Abstract: Today architecture has become as a powerful media
for introducing cultures to the world, which in turn brings about a
change in the global insight, power gaining, investment, and
development. Islamic architecture is based on the language of Koran
and shows the depth and richness of Islam through the spiritual soul.
This is in a way that belief in monotheism and faith in Islamic
teachings are manifested as Islam's aesthetic thought in Islamic
architecture. Unfortunately, Islamic architecture has been damaged a
lot due to the lack of the necessary information, and also successive
wars that have overtaken the Moslems as well as the dominance of
colonizing counties.
Islamic architecture is rooted in the history, culture and
civilization of Moslems, but its deficiencies and shortcomings should
be removed through systematizing the Islamic architecture
researchers. Islamic countries should act in a way that the art of
Islamic architecture shows its true place in different architecture eras
and makes everybody aware that Islamic architecture has a historical
root and is connected eternally to the genuineness, religious art, and
Moslems' culture and civilization.
Abstract: In this study, breeding biology and induced breeding
of freshwater mud eel, Monopterus cuchia was observed during the
experimental period from February to June, 2013. Breeding biology
of freshwater mud eel, Monopterus cuchia was considered in terms of
gonadosomatic index, length-weight relationship of gonad, ova
diameter and fecundity. The ova diameter was recorded from 0.3 mm
to 4.30 mm and the individual fecundity was recorded from 155 to
1495 while relative fecundity was found from 2.64 to 12.45. The
fecundity related to body weight and length of fish was also
discussed. A peak of GSI was observed 2.14±0.2 in male and 5.1
±1.09 in female. Induced breeding of freshwater mud eel,
Monopterus cuchia was also practiced with different doses of
different inducing agents like pituitary gland (PG), human chorionic
gonadotropin (HCG), Gonadotropin releasing hormone (GnRH) and
Ovuline-a synthetic hormone in different environmental conditions.
However, it was observed that the artificial breeding of freshwater
mud eel, Monopterus cuchia was not yet succeeded through inducing
agents in captive conditions, rather the inducing agent showed
negative impacts on fecundity and ovarian tissues. It was seen that
mature eggs in the oviduct were reduced, absorbed and some eggs
were found in spoiled condition.
Abstract: Obesity and osteoporosis are the two diseases whose
increasing prevalence and high impact on the global morbidity and
mortality, during the two recent decades, have gained a status of
major health threats worldwide. Obesity purports to affect the bone
metabolism through complex mechanisms. Debated data on the
connection between the bone mineral density and fracture prevalence
in the obese patients are widely presented in literature. There is
evidence that the correlation of weight and fracture risk is sitespecific.
This study is aimed at determining the connection between
the bone mineral density (BMD) and trabecular bone score (TBS)
parameters in Ukrainian women suffering from obesity. We
examined 1025 40-89-year-old women, divided them into the groups
according to their body mass index: Group A included 360 women
with obesity whose BMI was ≥30 kg/m2, and Group B – 665 women
with no obesity and BMI of
Abstract: To ensure targeting of apoferritin nanocarrier with
encapsulated doxorubicin drug, we used a peptide linker based on a
protein G with N-terminus affinity towards Fc region of antibodies.
To connect the peptide to the surface of apoferritin, the C-terminus of
peptide was made of cysteine with affinity to gold. The surface of
apoferritin with encapsulated doxorubicin (APODOX) was coated
either with gold nanoparticles (APODOX-Nano) or gold(III) chloride
hydrate reduced with sodium borohydride (APODOX-HAu). The
reduction with sodium borohydride caused a loss of doxorubicin
fluorescent properties and probably accompanied with the loss of its
biological activity. Fluorescent properties of APODOX-Nano were
similar to the unmodified APODOX; therefore it was more suited for
the intended use. To evaluate the specificity of apoferritin modified
with antibodies, ELISA-like method was used with the surface of
microtitration plate wells coated by the antigen (goat anti-human IgG
antibodies). To these wells, the nanocarrier was applied. APODOX
without the modification showed 5× lower affinity to the antigen than
APODOX-Nano modified gold and targeting antibodies (human IgG
antibodies).
Abstract: Community integration is a construct that an
increasing body of research has shown to have a significant impact
on the wellbeing and recovery of people with psychiatric problems.
