Abstract: In this paper, we study the application of Extreme
Learning Machine (ELM) algorithm for single layered feedforward
neural networks to non-linear chaotic time series problems. In this
algorithm the input weights and the hidden layer bias are randomly
chosen. The ELM formulation leads to solving a system of linear
equations in terms of the unknown weights connecting the hidden
layer to the output layer. The solution of this general system of
linear equations will be obtained using Moore-Penrose generalized
pseudo inverse. For the study of the application of the method we
consider the time series generated by the Mackey Glass delay
differential equation with different time delays, Santa Fe A and
UCR heart beat rate ECG time series. For the choice of sigmoid,
sin and hardlim activation functions the optimal values for the
memory order and the number of hidden neurons which give the
best prediction performance in terms of root mean square error are
determined. It is observed that the results obtained are in close
agreement with the exact solution of the problems considered
which clearly shows that ELM is a very promising alternative
method for time series prediction.
Abstract: This paper describes a novel method for automatic
estimation of the contours of weld defect in radiography images.
Generally, the contour detection is the first operation which we apply
in the visual recognition system. Our approach can be described as a
region based maximum likelihood formulation of parametric
deformable contours. This formulation provides robustness against
the poor image quality, and allows simultaneous estimation of the
contour parameters together with other parameters of the model.
Implementation is performed by a deterministic iterative algorithm
with minimal user intervention. Results testify for the very good
performance of the approach especially in synthetic weld defect
images.
Abstract: Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Abstract: An accurate procedure to determine free vibrations of
beams and plates is presented.
The natural frequencies are exact solutions of governing vibration
equations witch load to a nonlinear homogeny system.
The bilinear and linear structures considered simulate a bridge.
The dynamic behavior of this one is analyzed by using the theory of
the orthotropic plate simply supported on two sides and free on the
two others. The plate can be excited by a convoy of constant or
harmonic loads. The determination of the dynamic response of the
structures considered requires knowledge of the free frequencies and
the shape modes of vibrations. Our work is in this context. Indeed,
we are interested to develop a self-consistent calculation of the Eigen
frequencies.
The formulation is based on the determination of the solution of
the differential equations of vibrations. The boundary conditions
corresponding to the shape modes permit to lead to a homogeneous
system. Determination of the noncommonplace solutions of this
system led to a nonlinear problem in Eigen frequencies.
We thus, develop a computer code for the determination of the
eigenvalues. It is based on a method of bisection with interpolation
whose precision reaches 10 -12. Moreover, to determine the
corresponding modes, the calculation algorithm that we develop uses
the method of Gauss with a partial optimization of the "pivots"
combined with an inverse power procedure. The Eigen frequencies
of a plate simply supported along two opposite sides while
considering the two other free sides are thus analyzed. The results
could be generalized with the case of a beam by regarding it as a
plate with low width.
We give, in this paper, some examples of treated cases. The
comparison with results presented in the literature is completely
satisfactory.
Abstract: Formulation of biological profile is one of the modern roles of forensic anthropologist. The present study was conducted to estimate height using foot and shoeprint length of Malaysian population. The present work can be very useful information in the process of identification of individual in forensic cases based on shoeprint evidence. It can help to narrow down suspects and ease the police investigation. Besides, stature is important parameters in determining the partial identify of unidentified and mutilated bodies. Thus, this study can help the problem encountered in cases of mass disaster, massacre, explosions and assault cases. This is because it is very hard to identify parts of bodies in these cases where people are dismembered and become unrecognizable. Samples in this research were collected from 200 Malaysian adults (100 males and 100 females) with age ranging from 20 to 45 years old. In this research, shoeprint length were measured based on the print of the shoes made from the flat shoes. Other information like gender, foot length and height of subject were also recorded. The data was analyzed using IBM® SPSS Statistics 19 software. Results indicated that, foot length has a strong correlation with stature than shoeprint length for both sides of the feet. However, in the unknown, where the gender was undetermined have shown a better correlation in foot length and shoeprint length parameter compared to males and females analyzed separately. In addition, prediction equations are developed to estimate the stature using linear regression analysis of foot length and shoeprint length. However, foot lengths give better prediction than shoeprint length.
