Abstract: Medical image registration is the key technology in image guided radiation therapy (IGRT) systems. On the basis of the previous work on our IGRT prototype with a biorthogonal x-ray imaging system, we described a method focused on the 2D/2D rigid-body registration using multiresolution pyramid based mutual information in this paper. Three key steps were involved in the method : firstly, four 2D images were obtained including two x-ray projection images and two digital reconstructed radiographies(DRRs ) as the input for the registration ; Secondly, each pair of the corresponding x-ray image and DRR image were matched using multiresolution pyramid based mutual information under the ITK registration framework ; Thirdly, we got the final couch offset through a coordinate transformation by calculating the translations acquired from the two pairs of the images. A simulation example of a parotid gland tumor case and a clinical example of an anthropomorphic head phantom were employed in the verification tests. In addition, the influence of different CT slice thickness were tested. The simulation results showed that the positioning errors were 0.068±0.070, 0.072±0.098, 0.154±0.176mm along three axes which were lateral, longitudinal and vertical. The clinical test indicated that the positioning errors of the planned isocenter were 0.066, 0.07, 2.06mm on average with a CT slice thickness of 2.5mm. It can be concluded that our method with its verified accuracy and robustness can be effectively used in IGRT systems for patient setup.
Abstract: In intensity modulated radiation therapy (IMRT)
treatment planning, beam angles are usually preselected on the basis of
experience and intuition. Therefore, getting an appropriate beam
configuration needs a very long time. Based on the present situation,
the paper puts forward beam orientation optimization using ant colony
optimization (ACO). We use ant colony optimization to select the
beam configurations, after getting the beam configuration using
Conjugate Gradient (CG) algorithm to optimize the intensity profiles.
Combining with the information of the effect of pencil beam, we can
get the global optimal solution accelerating. In order to verify the
feasibility of the presented method, a simulated and clinical case was
tested, compared with dose-volume histogram and isodose line
between target area and organ at risk. The results showed that the
effect was improved after optimizing beam configurations. The
optimization approach could make treatment planning meet clinical
requirements more efficiently, so it had extensive application
perspective.