However, there are few studies that explore which factors can be
associated and predict community integration. Moreover, community
integration has been mostly studied in minority groups, and current
literature on the definition and manifestation of community
integration in the general population is scarcer. Thus, the current
study aims to characterize community integration and explore
possible predictor variables in a sample of participants with
psychiatric problems (PP, N=183) and a sample of participants from
the general population (GP, N=211).
Results show that people with psychiatric problems present above
average values of community integration, but are significantly lower
than their healthy counterparts. It was also possible to observe that
community integration does not vary in terms of the sociodemographic
characteristics of both groups in this study. Correlation
and multiple regression showed that, among several variables that
literature present as relevant in the community integration process,
only three variables emerged as having the most explanatory value in
community integration of both groups: sense of community, basic
needs satisfaction and submission. These results also shown that
those variables have increased explanatory power in the PP sample,
which leads us to emphasize the need to address this issue in future
studies and increase the understanding of the factors that can be
involved in the promotion of community integration, in order to
devise more effective interventions in this field.
Abstract: Background: Worldwide, at least 2.8 million people
die each year as a result of being overweight or obese, and 35.8
million (2.3%) of global DALYs are caused by overweight or
obesity. Obesity is acknowledged as one of the burning public
health problems reducing life expectancy and quality of life. The
body composition analysis of the university population is essential
in assessing the nutritional status, as well as the risk of developing
diseases associated with abnormal body fat content so as to make
nutritional recommendations. Objectives: The main aim was to
determine the prevalence of obesity and overweight in University
students using Anthropometric analysis and BIA methods. Material
and Methods: In this cross-sectional study, 283 university students
participated. The body composition analysis was undertaken by
using mainly: i) Anthropometric Measurement: Height, Weight,
BMI, waist circumference, hip circumference and skin fold
thickness, ii) Bio-electrical impedance was used for analysis of
body fat mass, fat percent and visceral fat which was measured by
Tanita SC-330P Professional Body Composition Analyzer. The
data so collected were compiled in MS Excel and analyzed for
males and females using SPSS 16. Results and Discussion: The
mean age of the male (n= 153) studied subjects was 25.37 ±2.39
years and females (n=130) was 22.53 ±2.31. The data of BIA
revealed very high mean fat per cent of the female subjects i.e.
30.3±6.5 per cent whereas mean fat per cent of the male subjects
was 15.60±6.02 per cent indicating a normal body fat range. The
findings showed high visceral fat of both males (12.92±3.02) and
females (16.86±4.98). BMI, BF% and WHR were higher among
females, and BMI was higher among males. The most evident
correlation was verified between BF% and WHR for female
students (r=0.902; p
Abstract: Plasmin plays an important role in the human
circulatory system owing to its catalytic ability of fibrinolysis. The
immediate injection of plasmin in patients of strokes has intrigued
many scientists to design vectors that can transport plasmin to the
desired location in human body. Here we predict the structure of
human plasmin and investigate the interaction of plasmin with the
gold-nanoparticle.
Because the crystal structure of plasminogen has been solved, we
deleted N-terminal domain (Pan-apple domain) of plasminogen and
generate a mimic of the active form of this enzyme (plasmin). We
conducted a simulated annealing process on plasmin and discovered a
very large conformation occurs. Kringle domains 1, 4 and 5 had been
observed to leave its original location relative to the main body of the
enzyme and the original doughnut shape of this enzyme has been
transformed to a V-shaped by opening its two arms. This observation
of conformational change is consistent with the experimental results of
neutron scattering and centrifugation.
We subsequently docked the plasmin on the simulated gold surface
to predict their interaction. The V-shaped plasmin could utilize its
Kringle domain and catalytic domain to contact the gold surface.
Our findings not only reveal the flexibility of plasmin structure but
also provide a guide for the design of a plasmin-gold nanoparticle.
Abstract: This research paper presents highly optimized barrel
shifter at 22nm Hi K metal gate strained Si technology node. This
barrel shifter is having a unique combination of static and dynamic
body bias which gives lowest power delay product. This power delay
product is compared with the same circuit at same technology node
with static forward biasing at ‘supply/2’ and also with normal reverse
substrate biasing and still found to be the lowest. The power delay
product of this barrel sifter is .39362X10-17J and is lowered by
approximately 78% to reference proposed barrel shifter at 32nm bulk
CMOS technology. Power delay product of barrel shifter at 22nm Hi
K Metal gate technology with normal reverse substrate bias is
2.97186933X10-17J and can be compared with this design’s PDP of
.39362X10-17J. This design uses both static and dynamic substrate
biasing and also has approximately 96% lower power delay product
compared to only forward body biased at half of supply voltage. The
NMOS model used are predictive technology models of Arizona state
university and the simulations to be carried out using HSPICE
simulator.
