Abstract: Pomegranate (Punica granatum L.) is an ancient fruit of great medical interest and rich source of antioxidants. Pesticides as dimethoate play a crucial role in the occurrence many diseases in plants, animal and human. Therefore the ability of Pomegranate (Punica granatum L.) to alleviate hepatotoxicity induced by organophosphate pesticide dimethoate was investigated. Albino male rats were divided randomly into 4 groups and kept at 7 animals per group in an environmentally controlled condition for 6 weeks. The first group was served as a control group (basal diet), the second group fed on basal diet supplemented with 5% freeze dried pomegranate seeds, the third group fed on 20 ppm dimethoate contaminated diet and the last group fed on dimethoate contaminated diet supplemented with 5% freeze dried pomegranate seeds. The results revealed that administration of dimethoate caused high significant increased in liver functions: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) activities as well as lipid peroxide (malonaldhyde, MDA); on the other hand high significant decreased on glutathione (GSH), glutathione peroxidase (GPx), albumin and total protein were observed. However addition of 5% freeze dried pomegranate seeds significantly improved all previously mentioned parameters. These results indicate the dimethoate induced hepatotoxicity and highlight the protective effect of pomegranate seeds as a potential protective agent against dimethoate induced hepatotoxicity. This may be attributed to the powerful antioxidants (polyphenols, total phenols, and total flavonoids) which present in high levels in pomegranate as well as improving the immunity by activation of antioxidant enzymes GSH and GPx.
Abstract: This paper aims at finding a suitable neural network
for monitoring congestion level in electrical power systems. In this
paper, the input data has been framed properly to meet the target
objective through supervised learning mechanism by defining normal
and abnormal operating conditions for the system under study. The
congestion level, expressed as line congestion index (LCI), is
evaluated for each operating condition and is presented to the NN
along with the bus voltages to represent the input and target data.
Once, the training goes successful, the NN learns how to deal with a
set of newly presented data through validation and testing
mechanism. The crux of the results presented in this paper rests on
performance comparison of a multi-layered feed forward neural
network with eleven types of back propagation techniques so as to
evolve the best training criteria. The proposed methodology has been
tested on the standard IEEE-14 bus test system with the support of
MATLAB based NN toolbox. The results presented in this paper
signify that the Levenberg-Marquardt backpropagation algorithm
gives best training performance of all the eleven cases considered in
this paper, thus validating the proposed methodology.
Abstract: This research paper aims to identify, analyze and rank
factors affecting labor productivity in Spain with respect to their
relative importance. Using a selected set of 35 factors, a structured
questionnaire survey was utilized as the method to collect data from
companies. Target population is comprised by a random
representative sample of practitioners related with the Spanish
construction industry. Findings reveal the top five ranked factors are
as follows: (1) shortage or late supply of materials; (2) clarity of the
drawings and project documents; (3) clear and daily task assignment;
(4) tools or equipment shortages; (5) level of skill and experience of
laborers. Additionally, this research also pretends to provide simple
and comprehensive recommendations so that they could be
implemented by construction managers for an effective management
of construction labor forces.
Abstract: The article presents the trends in Georgian wine
market development and evaluates the competitive advantages of
Georgia to enter the wine market based on its customs, traditions and
historical practices combined with modern technologies.
In order to analyze the supply of wine, dynamics of vineyard land
area and grape varieties are discussed, trends in wine production are
presented, trends in export and import are evaluated, local wine
market, its micro and macro environments are studied and analyzed
based on the interviews with experts and analysis of initial recording
materials.
For strengthening its position on the international market, the level
of competitiveness of Georgian wine is defined, which is evaluated
by “ex-ante” and “ex-post” methods, as well as by four basic and two
additional factors of the Porter’s diamond method; potential
advantages and disadvantages of Georgian wine are revealed.
Conclusions are made by identifying the factors that hinder the
development of Georgian wine market. Based on the conclusions,
relevant recommendations are developed.
Abstract: The paper discusses economic policy of Georgia
aiming to increase national competitiveness as well as the tools and
means which will help to improve the competitiveness of the country.
