Abstract: Adult mesenchymal stem cells (MSCs) have been investigated using preclinical approaches for tissue regeneration. Porcine MSCs (pMSCs) are capable of growing and attaching to plastic with a fibroblast-like morphology and then differentiating into bone, adipose, and cartilage tissues in vitro. This study was conducted to investigate the proliferating abilities, differentiation potentials, and multipotency of miniature pig adipose tissue-derived MSCs (mpAD-MSCs) with or without long-term cryopreservation, considering that cryostorage has the potential for use in clinical applications. After confirming the characteristics of the mpAD-MSCs, we examined the effect of long-term cryopreservation (> 2 years) on expression of cell surface markers (CD34, CD90 and CD105), proliferating abilities (cumulative population doubling level, doubling time, colony-forming unit, and MTT assay) and differentiation potentials into mesodermal cell lineages. As a result, the expression of cell surface markers is similar between thawed and fresh mpAD-MSCs. However, long-term cryopreservation significantly lowered the differentiation potentials (adipogenic, chondrogenic, and osteogenic) of mpAD-MSCs. When compared with fresh mpAD-MSCs, thawed mpAD-MSCs exhibited lower expression of mesodermal cell lineage-related genes such as peroxisome proliferator-activated receptor-g2, lipoprotein lipase, collagen Type II alpha 1, osteonectin, and osteocalcin. Interestingly, long-term cryostoraged mpAD-MSCs exhibited significantly higher cell viability than the fresh mpAD-MSCs. Long-term cryopreservation induced a 30% increase in the cell viability of mpAD-MSCs when compared with the fresh mpAD-MSCs at 5 days after thawing. However, long-term cryopreservation significantly lowered expression of stemness markers such as Oct3/4, Sox2, and Nanog. Furthermore, long-term cryopreservation negatively affected expression of senescence-associated genes such as telomerase reverse transcriptase and heat shock protein 90 of mpAD-MSCs when compared with the fresh mpAD-MSCs. The results from this study might be important for the successful application of MSCs in clinical trials after long-term cryopreservation.
Abstract: This paper explores the effectiveness of approaches used for the implementation of technology within central governments specifically Geographic Information Systems (GIS). It examines the extent to which various strategies to GIS implementation and its roll out to users within an organization is crucial for its long term assimilation. Depending on the contextual requirements, various implementation strategies exist spanning from the most revolutionary to the most evolutionary, which have an influence on the success of GIS projects and the realization of resulting business benefits within the central governments. This research compares between two strategies of GIS implementation within the Lebanese Municipalities. The first strategy is the “Technological Approach” which is focused on technology acquisition, overlaid on existing governmental frameworks. This approach gives minimal attention to capability building and the long term sustainability of the implemented program. The second strategy, referred to as the “Ecological Approach”, is naturally oriented to the function of the organization. This approach stresses on fostering the evolution of the program and on building the human capabilities. The Union of the Joumeh Municipalities will be presented as a case study under the “Ecological Approach” and the role of the GIS Center at the University of Balamand will be highlighted. Thus, this research contributes to the development of knowledge on technology implementation and the vital role of academia in the specific context of the Lebanese public sector so that this experience may pave the way for further applications.
Abstract: Six peculiar architecture designs from the Frankfurt University will be discussed within this paper and their future potential of the adaptable and solar thin-film sheets implemented facades will be shown acting and reacting on climate/solar changes of their specific sites. The different aspects, as well as limitations with regard to technical and functional restrictions, will be named. The design process for a “multi-purpose building”, a “high-rise building refurbishment” and a “biker’s lodge” on the river Rheine valley, has been critically outlined and developed step by step from an international studentship towards an overall energy strategy, that firstly had to push the design to a plus-energy building and secondly had to incorporate bionic aspects into the building skins design. Both main parameters needed to be reviewed and refined during the whole design process. Various basic bionic approaches have been given [e.g. solar ivy TM, flectofin TM or hygroskin TM, which were to experiment with, regarding the use of bendable photovoltaic thin film elements being parts of a hybrid, kinetic façade system.