Abstract: Protective effect of ethanolic extract of polyherbal formulation (PHF) was studied on carbon tetrachloride induced liver damage on carbon tetrachloride induced liver damage. Treatment of rats with 250mg /kg body weight of ethanolic extract of PHF protected rats against carbon tetrachloride liver injury by significant lowerering 5’ nucleotidase (5’NT), Gamma Glutamyl transferase (GGT), Glutamate dehdyrogenasse (GDH) and Succinate Dehydrogenase (SDH) levels compared to control. Normalization in these enzyme levels indicates strong hepatoprotective property of PHF extract.
Abstract: The seismic response of steel shear wall system considering nonlinearity effects using finite element method is investigated in this paper. The non-linear finite element analysis has potential as usable and reliable means for analyzing of civil structures with the availability of computer technology. In this research the large displacements and materially nonlinear behavior of shear wall is presented with developing of finite element code. A numerical model based on the finite element method for the seismic analysis of shear wall is presented with developing of finite element code in this research. To develop the finite element code, the standard Galerkin weighted residual formulation is used. Two-dimensional plane stress model and total Lagrangian formulation was carried out to present the shear wall response and the Newton-Raphson method is applied for the solution of nonlinear transient equations. The presented model in this paper can be developed for analysis of civil engineering structures with different material behavior and complicated geometry.
Abstract: Shear walls are used in most of the tall buildings for
carrying the lateral load. When openings for doors or windows are
necessary to be existed in the shear walls, a special type of the shear
walls is used called "coupled shear walls" which in some cases is
stiffened by specific beams and so, called "stiffened coupled shear
walls".
In this paper, a mathematical method for geometrically nonlinear
analysis of the stiffened coupled shear walls has been presented.
Then, a suitable formulation for determining the critical load of the
stiffened coupled shear walls under gravity force has been proposed.
The governing differential equations for equilibrium and deformation
of the stiffened coupled shear walls have been obtained by setting up
the equilibrium equations and the moment-curvature relationships for
each wall. Because of the complexity of the differential equation, the
energy method has been adopted for approximate solution of the
equations.
Abstract: This paper is concerned with propagation of thermoelastic longitudinal vibrations of an infinite circular cylinder, in the context of the linear theory of generalized thermoelasticity with two relaxation time parameters (Green and Lindsay theory). Three displacement potential functions are introduced to uncouple the equations of motion. The frequency equation, by using the traction free boundary conditions, is given in the form of a determinant involving Bessel functions. The roots of the frequency equation give the value of the characteristic circular frequency as function of the wave number. These roots, which correspond to various modes, are numerically computed and presented graphically for different values of the thermal relaxation times. It is found that the influences of the thermal relaxation times on the amplitudes of the elastic and thermal waves are remarkable. Also, it is shown in this study that the propagation of thermoelastic longitudinal vibrations based on the generalized thermoelasticity can differ significantly compared with the results under the classical formulation. A comparison of the results for the case with no thermal effects shows well agreement with some of the corresponding earlier results.
Abstract: The paper presents new results of a recent industry
supported research and development study in which an efficient
framework for evaluating practical and meaningful power system
reliability and quality indices was applied. The system-wide
integrated performance indices are capable of addressing and
revealing areas of deficiencies and bottlenecks as well as
redundancies in the composite generation-transmission-demand
structure of large-scale power grids. The technique utilizes a linear
programming formulation, which simulates practical operating
actions and offers a general and comprehensive framework to assess
the harmony and compatibility of generation, transmission and
demand in a power system. Practical applications to a reduced
system model as well as a portion of the Saudi power grid are also
presented in the paper for demonstration purposes.
