Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: The atmospheres in many cities along the coastal lines
in the world have been rapidly changed to coastal-industrial
atmosphere. Hence, it is vital to investigate the corrosion behavior of
steel exposed to this kind of environment. In this present study,
Electrochemical Impedance Spectrography (EIS) and film thickness
measurement were applied to monitor the corrosion behavior of
weathering steel covered with a thin layer of the electrolyte in a
wet-dry cyclic condition, simulating a coastal-industrial environment
at 25oC and 60% RH. The results indicate that in all cycles, the
corrosion rate increases during the drying process due to an increase in
anion concentration and an acceleration of oxygen diffusion enhanced
by the effect of the thinning out of the electrolyte. During the wet-dry
cyclic corrosion test, the long-term corrosion behavior of this steel
depends on the periods of exposure. Corrosion process is first
accelerated and then decelerated. The decelerating corrosion process is
contributed to the formation of the protective rust, favored by the
wet-dry cycle and the acid regeneration process during the rusting
process.
Abstract: In Hungary, the society has changed a lot for the past
25 years, and these changes could be detected in educational
situations as well. The number and the intensity of conflicts have
been increased in most fields of life, as well as at schools. Teachers
have difficulties to be able to handle school conflicts. What is more,
the new net generation, generation Z has values and behavioural
patterns different from those of the previous one, which might
generate more serious conflicts at school, especially with teachers
who were mainly socialising in a traditional teacher – student
relationship.
In Hungary, the bill CCIV of 2011 declared the foundation of
Institutes of Teacher Training in higher education institutes. One of
the tasks of the Institutes is to survey the competences and needs of
teachers working in public education and to provide further trainings
and services for them according to their needs and requirements. This
job is supported by the Social Renewal Operative Programs 4.1.2.B.
The professors of a college carried out a questionnaire and surveyed
the needs and the requirements of teachers working in the region.
Based on the results, the professors of the Institute of Teacher
Training decided to meet the requirements of teachers and to launch
short teacher further training courses in spring 2015. One of the
courses is going to focus on school conflict management through
mediation.
The aim of the pilot course is to provide conflict management
techniques for teachers and to present different mediation techniques
to them. The theoretical part of the course (5 hours) will enable
participants to understand the main points and the advantages of
mediation, while the practical part (10 hours) will involve teachers in
role plays to learn how to cope with conflict situations applying
mediation. We hope if conflicts could be reduced, it would influence
school atmosphere in a positive way and the teaching – learning
process could be more successful and effective.
Abstract: In this work, we explore the capability of the mean
shift algorithm as a powerful preprocessing tool for improving the
quality of spatial data, acquired from airborne scanners, from densely
built urban areas. On one hand, high resolution image data corrupted
by noise caused by lossy compression techniques are appropriately
smoothed while at the same time preserving the optical edges and, on
the other, low resolution LiDAR data in the form of normalized
Digital Surface Map (nDSM) is upsampled through the joint mean
shift algorithm. Experiments on both the edge-preserving smoothing
and upsampling capabilities using synthetic RGB-z data show that the
mean shift algorithm is superior to bilateral filtering as well as to
other classical smoothing and upsampling algorithms. Application of
the proposed methodology for 3D reconstruction of buildings of a
pilot region of Athens, Greece results in a significant visual
improvement of the 3D building block model.
Abstract: Prosperity of electronic equipment in photocopying
environment not only has improved work efficiency, but also has
changed indoor air quality. Considering the number of photocopying
employed, indoor air quality might be worse than in general office
environments. Determining the contribution from any type of
equipment to indoor air pollution is a complex matter. Non-methane
hydrocarbons are known to have an important role on air quality due
to their high reactivity. The presence of hazardous pollutants in
indoor air has been detected in one photocopying shop in Novi Sad,
Serbia. Air samples were collected and analyzed for five days, during
8-hr working time in three time intervals, whereas three different
sampling points were determined. Using multiple linear regression
model and software package STATISTICA 10 the concentrations of
occupational hazards and microclimates parameters were mutually
correlated. Based on the obtained multiple coefficients of
determination (0.3751, 0.2389 and 0.1975), a weak positive
correlation between the observed variables was determined. Small
values of parameter F indicated that there was no statistically
significant difference between the concentration levels of nonmethane
hydrocarbons and microclimates parameters. The results
showed that variable could be presented by the general regression
model: y = b0 + b1xi1+ b2xi2. Obtained regression equations allow to
measure the quantitative agreement between the variables and thus
obtain more accurate knowledge of their mutual relations.
