liquidity, rapid credit
growth, and a low-inflation environment followed by an asset-price
bubble). The current market turbulence began in mid-2000s when the
US economy shifted to imbalanced both internal and external
macroeconomic positions. We see two key causes of these problems
– loose US monetary policy in early 2000s and US government
guarantees issued on the securities by government-sponsored
enterprises what was further fueled by financial innovations such as
structured credit products. We have discovered both negative and
positive lessons deriving from this crisis and divided the negative
lessons into three groups: financial products and valuation, processes
and business models, and strategic issues. Moreover, we address key
risk management lessons and exit strategies derived from the current
crisis and recommend policies that should help diminish the negative
impact of future potential crises.
Abstract: The literature reports a large number of approaches for
measuring the similarity between protein sequences. Most of these
approaches estimate this similarity using alignment-based techniques
that do not necessarily yield biologically plausible results, for two
reasons.
First, for the case of non-alignable (i.e., not yet definitively aligned
and biologically approved) sequences such as multi-domain, circular
permutation and tandem repeat protein sequences, alignment-based
approaches do not succeed in producing biologically plausible results.
This is due to the nature of the alignment, which is based on the
matching of subsequences in equivalent positions, while non-alignable
proteins often have similar and conserved domains in non-equivalent
positions.
Second, the alignment-based approaches lead to similarity measures
that depend heavily on the parameters set by the user for the alignment
(e.g., gap penalties and substitution matrices). For easily alignable
protein sequences, it's possible to supply a suitable combination of
input parameters that allows such an approach to yield biologically
plausible results. However, for difficult-to-align protein sequences,
supplying different combinations of input parameters yields different
results. Such variable results create ambiguities and complicate the
similarity measurement task.
To overcome these drawbacks, this paper describes a novel and
effective approach for measuring the similarity between protein
sequences, called SAF for Substitution and Alignment Free. Without
resorting either to the alignment of protein sequences or to substitution
relations between amino acids, SAF is able to efficiently detect the
significant subsequences that best represent the intrinsic properties of
protein sequences, those underlying the chronological dependencies of
structural features and biochemical activities of protein sequences.
Moreover, by using a new efficient subsequence matching scheme,
SAF more efficiently handles protein sequences that contain similar
structural features with significant meaning in chronologically
non-equivalent positions. To show the effectiveness of SAF, extensive
experiments were performed on protein datasets from different
databases, and the results were compared with those obtained by
several mainstream algorithms.
Abstract: This work proposes a novel market-based air traffic flow control model considering competitive airlines in air traffic network. In the flow model, an agent based framework for resources (link/time pair) pricing is described. Resource agent and auctioneer for groups of resources are also introduced to simulate the flow management in Air Traffic Control (ATC). Secondly, the distributed group pricing algorithm is introduced, which efficiently reflect the competitive nature of the airline industry. Resources in the system are grouped according to the degree of interaction, and each auctioneer adjust s the price of one group of resources respectively until the excess demand of resources becomes zero when the demand and supply of resources of the system changes. Numerical simulation results show the feasibility of solving the air traffic flow control problem using market mechanism and pricing algorithms on the air traffic network.
Abstract: In this paper, we introduce GODYS-PC software
package for modeling, simulating and analyzing dynamic systems.
To illustrate the use of GODYS-PC we present a few examples
which concern modeling and simulating of engineering systems. In
order to compare GODYS-PC with widely used in academia and
industry Simulink®, the same examples are provided both in
GODYS-PC and Simulink®.
Abstract: This paper reports the tensile fracture location
characterizations of dissimilar friction stir welds between 5754
aluminium alloy and C11000 copper. The welds were produced using
three shoulder diameter tools; namely, 15, 18 and 25 mm by varying
the process parameters. The rotational speeds considered were 600,
950 and 1200 rpm while the feed rates employed were 50, 150 and
300 mm/min to represent the low, medium and high settings
respectively. The tensile fracture locations were evaluated using the
optical microscope to identify the fracture locations and were
characterized. It was observed that 70% of the tensile samples failed
in the Thermo Mechanically Affected Zone (TMAZ) of copper at the
weld joints. Further evaluation of the fracture surfaces of the pulled
tensile samples revealed that welds with low Ultimate Tensile
Strength either have defects or intermetallics present at their joint
interfaces.