Abstract: The problem of construction material waste remains unresolved, as a significant percentage of the materials delivered to some project sites end up as waste which might result in additional project cost. Cost overrun is a problem which affects 90% of the completed projects in the world. The argument on how to eliminate it has been on-going for the past 70 years, but there is neither substantial improvement nor significant solution for mitigating its detrimental effects. Research evidence has proposed various construction cost overruns and material-waste management approaches; nonetheless, these studies failed to give a clear indication on the framework and the equation for managing construction material waste and cost overruns. Hence, this research aims to develop a conceptual framework and a mathematical equation for managing material waste and cost overrun in the construction industry. The paper adopts the desktop methodological approach. This involves comparing the causes of material waste and those of cost overruns from the literature to determine the possible relationship. The review revealed a relationship between material waste and cost overrun that; increase in material waste would result to a corresponding increase in the amount of cost overrun at both the pre-contract and the post contract stages of a project. It was found from the equation that achieving an effective construction material waste management must ensure a “Good Quality-of-Planning, Estimating, and Design Management” and a “Good Quality- of-Construction, Procurement and Site Management”; a decrease in “Design Complexity” which would reduce “Material Waste” and subsequently reduce the amount of cost overrun by 86.74%. The conceptual framework and the mathematical equation developed in this study are recommended to the professionals of the construction industry.
Abstract: Web service adaptation involves the creation of adapters that solve Web services incompatibilities known as mismatches. Since the importance of Web services adaptation is increasing because of the frequent implementation and use of online Web services, this paper presents a literature review of web services to investigate the main methods of adaptation, their theoretical underpinnings and the metrics used to measure adapters performance. Eighteen publications were reviewed independently by two researchers. We found that adaptation techniques are needed to solve different types of problems that may arise due to incompatibilities in Web service interfaces, including protocols, messages, data and semantics that affect the interoperability of the services. Although adapters are non-invasive methods that can improve Web services interoperability and there are current approaches for service adaptation; there is, however, not yet one solution that fits all types of mismatches. Our results also show that only a few research projects incorporate theoretical frameworks and that metrics to measure adapters’ performance are very limited. We conclude that further research on software adaptation should improve current adaptation methods in different layers of the service interoperability and that an adaptation theoretical framework that incorporates a theoretical underpinning and measures of qualitative and quantitative performance needs to be created.
Abstract: This paper reviews a number of theoretical aspects
for implementing an explicit spatial perspective in econometrics
for modelling non-continuous data, in general, and count data, in
particular. It provides an overview of the several spatial econometric
approaches that are available to model data that are collected with
reference to location in space, from the classical spatial econometrics
approaches to the recent developments on spatial econometrics to
model count data, in a Bayesian hierarchical setting. Considerable
attention is paid to the inferential framework, necessary for
structural consistent spatial econometric count models, incorporating
spatial lag autocorrelation, to the corresponding estimation and
testing procedures for different assumptions, to the constrains and
implications embedded in the various specifications in the literature. This review combines insights from the classical spatial
econometrics literature as well as from hierarchical modeling and
analysis of spatial data, in order to look for new possible directions
on the processing of count data, in a spatial hierarchical Bayesian
econometric context.
Abstract: Climate change and sea level rise is one of the greatest challenges facing human beings in the 21st century. Because of sea level rise, several low-lying coastal areas around the globe are at risk of being completely submerged, disappearing under water. Particularly in Viet Nam, the rise in sea level is predicted to result in more frequent and even permanently inundated coastal plains. As a result, land reserving fund of coastal cities is going to be narrowed in near future, while construction ground is becoming increasingly limited due to a rapid growth in population. Faced with this reality, the solutions are being discussed not only in tradition view such as accommodation is raised or moved to higher areas, or “living with the water”, but also forwards to “living on the water”. Therefore, the concept of a sustainable floating community with floating houses based on the precious value of long term historical tradition of water dwellings in Viet Nam would be a sustainable solution for adaptation of climate change and sea level rise in the coastal areas. The sustainable floating community is comprised of sustainability in four components: architecture, environment, socio-economic and living quality. This research paper is focused on sustainability in architectural component of floating community. Through detailed architectural analysis of current floating houses and floating communities in Viet Nam, this research not only accumulates precious values of traditional architecture that need to be preserved and developed in the proposed concept, but also illustrates its weaknesses that need to address for optimal design of the future sustainable floating communities. Based on these studies the research would provide guidelines with appropriate architectural solutions for the concept of sustainable floating community with floating housing units that are adapted to climate change and sea level rise in Viet Nam.
