Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.
Abstract: The paper deals with determination of electromagnetic
and temperature field distribution of induction heating system used
for pipe brazing. The problem is considered as coupled – time
harmonic electromagnetic and transient thermal field. It has been
solved using finite element method. The detailed maps of
electromagnetic and thermal field distribution have been obtained.
The good understanding of the processes in the considered system
ensures possibilities for control, management and increasing the
efficiency of the welding process.
Abstract: Cloud Computing is an approach that provides computation and storage services on-demand to clients over the network, independent of device and location. In the last few years, cloud computing became a trend in information technology with many companies that transfer their business processes and applications in the cloud. Cloud computing with service oriented architecture has contributed to rapid development of Geographic Information Systems. Open Geospatial Consortium with its standards provides the interfaces for hosted spatial data and GIS functionality to integrated GIS applications. Furthermore, with the enormous processing power, clouds provide efficient environment for data intensive applications that can be performed efficiently, with higher precision, and greater reliability. This paper presents our work on the geospatial data services within the cloud computing environment and its technology. A cloud computing environment with the strengths and weaknesses of the geographic information system will be introduced. The OGC standards that solve our application interoperability are highlighted. Finally, we outline our system architecture with utilities for requesting and invoking our developed data intensive applications as a web service.
Abstract: The application of stability theory has led to detailed studies of different types of vessels; however, the shortage of information relating to multihull vessels demanded further investigation. This study shows that the position of the hulls has a very influential effect on both the transverse and longitudinal stability of the tricore. HSC stability code is applied for the optimisation of the hull configurations. Such optimization criteria would undoubtedly aid the performance of the vessel for both commercial or leisure purposes
Abstract: Interaction Model plays an important role in Modelbased
Intelligent Interface Agent Architecture for developing
Intelligent User Interface. In this paper we are presenting some
improvements in the algorithms for development interaction model of
interface agent including: the action segmentation algorithm, the
action pair selection algorithm, the final action pair selection
algorithm, the interaction graph construction algorithm and the
probability calculation algorithm. The analysis of the algorithms also
presented. At the end of this paper, we introduce an experimental
program called “Personal Transfer System".
Abstract: Saturated two-phase fluid flows are often subject to
pressure induced oscillations. Due to compressibility the vapor
bubbles act as a spring with an asymmetric non-linear characteristic.
The volume of the vapor bubbles increases or decreases differently if
the pressure fluctuations are compressing or expanding;
consequently, compressing pressure fluctuations in a two-phase pipe
flow cause less displacement in the direction of the pipe flow than
expanding pressure fluctuations. The displacement depends on the
ratio of liquid to vapor, the ratio of pressure fluctuations over average
pressure and on the exciting frequency of the pressure fluctuations.
In addition, pressure fluctuations in saturated vapor bubbles cause
condensation and evaporation within the bubbles and change
periodically the ratio between liquid to vapor, and influence the
dynamical parameters for the oscillation. The oscillations are
conforming to an isenthalpic process at constant enthalpy with no
heat transfer and no exchange of work.
The paper describes the governing non-linear equation for twophase
fluid oscillations with condensation and evaporation, and
presents steady state approximate solutions for free and for pressure
induced oscillations. Resonance criteria and stability are discussed.
Abstract: In this paper, three dimensional flow characteristic was
presented by a revision of an impeller of an axial turbo fan for
improving the airflow rate and the static pressure. TO consider an
incompressible steady three-dimensional flow, the RANS equations
are used as the governing equations, and the standard k-ε turbulence
model is chosen. The pitch angles of 44°, 54°, 59°, and 64° are
implemented for the numerical model. The numerical results show that
airflow rates of each pitch angle are 1,175 CMH, 1,270 CMH, 1,340
CMH, and 800 CMH, respectively. The difference of the static
pressure at impeller inlet and outlet are 120 Pa, 214 Pa, 242 Pa, and 60
Pa according to respective pitch angles. It means that the 59° of the
impeller pitch angle is optimal to improve the airflow rate and the
static pressure.
Abstract: The accelerated growth in aircraft industries desire
effectual schemes, programs, innovative designs of advanced systems
to accomplishing the augmenting need for home-free air
transportation. In this paper, a contemporary conceptual design of an
airplane has been proposed without landing gear systems in order to
reducing accidents, time consumption, and to eliminating drawbacks
by using superconducting levitation phenomenon. This invention of
an airplane with superconductive material coating, on the solar plexus
region assist to reduce weight by approximately 4% of the total takeoff
weight, and cost effective. Moreover, we conjectured that
superconductor landing system reduces ground friction, mission fuel,
total drag, take-off and landing distance.
