Abstract: Mass media campaigns against obesity are often
designed to impact large audiences. This usually means that their
audience is defined based on general demographic characteristics like
age, gender, occupation etc., not taking into account psychographics
like behavior, motivations, wants, etc. Using psychographics, as the
base for the audience segmentation, is a common practice in case of
successful campaigns, as it allows developing more relevant
messages. It also serves a purpose of identifying key segments, those
that generate the best return on investment. For a health campaign,
that would be segments that have the best chance of being converted
into healthy lifestyle at the lowest cost. This paper presents the
limitations of the demographic targeting, based on the findings from
the reception study of IMSS (Mexican Social Security Institute) antiobesity
TV commercials and proposes mothers as the first level of
segmentation, in the process of identifying the key segment for these
campaigns.
Abstract: Customarily, the LMTD correction factor, FT, is used
to screen alternative designs for a heat exchanger. Designs with
unacceptably low FT values are discarded. In this paper, authors have
proposed a more fundamental criterion, based on feasibility of a
multipass exchanger as the only criteria, followed by economic
optimization. This criterion, coupled with asymptotic energy targets,
provide the complete optimization space in a heat exchanger network
(HEN), where cost-optimization of HEN can be performed with only
Heat Recovery Approach temperature (HRAT) and number-of-shells
as variables.
Abstract: pH-sensitive drug targeting using nanoparticles for
cancer chemotherapy have been spotlighted in recent decades. Graft
copolymer composed of poly (L-histidine) (PHS) and dextran
(DexPHS) was synthesized and pH-sensitive nanoparticles were
fabricated for pH-responsive drug delivery of doxorubicin (DOX).
Nanoparticles of DexPHS showed pH-sensitive changes in particle
sizes and drug release behavior, i.e. particle sizes and drug release rate
were increased at acidic pH, indicating that DexPHS nanoparticles
have pH-sensitive drug delivery potentials. Antitumor activity of
DOX-incorporated DexPHS nanoparticles were studied using CT26
colorectal carcinoma cells. Results indicated that fluorescence
intensity was higher at acidic pH than basic pH. These results
indicated that DexPHS nanoparticles have pH-responsive drug
targeting.