Abstract: This study involves the modeling and monitoring of an ammonia synthesis fixed-bed reactor using partial least squares (PLS) and its variants. The process exhibits complex dynamic behavior due to the presence of heat recycling and feed quench. One limitation of static PLS model in this situation is that it does not take account of the process dynamics and hence dynamic PLS was used. Although it showed, superior performance to static PLS in terms of prediction, the monitoring scheme was inappropriate hence adaptive PLS was considered. A limitation of adaptive PLS is that non-conforming observations also contribute to the model, therefore, a new adaptive approach was developed, robust adaptive dynamic PLS. This approach updates a dynamic PLS model and is robust to non-representative data. The developed methodology showed a clear improvement over existing approaches in terms of the modeling of the reactor and the detection of faults.
Abstract: Increasing our ability to solve complex engineering problems is directly related to the processing capacity of computers. By means of such equipments, one is able to fast and accurately run numerical algorithms. Besides the increasing interest in numerical simulations, probabilistic approaches are also of great importance. This way, statistical tools have shown their relevance to the modelling of practical engineering problems. In general, statistical approaches to such problems consider that the random variables involved follow a normal distribution. This assumption tends to provide incorrect results when skew data is present since normal distributions are symmetric about their means. Thus, in order to visualize and quantify this aspect, 9 statistical distributions (symmetric and skew) have been considered to model a hypothetical slope stability problem. The data modeled is the friction angle of a superficial soil in Brasilia, Brazil. Despite the apparent universality, the normal distribution did not qualify as the best fit. In the present effort, data obtained in consolidated-drained triaxial tests and saturated direct shear tests have been modeled and used to analytically derive the probability density function (PDF) of the safety factor of a hypothetical slope based on Mohr-Coulomb rupture criterion. Therefore, based on this analysis, it is possible to explicitly derive the failure probability considering the friction angle as a random variable. Furthermore, it is possible to compare the stability analysis when the friction angle is modelled as a Dagum distribution (distribution that presented the best fit to the histogram) and as a Normal distribution. This comparison leads to relevant differences when analyzed in light of the risk management.
Abstract: During manned exploration of space, missions will require astronaut crewmembers to perform Extra Vehicular Activities (EVAs) for a variety of tasks. These EVAs take place after long periods of operations in space, and in and around unique vehicles, space structures and systems. Considering the remoteness and time spans in which these vehicles will operate, EVA system operations should utilize common worksites, tools and procedures as much as possible to increase the efficiency of training and proficiency in operations. All of the preparations need to be carried out based on studies of astronaut motions. Until now, development and training activities associated with the planned EVAs in Russian and U.S. space programs have relied almost exclusively on physical simulators. These experimental tests are expensive and time consuming. During the past few years a strong increase has been observed in the use of computer simulations due to the fast developments in computer hardware and simulation software. Based on this idea, an effort to develop a computational simulation system to model human dynamic motion for EVA is initiated. This study focuses on the simulation of an astronaut moving the orbital replaceable units into the worksites or removing them from the worksites. Our physics-based methodology helps fill the gap in quantitative analysis of astronaut EVA by providing a multisegment human arm model. Simulation work described in the study improves on the realism of previous efforts, incorporating joint stops to account for the physiological limits of range of motion. To demonstrate the utility of this approach human arm model is simulated virtually using ADAMS/LifeMOD® software. Kinematic mechanism for the astronaut’s task is studied from joint angles and torques. Simulation results obtained is validated with numerical simulation based on the principles of Newton-Euler method. Torques determined using mathematical model are compared among the subjects to know the grace and consistency of the task performed. We conclude that due to uncertain nature of exploration-class EVA, a virtual model developed using multibody dynamics approach offers significant advantages over traditional human modeling approaches.