Abstract: Over last two decades, due to hostilities of environment
over the internet the concerns about confidentiality of information
have increased at phenomenal rate. Therefore to safeguard the information
from attacks, number of data/information hiding methods have
evolved mostly in spatial and transformation domain.In spatial domain
data hiding techniques,the information is embedded directly on
the image plane itself. In transform domain data hiding techniques the
image is first changed from spatial domain to some other domain and
then the secret information is embedded so that the secret information
remains more secure from any attack. Information hiding algorithms
in time domain or spatial domain have high capacity and relatively
lower robustness. In contrast, the algorithms in transform domain,
such as DCT, DWT have certain robustness against some multimedia
processing.In this work the authors propose a novel steganographic
method for hiding information in the transform domain of the gray
scale image.The proposed approach works by converting the gray
level image in transform domain using discrete integer wavelet
technique through lifting scheme.This approach performs a 2-D
lifting wavelet decomposition through Haar lifted wavelet of the cover
image and computes the approximation coefficients matrix CA and
detail coefficients matrices CH, CV, and CD.Next step is to apply the
PMM technique in those coefficients to form the stego image. The
aim of this paper is to propose a high-capacity image steganography
technique that uses pixel mapping method in integer wavelet domain
with acceptable levels of imperceptibility and distortion in the cover
image and high level of overall security. This solution is independent
of the nature of the data to be hidden and produces a stego image
with minimum degradation.
Abstract: Recent advances in both the testing and verification of software based on formal specifications of the system to be built have reached a point where the ideas can be applied in a powerful way in the design of agent-based systems. The software engineering research has highlighted a number of important issues: the importance of the type of modeling technique used; the careful design of the model to enable powerful testing techniques to be used; the automated verification of the behavioural properties of the system; the need to provide a mechanism for translating the formal models into executable software in a simple and transparent way. This paper introduces the use of the X-machine formalism as a tool for modeling biology inspired agents proposing the use of the techniques built around X-machine models for the construction of effective, and reliable agent-based software systems.
Abstract: A new approach for protection of power transformer is
presented using a time-frequency transform known as Wavelet transform.
Different operating conditions such as inrush, Normal, load,
External fault and internal fault current are sampled and processed
to obtain wavelet coefficients. Different Operating conditions provide
variation in wavelet coefficients. Features like energy and Standard
deviation are calculated using Parsevals theorem. These features
are used as inputs to PNN (Probabilistic neural network) for fault
classification. The proposed algorithm provides more accurate results
even in the presence of noise inputs and accurately identifies inrush
and fault currents. Overall classification accuracy of the proposed
method is found to be 96.45%. Simulation of the fault (with and
without noise) was done using MATLAB AND SIMULINK software
taking 2 cycles of data window (40 m sec) containing 800 samples.
The algorithm was evaluated by using 10 % Gaussian white noise.
Abstract: To meet the demands of wireless sensor networks
(WSNs) where data are usually aggregated at a single source prior to
transmitting to any distant user, there is a need to establish a tree
structure inside any given event region. In this paper , a novel
technique to create one such tree is proposed .This tree preserves the
energy and maximizes the lifetime of event sources while they are
constantly transmitting for data aggregation. The term Decentralized
Lifetime Maximizing Tree (DLMT) is used to denote this tree.
DLMT features in nodes with higher energy tend to be chosen as data
aggregating parents so that the time to detect the first broken tree link
can be extended and less energy is involved in tree maintenance. By
constructing the tree in such a way, the protocol is able to reduce the
frequency of tree reconstruction, minimize the amount of data loss
,minimize the delay during data collection and preserves the energy.
Abstract: It was determined that woody biomass and livestock excreta can be utilized as hydrogen resources and hydrogen produced from such sources can be used to fill fuel cell vehicles (FCVs) at hydrogen stations. It was shown that the biomass transport costs for hydrogen production may be reduced the costs for co-generation. In the Tokyo Metropolitan Area, there are only a few sites capable of producing hydrogen from woody biomass in amounts greater than 200 m3/h-the scale required for a hydrogen station to be operationally practical. However, in the case of livestock excreta, it was shown that 15% of the municipalities in this area are capable of securing sufficient biomass to be operationally practical for hydrogen production. The differences in feasibility of practical operation depend on the type of biomass.
Abstract: Under the limitation of investment budget, a utility
company is required to maximize the utilization of their existing
assets during their life cycle satisfying both engineering and financial
requirements. However, utility does not have knowledge about the
status of each asset in the portfolio neither in terms of technical nor
financial values. This paper presents a knowledge based model for
the utility companies in order to make an optimal decision on power
transformer with their utilization. CommonKADS methodology, a
structured development for knowledge and expertise representation,
is utilized for designing and developing knowledge based model. A
case study of One MVA power transformer of Nepal Electricity
Authority is presented. The results show that the reusable knowledge
can be categorized, modeled and utilized within the utility company
using the proposed methodologies. Moreover, the results depict that
utility company can achieve both engineering and financial benefits
from its utilization.
