Abstract: Bioinformatics methods for predicting the T cell
coreceptor usage from the array of membrane protein of HIV-1 are
investigated. In this study, we aim to propose an effective prediction
method for dealing with the three-class classification problem of
CXCR4 (X4), CCR5 (R5) and CCR5/CXCR4 (R5X4). We made
efforts in investigating the coreceptor prediction problem as follows: 1)
proposing a feature set of informative physicochemical properties
which is cooperated with SVM to achieve high prediction test
accuracy of 81.48%, compared with the existing method with
accuracy of 70.00%; 2) establishing a large up-to-date data set by
increasing the size from 159 to 1225 sequences to verify the proposed
prediction method where the mean test accuracy is 88.59%, and 3)
analyzing the set of 14 informative physicochemical properties to
further understand the characteristics of HIV-1coreceptors.
Abstract: In recent years, though, the concept of fit has been
now in widespread used in strategic management research, it is in its
infancy for applying fit concept to service innovation issue. Therefore,
drawing on the concept of fit, this present research proposed an
innovation service fit model within service innovation, market
orientation, marketing strategy, and IT adoption are coexisted. The
perspective of fit as covariation will be employed to test the hypothesis
and identify the effects of fit. We contend that the fit among these four
factors will contribution to business performance. Finally, according
to the empirical data collected from manufacturing, service, and
financial industry in Taiwan, meaningful findings and conclusions
will be proposed and discussed.
Abstract: Recently, a great number of theoretical frameworks
have been proposed to develop the linkages between knowledge
management (KM) and organizational strategies. However, while
there has been much theorizing and case study in the area, validated
research models integrating KM and information technology
strategies for empirical testing of these theories have been scarce. In
this research, we try to develop a research model for explaining the
relationship between KM strategy and IT strategy and their effects on
performance. Finally, meaningful propositions and conclusions are
derived, and suggestions for future research are proposed and
discussed.