Abstract: Purpose: The study aimed to assess the depressant or
antidepressant effects of several Nonsteroidal Anti-Inflammatory
Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2)
inhibitor meloxicam, and the non-selective COX-1 and COX-2
inhibitors lornoxicam, sodium metamizole, and ketorolac. The
current literature data regarding such effects of these agents are
scarce.
Materials and methods: The study was carried out on NMRI mice
weighing 20-35 g, kept in a standard laboratory environment. The
study was approved by the Ethics Committee of the University of
Medicine and Pharmacy „Carol Davila”, Bucharest. The study agents
were injected intraperitoneally, 10 mL/kg body weight (bw) 1 hour
before the assessment of the locomotor activity by cage testing (n=10
mice/ group) and 2 hours before the forced swimming tests (n=15).
The study agents were dissolved in normal saline (meloxicam,
sodium metamizole), ethanol 11.8% v/v in normal saline (ketorolac),
or water (lornoxicam), respectively. Negative and positive control
agents were also given (amitryptilline in the forced swimming test).
The cage floor used in the locomotor activity assessment was divided
into 20 equal 10 cm squares. The forced swimming test involved
partial immersion of the mice in cylinders (15/9cm height/diameter)
filled with water (10 cm depth at 28C), where they were left for 6
minutes. The cage endpoint used in the locomotor activity assessment
was the number of treaded squares. Four endpoints were used in the
forced swimming test (immobility latency for the entire 6 minutes,
and immobility, swimming, and climbing scores for the final 4
minutes of the swimming session), recorded by an observer that was
„blinded” to the experimental design. The statistical analysis used the
Levene test for variance homogeneity, ANOVA and post-hoc
analysis as appropriate, Tukey or Tamhane tests.
Results: No statistically significant increase or decrease in the
number of treaded squares was seen in the locomotor activity
assessment of any mice group. In the forced swimming test,
amitryptilline showed an antidepressant effect in each experiment, at
the 10 mg/kg bw dosage. Sodium metamizole was depressant at 100
mg/kg bw (increased the immobility score, p=0.049, Tamhane test),
but not in lower dosages as well (25 and 50 mg/kg bw). Ketorolac
showed an antidepressant effect at the intermediate dosage of 5
mg/kg bw, but not so in the dosages of 2.5 and 10 mg/kg bw,
respectively (increased the swimming score, p=0.012, Tamhane test).
Meloxicam and lornoxicam did not alter the forced swimming
endpoints at any dosage level.
Discussion: 1) Certain NSAIDs caused changes in the forced
swimming patterns without interfering with locomotion. 2) Sodium
metamizole showed a depressant effect, whereas ketorolac proved
antidepressant. Conclusion: NSAID-induced mood changes are not
class effects of these agents and apparently are independent of the
type of inhibited cyclooxygenase (COX-1 or COX-2).
Disclosure: This paper was co-financed from the European Social
Fund, through the Sectorial Operational Programme Human Resources Development 2007-2013, project number POSDRU /159
/1.5 /S /138907 "Excellence in scientific interdisciplinary research,
doctoral and postdoctoral, in the economic, social and medical fields
-EXCELIS", coordinator The Bucharest University of Economic
Studies.
Abstract: Hypersonic flows around spatial vehicles during their reentry phase in planetary atmospheres are characterized by intense aerothermodynamics phenomena. The aim of this work is to analyze high temperature flows around an axisymmetric blunt body taking into account chemical and vibrational non-equilibrium for air mixture species and the no slip condition at the wall. For this purpose, the Navier-Stokes equations system is resolved by the finite volume methodology to determine the flow parameters around the axisymmetric blunt body especially at the stagnation point and in the boundary layer along the wall of the blunt body. The code allows the capture of shock wave before a blunt body placed in hypersonic free stream. The numerical technique uses the Flux Vector Splitting method of Van Leer. CFL coefficient and mesh size level are selected to ensure the numerical convergence.