Abstract: The growth in the volume of text data such as books
and articles in libraries for centuries has imposed to establish
effective mechanisms to locate them. Early techniques such as
abstraction, indexing and the use of classification categories have
marked the birth of a new field of research called "Information
Retrieval". Information Retrieval (IR) can be defined as the task of
defining models and systems whose purpose is to facilitate access to
a set of documents in electronic form (corpus) to allow a user to find
the relevant ones for him, that is to say, the contents which matches
with the information needs of the user. This paper presents a new
semantic indexing approach of a documentary corpus. The indexing
process starts first by a term weighting phase to determine the
importance of these terms in the documents. Then the use of a
thesaurus like Wordnet allows moving to the conceptual level.
Each candidate concept is evaluated by determining its level of
representation of the document, that is to say, the importance of the
concept in relation to other concepts of the document. Finally, the
semantic index is constructed by attaching to each concept of the
ontology, the documents of the corpus in which these concepts are
found.
Abstract: The relationship between the state and the religion is
different based on the fact that how powerful is the religion faith in a
state and of the influences that affected the views of the constitution
drafters according to the constitutional system they were based to
draft their constitution. This paper aims at providing, through a
comparative methodology, how it is regulated by the constitution the
relationship between the state and the religion. The object of this
study are the constitutions of Italy as a nation with catholic religious
tradition, Greece as a nation with orthodox religion tradition, and
Turkey as a nation which represents Muslim religion, while Albania
as a nation known for its religious plurality. In particular, the analysis
will be focused on the secular or religious principle provided in the
constitution of each respective state. This comparative overview
intends to discern which of the states analyzed is more tolerant and
fully respects the freedom of religion. It results that most of the states
subject of this study, despite their religious tradition have chosen the
secular principle in their constitutions, but the religious freedom is
differently guaranteed.
Abstract: In the Hierarchical Temporal Memory (HTM) paradigm
the effect of overlap between inputs on the activation of columns in
the spatial pooler is studied. Numerical results suggest that similar
inputs are represented by similar sets of columns and dissimilar inputs
are represented by dissimilar sets of columns. It is shown that the
spatial pooler produces these results under certain conditions for
the connectivity and proximal thresholds. Following the discussion
of the initialization of parameters for the thresholds, corresponding
qualitative arguments about the learning dynamics of the spatial
pooler are discussed.
Abstract: Evolutionary optimization methods such as genetic
algorithms have been used extensively for the construction site layout
problem. More recently, ant colony optimization algorithms, which
are evolutionary methods based on the foraging behavior of ants,
have been successfully applied to benchmark combinatorial
optimization problems. This paper proposes a formulation of the site
layout problem in terms of a sequencing problem that is suitable for
solution using an ant colony optimization algorithm.
In the construction industry, site layout is a very important
planning problem. The objective of site layout is to position
temporary facilities both geographically and at the correct time such
that the construction work can be performed satisfactorily with
minimal costs and improved safety and working environment. During
the last decade, evolutionary methods such as genetic algorithms
have been used extensively for the construction site layout problem.
This paper proposes an ant colony optimization model for
construction site layout. A simple case study for a highway project is
utilized to illustrate the application of the model.
Abstract: The use of engineered nanomaterials has increased as
a result of their positive impact on many sectors of the economy,
including agriculture. Silver nanoparticles (AgNPs) are now used to
enhance seed germination, plant growth, and photosynthetic quantum
efficiency and as antimicrobial agents to control plant diseases. In
this study, we examined the effect of AgNP dosage on the seed
germination of three plant species: corn (Zea mays L.), watermelon
(Citrullus lanatus [Thunb.] Matsum. & Nakai) and zucchini
(Cucurbita pepo L.). This experiment was designed to study the
effect of AgNPs on germination percentage, germination rate, mean
germination time, root length and fresh and dry weight of seedlings
for the three species. Seven concentrations (0.05, 0.1, 0.5, 1, 1.5, 2
and 2.5 mg/ml) of AgNPs were examined at the seed germination
stage. The three species had different dose responses to AgNPs in
terms of germination parameters and the measured growth
characteristics. The germination rates of the three plants were
enhanced in response to AgNPs. Significant enhancement of the
germination percentage values was observed after treatment of the
watermelon and zucchini plants with AgNPs in comparison with
untreated seeds. AgNPs showed a toxic effect on corn root
elongation, whereas watermelon and zucchini seedling growth were
positively affected by certain concentrations of AgNPs. This study
showed that exposure to AgNPs caused both positive and negative
effects on plant growth and germination.
Abstract: OPEN_EmoRec_II is an open multimodal corpus with
experimentally induced emotions. In the first half of the experiment,
emotions were induced with standardized picture material and in the
second half during a human-computer interaction (HCI), realized
with a wizard-of-oz design. The induced emotions are based on the
dimensional theory of emotions (valence, arousal and dominance).
