Abstract: A mechanical wave or vibration propagating through
granular media exhibits a specific signature in time. A coherent
pulse or wavefront arrives first with multiply scattered waves (coda)
arriving later. The coherent pulse is micro-structure independent i.e.
it depends only on the bulk properties of the disordered granular
sample, the sound wave velocity of the granular sample and hence
bulk and shear moduli. The coherent wavefront attenuates (decreases
in amplitude) and broadens with distance from its source. The
pulse attenuation and broadening effects are affected by disorder
(polydispersity; contrast in size of the granules) and have often been
attributed to dispersion and scattering. To study the effect of disorder
and initial amplitude (non-linearity) of the pulse imparted to the
system on the coherent wavefront, numerical simulations have been
carried out on one-dimensional sets of particles (granular chains).
The interaction force between the particles is given by a Hertzian
contact model. The sizes of particles have been selected randomly
from a Gaussian distribution, where the standard deviation of this
distribution is the relevant parameter that quantifies the effect of
disorder on the coherent wavefront. Since, the coherent wavefront is
system configuration independent, ensemble averaging has been used
for improving the signal quality of the coherent pulse and removing
the multiply scattered waves. The results concerning the width of the
coherent wavefront have been formulated in terms of scaling laws. An
experimental set-up of photoelastic particles constituting a granular
chain is proposed to validate the numerical results.
Abstract: Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index
Abstract: Antimicrobial resistant is becoming a major factor in
virtually all hospital acquired infection may soon untreatable is a
serious public health problem. These concerns have led to major
research effort to discover alternative strategies for the treatment of
bacterial infection. Nanobiotehnology is an upcoming and fast
developing field with potential application for human welfare. An
important area of nanotechnology for development of reliable and
environmental friendly process for synthesis of nanoscale particles
through biological systems In the present studies are reported on the
use of fungal strain Aspergillus species for the extracellular synthesis
of bionanoparticles from 1 mM silver nitrate (AgNO3) solution. The
report would be focused on the synthesis of metallic bionanoparticles
of silver using a reduction of aqueous Ag+ ion with the
culture supernatants of Microorganisms. The bio-reduction of the
Ag+ ions in the solution would be monitored in the aqueous
component and the spectrum of the solution would measure through
UV-visible spectrophotometer The bionanoscale particles were
further characterized by Atomic Force Microscopy (AFM), Fourier
Transform Infrared Spectroscopy (FTIR) and Thin layer
chromatography. The synthesized bionanoscale particle showed a
maximum absorption at 385 nm in the visible region. Atomic Force
Microscopy investigation of silver bionanoparticles identified that
they ranged in the size of 250 nm - 680 nm; the work analyzed the
antimicrobial efficacy of the silver bionanoparticles against various
multi drug resistant clinical isolates. The present Study would be
emphasizing on the applicability to synthesize the metallic
nanostructures and to understand the biochemical and molecular
mechanism of nanoparticles formation by the cell filtrate in order to
achieve better control over size and polydispersity of the
nanoparticles. This would help to develop nanomedicine against
various multi drug resistant human pathogens.