The sectors of the economy, in which the country can achieve the
competitive advantage, are studied. It is noted that the country’s
economic policy plays an important role in obtaining and maintaining
the competitive advantage - authority should take measures to ensure
high level of education; scientific and research activities should be
funded by the state; foreign direct investments should be attracted
mainly in science-intensive industries; adaptation with the latest
scientific achievements of the modern world and deepening of
scientific and technical cooperation. Stable business environment and
export oriented strategy is the basis for the country’s economic
growth.
As the outcome of the research, the paper suggests the strategy for
improving competitiveness in Georgia; recommendations are
provided based on relevant conclusions.
Abstract: Researches and concerns in power quality gained
significant momentum in the field of power electronics systems over
the last two decades globally. This sudden increase in the number of
concerns over power quality problems is a result of the huge increase
in the use of non-linear loads. In this paper, power quality evaluation
of some distribution networks at Misurata - Libya has been done
using a power quality and energy analyzer (Fluke 437 Series II). The
results of this evaluation are used to minimize the problems of power
quality. The analysis shows the main power quality problems that
exist and the level of awareness of power quality issues with the aim
of generating a start point which can be used as guidelines for
researchers and end users in the field of power systems.
Abstract: Sudoku is a logic-based combinatorial puzzle game
which people in different ages enjoy playing it. The challenging and
addictive nature of this game has made it a ubiquitous game. Most
magazines, newspapers, puzzle books, etc. publish lots of Sudoku
puzzles every day. These puzzles often come in different levels of
difficulty so that all people, from beginner to expert, can play the
game and enjoy it. Generating puzzles with different levels of
difficulty is a major concern of Sudoku designers. There are several
works in the literature which propose ways of generating puzzles
having a desirable level of difficulty. In this paper, we propose a
method based on constraint satisfaction problems to evaluate the
difficulty of the Sudoku puzzles. Then we propose a hill climbing
method to generate puzzles with different levels of difficulty.
Whereas other methods are usually capable of generating puzzles
with only few number of difficulty levels, our method can be used to
generate puzzles with arbitrary number of different difficulty levels.
We test our method by generating puzzles with different levels of
difficulty and having a group of 15 people solve all the puzzles and
recording the time they spend for each puzzle.
Abstract: The generalized wave equation models various
problems in sciences and engineering. In this paper, a new three-time
level implicit approach based on cubic trigonometric B-spline for the
approximate solution of wave equation is developed. The usual finite
difference approach is used to discretize the time derivative while
cubic trigonometric B-spline is applied as an interpolating function in
the space dimension. Von Neumann stability analysis is used to
analyze the proposed method. Two problems are discussed to exhibit
the feasibility and capability of the method. The absolute errors and
maximum error are computed to assess the performance of the
proposed method. The results were found to be in good agreement
with known solutions and with existing schemes in literature.
Abstract: Web search engines are designed to retrieve and
extract the information in the web databases and to return dynamic
web pages. The Semantic Web is an extension of the current web in
which it includes semantic content in web pages. The main goal of
semantic web is to promote the quality of the current web by
changing its contents into machine understandable form. Therefore,
the milestone of semantic web is to have semantic level information
in the web. Nowadays, people use different keyword- based search
engines to find the relevant information they need from the web.
But many of the words are polysemous. When these words are
used to query a search engine, it displays the Search Result Records
(SRRs) with different meanings. The SRRs with similar meanings are
grouped together based on Word Sense Disambiguation (WSD). In
addition to that semantic annotation is also performed to improve the
efficiency of search result records. Semantic Annotation is the
process of adding the semantic metadata to web resources. Thus the
grouped SRRs are annotated and generate a summary which
describes the information in SRRs. But the automatic semantic
annotation is a significant challenge in the semantic web. Here
ontology and knowledge based representation are used to annotate
the web pages.
