Abstract: In-vitro mouse co-culture of E14 embryonic stem cells
(ESCs) and OP9 stromal cells can recapitulate the earliest stages of
haematopoietic development, not accessible in human embryos,
supporting both haemogenic precursors and their primitive
haematopoietic progeny. 1α, 25-Dihydroxy-vitamin D3 (VD3) has
been demonstrated to be a powerful differentiation inducer for a wide
variety of neoplastic cells, and could enhance early differentiation of
ESCs into blood cells in E14/OP9 co-culture. This study aims to
ascertain whether VD3 is key in promoting differentiation and
suppressing proliferation, by separately investigating the effects of
VD3 on the proliferation phase of the E14 cell line and on stromal
OP9 cells.The results showed that VD3 inhibited the proliferation of
the cells in a dose-dependent manner, quantitatively by decreased cell
number, and qualitatively by alkaline-phosphatase staining that
revealed significant differences between VD3-treated and untreated
cells, characterised by decreased enzyme expression (colourless
cells). Propidium-iodide cell-cycle analyses showed no significant
percentage change in VD3-treated E14 and OP9 cells within their G
and S-phases, compared to the untreated controls, despite the
increased percentage of G-phase compared to the S-phase in a dosedependent
manner. These results with E14 and OP9 cells indicate that
adequate VD3 concentration enhances cellular differentiation and
inhibits proliferation. The results also suggest that if E14 and OP9
cells were co-cultured andVD3-treated, there would be furtherenhanced
differentiation of ESCs into blood cells.
Abstract: In this paper, we propose a novel concept of relative
distance measurement using Stereo Vision Technology and discuss
its implementation on a FPGA based real-time image processor. We
capture two images using two CCD cameras and compare them.
Disparity is calculated for each pixel using a real time dense disparity
calculation algorithm. This algorithm is based on the concept of
indexed histogram for matching. Disparity being inversely
proportional to distance (Proved Later), we can thus get the relative
distances of objects in front of the camera. The output is displayed on
a TV screen in the form of a depth image (optionally using pseudo
colors). This system works in real time on a full PAL frame rate (720
x 576 active pixels @ 25 fps).
Abstract: Mobile Ad hoc Networks is an autonomous system of
mobile nodes connected by multi-hop wireless links without
centralized infrastructure support. As mobile communication gains
popularity, the need for suitable ad hoc routing protocols will
continue to grow. Efficient dynamic routing is an important research
challenge in such a network. Bandwidth constrained mobile devices
use on-demand approach in their routing protocols because of its
effectiveness and efficiency. Many researchers have conducted
numerous simulations for comparing the performance of these
protocols under varying conditions and constraints. Most of them are
not aware of MAC Protocols, which will impact the relative
performance of routing protocols considered in different network
scenarios. In this paper we investigate the choice of MAC protocols
affects the relative performance of ad hoc routing protocols under
different scenarios. We have evaluated the performance of these
protocols using NS2 simulations. Our results show that the
performance of routing protocols of ad hoc networks will suffer when
run over different MAC Layer protocols.
Abstract: This article presents the results using a parametric approach and a Wavelet Transform in analysing signals emitting from the sperm whale. The extraction of intrinsic characteristics of these unique signals emitted by marine mammals is still at present a difficult exercise for various reasons: firstly, it concerns non-stationary signals, and secondly, these signals are obstructed by interfering background noise. In this article, we compare the advantages and disadvantages of both methods: Auto Regressive models and Wavelet Transform. These approaches serve as an alternative to the commonly used estimators which are based on the Fourier Transform for which the hypotheses necessary for its application are in certain cases, not sufficiently proven. These modern approaches provide effective results particularly for the periodic tracking of the signal's characteristics and notably when the signal-to-noise ratio negatively effects signal tracking. Our objectives are twofold. Our first goal is to identify the animal through its acoustic signature. This includes recognition of the marine mammal species and ultimately of the individual animal (within the species). The second is much more ambitious and directly involves the intervention of cetologists to study the sounds emitted by marine mammals in an effort to characterize their behaviour. We are working on an approach based on the recordings of marine mammal signals and the findings from this data result from the Wavelet Transform. This article will explore the reasons for using this approach. In addition, thanks to the use of new processors, these algorithms once heavy in calculation time can be integrated in a real-time system.