Abstract: A laboratory study on the influence of compactive
effort on expansive black cotton specimens treated with up to 8%
ordinary Portland cement (OPC) admixed with up to 8% bagasse ash
(BA) by dry weight of soil and compacted using the energies of the
standard Proctor (SP), West African Standard (WAS) or
“intermediate” and modified Proctor (MP) were undertaken. The
expansive black cotton soil was classified as A-7-6 (16) or CL using
the American Association of Highway and Transportation Officials
(AASHTO) and Unified Soil Classification System (USCS),
respectively. The 7day unconfined compressive strength (UCS)
values of the natural soil for SP, WAS and MP compactive efforts are
286, 401 and 515kN/m2 respectively, while peak values of 1019,
1328 and 1420kN/m2 recorded at 8% OPC/ 6% BA, 8% OPC/ 2% BA
and 6% OPC/ 4% BA treatments, respectively were less than the
UCS value of 1710kN/m2 conventionally used as criterion for
adequate cement stabilization. The soaked California bearing ratio
(CBR) values of the OPC/BA stabilized soil increased with higher
energy level from 2, 4 and 10% for the natural soil to Peak values of
55, 18 and 8% were recorded at 8% OPC/4% BA 8% OPC/2% BA
and 8% OPC/4% BA, treatments when SP, WAS and MP compactive
effort were used, respectively. The durability of specimens was
determined by immersion in water. Soils treatment at 8% OPC/ 4%
BA blend gave a value of 50% resistance to loss in strength value
which is acceptable because of the harsh test condition of 7 days
soaking period specimens were subjected instead of the 4 days
soaking period that specified a minimum resistance to loss in strength
of 80%. Finally An optimal blend of is 8% OPC/ 4% BA is
recommended for treatment of expansive black cotton soil for use as
a sub-base material.
Abstract: The provision of urban public transport in Indonesia is not free of problems. Some of the problems include: an overall lack of capacity, lack of quality and choice, severe traffic congestions and insufficient fund to renew and repair vehicles. Generally, the comfort and quality of the city bus is poor, and many of the vehicles are dilapidated and dirty. Surveys were carried out in the city of Yogyakarta, by counting city bus vehicles and occupancies, interviewing the bus passengers, drivers and institutional staffs, who involve in public transport management. This paper will then analyze the possible plan to develop the public transport system to become more attractive and to improve the public transport management. The short, medium and long term plans are analyzed, to find the best solutions. Some constraints such as social impacts and financial impact are also taken into accounts.
Abstract: The present paper deals with the analysis and development of noise-reduction transformer that has a filter function for conductive noise transmission. Two types of prototype noise-reduction transformers with two different output voltages are proposed. To determine an optimum design for the noise-reduction transformer, noise attenuation characteristics are discussed based on the experiments and the equivalent circuit analysis. The analysis gives a relation between the circuit parameters and the noise attenuation. High performance step-down noise-reduction transformer for direct power supply to electronics equipment is developed. The input voltage of the transformer is 100 V and the output voltage is 5 V. Frequency characteristics of noise attenuation are discussed, and prevention of pulse noise transmission is demonstrated. Normal mode noise attenuation of this transformer is –80 dB, and common mode exceeds –90 dB. The step-down noise-reduction transformer eliminates pulse noise efficiently.
Abstract: Facial recognition and expression analysis is rapidly
becoming an area of intense interest in computer science and humancomputer
interaction design communities. The most expressive way
humans display emotions is through facial expressions. In this paper
skin and non-skin pixels were separated. Face regions were extracted
from the detected skin regions. Facial expressions are analyzed from
facial images by applying Gabor wavelet transform (GWT) and
Discrete Cosine Transform (DCT) on face images. Radial Basis
Function (RBF) Network is used to identify the person and to classify
the facial expressions. Our method reliably works even with faces,
which carry heavy expressions.
Abstract: In this paper we study the boundedness properties of
certain oscillatory integrals with polynomial phase. We obtain sharp
estimates for these oscillatory integrals. By the virtue of these
estimates and extrapolation we obtain Lp boundedness for these
oscillatory integrals under rather weak size conditions on the kernel
function.
Abstract: Computer aided design accounts with the support of
parametric software in the design of machine components as well as
of any other pieces of interest. The complexities of the element under
study sometimes offer certain difficulties to computer design, or ever
might generate mistakes in the final body conception. Reverse
engineering techniques are based on the transformation of already
conceived body images into a matrix of points which can be
visualized by the design software. The literature exhibits several
techniques to obtain machine components dimensional fields, as
contact instrument (MMC), calipers and optical methods as laser
scanner, holograms as well as moiré methods. The objective of this
research work was to analyze the moiré technique as instrument of
reverse engineering, applied to bodies of nom complex geometry as
simple solid figures, creating matrices of points. These matrices were
forwarded to a parametric software named SolidWorks to generate
the virtual object. Volume data obtained by mechanical means, i.e.,
by caliper, the volume obtained through the moiré method and the
volume generated by the SolidWorks software were compared and
found to be in close agreement. This research work suggests the
application of phase shifting moiré methods as instrument of reverse
engineering, serving also to support farm machinery element designs.