Abstract: Male factor infertility due to endocrine disturbances
such as abnormalities in prolactin levels are encountered in a
significant proportion. This case control study was carried out to
determine the effects of prolactin on the male reproductive tract,
using 200 male white rats. The rats were maintained as the control
group (G1), hypoprolactinaemic group (G2), 3 hyperprolactinaemic
groups induced using oral largactil (G3), low dose fluphenazine (G4)
and high dose fluphenazine (G5). After 100 days, rats were subjected
to serum prolactin (PRL) level measurements and for basic seminal
fluid analysis (BSA). The difference between serum PRL
concentrations of rats in G2, G3, G4 and G5 as compared to the
control group were highly significant by Student’s t-test (p
Abstract: Lightning protection systems (LPS) for wind power
generation is becoming an important public issue. A serious damage
of blades, accidents where low-voltage and control circuit
breakdowns are frequently occur in many wind farms. A grounding
system is one of the most important components required for
appropriate LPSs in wind turbines WTs. Proper design of a wind
turbine grounding system is demanding and several factors for the
proper and effective implementation must taken into account. In this
paper proposed procedure of proper design of grounding systems for
a wind turbine was introduced. This procedure depends on measuring
of ground current of simulated wind farm under lightning taking into
consideration the soil ionization. The procedure also includes the
Ground Potential Rise (GPR) and the voltage distributions at ground
surface level and Touch potential. In particular, the contribution of
mitigating techniques, such as rings, rods and the proposed design
were investigated.
Abstract: The construction of a new airport or the extension of
an existing one requires massive investments and many times public
private partnerships were considered in order to make feasible such
projects. One characteristic of these projects is uncertainty with
respect to financial and environmental impacts on the medium to long
term. Another one is the multistage nature of these types of projects.
While many airport development projects have been a success, some
others have turned into a nightmare for their promoters.
This communication puts forward a new approach for airport
investment risk assessment. The approach takes explicitly into
account the degree of uncertainty in activity levels prediction and
proposes milestones for the different stages of the project for
minimizing risk. Uncertainty is represented through fuzzy dual theory
and risk management is performed using dynamic programming. An
illustration of the proposed approach is provided.
Abstract: Azadirachta excelsa or locally known as sentang are
frequently used as a traditional medicine by diabetes patients in
Malaysia. However, less attention has been given to their toxicity
effect. Thus, the study is an attempt to examine the protective effect
of A. excelsa on the pancreas and to determine possible toxicity
mediated by the extract. Diabetes was induced experimentally in rats
by high-fat-diet for 16 weeks followed by intraperitoneal injection of
streptozotocin at dosage of 35 mg/kg of body weight. Declination of
the fasting blood glucose level was observed after continuous
administration of A. excelsa for 14 days twice daily. This is due to the
refining structure of the pancreas. However, surprisingly, the plant
extract reduced the leukocytes, erythrocytes, hemoglobin, MCHC and
lymphocytes. In addition, the rat treated with the plant extract
exhibited increment in AST and eosinocytes level. Overall, the
finding shows that A. excelsa possesses antidiabetic activity by
improving the structure of pancreatic islet of Langerhans but
involved in ameliorating of hematology and biochemical parameters.
Abstract: Multipotent mesenchymal stromal cells (MSCs)
possess immunomodulatory properties. The effect of MSCs on the
crucial cellular immunity compartment – T-cells is of a special
interest. It is known that MSC tissue niche and expected milieu of
their interaction with T- cells are characterized by low oxygen
concentration, whereas the in vitro experiments usually are carried
out at a much higher ambient oxygen (20%). We firstly evaluated
immunomodulatory effects of MSCs on T-cells at tissue-related
oxygen (5%) after interaction implied cell-to-cell contacts and
paracrine factors only. It turned out that MSCs under reduced oxygen
can effectively suppress the activation and proliferation of PHAstimulated
T-cells and can provoke decrease in the production of
proinflammatory and increase in anti-inflammatory cytokines. In
hypoxia some effects were amplified (inhibition of proliferation, antiinflammatory
cytokine profile shift). This impact was more evident
after direct cell-to-cell interaction; lack of intercellular contacts could
revoke the potentiating effect of hypoxia.
Abstract: In this paper, GSM signal strength was measured in
order to detect the type of the signal fading phenomenon using onedimensional
multilevel wavelet residual method and neural network
clustering to determine the average GSM signal strength received in
the study area. The wavelet residual method predicted that the GSM
signal experienced slow fading and attenuated with MSE of 3.875dB.