Abstract: One of the most important causes of accidents is
driver fatigue. To reduce the accidental rate, the driver needs a
quick nap when feeling sleepy. Hence, searching for the minimum
time period of nap is a very challenging problem. The purpose of
this paper is twofold, i.e. to investigate the possible fastest time
period for nap and its relationship with stage 2 sleep, and to
develop an automatic stage 2 sleep detection and alarm device. The
experiment for this investigation is designed with 21 subjects. It
yields the result that waking up the subjects after getting into stage
2 sleep for 3-5 minutes can efficiently reduce the sleepiness.
Furthermore, the automatic stage 2 sleep detection and alarm
device yields the real-time detection accuracy of approximately
85% which is comparable with the commercial sleep lab system.
Abstract: This paper presents the characterization and design of a capacitive pressure sensor with LC-based 0.35 µm CMOS readout circuit. SPICE is employed to evaluate the characteristics of the readout circuit and COMSOL multiphysics structural analysis is used to simulate the behavior of the pressure sensor. The readout circuit converts the capacitance variation of the pressure sensor into the frequency output. Simulation results show that the proposed pressure sensor has output frequency from 2.50 to 2.28 GHz in a pressure range from 0.1 to 2 MPa almost linearly. The sensitivity of the frequency shift with respect to the applied pressure load is 0.11 GHz/MPa.
Abstract: This paper details few mechanical modeling and
design issues of RF MEMS switches. We concentrate on an
electrostatically actuated broad side series switch; surface
micromachined with a crab leg membrane. The same results are
extended to any complex structure. With available experimental data
and fabrication results, we present the variation in dynamic
performance and compliance of the switch with reference to few
design issues, which we find are critical in deciding the dynamic
behavior of the switch, without compromise on the RF
characteristics. The optimization of pull in voltage, transient time and
resonant frequency with regard to these critical design parameters are
also presented.
Abstract: Whilst there is growing evidence that activity across the lifespan is beneficial for improved health, there are also many changes involved with the aging process and subsequently the potential for reduced indices of health. Data gathered on a subsample of 535 football code athletes, aged 31-72 yrs ( = 47.4, s = ±7.1), competing at the Sydney World Masters Games (2009) demonstrated a significantly (p < 0.001), reduced classification of obesity using Body Mass Index (BMI) when compared to the general Australian population. This evidence of improved classification in one index of health (BMI < 30) for master athletes (when compared to the general population) implies there are either improved levels of this index of health due to adherence to sport or possibly the reduced BMI is advantageous and contributes to this cohort adhering (or being attracted) to masters sport. Demonstration of this proportionately under-investigated World Masters Games population having improved health over the general population is of particular interest.
Abstract: In this paper we report the technique of optical
induction of 2 and 3-dimensional (2D and 3D) photonic lattices in
photorefractive materials based on diffraction grating self replication
-Talbot effect. 1D and 2D different rotational symmery diffraction
masks with the periods of few tens micrometers and 532 nm cw laser
beam were used in the experiments to form an intensity modulated
light beam profile. A few hundred micrometric scale replications of
mask generated intensity structures along the beam propagation axis
were observed. Up to 20 high contrast replications were detected for
1D annular mask with 30
Abstract: An experiment was performed with a 24.5 MeV 14N
beam on a 12C target in the cyclotron DC-60 located in Astana,
Kazakhstan, to study the elastic scattering of 14N on 12C; the
scattering was also analyzed at different energies for tracking the
phenomenon of remarkable structure at large angles. Its aims were to
extend the measurements to very large angles, and attempt to
uniquely identify the elastic scattering potential. Good agreement
between the theoretical and experimental data has been obtained with
suitable optical potential parameters. Optical model calculations with
l -dependent imaginary potentials were also applied to the data and
relatively good agreement was found.
