Abstract: The study reports about the influence of binding of orthosteric ligands as well as point mutations on the conformational dynamics of β-2-adrenoreceptor. Using molecular dynamics simulation we found that there was a little fraction of active states of the receptor in its apo (ligand free) ensemble corresponded to its constitutive activity. Analysis of MD trajectories indicated that such spontaneous activation of the receptor is accompanied by the motion in intracellular part of its alpha-helices. Thus receptor’s constitutive activity directly results from its conformational dynamics. On the other hand the binding of a full agonist resulted in a significant shift of the initial equilibrium towards its active state. Finally, the binding of the inverse agonist stabilized the receptor in its inactive state. It is likely that the binding of inverse agonists might be a universal way of constitutive activity inhibition in vivo. Our results indicate that ligand binding redistribute pre-existing conformational degrees of freedom (in accordance to the Monod-Wyman-Changeux-Model) of the receptor rather than cause induced fit in it. Therefore, the ensemble of biologically relevant receptor conformations is encoded in its spatial structure, and individual conformations from that ensemble might be used by the cell in conformity with the physiological behavior.
Abstract: Excavators are high power machines used in the mining, agricultural and construction industry whose principal functions are digging (material removing), ground leveling and material transport operations. During the digging task there are certain unknown forces exerted by the bucket on the soil and the digging operation is repetitive in nature. Automation of the digging task can be performed by an automatically controlled excavator system, which is not only control the forces but also follow the planned digging trajectories. To develop such a controller for automated excavation, it is required to develop a dynamic model to describe the behavior of the control system during digging operation and motion of excavator with time. The presented work described a dynamic model needed for controller design and which is derived by applying Lagrange-Euler approach. The developed dynamic model is intended for further development of an automated excavation control system for light duty construction work and can be applied for heavy duty or all types of backhoe excavators.
Abstract: Although the importance of small and medium-size enterprises (SMEs) to local development is globally recognized, less attention is given to their design, development and promotion particularly in developing countries. The main focus of this paper is to examine the process of designing, developing and promoting SMEs in developing countries. Results of a study conducted in a SMEs’ enclave in Kumasi (Ghana) are presented and discussed. Results show that although SMEs in developing countries remain a major source of livelihood for many individuals, their potential contribution to local development can be enhanced and sustained through the creation of common geographical enclaves for related SMEs. Findings indicated that the concentration of SMEs involved in wood processing in one location in Kumasi has reduced the cost of production (e.g., transportation), and resulted in marginal increase in sales for many SMEs, despite the widespread challenges of lack of access to credit and low promotion of products.
Abstract: In recent years, several smart card solutions for transportation services of cities with different technical infrastructures and business models has emerged considerably, which triggers new business and technical opportunities. In order to create a unique system, we present a novel, promising system called Multifunctional City Smart Card System to be used in all cities that provides transportation and loyalty services based on the MasterCard M/Chip Advance standards. The proposed system provides a unique solution for transportation services of large cities over the world, aiming to answer all transportation needs of citizens. In this paper, development of the Multifunctional City Smart Card system and system requirements are briefly described. Moreover, performance analysis results of M/Chip Advance Compatible Validators which is the system's most important component are presented.
Abstract: The basic ability of a vehicle is to “run”, “turn” and “stop”. The safeness and comfort during a drive on various road surfaces and speed depends on the performance of these basic abilities of the vehicle. Stability and maneuverability of a vehicle are vital in automotive engineering. The stability of a vehicle is the ability of the vehicle to revert back to a stable state during a drive when faced with crosswinds and irregular road conditions. Maneuverability of a vehicle is the ability of the vehicle to change direction during a drive swiftly based on the steering of the driver. The stability and maneuverability of a vehicle can also be defined as the driving stability of the vehicle. Since the fossil fueled vehicle is the main type of transportation today, the environmental factor in automotive engineering is also vital. By improving the fuel efficiency of the vehicle, the overall carbon emission will be reduced, thus reducing the effect of global warming and greenhouse gas on the Earth. Another main focus of the automotive engineering is the safety performance of the vehicle, especially with the worrying increase of vehicle collision every day. With better safety performance of a vehicle, every driver will be more confident driving every day. Next, let us focus on the “turn” ability of a vehicle. By improving this particular ability of the vehicle, the cornering limit of the vehicle can be improved, thus increasing the stability and maneuverability factor. In order to improve the cornering limit of the vehicle, a study to find the balance between the steering systems, the stability of the vehicle, higher lateral acceleration and the cornering limit detection must be conducted. The aim of this research is to study and develop a new suspension system that will boost the lateral acceleration of the vehicle and ultimately improving the cornering limit of the vehicle. This research will also study environmental factor and the stability factor of the new suspension system. The double wishbone suspension system is widely used in a four-wheel vehicle, especially for high cornering performance sports car and racing car. The double wishbone designs allow the engineer to carefully control the motion of the wheel by controlling such parameters as camber angle, caster angle, toe pattern, roll center height, scrub radius, scuff, and more. The development of the new suspension system will focus on the ability of the new suspension system to optimize the camber control and to improve the camber limit during a cornering motion. The research will be carried out using the CAE analysis tool. Using this analysis tool we will develop a JSAE Formula Machine equipped with the double wishbone system and also the new suspension system and conduct simulation and conduct studies on the performance of both suspension systems.