Abstract: Theory of Mind (ToM) refers to the ability to infer
another’s mental state. With appropriate ToM, one can behave well in
social interactions. A growing body of evidence has demonstrated that
patients with temporal lobe epilepsy (TLE) may damage ToM by
affecting on regions of the underlying neural network of ToM.
However, the question of whether there is cerebral laterality for ToM
functions remains open. This study aimed to examine whether there is
cerebral lateralization for ToM abilities in TLE patients. Sixty-seven
adult TLE patients and 30 matched healthy controls (HC) were
recruited. Patients were classified into right (RTLE), left (LTLE), and
bilateral (BTLE) TLE groups on the basis of a consensus panel review
of their seizure semiology, EEG findings, and brain imaging results.
All participants completed an intellectual test and four tasks measuring
basic and advanced ToM. The results showed that, on all ToM tasks,
(1) each patient group performed worse than HC; (2) there were no
significant differences between LTLE and RTLE groups; and (3) the
BTLE group performed the worst. It appears that the neural network
responsible for ToM is distributed evenly between the cerebral
hemispheres.
Abstract: A numerical model has been developed to investigate the thermally triggered release kinetics for drug delivery using phase change material as shell of microcapsules. Biocompatible material n-Eicosane is used as demonstration. PCM shell of microcapsule will remain in solid form after the drug is taken, so the drug will be encapsulated by the shell, and will not be released until the target body part of lesion is exposed to external heat source, which will thermally trigger the release kinetics, leading to solid-to-liquid phase change. The findings can lead to better understanding on the key effects influencing the phase change process for drug delivery applications. The facile approach to release drug from core/shell structure of microcapsule can be well integrated with organic solvent free fabrication of microcapsules, using double emulsion as template in microfluidic aqueous two phase system.
Abstract: The textile industry plays a major role in the economy
of India and on the other side of the coin it is the major source for
water pollution. As azo dyes is the largest dye class they are
extensively used in many fields such as textile industry, leather
tanning industry, paper production, food, color photography,
pharmaceuticals and medicine, cosmetic, hair colorings, wood
staining, agricultural, biological and chemical research etc. In
addition to these, they can have acute and/or chronic effects on
organisms depending on their concentration and length of exposure
when they discharged as effluent in the environment. The aim of this
study was to assess the genotoxic and histotoxic potentials of
environmentally relevant concentrations of C. I. Reactive Red 120
(RR 120) on Catla catla, important edible freshwater fingerlings. For
this, healthy Catla catla fingerlings were procured from the
Government Fish Farm and acclimatized in 100 L capacity and
continuously aerated glass aquarium in laboratory for 15 days.
According to APHA some physic-chemical parameters were
measured and maintained such as temperature, pH, dissolve oxygen,
alkalinity, total hardness. Water along with excreta had been changed
every 24 hrs. All fingerlings were fed artificial food palates once a
day @ body weight. After 15 days fingerlings were grouped in 5 (10
in each) and exposed to various concentrations of RR 120 (Control,
10, 20, 30 and 40 mg.l-1) and samples (peripheral blood and gills,
kidney) were collected and analyzed at 96 hrs. All results were
compared with the control. Micronuclei (MN), nuclear buds (NB),
fragmented-apoptotic (FA) and bi-nucleated (BN) cells in blood
smears and in tissues (gills and kidney cells) were observed.
Prominent histopathological alterations were noticed in gills such as
aneurism, hyperplasia, degenerated central axis, lifting of gill
epithelium, curved secondary gill lamellae etc. Similarly kidney
showed some detrimental changes like shrunken glomeruli with
increased periglomerular space, degenerated renal tubules etc. Both
haematological and histopathological changes clearly reveal the toxic
potential of RR 120. This work concludes that water pollution
assessment can be done by these two biomarkers which provide
baseline to the further chromosomal or molecular work.
Abstract: In this paper, a numerical simulation of a finned store
separating from a wing-pylon configuration has been studied and
validated. A dynamic unstructured tetrahedral mesh approach is
accomplished by using three grid sizes to numerically solving the
discretized three dimensional, inviscid and compressible Euler
equations. The method used for computations of separation of an
external store assuming quasi-steady flow condition. Computations of
quasi-steady flow have been directly coupled to a six degree-offreedom
(6DOF) rigid-body motion code to generate store
trajectories. The pressure coefficients at four different angular cuts
and time histories of various trajectory parameters and wing pressure
distribution during the store separation are compared for every grid
size with published experimental data.