Abstract: The paper reports the preparation and photocatalytic
activity of ZnO/SnO2 and SnO2 nanoparticles. These nanoparticles
were synthesized by hydrothermal method. The products were
characterized by X-ray diffraction (XRD) and scanning electron
microscopy (SEM). Their grain sizes are about 50-100 nm. The
photocatalytic activities of these materials were investigated for
congo red removal from aqueous solution under UV light irradiation.
It was shown that the use of ZnO/SnO2 as photocatalyst have better
photocatalytic activity for degradation of congo red than SnO2 or
TiO2 (anatase, particle size: 30nm) alone.
Abstract: Considering the theory of attribute grammars, we use
logical formulas instead of traditional functional semantic rules.
Following the decoration of a derivation tree, a suitable algorithm
should maintain the consistency of the formulas together with the
evaluation of the attributes. This may be a Prolog-like resolution, but
this paper examines a somewhat different strategy, based on
production specialization, local consistency and propagation: given a
derivation tree, it is interactively decorated, i.e. incrementally
checked and evaluated. The non-directed dependencies are
dynamically directed during attribute evaluation.
Abstract: The leisure boatbuilding industry has tight profit margins that demand that boats are created to a high quality but with low cost. This requirement means reduced design times combined with increased use of design for production can lead to large benefits. The evolutionary nature of the boatbuilding industry can lead to a large usage of previous vessels in new designs. With the increase in automated tools for concurrent engineering within structural design it is important that these tools can reuse this information while subsequently feeding this to designers. The ability to accurately gather this materials and parts data is also a key component to these tools. This paper therefore aims to develop an architecture made up of neural networks and databases to feed information effectively to the designers based on previous design experience.
Abstract: In this paper, a new Genetic Algorithm (GA) based
methodology is proposed to optimize the Degree of Hybridization
(DOH) in a passenger parallel hybrid car. At first step, target
parameters for the vehicle are decided and then using ADvanced
VehIcle SimulatOR (ADVISOR) software, the variation pattern of
these target parameters, across the different DOHs, is extracted. At
the next step, a suitable cost function is defined and is optimized
using GA. In this paper, also a new technique has been proposed for
deciding the number of battery modules for each DOH, which leads
to a great improvement in the vehicle performance. The proposed
methodology is so simple, fast and at the same time, so efficient.
Abstract: Message Passing Interface is widely used for Parallel
and Distributed Computing. MPICH and LAM are popular open
source MPIs available to the parallel computing community also
there are commercial MPIs, which performs better than MPICH etc.
In this paper, we discuss a commercial Message Passing Interface, CMPI
(C-DAC Message Passing Interface). C-MPI is an optimized
MPI for CLUMPS. It is found to be faster and more robust compared
to MPICH. We have compared performance of C-MPI and MPICH
on Gigabit Ethernet network.
Abstract: This paper discusses a qualitative simulator QRiOM
that uses Qualitative Reasoning (QR) technique, and a process-based
ontology to model, simulate and explain the behaviour of selected
organic reactions. Learning organic reactions requires the application
of domain knowledge at intuitive level, which is difficult to be
programmed using traditional approach. The main objective of
QRiOM is to help learners gain a better understanding of the
fundamental organic reaction concepts, and to improve their
conceptual comprehension on the subject by analyzing the multiple
forms of explanation generated by the software. This paper focuses
on the generation of explanation based on causal theories to explicate
various phenomena in the chemistry subject. QRiOM has been tested
with three classes problems related to organic chemistry, with
encouraging results. This paper also presents the results of
preliminary evaluation of QRiOM that reveal its explanation
capability and usefulness.
Abstract: The bridge vibration due to traffic loading has been a
subject of extensive research during the last decades. A number of
these studies are concerned with the effects of the unevenness of
roadways on the dynamic responses of highway bridges. The road
unevenness is often described as a random process that constitutes
of different wavelengths. Thus, the study focuses on examining
the effects of the random description of roadways on the dynamic
response and its variance. A new setting of variance based sensitivity
analysis is proposed and used to identify and quantify the
contributions of the roadway-s wavelengths to the variance of the
dynamic response. Furthermore, the effect of the vehicle-s speed on
the dynamic response is studied.
