Abstract: Stochastic models of biological networks are well established in systems biology, where the computational treatment of such models is often focused on the solution of the so-called chemical master equation via stochastic simulation algorithms. In contrast to this, the development of storage-efficient model representations that are directly suitable for computer implementation has received significantly less attention. Instead, a model is usually described in terms of a stochastic process or a "higher-level paradigm" with graphical representation such as e.g. a stochastic Petri net. A serious problem then arises due to the exponential growth of the model-s state space which is in fact a main reason for the popularity of stochastic simulation since simulation suffers less from the state space explosion than non-simulative numerical solution techniques. In this paper we present transition class models for the representation of biological network models, a compact mathematical formalism that circumvents state space explosion. Transition class models can also serve as an interface between different higher level modeling paradigms, stochastic processes and the implementation coded in a programming language. Besides, the compact model representation provides the opportunity to apply non-simulative solution techniques thereby preserving the possible use of stochastic simulation. Illustrative examples of transition class representations are given for an enzyme-catalyzed substrate conversion and a part of the bacteriophage λ lysis/lysogeny pathway.
Abstract: Since the 1990s the American furniture industry faces
a transition period. Manufacturers, one of its most important actors
made its entrance into the retail industry. This shift has had deep
consequences not only for the American furniture industry as a
whole, but also for other international furniture industries, especially
the Chinese. The present work aims to analyze this actor based on the
distinction provided by the Global Commodity Chain Theory. It
stresses its characteristics, structure, operational way and importance
for both the U.S. and the Chinese furniture industries.
Abstract: We present in this paper an acquisition and treatment system designed for semi-analog Gamma-camera. It consists of a nuclear medical Image Acquisition, Treatment and Display chain(IATD) ensuring the acquisition, the treatment of the signals(resulting from the Gamma-camera detection head) and the scintigraphic image construction in real time. This chain is composed by an analog treatment board and a digital treatment board. We describe the designed systems and the digital treatment algorithms in which we have improved the performance and the flexibility. The digital treatment algorithms are implemented in a specific reprogrammable circuit FPGA (Field Programmable Gate Array).interface for semi-analog cameras of Sopha Medical Vision(SMVi) by taking as example SOPHY DS7. The developed system consists of an Image Acquisition, Treatment and Display (IATD) ensuring the acquisition and the treatment of the signals resulting from the DH. The developed chain is formed by a treatment analog board and a digital treatment board designed around a DSP [2]. In this paper we have presented the architecture of a new version of our chain IATD in which the integration of the treatment algorithms is executed on an FPGA (Field Programmable Gate Array)
Abstract: Many firms implemented various initiatives such as outsourced manufacturing which could make a supply chain (SC) more vulnerable to various types of disruptions. So managing risk has become a critical component of SC management. Different types of SC vulnerability management methodologies have been proposed for managing SC risk, most offer only point-based solutions that deal with a limited set of risks. This research aims to reinforce SC risk management by proposing an integrated approach. SC risks are identified and a risk index classification structure is created. Then we develop a SC risk assessment approach based on the analytic network process (ANP) and the VIKOR methods under the fuzzy environment where the vagueness and subjectivity are handled with linguistic terms parameterized by triangular fuzzy numbers. By using FANP, risks weights are calculated and then inserted to the FVIKOR to rank the SC members and find the most risky partner.
Abstract: We have developed an energy based approach for identifying the binding sites and important residues for binding in protein-protein complexes. We found that the residues and residuepairs with charged and aromatic side chains are important for binding. These residues influence to form cation-¤Ç, electrostatic and aromatic interactions. Our observation has been verified with the experimental binding specificity of protein-protein complexes and found good agreement with experiments. The analysis on surrounding hydrophobicity reveals that the binding residues are less hydrophobic than non-binding sites, which suggests that the hydrophobic core are important for folding and stability whereas the surface seeking residues play a critical role in binding. Further, the propensity of residues in the binding sites of receptors and ligands, number of medium and long-range contacts, and influence of neighboring residues will be discussed.