Abstract: The Deposit Guarantee Fund (DGF) and its communication with the Society, in general, and with the deposit client of Financial Institutions, in particular, is discussed through the challenges of the accounting and financial report. The Bank of Portugal promotes the Portuguese Deposit Guarantee Fund (PDGF) as a financial institution that enhanced the market confidence and stability on the deposit-insurance system. Due to the nature of their functions, it must be subject to regulation and supervision that provides a first line of defense against adversely affect confidence on the Portuguese financial market. First, this research provides evidence of the effectiveness of the protection mechanisms on the deposit insurance system, which provides high and equal protection to all stakeholders. Second, it emphasizes the need of requirements of rigorous accounting process and effective financial report to reduce the moral hazard implications. Third, this research focuses on the need of total disclosure of the financial information which gives higher transparency and protection to deposit client of financial institutions.
Abstract: In a deregulated power system structure, power producers and customers share a common transmission network for wheeling power from the point of generation to the point of consumption. All parties in this open access environment may try to purchase the energy from the cheaper source for greater profit margins, which may lead to overloading and congestion of certain corridors of the transmission network. This may result in violation of line flow, voltage and stability limits and thereby undermine the system security. Utilities therefore need to determine adequately their available transfer capability (ATC) to ensure that system reliability is maintained while serving a wide range of bilateral and multilateral transactions. This paper presents power transfer distribution factor based on AC load flow for the determination and enhancement of ATC. The study has been carried out for IEEE 24 bus Reliability Test System.
Abstract: The calcarenites carbonate rocks of the Quaternary ridges, which extend along the northwestern Mediterranean coastal plain of Egypt, represent an excellent model for the transformation of loose sediments to real sedimentary rocks by the different stages of meteoric diagenesis. The depositional and diagenetic fabrics of the rocks, in addition to the strata orientation, highly affect their ultimate compressive strength and other geotechnical properties.
There is a marked increase in the compressive strength (UCS) from the first to the fourth ridge rock samples. The lowest values are related to the loose packing, weakly cemented aragonitic ooid sediments with high porosity, besides the irregularly distributed of cement, which result in decreasing the ability of these rocks to withstand crushing under direct pressure. The high (UCS) values are attributed to the low porosity, the presence of micritic cement, the reduction in grain size and the occurrence of micritization and calcretization processes.
The strata orientation has a notable effect on the measured (UCS). The lowest values have been recorded for the samples cored in the inclined direction; whereas the highest values have been noticed in most samples cored in the vertical and parallel directions to bedding plane. In case of the inclined direction, the bedding planes were oriented close to the plane of maximum shear stress. The lowest and highest anisotropy values have been recorded for the first and the third ridges rock samples, respectively, which may attributed to the relatively homogeneity and well sorted grainstone of the first ridge rock samples, and relatively heterogeneity in grain and pore size distribution and degree of cementation of the third ridge rock samples, besides, the abundance of shell fragments with intraparticle pore spaces, which may produce lines of weakness within the rock.
Abstract: An effort for the detection of damages in the
reinforcement bars of reinforced concrete members using PZTs is
presented. The damage can be the result of excessive elongation of
the steel bar due to steel yielding or due to local steel corrosion. In
both cases the damage is simulated by considering reduced diameter
of the rebar along the damaged part of its length. An integration
approach based on both electromechanical admittance methodology
and guided wave propagation technique is used to evaluate the
artificial damage on the examined longitudinal steel bar. Two
actuator PZTs and a sensor PZT are considered to be bonded on the
examined steel bar. The admittance of the Sensor PZT is calculated
using COMSOL 3.4a. Fast Furrier Transformation for a better
evaluation of the results is employed. An effort for the quantification
of the damage detection using the root mean square deviation
(RMSD) between the healthy condition and damage state of the
sensor PZT is attempted. The numerical value of the RSMD yields a
level for the difference between the healthy and the damaged
admittance computation indicating this way the presence of damage
in the structure. Experimental measurements are also presented.