Abstract: None of the processing models in the software
development has explained the software systems performance
evaluation and modeling; likewise, there exist uncertainty in the
information systems because of the natural essence of requirements,
and this may cause other challenges in the processing of software
development. By definition an extended version of UML (Fuzzy-
UML), the functional requirements of the software defined
uncertainly would be supported. In this study, the behavioral
description of uncertain information systems by the aid of fuzzy-state
diagram is crucial; moreover, the introduction of behavioral diagrams
role in F-UML is investigated in software performance modeling
process. To get the aim, a fuzzy sub-profile is used.
Abstract: This paper presents an exact analytical model for
optimizing stability of thin-walled, composite, functionally graded
pipes conveying fluid. The critical flow velocity at which divergence
occurs is maximized for a specified total structural mass in order to
ensure the economic feasibility of the attained optimum designs. The
composition of the material of construction is optimized by defining
the spatial distribution of volume fractions of the material
constituents using piecewise variations along the pipe length. The
major aim is to tailor the material distribution in the axial direction so
as to avoid the occurrence of divergence instability without the
penalty of increasing structural mass. Three types of boundary
conditions have been examined; namely, Hinged-Hinged, Clamped-
Hinged and Clamped-Clamped pipelines. The resulting optimization
problem has been formulated as a nonlinear mathematical
programming problem solved by invoking the MatLab optimization
toolbox routines, which implement constrained function
minimization routine named “fmincon" interacting with the
associated eigenvalue problem routines. In fact, the proposed
mathematical models have succeeded in maximizing the critical flow
velocity without mass penalty and producing efficient and economic
designs having enhanced stability characteristics as compared with
the baseline designs.
Abstract: As part of national epidemiological survey on bovine
viral diarrhea virus (BVDV), a total of 274 dejecta samples were
collected from 14 cattle farms in 8 areas of Xinjiang Uygur
Autonomous Region in northwestern China. Total RNA was extracted
from each sample, and 5--untranslated region (UTR) of BVDV
genome was amplified by using two-step reverse
transcriptase-polymerase chain reaction (RT-PCR). The PCR products
were subsequently sequenced to study the genetic variations of BVDV
in these areas. Among the 274 samples, 33 samples were found
virus-positive. According to sequence analysis of the PCR products,
the 33 samples could be arranged into 16 groups. All the sequences,
however, were highly conserved with BVDV Osloss strains. The virus
possessed theses sequences belonged to BVDV-1b subtype by
phylogenetic analysis. Based on these data, we established a typing
tree for BVDV in these areas. Our results suggested that BVDV-1b
was a predominant subgenotype in northwestern China and no
correlation between the genetic and geographical distances could be
observed above the farm level.
Abstract: In Algeria, some fruit trees produce fruits in free nature. Such trees are Celtis australis, Crataegus azarolus, Crataegus monogyna and Zizyphus lotus. In spite of their appreciable consumption, their nutritional value remains unknown. The objective of this study is the determination of sugars in the pulpe and almond of the above fruits. The biochemical analysis shows that these fruits present interesting contents of soluble sugars which confers significant caloric intakes to them. As well as significant fibres which give them therapeutic and industrial benefits? The analysis of the almonds shows that it contains considerable contents of sugars which enable them to be an energetic food.
Abstract: Palestinian cities face the challenges of land scarcity,
high population growth rates, rapid urbanization, uneven
development and territorial fragmentation. Due to geopolitical
constrains and the absence of an effective Palestinian planning
institution, urban development in Palestinian cities has not followed
any discernable planning scheme. This has led to a number of
internal contradictions in the structure of cities, and adversely
affected land use, the provision of urban services, and the quality of
the living environment.
This paper explores these challenges, and the potential that exists
for introducing a more sustainable urban development pattern in
Palestinian cities. It assesses alternative development approaches
with a particular focus on sustainable development, promoting ecodevelopment
imperatives, limiting random urbanization, and meeting
present and future challenges, including fulfilling the needs of the
people and conserving the scarce land and limited natural resources.
This paper concludes by offering conceptual proposals and guidelines
for promoting sustainable physical development in Palestinian cities.
