Abstract: Inferring the network structure from time series data
is a hard problem, especially if the time series is short and noisy.
DNA microarray is a technology allowing to monitor the mRNA
concentration of thousands of genes simultaneously that produces
data of these characteristics. In this study we try to investigate the
influence of the experimental design on the quality of the result.
More precisely, we investigate the influence of two different types of
random single gene perturbations on the inference of genetic networks
from time series data. To obtain an objective quality measure for
this influence we simulate gene expression values with a biologically
plausible model of a known network structure. Within this framework
we study the influence of single gene knock-outs in opposite to
linearly controlled expression for single genes on the quality of the
infered network structure.
Abstract: In a transcutanious inductive coupling of a biomedical
implant, a new formula is given for the study of the Radio Frequency
power attenuation by the biological tissue. The loss of the signal
power is related to its interaction with the biological tissue and the
composition of this one. A confrontation with the practical
measurements done with a synthetic muscle into a Faraday cage,
allowed a checking of the obtained theoretical results. The
supply/data transfer systems used in the case of biomedical implants,
can be well dimensioned by taking in account this type of power
attenuation.
Abstract: Many digital signal processing, techniques have been used to automatically distinguish protein coding regions (exons) from non-coding regions (introns) in DNA sequences. In this work, we have characterized these sequences according to their nonlinear dynamical features such as moment invariants, correlation dimension, and largest Lyapunov exponent estimates. We have applied our model to a number of real sequences encoded into a time series using EIIP sequence indicators. In order to discriminate between coding and non coding DNA regions, the phase space trajectory was first reconstructed for coding and non-coding regions. Nonlinear dynamical features are extracted from those regions and used to investigate a difference between them. Our results indicate that the nonlinear dynamical characteristics have yielded significant differences between coding (CR) and non-coding regions (NCR) in DNA sequences. Finally, the classifier is tested on real genes where coding and non-coding regions are well known.
Abstract: Hearing impairment is the number one chronic
disability affecting many people in the world. Background noise is
particularly damaging to speech intelligibility for people with
hearing loss especially for sensorineural loss patients. Several
investigations on speech intelligibility have demonstrated
sensorineural loss patients need 5-15 dB higher SNR than the normal
hearing subjects. This paper describes Discrete Hartley Transform
Power Normalized Least Mean Square algorithm (DHT-LMS) to
improve the SNR and to reduce the convergence rate of the Least
Means Square (LMS) for sensorineural loss patients. The DHT
transforms n real numbers to n real numbers, and has the convenient
property of being its own inverse. It can be effectively used for noise
cancellation with less convergence time. The simulated result shows
the superior characteristics by improving the SNR at least 9 dB for
input SNR with zero dB and faster convergence rate (eigenvalue ratio
12) compare to time domain method and DFT-LMS.
Abstract: This paper presents the region based segmentation method for ultrasound images using local statistics. In this segmentation approach the homogeneous regions depends on the image granularity features, where the interested structures with dimensions comparable to the speckle size are to be extracted. This method uses a look up table comprising of the local statistics of every pixel, which are consisting of the homogeneity and similarity bounds according to the kernel size. The shape and size of the growing regions depend on this look up table entries. The algorithms are implemented by using connected seeded region growing procedure where each pixel is taken as seed point. The region merging after the region growing also suppresses the high frequency artifacts. The updated merged regions produce the output in formed of segmented image. This algorithm produces the results that are less sensitive to the pixel location and it also allows a segmentation of the accurate homogeneous regions.
Abstract: In this paper we investigate the influence of external
noise on the inference of network structures. The purpose of our
simulations is to gain insights in the experimental design of microarray
experiments to infer, e.g., transcription regulatory networks
from microarray experiments. Here external noise means, that the
dynamics of the system under investigation, e.g., temporal changes of
mRNA concentration, is affected by measurement errors. Additionally
to external noise another problem occurs in the context of microarray
experiments. Practically, it is not possible to monitor the mRNA
concentration over an arbitrary long time period as demanded by the
statistical methods used to learn the underlying network structure. For
this reason, we use only short time series to make our simulations
more biologically plausible.
Abstract: Diagnosis can be achieved by building a model of a
certain organ under surveillance and comparing it with the real time
physiological measurements taken from the patient. This paper deals
with the presentation of the benefits of using Data Mining techniques
in the computer-aided diagnosis (CAD), focusing on the cancer
detection, in order to help doctors to make optimal decisions quickly
and accurately. In the field of the noninvasive diagnosis techniques,
the endoscopic ultrasound elastography (EUSE) is a recent elasticity
imaging technique, allowing characterizing the difference between
malignant and benign tumors. Digitalizing and summarizing the main
EUSE sample movies features in a vector form concern with the use
of the exploratory data analysis (EDA). Neural networks are then
trained on the corresponding EUSE sample movies vector input in
such a way that these intelligent systems are able to offer a very
precise and objective diagnosis, discriminating between benign and
malignant tumors. A concrete application of these Data Mining
techniques illustrates the suitability and the reliability of this
methodology in CAD.
Abstract: Background noise is particularly damaging to speech
intelligibility for people with hearing loss especially for sensorineural
loss patients. Several investigations on speech intelligibility have
demonstrated sensorineural loss patients need 5-15 dB higher SNR
than the normal hearing subjects. This paper describes Discrete
Cosine Transform Power Normalized Least Mean Square algorithm
to improve the SNR and to reduce the convergence rate of the LMS
for Sensory neural loss patients. Since it requires only real arithmetic,
it establishes the faster convergence rate as compare to time domain
LMS and also this transformation improves the eigenvalue
distribution of the input autocorrelation matrix of the LMS filter.
The DCT has good ortho-normal, separable, and energy compaction
property. Although the DCT does not separate frequencies, it is a
powerful signal decorrelator. It is a real valued function and thus
can be effectively used in real-time operation. The advantages of
DCT-LMS as compared to standard LMS algorithm are shown via
SNR and eigenvalue ratio computations. . Exploiting the symmetry
of the basis functions, the DCT transform matrix [AN] can be
factored into a series of ±1 butterflies and rotation angles. This
factorization results in one of the fastest DCT implementation. There
are different ways to obtain factorizations. This work uses the fast
factored DCT algorithm developed by Chen and company. The
computer simulations results show superior convergence
characteristics of the proposed algorithm by improving the SNR at
least 10 dB for input SNR less than and equal to 0 dB, faster
convergence speed and better time and frequency characteristics.