Abstract: This article is concerned with the determination of the static interaction of a vertically loaded rigid circular disc embedded at the interface of a horizontal layer sandwiched in between two different transversely isotropic half-spaces called as tri-material full-space. The axes of symmetry of different regions are assumed to be normal to the horizontal interfaces and parallel to the movement direction. With the use of a potential function method, and by implementing Hankel integral transforms in the radial direction, the government partial differential equation for the solely scalar potential function is transformed to an ordinary 4th order differential equation, and the mixed boundary conditions are transformed into a pair of integral equations called dual integral equations, which can be reduced to a Fredholm integral equation of the second kind, which is solved analytically. Then, the displacements and stresses are given in the form of improper line integrals, which is due to inverse Hankel integral transforms. It is shown that the present solutions are in exact agreement with the existing solutions for a homogeneous full-space with transversely isotropic material. To confirm the accuracy of the numerical evaluation of the integrals involved, the numerical results are compared with the solutions exists for the homogeneous full-space. Then, some different cases with different degrees of material anisotropy are compared to portray the effect of degree of anisotropy.
Abstract: Rogowski coils are increasingly used for measurement
of AC and transient electric currents. Mostly used Rogowski coils
now are with circular or rectangular cores. In order to increase the
sensitivity of the measurement of Rogowski coil and perform smooth
wire winding, this paper studies the effect of increasing the mutual
inductance in order to increase the coil sensitivity by presenting the
calculation and simulation of a Rogowski coil with equilateral
hexagonal shaped core and comparing the resulted mutual inductance
with commonly used core shapes.
Abstract: Numerical study of heat transfer and fluid flow over vertical double forward facing step were presented. The k-w model with finite volume method was employed to solve continuity, momentum, and energy equations. Different step heights were adopted for range of Reynolds number varied from 10000 to 40000, and range of temperature varied from 310K to 340 K. The straight side of duct is insulated while the side of double forward facing step is heated. The result shows augmentation of heat transfer due to the recirculation region created after and before steps. Effect of step length and Reynolds number observed on increase of local Nusselt number particularly at recirculation regions. Contour of streamline velocity is plotted to show recirculation regions after and before steps. Numerical simulation in this paper done by used ANSYS FLUENT 14.
Abstract: Heat transfer and laminar fluid flow over backward facing step with and without obstacle numerically studied in this paper. The finite volume method adopted to solve continuity, momentum and energy equations in two dimensions. Backward facing step without obstacle and with different dimension of obstacle were presented. The step height and expansion ratio of channel were 4.8mm and 2 respectively, the range of Reynolds number varied from 75 to 225, constant heat flux subjected on downstream of wall was 2000W/m2, and length of obstacle was 1.5, 3, and 4.5mm with width 1.5mm. The separation length noticed increase with increase Reynolds number and height of obstacle. The result shows increase of heat transfer coefficient for backward facing step with obstacle in compared to those without obstacle. The maximum enhancement of heat transfer observed at 4.5mm of height obstacle due to increase recirculation flow after the obstacle in addition that at backward. Streamline of velocity showing the increase of recirculation region with used obstacle in compared without obstacle and highest recirculation region observed at obstacle height 4.5mm. The amount of enhancement heat transfer was varied between 3-5% compared to backward without obstacle.
Abstract: Recently, ‘play of learning’ becomes important and is
emphasized as a useful learning tool. Therefore, interest in
edutainment contents is growing. Storytelling is considered first as a
method that improves the transmission of information and learner's
interest when planning edutainment contents. In this study, we
designed edutainment contents in the form of an adventure game that
applies the storytelling method. This content provides questions and
items constituted dynamically and reorganized learning contents
through analysis of test results. It allows learners to solve various
questions through effective iterative learning. As a result, the learners
can reach mastery learning.
Abstract: Patients under health treatments that involve long
stays at a hospital or health center (e.g. cancer, organ transplants and
severe burns), tend to get bored or depressed because of the lack of
social interaction with family and friends. Such a situation also
affects the evolution and effectiveness of their treatments. In many
cases, the solution to this problem involves extra challenges, since
many patients need to rest quietly (or remain in bed) to their being
contagious. Considering the weak health condition in which usually
are these kinds, keeping them motivated and quiet represents an
important challenge for nurses and caregivers. This article presents a
mobile ubiquitous game called MagicRace, which allows hospitalized
kinds to interact socially with one another without putting to risk
their sensitive health conditions. The game does not require a
communication infrastructure at the hospital, but instead, it uses a
mobile ad hoc network composed of the handheld devices used by
the kids to play. The usability and performance of this application
was tested in two different sessions. The preliminary results show
that users experienced positive feelings from this experience.