Abstract: The grey oyster mushroom, Pleurotus sajor-caju
(PSC), is a common edible mushroom and is now grown
commercially around the world for food. This fungus has been
broadly used as food or food ingredients in various food products for
a long time. To enhance the nutritional quality and sensory attributes
of bakery-based products, PSC powder is used in the present study to
partially replace wheat flour in baked product formulations. The
nutrient content and sensory properties of rice-porridge and
unleavened bread (paratha) incorporated with various levels of PSC
powder were studied. These food items were formulated with either
0%, 2%, 4% or 6% of PSC powder. Results show PSC powder
recorded β-glucan at 3.57g/100g. In sensory evaluation, consumers
gave higher score to both rice-porridge and paratha bread containing
2-4% PSC compared to those that are not added with PSC powder.
The paratha containing 4% PSC powder can be formulated with the
intention in improving overall acceptability of paratha bread.
Meanwhile, for rice-porridge, consumers prefer the formulated
product added with 4% PSC powder. In conclusion, the addition of
PSC powder to partially wheat flour can be recommended for the
purpose of enhancing nutritional composition and maintaining the
acceptability of carbohydrate-based products.
Abstract: The aim of the present study was to evaluate the
mucoadhesion and the release of nicotinamide gel formulations using
in vitro methods. An agar plate technique was used to investigate the
adhesiveness of the gels whereas a diffusion apparatus was employed
to determine the release of nicotinamide from the gels. In this
respect, 10% w/w nicotinamide gels containing bioadhesive
polymers: Carbopol 934P (0.5-2% w/w), hydroxypropylmethyl
cellulose (HPMC) (4-10% w/w), sodium carboxymethyl cellulose
(SCMC) (4-6% w/w) and methylcellulose 4000 (MC) (3-5% w/w)
were prepared. The gel formulations had pH values in the range of
7.14 - 8.17, which were considered appropriate to oral mucosa
application. In general, the rank order of pH values appeared to be
SCMC > MC4000 > HPMC > Carbopol 934P. Types and
concentrations of polymers used somewhat affected the
adhesiveness. It was found that anionic polymers (Carbopol 934 and
SCMC) adhered more firmly to the agar plate than the neutral
polymers (HPMC and MC 4000). The formulation containing 0.5%
Carbopol 934P (F1) showed the highest release rate. With the
exception of the formulation F1, the neutral polymers tended to give
higher relate rates than the anionic polymers. For oral tissue
treatment, the optimum has to be balanced between the residence
time (adhesiveness) of the formulations and the release rate of the
drug. The formulations containing the anionic polymers: Carbopol
934P or SCMC possessed suitable physical properties (appearance,
pH and viscosity). In addition, for anionic polymer formulations,
justifiable mucoadhesive properties and reasonable release rates of
nicotinamide were achieved. Accordingly, these gel formulations
may be applied for the treatment of oral mucosal lesions.
Abstract: The paper proposes and validates a new method of solving instances of the vehicle routing problem (VRP). The approach is based on a multiple agent system paradigm. The paper contains the VRP formulation, an overview of the multiple agent environment used and a description of the proposed implementation. The approach is validated experimentally. The experiment plan and the discussion of experiment results follow.
Abstract: This study describes the methodology for the development of a validated in-vitro in-vivo correlation (IVIVC) for metoprolol tartrate modified release dosage forms with distinctive release rate characteristics. Modified release dosage forms were formulated by microencapsulation of metoprolol tartrate into different amounts of ethylcellulose by non-solvent addition technique. Then in-vitro and in-vivo studies were conducted to develop and validate level A IVIVC for metoprolol tartrate. The values of regression co-efficient (R2-values) for IVIVC of T2 and T3 formulations were not significantly (p
Abstract: In this paper, linear multistep technique using power
series as the basis function is used to develop the block methods
which are suitable for generating direct solution of the special second
order ordinary differential equations with associated initial or
boundary conditions. The continuous hybrid formulations enable us
to differentiate and evaluate at some grids and off – grid points to
obtain two different four discrete schemes, each of order (5,5,5,5)T,
which were used in block form for parallel or sequential solutions of
the problems. The computational burden and computer time wastage
involved in the usual reduction of second order problem into system
of first order equations are avoided by this approach. Furthermore, a
stability analysis and efficiency of the block methods are tested on
linear and non-linear ordinary differential equations and the results
obtained compared favorably with the exact solution.