Abstract: Freshly laid eggs from green turtles, Chelonia mydas,
were randomly collected from Ras Al-Hadd Reserve, Oman.
Eggshells taken from eggs and sand collected from the body chamber
were analyzed for eight heavy metals (Al, Br, Cd, Co, Cu, Fe, S, and
Zn) using inductively coupled plasma mass spectrometry (ICP).
Heavy metal concentrations varied significantly (P
Abstract: This paper describes an Action Research project
which was undertaken to inform professional practice in order to
develop a newly created Centre for Student Success in the specific
context of transnational medical and nursing education in the Middle
East. The objectives were to enhance the academic performance,
persistence, integration and personal and professional development of
a multinational study body, in particular in relation to pre-clinical
medical students, and to establish a comfortable, friendly and
student-driven environment within an Irish medical university
recently established in Bahrain. The outcomes of the project resulted
in the development of a specific student success ‘signature’ for this
particular transnational higher education context.
Abstract: The effects of hypertension are often lethal thus its
early detection and prevention is very important for everybody. In
this paper, a neural network (NN) model was developed and trained
based on a dataset of hypertension causative parameters in order to
forecast the likelihood of occurrence of hypertension in patients. Our
research goal was to analyze the potential of the presented NN to
predict, for a period of time, the risk of hypertension or the risk of
developing this disease for patients that are or not currently
hypertensive. The results of the analysis for a given patient can
support doctors in taking pro-active measures for averting the
occurrence of hypertension such as recommendations regarding the
patient behavior in order to lower his hypertension risk. Moreover,
the paper envisages a set of three example scenarios in order to
determine the age when the patient becomes hypertensive, i.e.
determine the threshold for hypertensive age, to analyze what
happens if the threshold hypertensive age is set to a certain age and
the weight of the patient if being varied, and, to set the ideal weight
for the patient and analyze what happens with the threshold of
hypertensive age.
Abstract: In this paper, a new design of spherical robotic system
based on the concepts of gimbal structure and gyro dynamics is
presented. Robots equipped with multiple wheels and complex
steering mechanics may increase the weight and degrade the energy
transmission efficiency. In addition, the wheeled and legged robots are
relatively vulnerable to lateral impact and lack of lateral mobility.
Therefore, the proposed robotic design uses a spherical shell as the
main body for ground locomotion, instead of using wheel devices.
Three spherical shells are structured in a similar way to a gimbal
device and rotate like a gyro system. The design and mechanism of the
proposed robotic system is introduced. In addition, preliminary results
of the dynamic model based on the principles of planar rigid body
kinematics and Lagrangian equation are included. Simulation results
and rig construction are presented to verify the concepts.
Abstract: Epidermal Growth Factor (EGF, Mw=6,045) has been
reported to have high efficiency of wound repair and anti-wrinkle
effect. However, the half-life of EGF in the body is too short to exert
the biological activity effectively when applied in free form. Growth
Factors can be stabilized by immobilization with carbohydrates from
thermal and proteolytic degradation. Low molecular weight chitosan
(LMCS) and its derivate prepared by hydrogen peroxide has high
solubility. LM6A6DC was successfully prepared as a reactive
carbohydrate for the stabilization of EGF by the reactions of LMCS
with alkalization, tosylation, azidation and reduction. The structure of
LM6A6DC was confirmed by FT-IR, 1H NMR and elementary
analysis. For enhancing the stability of free EGF, EGF was attached
with LM6A6DC by using water-soluble carbodiimide.
EGF-LM6A6DC conjugates did not show any cytotoxicity on the
Normal Human Dermal Fibroblast (NHDF) 3T3 proliferation at least
under 100 μg/ml. In the result, it was considered that LM6A6DC is
suitable to immobilize of growth factor.
Abstract: For a bluff body, dimples behave like roughness
elements in stimulating a turbulent boundary layer, leading to delayed
flow separation, a smaller wake and lower form drag. This is very
different in principle from the application of dimples to streamlined
body, where any reduction in drag would be predominantly due to a
reduction in skin friction. In the present work, a car model with
different dimple geometry is simulated using k-ε turbulence modeling
to determine its effect to the aerodynamics performance. Overall, the
results show that the application of dimples manages to reduce the
drag coefficient of the car model.