Abstract: This paper covers application of an elitist selfadaptive
step-size search (ESASS) to optimum design of steel
skeletal structures. In the ESASS two approaches are considered for
improving the convergence accuracy as well as the computational
efficiency of the original technique namely the so called selfadaptive
step-size search (SASS). Firstly, an additional randomness
is incorporated into the sampling step of the technique to preserve
exploration capability of the algorithm during the optimization.
Moreover, an adaptive sampling scheme is introduced to improve the
quality of final solutions. Secondly, computational efficiency of the
technique is accelerated via avoiding unnecessary analyses during the
optimization process using an upper bound strategy. The numerical
results demonstrate the usefulness of the ESASS in the sizing
optimization problems of steel truss and frame structures.
Abstract: Recently, the world main problem is a global warming and climate change affecting both outdoor and indoor environments, especially the air quality (AQ) as a result of vast migration of people from rural areas to urban areas. Therefore, cities became more crowded and denser from an irregular population increase, along with increasing urbanization caused many problems for the environment such as increasing the land prices, changes in life style, and the new buildings are not adapted to the climate producing uncomfortable and unhealthy indoor building conditions. As interior environments are the places that create the most intimate relationship with the user. Consequently, the indoor environment quality (IEQ) for buildings became uncomfortable and unhealthy for its occupants. The symptoms commonly associated with poor indoor environment such as itchy, headache, fatigue, and respiratory complaints such as cough and congestion, etc. The symptoms tend to improve over time or even disappear when people are away from the building. Therefore, designing a healthy indoor environment to fulfill human needs is the main concern for architects and interior designer. However, this research explores how occupant expectations and environmental attitudes may influence occupant health and satisfaction within the context of the indoor environment. In doing so, it reviews and contributes to the methods and tools used to evaluate only the indoor environment quality (IEQ) components of building performance. Its main aim is to review the literature on indoor human comfort. This is followed by a review of previous papers published related to human comfort. Finally, this paper will provide possible approaches in design level of healthy buildings.
Abstract: Despite the benefits of innovation diffusion in the
South African public service, implementation thereof seems to be
problematic, particularly with regard to e-governance which would
enhance the quality of service delivery, especially accessibility,
choice, and mode of operation. This paper reports on differences
between the public service and the private sector in terms of
innovation diffusion. Innovation diffusion will be investigated to
explore identified obstacles that are hindering successful
implementation of e-governance. The research inquiry is underpinned
by the diffusion of innovation theory, which is premised on the
assumption that innovation has a distinct channel, time, and mode of
adoption within the organisation. A comparative thematic document
analysis was conducted to investigate organisational differences with
regard to innovation diffusion. A similar approach has been followed
in other countries, where the same conceptual framework has been
used to guide document analysis in studies in both the private and the
public sectors. As per the recommended conceptual framework, three
organisational characteristics were emphasised, namely the external
characteristics of the organisation, the organisational structure, and
the inherent characteristics of the leadership. The results indicated
that the main difference in the external characteristics lies in the
focus and the clientele of the private sector. With regard to
organisational structure, private organisations have veto power,
which is not the case in the public service. Regarding leadership,
similarities were observed in social and environmental responsibility
and employees’ attitudes towards immediate supervision. Differences
identified included risk taking, the adequacy of leadership
development, organisational approaches to motivation and
involvement in decision making, and leadership style. Due to the
organisational differences observed, it is recommended that
differentiated strategies be employed to ensure effective innovation
diffusion, and ultimately e-governance. It is recommended that the
results of this research be used to stimulate discussion on ways to
improve collaboration between the mentioned sectors, to capitalise on
the benefits of each sector.
