Abstract: Particle detection in very noisy and low contrast images
is an active field of research in image processing. In this article, a
method is proposed for the efficient detection and sizing of subsurface
spherical particles, which is used for the processing of softly fused
Au nanoparticles. Transmission Electron Microscopy is used for
imaging the nanoparticles, and the proposed algorithm has been
tested with the two-dimensional projected TEM images obtained.
Results are compared with the data obtained by transmission optical
spectroscopy, as well as with conventional circular object detection
algorithms.
Abstract: Cancer becomes one of the leading cause of death in
many countries over the world. Fourier-transform infrared (FTIR)
spectra of human lung cancer cells (A549) treated with PMF (natural
product extracted from PM 701) for different time intervals were
examined. Second derivative and difference method were taken in
comparison studies. Cesium (Cs) and Rubidium (Rb) nanoparticles in
PMF were detected by Energy Dispersive X-ray attached to Scanning
Electron Microscope SEM-EDX. Characteristic changes in protein
secondary structure, lipid profile and changes in the intensities of
DNA bands were identified in treated A549 cells spectra. A
characteristic internucleosomal ladder of DNA fragmentation was
also observed after 30 min of treatment. Moreover, the pH values
were significantly increases upon treatment due to the presence of Cs
and Rb nanoparticles in the PMF fraction. These results support the
previous findings that PMF is selective anticancer agent and can
produce apoptosis to A549 cells.
Abstract: This study determines the effect of naked and heparinbased
super-paramagnetic iron oxide nanoparticles on the human
cancer cell lines of A2780. Doxorubicin was used as the anticancer
drug, entrapped in the SPIO-NPs. This study aimed to decorate
nanoparticles with heparin, a molecular ligand for 'active' targeting
of cancerous cells and the application of modified-nanoparticles in
cancer treatment. The nanoparticles containing the anticancer drug
DOX were prepared by a solvent evaporation and emulsification
cross-linking method. The physicochemical properties of the
nanoparticles were characterized by various techniques, and uniform
nanoparticles with an average particle size of 110±15 nm with high
encapsulation efficiencies (EE) were obtained. Additionally, a
sustained release of DOX from the SPIO-NPs was successful.
Cytotoxicity tests showed that the SPIO-DOX-HP had higher cell
toxicity than the individual HP and confocal microscopy analysis
confirmed excellent cellular uptake efficiency. These results indicate
that HP based SPIO-NPs have potential uses as anticancer drug
carriers and also have an enhanced anticancer effect.
Abstract: Nanostructured Iron Oxide with different
morphologies of rod-like and granular have been suc-cessfully
prepared via a solid-state reaction in the presence of NaCl, NaBr, NaI
and NaN3, respectively. The added salts not only prevent a drastic
increase in the size of the products but also provide suitable
conditions for the oriented growth of primary nanoparticles. The
formation mechanisms of these materials by solid-state reaction at
ambient temperature are proposed. The photocatalytic experiments
for congo red (CR) have demonstrated that the mixture of α-Fe2O3
and Fe3O4 nanostructures were more efficient than α-Fe2O3
nanostructures.
Abstract: Application of nanoparticles as additives in membrane
synthesis for improving the resistance of membranes against fouling
has triggered recent interest in new membrane types. However, most
nanoparticle-enhanced membranes suffer from the tradeoff between
permeability and selectivity. In this study, nano-WS2 was explored as
the additive in membrane synthesis by non-solvent induced phase
separation. Blended PES-WS2 flat-sheet membranes with the
incorporation of ultra-low concentrations of nanoparticles (from 0.025
to 0.25%, WS2/PES ratio) were manufactured and investigated in
terms of permeability, fouling resistance and solute rejection.
Remarkably, a significant enhancement in the permeability was
observed as a result of the incorporation of ultra-low fractions of
nano-WS2 to the membrane structure. Optimal permeability values
were obtained for modified membranes with 0.10%
nanoparticle/polymer concentration ratios. Furthermore, fouling
resistance and solute rejection were significantly improved by the
incorporation of nanoparticles into the membrane matrix. Specifically,
fouling resistance of modified membrane can increase by around 50%.
Abstract: Today, cancer remains one of the major diseases that
lead to death. The main obstacle in chemotherapy as a main cancer
treatment is the toxicity to normal cells due to Multidrug Resistance
(MDR) after the use of anticancer drugs. Proposed solution to
overcome this problem is the use of MDR efflux inhibitor of cinchona
alkaloids which is delivered together with anticancer drugs
encapsulated in the form of polymeric nanoparticles. The particles
were prepared by the hydration method. The characterization of
nanoparticles was particle size, zeta potential, entrapment efficiency
and in vitro drug release. Combination nanoparticle size ranged 29-45
nm with a neutral surface charge. Entrapment efficiency was above
87% for the use quinine, quinidine or cinchonidine in combination
with etoposide. The release test results exhibited that the cinchona
alkaloids release released faster than that of etoposide. Collectively,
cinchona alkaloids can be packaged along with etoposide in
nanomicelles for better cancer therapy.
Abstract: The morphological parameter of a thin film surface
can be characterized by power spectral density (PSD) functions
which provides a better description to the topography than the RMS
roughness and imparts several useful information of the surface
including fractal and superstructure contributions. Through the
present study Nanoparticle copper/carbon composite films were
prepared by co-deposition of RF-Sputtering and RF-PECVD method
from acetylene gas and copper target. Surface morphology of thin
films is characterized by using atomic force microscopy (AFM). The
Carbon content of our films was obtained by Rutherford Back
Scattering (RBS) and it varied from .4% to 78%. The power values of
power spectral density (PSD) for the AFM data were determined by
the fast Fourier transform (FFT) algorithms. We investigate the effect
of carbon on the roughness of thin films surface. Using such
information, roughness contributions of the surface have been
successfully extracted.