Abstract: Open urban public spaces comprise an important
element for the development of social, cultural and economic
activities of the population in the modern cities. These spaces are also
considered regulators of the region-s climate conditions, providing
better thermal, visual and auditory conditions which can be optimized
by the application of appropriate strategies of bioclimatic design. The
paper focuses on the analysis and evaluation of the recent unification
of the open spaces in the centre of Xanthi, a medium – size city in
northern Greece, from a bioclimatic perspective, as well as in the
creation of suitable methodology. It is based both on qualitative
observation of the interventions by fieldwork research and
assessment and on quantitative analysis and modeling of the research
area.
Abstract: Erroneous computer entry problems [here: 'e'errors] in hospital labs threaten the patients-–health carers- relationship, undermining the health system credibility. Are e-errors random, and do lab professionals make them accidentally, or may they be traced through meaningful determinants? Theories on internal causality of mistakes compel to seek specific causal ascriptions of hospital lab eerrors instead of accepting some inescapability. Undeniably, 'To Err is Human'. But in view of rapid global health organizational changes, e-errors are too expensive to lack in-depth considerations. Yet, that efunction might supposedly be entrenched in the health carers- job description remains under dispute – at least for Hellenic labs, where e-use falls behind generalized(able) appreciation and application. In this study: i) an empirical basis of a truly high annual cost of e-errors at about €498,000.00 per rural Hellenic hospital was established, hence interest in exploring the issue was sufficiently substantiated; ii) a sample of 270 lab-expert nurses, technicians and doctors were assessed on several personality, burnout and e-error measures, and iii) the hypothesis that the Hardiness vs Alienation personality construct disposition explains resistance vs proclivity to e-errors was tested and verified: Hardiness operates as a resilience source in the encounter of high pressures experienced in the hospital lab, whereas its 'opposite', i.e., Alienation, functions as a predictor, not only of making e-errors, but also of leading to burn-out. Implications for apt interventions are discussed.
Abstract: Out of all visual arts including: painting, sculpture,
graphics, photography, architecture, and others, architecture is by far
the most complex one, because the art category is only one of its
determinants. Architecture, to some extent includes other arts which
can significantly influence the shaping of an urban space (artistic
interventions). These arts largely shape the visual culture in
combination with other categories: film, TV, Internet, information
technologies that are "changing the world" etc. In the area of
architecture and urbanism, visual culture is achieved through the
aspects of visual spatial effects. In this context, a complex visual
deliberation about designing urban areas in order to contribute to the
urban visual culture, and with it restore the cultural identity of the
city, is becoming almost the primary concept of contemporary urban
and architectural practice. Research in this paper relate to the city of
Niksic and its place in the visual urban culture. We are looking at the
city’s existing visual effects and determining the directions of
transformability of its physical structure in order to achieve the visual
realization of an urban area and the renewal of cultural identity of a
modern city.
Abstract: Bone growth factors, such as Bone Morphogenic
Protein-2 (BMP-2) have been approved by the FDA to replace grafting for some surgical interventions, but the high dose requirement limits its use in patients. Noggin, an extracellular protein, blocks the effect of BMP-2 by binding to BMP. Preventing
the BMP-2/noggin interaction will help increase the free
concentration of BMP-2 and therefore should enhance its efficacy to
induce bone formation. The work presented here involves
computational design of novel small molecule inhibitory agents of BMP-2/noggin interaction, based on our current understanding of
BMP-2, and its known putative ligands (receptors and antagonists). A
successful acquisition of such an inhibitory agent of BMP-2/noggin interaction would allow clinicians to reduce the dose required of
BMP-2 protein in clinical applications to promote osteogenesis. The
available crystal structures of the BMPs, its receptors, and the binding partner noggin were analyzed to identify the critical residues
involved in their interaction. In presenting this study, LUDI de novo design method was utilized to perform virtual screening of a large
number of compounds from a commercially available library against the binding sites of noggin to identify the lead chemical compounds
that could potentially block BMP-noggin interaction with a high specificity.
Abstract: The purpose of this paper is to consider the
introduction of online courses to replace the current classroom-based
staff training. The current training is practical, and must be
completed before access to the financial computer system is
authorized. The long term objective is to measure the efficacy,
effectiveness and efficiency of the training, and to establish whether
a transfer of knowledge back to the workplace has occurred. This
paper begins with an overview explaining the importance of staff
training in an evolving, competitive business environment and
defines the problem facing this particular organization. A summary
of the literature review is followed by a brief discussion of the
research methodology and objective. The implementation of the
alpha version of the online course is then described. This paper may
be of interest to those seeking insights into, or new theory regarding,
practical interventions of online learning in the real world.