Abstract: Liquid storage tanks have become widespread during the recent decades due to their extensive usage. Analysis of liquid containing tanks is known to be complex due to hydrodynamic force exerted on tank which makes the analysis a complex one. The objective of this research is to carry out analysis of liquid domain along with structural interaction for various geometries of circular tanks considering seismic effects. An attempt has been made to determine hydrodynamic pressure distribution on the tank wall considering impulsive and convective components of liquid mass. To get a better picture, a comparative study of Draft IS 1893 Part 2, ACI 350.3 and Eurocode 8 for Circular Shaped Tank has been performed. Further, the differences in the magnitude of shear and moment at base as obtained from static (IS 3370 IV) and dynamic (Draft IS 1892 Part 2) analysis of ground supported circular tank highlight the need for us to mature from the old code to a newer code, which is more accurate and reliable.
Abstract: Community living adjacent to forests and Protected
Areas, especially in South Asian countries, have a common practice
in extracting resources for their living and livelihoods. This
extraction of resources, because the way it is done, destroys the biophysical
features of the area. Deforestation, wildlife poaching, illegal
logging, unauthorized hill cutting etc. are some of the serious issues
of concern for the sustainability of the natural resources that has a
direct impact on environment and climate as a whole. To ensure
community involvement in conservation initiatives of the state,
community based forest management, commonly known as Comanagement,
has been in practice in 6 South Asian countries. These
are -India, Nepal, Sri Lanka, Pakistan, Bhutan and Bangladesh.
Involving community in forestry management was initiated first in
Bangladesh in 1979 and reached as an effective co-management
approach through a several paradigm shifts. This idea of Comanagement
has been institutionalized through a Government Order
(GO) by the Ministry of Environment and Forests, Government of
Bangladesh on November 23, 2009. This GO clearly defines the
structure and functions of Co-management and its different bodies.
Bangladesh Forest Department has been working in association with
community to conserve and manage the Forests and Protected areas
of Bangladesh following this legal document. Demographically
young people constitute the largest segment of population in
Bangladesh. This group, if properly sensitized, can produce valuable
impacts on the conservation initiatives, both by community and
government. This study traced the major factors that motivate
community youths to work effectively with different tiers of comanagement
organizations in conservation of forests and Protected
Areas of Bangladesh. For the purpose of this study, 3 FGDs were
conducted with 30 youths from the community living around the
Protected Areas of Cox’s bazar, South East corner of Bangladesh,
who are actively involved in Co-management organizations. KII were
conducted with 5 key officials of Forest Department stationed at
Cox’s Bazar. 2 FGDs were conducted with the representatives of 7
Co-management organizations working in Cox’s Bazar region and
approaches of different community outreach activities conducted for
forest conservation by 3 private organizations and Projects have been
reviewed. Also secondary literatures were reviewed for the history
and evolution of Co-management in Bangladesh and six South Asian
countries. This study found that innovative community outreach
activities that are financed by public and private sectors involving
youths and community as a whole have played a pivotal role in
conservation of forests and Protected Areas of the region. This
approach can be replicated in other regions of Bangladesh as well as
other countries of South Asia where Co-Management exists in
practice.
Abstract: This paper investigates the effects of breaks in bonds,
breaks in the earthing system and breaks in earth wire on the rise of
the earth potential (EPR) in a substation and at the transmission tower
bases using various models of an L6 tower. Different approaches
were adopted to examine the integrity of the earthing system and the
terminal towers. These effects were investigated to see the associated
difference in the EPR magnitudes with respect to a healthy system at
various locations. Comparisons of the computed EPR magnitudes
were then made between the healthy and unhealthy system to detect
any difference. The studies were conducted at power frequency for a
uniform soil with different soil resistivities. It was found that full
breaks in the double bond of the terminal towers increase the EPR
significantly at the fault location, while they reduce EPR at the
terminal tower bases. A fault on the isolated section of the grid can
result in EPR values up to 8 times of those on a healthy system at
higher soil resistivities, provided that the extended earthing system
stays connected to the grid.