The neural network clustering revealed that mostly -75dB, -85dB and
-95dB were received. This means that the signal strength received in
the study is a weak signal.
Abstract: This work studied the ability of adipose tissue-derived
mesenchymal stromal cells (MSCs) to form stroma for expansion of
cord blood hematopoietic cells. We showed that 72-hour interaction
of MSCs with cord blood mononuclear cells (MNCs) in vitro at
atmospheric (20%) and low (5%) O2 conditions increased the
expression of ICAM-1, HCAM (at the beginning of interaction) on
MSCs. Viability of MSCs and MNCs were maintained at high level.
Adhesion of MNCs to MSCs was faster at 20% O2. MSCs promoted
the proliferation of adhered MNCs to form the suspension containing
great number of hematopoietic colony-forming units, and this effect
was more pronounced at 5% O2. Thus, adipose-derived MSCs
supplied sufficient stromal support to cord blood MNCs both at 20%
and 5% О2, providing their adhesion with further expansion of new
generation of different hematopoietic lineages.
Abstract: The Analytic Hierarchy Process is frequently used
approach for solving decision making problems. There exists wide
range of software programs utilizing that approach. Their main
disadvantage is that they are relatively expensive and missing
intermediate calculations. This work introduces a Microsoft Excel
add-in called DAME – Decision Analysis Module for Excel.
Comparing to other computer programs DAME is free, can work
with scenarios or multiple decision makers and displays intermediate
calculations. Users can structure their decision models into three
levels – scenarios/users, criteria and variants. Items on all levels can
be evaluated either by weights or pair-wise comparisons. There are
provided three different methods for the evaluation of the weights of
criteria, the variants as well as the scenarios – Saaty’s Method,
Geometric Mean Method and Fuller’s Triangle Method.
Multiplicative and additive syntheses are supported. The proposed
software package is demonstrated on couple of illustrating examples
of real life decision problems.
Abstract: The paper deals with the importance of information flow for providing of defined level of customer service in the firms. Setting of the criteria for the selection and implementation of logistics information system is a prerequisite for ensuring of the flow of information in firms. The decision on the selection and implementation of logistics information system is linked to the investment costs and operating costs, which are included in the total logistics costs. The article also deals with the conclusions of the research focused on the logistics information system selection in companies in the Czech Republic.
Abstract: The present environmental issues have made aircraft jet noise reduction a crucial problem in aero-acoustics research. Acoustic studies reveal that addition of chevrons to the nozzle reduces the sound pressure level reasonably with acceptable reduction in performance. In this paper comprehensive numerical studies on acoustic characteristics of different types of chevron nozzles have been carried out with non-reacting flows for the shape optimization of chevrons in supersonic nozzles for aerospace applications. The numerical studies have been carried out using a validated steady 3D density based, k-ε turbulence model. In this paper chevron with sharp edge, flat edge, round edge and U-type edge are selected for the jet acoustic characterization of supersonic nozzles. We observed that compared to the base model a case with round-shaped chevron nozzle could reduce 4.13% acoustic level with 0.6% thrust loss. We concluded that the prudent selection of the chevron shape will enable an appreciable reduction of the aircraft jet noise without compromising its overall performance. It is evident from the present numerical simulations that k-ε model can predict reasonably well the acoustic level of chevron supersonic nozzles for its shape optimization.
Abstract: This paper presents the findings of an experimental investigation of important machining parameters for the horizontal boring tool modified to mouth with a horizontal lathe machine to bore an overlength workpiece. In order to verify a usability of a modified tool, design of experiment based on Taguchi method is performed. The parameters investigated are spindle speed, feed rate, depth of cut and length of workpiece. Taguchi L9 orthogonal array is selected for four factors three level parameters in order to minimize surface roughness (Ra and Rz) of S45C steel tubes. Signal to noise ratio analysis and analysis of variance (ANOVA) is performed to study an effect of said parameters and to optimize the machine setting for best surface finish. The controlled factors with most effect are depth of cut, spindle speed, length of workpiece, and feed rate in order. The confirmation test is performed to test the optimal setting obtained from Taguchi method and the result is satisfactory.