Abstract: Cardiovascular diseases (CVD) are related to affectations of the heart and blood vessels, within these are pathologies such as coronary or peripheral heart disease, caused by the narrowing of the vessel wall (atherosclerosis), which is related to the accumulation of Low-Density Lipoproteins (LDL) in the arterial walls that leads to a progressive reduction of the lumen of the vessel and alterations in blood perfusion. Currently, the main therapeutic strategy for this type of alteration is drug treatment with statins, which inhibit the enzyme 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), responsible for modulating the rate of cholesterol production and other isoprenoids in the mevalonate pathway. This enzyme induces the expression of LDL receptors in the liver, increasing their number on the surface of liver cells, reducing the plasma concentration of cholesterol. On the other hand, when the blood vessel presents stenosis, a surgical procedure with vascular implants is indicated, which are used to restore circulation in the arterial or venous bed. Among the materials used for the development of vascular implants are Dacron® and Teflon®, which perform the function of re-waterproofing the circulatory circuit, but due to their low biocompatibility, they do not have the ability to promote remodeling and tissue regeneration processes. Based on this, the present research proposes the development of a hydrolyzed collagen and polyethylene oxide electrospun membrane reinforced with medium and high-intensity statins, so that in future research it can favor tissue remodeling processes from its microarchitecture.
Abstract: Osteoporosis is a multifactorial disease that results in reduced quality of life, causes decreased bone strength, and changes in their microarchitecture. Mostly postmenopausal women are at risk. In our study, we measured anthropometric parameters of postmenopausal women (104 women of control group – CG and 105 women of osteoporotic group - OG) and determined TSH hormone levels and PTH as well as mineral elements - Ca, P, Mg and enzyme alkaline phosphatase. Through the correlation analysis in CG, we have found association based on age and BMI, P and Ca, as well as Mg and Ca; in OG we determined interdependence based on an association of age and BMI, age and Ca. Using the Student's t test, we found significantly important differences in biochemical parameters of Mg (p ˂ 0,001) and TSH (p ˂ 0,05) between CG and OG.
Abstract: This paper presents design trade-off and performance impacts of
the amount of pipeline phase of control path signals in a wormhole-switched
network-on-chip (NoC). The numbers of the pipeline phase of the control
path vary between two- and one-cycle pipeline phase. The control paths
consist of the routing request paths for output selection and the arbitration
paths for input selection. Data communications between on-chip routers are
implemented synchronously and for quality of service, the inter-router data
transports are controlled by using a link-level congestion control to avoid
lose of data because of an overflow. The trade-off between the area (logic
cell area) and the performance (bandwidth gain) of two proposed NoC router
microarchitectures are presented in this paper. The performance evaluation is
made by using a traffic scenario with different number of workloads under
2D mesh NoC topology using a static routing algorithm. By using a 130-nm
CMOS standard-cell technology, our NoC routers can be clocked at 1 GHz,
resulting in a high speed network link and high router bandwidth capacity
of about 320 Gbit/s. Based on our experiments, the amount of control path
pipeline stages gives more significant impact on the NoC performance than
the impact on the logic area of the NoC router.