Abstract: With 40% of total world energy consumption,
building systems are developing into technically complex large
energy consumers suitable for application of sophisticated power
management approaches to largely increase the energy efficiency
and even make them active energy market participants. Centralized
control system of building heating and cooling managed by
economically-optimal model predictive control shows promising
results with estimated 30% of energy efficiency increase. The research
is focused on implementation of such a method on a case study
performed on two floors of our faculty building with corresponding
sensors wireless data acquisition, remote heating/cooling units and
central climate controller. Building walls are mathematically modeled
with corresponding material types, surface shapes and sizes. Models
are then exploited to predict thermal characteristics and changes in
different building zones. Exterior influences such as environmental
conditions and weather forecast, people behavior and comfort
demands are all taken into account for deriving price-optimal climate
control. Finally, a DC microgrid with photovoltaics, wind turbine,
supercapacitor, batteries and fuel cell stacks is added to make the
building a unit capable of active participation in a price-varying
energy market. Computational burden of applying model predictive
control on such a complex system is relaxed through a hierarchical
decomposition of the microgrid and climate control, where the
former is designed as higher hierarchical level with pre-calculated
price-optimal power flows control, and latter is designed as lower
level control responsible to ensure thermal comfort and exploit
the optimal supply conditions enabled by microgrid energy flows
management. Such an approach is expected to enable the inclusion
of more complex building subsystems into consideration in order to
further increase the energy efficiency.
Abstract: Data fusion technology can be the best way to extract
useful information from multiple sources of data. It has been widely
applied in various applications. This paper presents a data fusion
approach in multimedia data for event detection in twitter by using
Dempster-Shafer evidence theory. The methodology applies a mining
algorithm to detect the event. There are two types of data in the
fusion. The first is features extracted from text by using the bag-ofwords
method which is calculated using the term frequency-inverse
document frequency (TF-IDF). The second is the visual features
extracted by applying scale-invariant feature transform (SIFT). The
Dempster - Shafer theory of evidence is applied in order to fuse the
information from these two sources. Our experiments have indicated
that comparing to the approaches using individual data source, the
proposed data fusion approach can increase the prediction accuracy
for event detection. The experimental result showed that the proposed
method achieved a high accuracy of 0.97, comparing with 0.93 with
texts only, and 0.86 with images only.
Abstract: Pedagogical approaches in Asia nowadays are
imported from the West. In Confucian Heritage Culture (CHC),
however, there is a dichotomy between the perceived benefits of
Western pedagogies and the real classroom practices in Chinese
societies. The success of Hong Kong students in large-scale
international assessments has proved that both the strengths of both
Western pedagogies and CHC educational approaches should be
integrated for the sake of the students. University students aim to equip themselves with employability
skills upon graduation. Formative assessments allow students to
receive detailed, positive, and timely feedback and they can identify
their strengths and weaknesses before they start working. However,
there remains a question of whether university year 1 students who
come from an examination-driven secondary education background
are ready to respond to more formative assessments. The findings show that year 1 students are less concerned about
competition in the university and more open to new teaching
approaches that will allow them to improve as professionals in their
major study areas.
Abstract: With the increasing number of people reviewing
products online in recent years, opinion sharing websites has become
the most important source of customers’ opinions. Unfortunately,
spammers generate and post fake reviews in order to promote or
demote brands and mislead potential customers. These are notably
destructive not only for potential customers, but also for business
holders and manufacturers. However, research in this area is not
adequate, and many critical problems related to spam detection have
not been solved to date. To provide green researchers in the domain
with a great aid, in this paper, we have attempted to create a highquality
framework to make a clear vision on review spam-detection
methods. In addition, this report contains a comprehensive collection
of detection metrics used in proposed spam-detection approaches.
These metrics are extremely applicable for developing novel
detection methods.