Abstract: The current situation in the eurozone raises a number of topics for discussion and to help in finding an answer to the question of whether a common currency is a more suitable means of coping with the impact of the financial crisis or whether national currencies are better suited to this. The economic situation in the EU is now considerably volatile and, due to problems with the fulfilment of the Maastricht convergence criteria, it is now being considered whether, in their further development, new member states will decide to distance themselves from the euro or will, in an attempt to overcome the crisis, speed up the adoption of the euro. The Czech Republic is one country with little interest in adopting the euro, justified by the fact that a better alternative to dealing with this crisis is an independent monetary policy and its ability to respond flexibly to the economic situation not only in Europe, but around the world. One attribute of the crisis in the Czech Republic and its mitigation is the freely floating exchange rate of the national currency. It is not only the Czech Republic that is attempting to alleviate the impact of the crisis, but also new EU member countries facing fresh questions to which theory have yet to provide wholly satisfactory answers. These questions undoubtedly include the problem of inflation targeting and the choice of appropriate instruments for achieving financial stability. The difficulty lies in the fact that these objectives may be contradictory and may require more than one means of achieving them. In this respect we may assume that membership of the euro zone might not in itself mitigate the development of the recession or protect the nation from future crises. We are of the opinion that the decisive factor in the development of any economy will continue to be the domestic economic policy and the operability of market economic mechanisms. We attempt to document this fact using selected countries as examples, these being the Czech Republic, Poland, Hungary, and Slovakia.
Abstract: Pharmacology curriculum plays an integral role in
medical education. Learning pharmacology to choose and prescribe
drugs is a major challenge encountered by students. We developed
pharmacology applied learning activities for first year medical
students that included realistic clinical situations with escalating
complications which required the students to analyze the situation
and think critically to choose a safe drug. Tutor feedback was
provided at the end of session. Evaluation was done to assess the
students- level of interest and usefulness of the sessions in rational
selection of drugs. Majority (98 %) of the students agreed that the
session was an extremely useful learning exercise and agreed that
similar sessions would help in rational selection of drugs. Applied
learning sessions in the early years of medical program may promote
deep learning and bridge the gap between pharmacology theory and
clinical practice. Besides, it may also enhance safe prescribing skills.
Abstract: In this study, a low temperature sensor highly selective to CO in presence of methane is fabricated by using 4 nm SnO2 quantum dots (QDs) prepared by sonication assisted precipitation. SnCl4 aqueous solution was precipitated by ammonia under sonication, which continued for 2 h. A part of the sample was then dried and calcined at 400°C for 1.5 h and characterized by XRD and BET. The average particle size and the specific surface area of the SnO2 QDs as well as their sensing properties were compared with the SnO2 nano-particles which were prepared by conventional sol-gel method. The BET surface area of sonochemically as-prepared product and the one calcined at 400°C after 1.5 hr are 257 m2/gr and 212 m2/gr respectively while the specific surface area for SnO2 nanoparticles prepared by conventional sol-gel method is about 80m2/gr. XRD spectra revealed pure crystalline phase of SnO2 is formed for both as-prepared and calcined samples of SnO2 QDs. However, for the sample prepared by sol-gel method and calcined at 400°C SnO crystals are detected along with those of SnO2. Quantum dots of SnO2 show exceedingly high sensitivity to CO with different concentrations of 100, 300 and 1000 ppm in whole range of temperature (25- 350°C). At 50°C a sensitivity of 27 was obtained for 1000 ppm CO, which increases to a maximum of 147 when the temperature rises to 225°C and then drops off while the maximum sensitivity for the SnO2 sample prepared by the sol-gel method was obtained at 300°C with the amount of 47.2. At the same time no sensitivity to methane is observed in whole range of temperatures for SnO2 QDs. The response and recovery times of the sensor sharply decreases with temperature, while the high selectivity to CO does not deteriorate.