Abstract: This paper gave an attempt in prioritizing information
technologies that organizations should give concentration. The case
study was organizations in the automotive assembly industry in
Thailand. Data were first collected to gather all information
technologies known and used in the automotive assembly industry in
Thailand. Five experts from the industries were surveyed based on
the concept of fuzzy DEMATEL. The information technologies were
categorized into six groups, which were communication, transaction,
planning, organization management, warehouse management, and
transportation. The cause groups of information technologies for each
group were analyzed and presented. Moreover, the relationship
between the used and the significant information technologies was
given. Discussions based on the used information technologies and
the research results are given.
Abstract: The main aim of the current work is to examine if 14N
is candidate to be clusterized nuclei or not. In order to check this
attendance, we have measured the angular distributions for 14N ion
beam elastically scattered on 12C target nuclei at different low
energies; 17.5, 21, and 24.5MeV which are close to the Coulomb
barrier energy for 14N+12C nuclear system. Study of various transfer
reactions could provide us with useful information about the
attendance of nuclei to be in a composite form (core + valence). The
experimental data were analyzed using two approaches;
Phenomenological (Optical Potential) and semi-microscopic (Double
Folding Potential). The agreement between the experimental data and
the theoretical predictions is fairly good in the whole angular range.
Abstract: Industries using conventional fossil fuels have an
interest in better understanding the mechanism of particulate
formation during combustion since such is responsible for emission
of undesired inorganic elements that directly impact the atmospheric
pollution level. Fine and ultrafine particulates have tendency to
escape the flue gas cleaning devices to the atmosphere. They also
preferentially collect on surfaces in power systems resulting in
ascending in corrosion inclination, descending in the heat transfer
thermal unit, and severe impact on human health. This adverseness
manifests particularly in the regions of world where coal is the
dominated source of energy for consumption.
This study highlights the behavior of calcium transformation as
mineral grains verses organically associated inorganic components
during pulverized coal combustion. The influence of existing type of
calcium on the coarse, fine and ultrafine mode formation mechanisms
is also presented. The impact of two sub-bituminous coals on particle
size and calcium composition evolution during combustion is to be
assessed. Three mixed blends named Blends 1, 2, and 3 are selected
according to the ration of coal A to coal B by weight. Calcium
percentage in original coal increases as going from Blend 1 to 3.
A mathematical model and a new approach of describing
constituent distribution are proposed. Analysis of experiments of
calcium distribution in ash is also modeled using Poisson distribution.
A novel parameter, called elemental index λ, is introduced as a
measuring factor of element distribution.
Results show that calcium in ash that originally in coal as mineral
grains has index of 17, whereas organically associated calcium
transformed to fly ash shown to be best described when elemental
index λ is 7.
As an alkaline-earth element, calcium is considered the
fundamental element responsible for boiler deficiency since it is the
major player in the mechanism of ash slagging process. The
mechanism of particle size distribution and mineral species of ash
particles are presented using CCSEM and size-segregated ash
characteristics. Conclusions are drawn from the analysis of
pulverized coal ash generated from a utility-scale boiler.
Abstract: In this paper, a numerical algorithm using a coupled Galerkin-Differential Quadrature (DQ) method is proposed for the solution of dam-reservoir interaction problem. The governing differential equation of motion of the dam structure is discretized by the Galerkin method and the DQM is used to discretize the fluid domain. The resulting systems of ordinary differential equations are then solved by the Newmark time integration scheme. The mixed scheme combines the simplicity of the Galerkin method and high accuracy and efficiency of the DQ method. Its accuracy and efficiency are demonstrated by comparing the calculated results with those of the existing literature. It is shown that highly accurate results can be obtained using a small number of Galerkin terms and DQM sampling points. The technique presented in this investigation is general and can be used to solve various fluid-structure interaction problems.
Abstract: Pioneer networked systems assume that connections are reliable, and a faulty operation will be considered in case of losing a connection. Transient connections are typical of mobile devices. Areas of application of data sharing system such as these, lead to the conclusion that network connections may not always be reliable, and that the conventional approaches can be improved. Nigerian commercial banking industry is a critical system whose operation is increasingly becoming dependent on information technology (IT) driven information system. The proposed solution to this problem makes use of a hierarchically clustered network structure which we selected to reflect (as much as possible) the typical organizational structure of the Nigerian commercial banks. Representative transactions such as data updates and replication of the results of such updates were used to simulate the proposed model to show its applicability.