Abstract: The radio frequency identification (RFID) is a
technology for automatic identification of items, particularly in
supply chain, but it is becoming increasingly important for industrial
applications. Unlike barcode technology that detects the optical
signals reflected from barcode labels, RFID uses radio waves to
transmit the information from an RFID tag affixed to the physical
object. In contrast to today most often use of this technology in
warehouse inventory and supply chain, the focus of this paper is an
overview of the structure of RFID systems used by RFID technology
and it also presents a solution based on the application of RFID for
brand authentication, traceability and tracking, by implementing a
production management system and extending its use to traders.
Abstract: Thailand-s health system is challenged by the rising
number of patients and decreasing ratio of medical
practitioners/patients, especially in rural areas. This may tempt
inexperienced GPs to rush through the process of anamnesis with the
risk of incorrect diagnosis. Patients have to travel far to the hospital
and wait for a long time presenting their case. Many patients try to
cure themselves with traditional Thai medicine. Many countries are
making use of the Internet for medical information gathering,
distribution and storage. Telemedicine applications are a relatively
new field of study in Thailand; the infrastructure of ICT had
hampered widespread use of the Internet for using medical
information. With recent improvements made health and technology
professionals can work out novel applications and systems to help
advance telemedicine for the benefit of the people. Here we explore
the use of telemedicine for people with health problems in rural areas
in Thailand and present a Telemedicine Diagnosis System for Rural
Thailand (TEDIST) for diagnosing certain conditions that people
with Internet access can use to establish contact with Community
Health Centers, e.g. by mobile phone. The system uses a Web-based
input method for individual patients- symptoms, which are taken by
an expert system for the analysis of conditions and appropriate
diseases. The analysis harnesses a knowledge base and a backward
chaining component to find out, which health professionals should be
presented with the case. Doctors have the opportunity to exchange
emails or chat with the patients they are responsible for or other
specialists. Patients- data are then stored in a Personal Health Record.
Abstract: Today global warming, climate change and energy supply are of greater concern as it is widely realized that the planet earth does not provide an infinite capacity for absorbing human industrialization in the 21st century. The aim of this paper is to analyze upstream and downstream electricity production in selected case studies: a coal power plant, a pump system and a microwave oven covering and consumption to explore the position of energy efficiency in engineering sustainability. Collectively, the analysis presents energy efficiency as a major pathway towards sustainability that requires an inclusive and a holistic supply chain response in the engineering design process.
Abstract: In this paper we study a food chain model with three trophic levels and Michaelis-Menten type ratio-dependent functional response. Distinctive feature of this model is the sensitive dependence of the dynamical behavior on the initial populations and parameters of the real world. The stability of the equilibrium points are also investigated.
Abstract: The paper is devoted to stochastic analysis of finite
dimensional difference equation with dependent on ergodic Markov
chain increments, which are proportional to small parameter ". A
point-form solution of this difference equation may be represented
as vertexes of a time-dependent continuous broken line given on the
segment [0,1] with "-dependent scaling of intervals between vertexes.
Tending " to zero one may apply stochastic averaging and diffusion
approximation procedures and construct continuous approximation of
the initial stochastic iterations as an ordinary or stochastic Ito differential
equation. The paper proves that for sufficiently small " these
equations may be successfully applied not only to approximate finite
number of iterations but also for asymptotic analysis of iterations,
when number of iterations tends to infinity.
Abstract: The world's population continues to grow at a quarter of a million people per day, increasing the consumption of energy. This has made the world to face the problem of energy crisis now days. In response to the energy crisis, the principles of renewable energy gained popularity. There are much advancement made in developing the wind and solar energy farms across the world. These energy farms are not enough to meet the energy requirement of world. This has attracted investors to procure new sources of energy to be substituted. Among these sources, extraction of energy from the waves is considered as best option. The world oceans contain enough energy to meet the requirement of world. Significant advancements in design and technology are being made to make waves as a continuous source of energy. One major hurdle in launching wave energy devices in a developing country like Pakistan is the initial cost. A simple, reliable and cost effective wave energy converter (WEC) is required to meet the nation-s energy need. This paper will present a novel design proposed by team SAS for harnessing wave energy. This paper has three major sections. The first section will give a brief and concise view of ocean wave creation, propagation and the energy carried by them. The second section will explain the designing of SAS-2. A gear chain mechanism is used for transferring the energy from the buoy to a rotary generator. The third section will explain the manufacturing of scaled down model for SAS-2 .Many modifications are made in the trouble shooting stage. The design of SAS-2 is simple and very less maintenance is required. SAS-2 is producing electricity at Clifton. The initial cost of SAS-2 is very low. This has proved SAS- 2 as one of the cost effective and reliable source of harnessing wave energy for developing countries.