These emotional sequences - recorded with multimodal data (facial
reactions, speech, audio and physiological reactions) during a
naturalistic-like HCI-environment one can improve classification
methods on a multimodal level.
This database is the result of an HCI-experiment, for which 30
subjects in total agreed to a publication of their data including the
video material for research purposes*. The now available open
corpus contains sensory signal of: video, audio, physiology (SCL,
respiration, BVP, EMG Corrugator supercilii, EMG Zygomaticus
Major) and facial reactions annotations.
Abstract: OPEN_EmoRec_II is an open multimodal corpus with
experimentally induced emotions. In the first half of the experiment,
emotions were induced with standardized picture material and in the
second half during a human-computer interaction (HCI), realized
with a wizard-of-oz design. The induced emotions are based on the
dimensional theory of emotions (valence, arousal and dominance).
These emotional sequences - recorded with multimodal data (facial
reactions, speech, audio and physiological reactions) during a
naturalistic-like HCI-environment one can improve classification
methods on a multimodal level.
This database is the result of an HCI-experiment, for which 30
subjects in total agreed to a publication of their data including the
video material for research purposes*. The now available open
corpus contains sensory signal of: video, audio, physiology (SCL,
respiration, BVP, EMG Corrugator supercilii, EMG Zygomaticus
Major) and facial reactions annotations.
Abstract: This work assesses the cortical and the sub-cortical
neural activity recorded from rodents using entropy and mutual
information based approaches to study how hypothermia affects neural
activity. By applying the multi-scale entropy and Shannon entropy, we
quantify the degree of the regularity embedded in the cortical and
sub-cortical neurons and characterize the dependency of entropy of
these regions on temperature. We study also the degree of the mutual
information on thalamocortical pathway depending on temperature.
The latter is most likely an indicator of coupling between these highly
connected structures in response to temperature manipulation leading
to arousal after global cerebral ischemia.
Abstract: The seismic risk mitigation from the perspective of
the old buildings stock is truly essential in Algerian urban areas,
particularly those located in seismic prone regions, such as Annaba
city, and which the old buildings present high levels of degradation
associated with no seismic strengthening and/or rehabilitation
concerns. In this sense, the present paper approaches the issue of the
seismic vulnerability assessment of old masonry building stocks
through the adaptation of a simplified methodology developed for a
European context area similar to that of Annaba city, Algeria.
Therefore, this method is used for the first level of seismic
vulnerability assessment of the masonry buildings stock of the old
city center of Annaba. This methodology is based on a vulnerability
index that is suitable for the evaluation of damage and for the
creation of large-scale loss scenarios. Over 380 buildings were
evaluated in accordance with the referred methodology and the
results obtained were then integrated into a Geographical Information
System (GIS) tool. Such results can be used by the Annaba city
council for supporting management decisions, based on a global view
of the site under analysis, which led to more accurate and faster
decisions for the risk mitigation strategies and rehabilitation plans.
Abstract: Polymer Electrolyte Membrane Fuel Cell (PEMFC) is
such a time-vary nonlinear dynamic system. The traditional linear
modeling approach is hard to estimate structure correctly of PEMFC
system. From this reason, this paper presents a nonlinear modeling of
the PEMFC using Neural Network Auto-regressive model with
eXogenous inputs (NNARX) approach. The multilayer perception
(MLP) network is applied to evaluate the structure of the NNARX
model of PEMFC. The validity and accuracy of NNARX model are
tested by one step ahead relating output voltage to input current from
measured experimental of PEMFC. The results show that the obtained
nonlinear NNARX model can efficiently approximate the dynamic
mode of the PEMFC and model output and system measured output
consistently.
Abstract: Design concepts of real-time embedded system can be
realized initially by introducing novel design approaches. In this
literature, model based design approach and in-the-loop testing were
employed early in the conceptual and preliminary phase to formulate
design requirements and perform quick real-time verification. The
design and analysis methodology includes simulation analysis, model
based testing, and in-the-loop testing. The design of conceptual driveby-
wire, or DBW, algorithm for electronic control unit, or ECU, was
presented to demonstrate the conceptual design process, analysis, and
functionality evaluation. The concepts of DBW ECU function can be
implemented in the vehicle system to improve electric vehicle, or EV,
conversion drivability. However, within a new development process,
conceptual ECU functions and parameters are needed to be evaluated.