Abstract: Using logarithmic mean Divisia decomposition technique, this paper analyzes the change in industrial energy intensity of Fujian Province in China, based on data sets of added value and energy consumption for 35 selected industrial sub-sectors from 1999 to 2009. The change in industrial energy intensity is decomposed into intensity effect and structure effect. Results show that the industrial energy intensity of Fujian Province has achieved a reduction of 51% over the past ten years. The structural change, a shift in the mix of industrial sub-sectors, made overwhelming contribution to the reduction. The impact of energy efficiency’s improvement was relatively small. However, the aggregate industrial energy intensity was very sensitive to both the changes in energy intensity and in production share of energy-intensive sub-sectors, such as production and supply of electric power, steam and hot water. Pathway to reduce industrial energy intensity for energy conservation in Fujian Province is proposed in the end.
Abstract: Bonding has become a routine procedure in several
dental specialties – from prosthodontics to conservative dentistry and
even orthodontics. In many of these fields it is important to be able to
investigate the bonded interfaces to assess their quality. All currently
employed investigative methods are invasive, meaning that samples
are destroyed in the testing procedure and cannot be used again. We
have investigated the interface between human enamel and bonded
ceramic brackets non-invasively, introducing a combination of new
investigative methods – optical coherence tomography (OCT),
fluorescence OCT and confocal microscopy (CM). Brackets were
conventionally bonded on conditioned buccal surfaces of teeth. The
bonding was assessed using these methods. Three dimensional
reconstructions of the detected material defects were developed using
manual and semi-automatic segmentation. The results clearly prove
that OCT, fluorescence OCT and CM are useful in orthodontic
bonding investigations.
Abstract: This study is designed to investigate errors emerged in written texts produced by 30 Turkish EFL learners with an explanatory, and thus, qualitative perspective. Erroneous language elements were identified by the researcher first and then their grammaticality and intelligibility were checked by five native speakers of English. The analysis of the data showed that it is difficult to claim that an error stems from only one single factor since different features of an error are triggered by different factors. Our findings revealed two different types of errors: those which stem from the interference of L1 with L2 and those which are developmental ones. The former type contains more global errors whereas the errors in latter type are more intelligible.
Abstract: Network reconfiguration in distribution system is realized by changing the status of sectionalizing switches to reduce the power loss in the system. This paper presents a new method which applies an artificial bee colony algorithm (ABC) for determining the sectionalizing switch to be operated in order to solve the distribution system loss minimization problem. The ABC algorithm is a new population based metaheuristic approach inspired by intelligent foraging behavior of honeybee swarm. The advantage of ABC algorithm is that it does not require external parameters such as cross over rate and mutation rate as in case of genetic algorithm and differential evolution and it is hard to determine these parameters in prior. The other advantage is that the global search ability in the algorithm is implemented by introducing neighborhood source production mechanism which is a similar to mutation process. To demonstrate the validity of the proposed algorithm, computer simulations are carried out on 14, 33, and 119-bus systems and compared with different approaches available in the literature. The proposed method has outperformed the other methods in terms of the quality of solution and computational efficiency.
Abstract: In this paper, based on linear matrix inequality (LMI), by using Lyapunov functional theory, the exponential stability criterion is obtained for a class of uncertain Takagi-Sugeno fuzzy Hopfield neural networks (TSFHNNs) with time delays. Here we choose a generalized Lyapunov functional and introduce a parameterized model transformation with free weighting matrices to it, these techniques lead to generalized and less conservative stability condition that guarantee the wide stability region. Finally, an example is given to illustrate our results by using MATLAB LMI toolbox.
Abstract: The ITE Project is a project that has 1800 km length
and across the Turkey's land through east to west. The project of
pipeline enters geographically from Iran to Doğubayazit (Turkey) in
the east, exits to Greece from Ipsala province of Turkey in the west.
This project is the one of the international projects in such scale that
provides the natural gas of Iran and Caspian Sea through the
European continent. In this investigation, some information will be
given about the methods used to verify the direction of the pipeline
and the technical properties of the results obtained. The cost of
project itself entirely depends on the direction of the pipeline which
would be as short as possible and the specifications of the land cover.
Production standards of 1/2000 scaled digital orthophoto and vectoral
maps as a results of the use of map production materials and methods
(such as high resolution satellite images, and digital aerial images
captured from digital aerial cameras), will also be given in this report.
According to Turkish national map production standards, TM
((Transversal Mercator, 3 degree) projection is used for large scale
map and UTM (Universal Transversal Mercator, 6 degree) is used for
small scale map production standards. Some information is also given
about the projection used in the ITE natural gas pipeline project.