Abstract: A homologous series of aromatic esters, 4-nalkanoyloxybenzylidene-
4--bromoanilines, nABBA,
consisting of two 1,4-disubstituted phenyl cores and a Schiff
base central linkage was synthesized. All the members can be
differed by the number of carbon atoms at terminal
alkanoyloxy chain (CnH2n-1COO-, n = 2, 6, 18). The molecular
structure of nABBA was confirmed with infrared
spectroscopy, nuclear magnetic resonance (NMR)
spectroscopy and electron-ionization mass (EI-MS)
spectrometry. Mesomorphic properties were studied using
differential scanning calorimetry and polarizing optical
microscopy.
Abstract: An ontology is a data model that represents a set of
concepts in a given field and the relationships among those concepts.
As the emphasis on achieving a semantic web continues to escalate,
ontologies for all types of domains increasingly will be developed.
These ontologies may become large and complex, and as their size
and complexity grows, so will the need for multi-user interfaces for
ontology curation. Herein a functionally comprehensive, generic
approach to maintaining an ontology as a relational database is
presented. Unlike many other ontology editors that utilize a database,
this approach is entirely domain-generic and fully supports Webbased,
collaborative editing including the designation of different
levels of authorization for users.
Abstract: As more people from non-technical backgrounds
are becoming directly involved with large-scale ontology
development, the focal point of ontology research has shifted
from the more theoretical ontology issues to problems
associated with the actual use of ontologies in real-world,
large-scale collaborative applications. Recently the National
Science Foundation funded a large collaborative ontology
development project for which a new formal ontology model,
the Ontology Abstract Machine (OAM), was developed to
satisfy some unique functional and data representation
requirements. This paper introduces the OAM model and the
related algorithms that enable maintenance of an ontology that
supports node-based user access. The successful software
implementation of the OAM model and its subsequent
acceptance by a large research community proves its validity
and its real-world application value.
Abstract: Protein 3D structure prediction has always been an
important research area in bioinformatics. In particular, the
prediction of secondary structure has been a well-studied research
topic. Despite the recent breakthrough of combining multiple
sequence alignment information and artificial intelligence algorithms
to predict protein secondary structure, the Q3 accuracy of various
computational prediction algorithms rarely has exceeded 75%. In a
previous paper [1], this research team presented a rule-based method
called RT-RICO (Relaxed Threshold Rule Induction from Coverings)
to predict protein secondary structure. The average Q3 accuracy on
the sample datasets using RT-RICO was 80.3%, an improvement
over comparable computational methods. Although this demonstrated
that RT-RICO might be a promising approach for predicting
secondary structure, the algorithm-s computational complexity and
program running time limited its use. Herein a parallelized
implementation of a slightly modified RT-RICO approach is
presented. This new version of the algorithm facilitated the testing of
a much larger dataset of 396 protein domains [2]. Parallelized RTRICO
achieved a Q3 score of 74.6%, which is higher than the
consensus prediction accuracy of 72.9% that was achieved for the
same test dataset by a combination of four secondary structure
prediction methods [2].