As a result, the testing system was employed to support conceptual
DBW ECU functions evaluation. For the current setup, the system
components were consisted of actual DBW ECU hardware, electric
vehicle models, and control area network or CAN protocol. The
vehicle models and CAN bus interface were both implemented as
real-time applications where ECU and CAN protocol functionality
were verified according to the design requirements. The proposed
system could potentially benefit in performing rapid real-time
analysis of design parameters for conceptual system or software
algorithm development.
Abstract: Corrosion of concrete sewer pipes induced by
sulphuric acid attack is a recognised problem worldwide, which is not
only an attribute of countries with hot climate conditions as thought
before. The significance of this problem is by far only realised when
the pipe collapses causing surface flooding and other severe
consequences. To change the existing post-reactive attitude of
managing companies, easy to use and robust models are required to
be developed which currently lack reliable data to be correctly
calibrated. This paper focuses on laboratory experiments of
establishing concrete pipe corrosion rate by submerging samples in to
0.5pH sulphuric acid solution for 56 days under 10ºC, 20ºC and 30ºC
temperature regimes. The result showed that at very early stage of the
corrosion process the samples gained overall mass, at 30ºC the
corrosion progressed quicker than for other temperature regimes,
however with time the corrosion level for 10ºC and 20ºC regimes
tended towards those at 30ºC. Overall, at these conditions the
corrosion rates of 10 mm/year, 13,5 mm/year and 17 mm/year were
observed.
Abstract: The structures obtained with the use of sandwich
technologies combine low weight with high energy absorbing
capacity and load carrying capacity. Hence, there is a growing and
markedly interest in the use of sandwiches with aluminum foam core
because of very good properties such as flexural rigidity and energy
absorption capability. In the current investigation, the static threepoint
bending tests were carried out on the sandwiches with
aluminum foam core and glass fiber reinforced polymer (GFRP)
skins at different values of support span distances aiming the analyses
of their flexural performance. The influence of the core thickness and
the GFRP skin type was reported in terms of peak load and energy
absorption capacity. For this purpose, the skins with two different
types of fabrics which have same thickness value and the aluminum
foam core with two different thicknesses were bonded with a
commercial polyurethane based flexible adhesive in order to combine
the composite sandwich panels. The main results of the bending tests
are: force-displacement curves, peak force values, absorbed energy,
collapse mechanisms and the effect of the support span length and
core thickness. The results of the experimental study showed that the
sandwich with the skins made of S-Glass Woven fabrics and with the
thicker foam core presented higher mechanical values such as load
carrying and energy absorption capacities. The increment of the
support span distance generated the decrease of the mechanical
values for each type of panels, as expected, because of the inverse
proportion between the force and span length. The most common
failure types of the sandwiches are debonding of the lower skin and
the core shear. The obtained results have particular importance for
applications that require lightweight structures with a high capacity
of energy dissipation, such as the transport industry (automotive,
aerospace, shipbuilding and marine industry), where the problems of
collision and crash have increased in the last years.
Abstract: One of the main challenges in using the Discrete
Element Method (DEM) is to specify the correct input parameter
values. In general, the models are sensitive to the input parameter
values and accurate results can only be achieved if the correct values
are specified. For the linear contact model, micro-parameters such as
the particle density, stiffness, coefficient of friction, as well as the
particle size and shape distributions are required. There is a need for
a procedure to accurately calibrate these parameters before any
attempt can be made to accurately model a complete bulk materials
handling system. Since DEM is often used to model applications in
the mining and quarrying industries, a calibration procedure was
developed for materials that consist of relatively large (up to 40 mm
in size) particles. A coarse crushed aggregate was used as the test
material. Using a specially designed large shear box with a diameter
of 590 mm, the confined Young’s modulus (bulk stiffness) and
internal friction angle of the material were measured by means of the
confined compression test and the direct shear test respectively. DEM
models of the experimental setup were developed and the input
parameter values were varied iteratively until a close correlation
between the experimental and numerical results was achieved. The
calibration process was validated by modelling the pull-out of an
anchor from a bed of material. The model results compared well with
experimental measurement.
Abstract: In this paper, an analytical simplified method for
calculating elasto-plastic stresses strains of notched bodies subject to
non-proportional loading paths is discussed. The method was based
on the Neuber notch correction, which relates the incremental elastic
and elastic-plastic strain energy densities at the notch root and the
material constitutive relationship. The validity of the method was
presented by comparing computed results of the proposed model
against finite element numerical data of notched shaft. The
comparison showed that the model estimated notch-root elasto-plastic
stresses strains with good accuracy using linear-elastic stresses. The
prosed model provides more efficient and simple analysis method
preferable to expensive experimental component tests and more
complex and time consuming incremental non-linear FE analysis.
The model is particularly suitable to perform fatigue life and fatigue
damage estimates of notched components subjected to nonproportional
loading paths.