Abstract: According to celebrated Hurwitz theorem, there exists
four division algebras consisting of R (real numbers), C (complex
numbers), H (quaternions) and O (octonions). Keeping in view
the utility of octonion variable we have tried to extend the three
dimensional vector analysis to seven dimensional one. Starting with
the scalar and vector product in seven dimensions, we have redefined
the gradient, divergence and curl in seven dimension. It is shown
that the identity n(n - 1)(n - 3)(n - 7) = 0 is satisfied only
for 0, 1, 3 and 7 dimensional vectors. We have tried to write all
the vector inequalities and formulas in terms of seven dimensions
and it is shown that same formulas loose their meaning in seven
dimensions due to non-associativity of octonions. The vector formulas
are retained only if we put certain restrictions on octonions and split
octonions.
Abstract: In this work, a radial basis function (RBF) neural network is developed for the identification of hyperbolic distributed parameter systems (DPSs). This empirical model is based only on process input-output data and used for the estimation of the controlled variables at specific locations, without the need of online solution of partial differential equations (PDEs). The nonlinear model that is obtained is suitably transformed to a nonlinear state space formulation that also takes into account the model mismatch. A stable robust control law is implemented for the attenuation of external disturbances. The proposed identification and control methodology is applied on a long duct, a common component of thermal systems, for a flow based control of temperature distribution. The closed loop performance is significantly improved in comparison to existing control methodologies.
Abstract: Healthcare providers sometimes use the power of
humor as a treatment and therapy for buffering mental health or easing
mental disorders because humor can provide relief from distress and
conflict. Humor is also very suitable for advertising because of similar
benefits. This study carefully examines humor's widespread use in
advertising and identifies relationships among humor mechanisms,
female depictions, and product types. The purpose is to conceptualize
how humor theories can be used not only to successfully define a
product as fitting within one of four color categories of the product
color matrix, but also to identify compelling contemporary female
depictions through humor in ads. The results can offer an idealization
for marketing managers and consumers to help them understand how
female role depictions can be effectively used with humor in ads. The
four propositions developed herein are derived from related literature,
through the identification of marketing strategy formulations that
achieve product memory enhancement by adopting humor
mechanisms properly matched with female role depictions.
Abstract: Power system state estimation is the process of
calculating a reliable estimate of the power system state vector
composed of bus voltages' angles and magnitudes from telemetered
measurements on the system. This estimate of the state vector
provides the description of the system necessary for the operation
and security monitoring. Many methods are described in the
literature for solving the state estimation problem, the most important
of which are the classical weighted least squares method and the nondeterministic
genetic based method; however both showed
drawbacks. In this paper a modified version of the genetic
algorithm power system state estimation is introduced, Sensitivity of
the proposed algorithm to genetic operators is discussed, the
algorithm is applied to case studies and finally it is compared with
the classical weighted least squares method formulation.
Abstract: A dual-reciprocity boundary element method is presented
for the numerical solution of a class of axisymmetric elastodynamic
problems. The domain integrals that arise in the integrodifferential
formulation are converted to line integrals by using the
dual-reciprocity method together suitably constructed interpolating
functions. The second order time derivatives of the displacement
in the governing partial differential equations are suppressed by
using Laplace transformation. In the Laplace transform domain, the
problem under consideration is eventually reduced to solving a system
of linear algebraic equations. Once the linear algebraic equations are
solved, the displacement and stress fields in the physical domain can
be recovered by using a numerical technique for inverting Laplace
transforms.