Abstract: The aim of this paper is to present a methodology in
three steps to forecast supply chain demand. In first step, various data
mining techniques are applied in order to prepare data for entering
into forecasting models. In second step, the modeling step, an
artificial neural network and support vector machine is presented
after defining Mean Absolute Percentage Error index for measuring
error. The structure of artificial neural network is selected based on
previous researchers' results and in this article the accuracy of
network is increased by using sensitivity analysis. The best forecast
for classical forecasting methods (Moving Average, Exponential
Smoothing, and Exponential Smoothing with Trend) is resulted based
on prepared data and this forecast is compared with result of support
vector machine and proposed artificial neural network. The results
show that artificial neural network can forecast more precisely in
comparison with other methods. Finally, forecasting methods'
stability is analyzed by using raw data and even the effectiveness of
clustering analysis is measured.
Abstract: As a result of urbanization, the unpredictable growth of industry and transport, production of chemicals, military activities, etc. the concentration of anthropogenic toxicants spread in nature exceeds all the permissible standards. Most dangerous among these contaminants are organic compounds having great persistence, bioaccumulation, and toxicity along with our awareness of their prominent occurrence in the environment and food chain. Among natural ecological tools, plants still occupying above 40% of the world land, until recently, were considered as organisms having only a limited ecological potential, accumulating in plant biomass and partially volatilizing contaminants of different structure. However, analysis of experimental data of the last two decades revealed the essential role of plants in environment remediation due to ability to carry out intracellular degradation processes leading to partial or complete decomposition of carbon skeleton of different structure contaminants. Though, phytoremediation technologies still are in research and development, their various applications have been successfully used. The paper aims to analyze mechanisms of organic contaminants uptake and detoxification in plants, being the less studied issue in evaluation and exploration of plants potential for environment remediation.
Abstract: Background: Dialign is a DNA/Protein alignment tool
for performing pairwise and multiple pairwise alignments through the
comparison of gap-free segments (fragments) between sequence
pairs. An alignment of two sequences is a chain of fragments, i.e
local gap-free pairwise alignments, with the highest total score.
METHOD: A new approach is defined in this article which relies on
the concept of using three-dimensional fragments – i.e. local threeway
alignments -- in the alignment process instead of twodimensional
ones. These three-dimensional fragments are gap-free
alignments constituting of equal-length segments belonging to three
distinct sequences. RESULTS: The obtained results showed good
improvments over the performance of DIALIGN.
Abstract: Supply chain networks are frequently hit by
unplanned events which lead to disruptions and cause operational and
financial consequences. It is neither possible to avoid disruption risk
entirely, nor are network members able to prepare for every possible
disruptive event. Therefore a continuity planning should be set up
which supports effective operational responses in supply chain
networks in times of emergencies. In this research network related
degrees of freedom which determine the options for responsive
actions are derived from interview data. The findings are further
embedded into a common risk management process. The paper
provides support for researchers and practitioners to identify the
network related options for responsive actions and to determine the
need for improving the reaction capabilities.
Abstract: Many experimental results suggest that more precise
spike timing is significant in neural information processing. We
construct a self-organization model using the spatiotemporal patterns,
where Spike-Timing Dependent Plasticity (STDP) tunes the
conduction delays between neurons. We show that the fluctuation of
conduction delays causes globally continuous and locally distributed
firing patterns through the self-organization.
Abstract: In this study, an OCR system for segmentation,
feature extraction and recognition of Ottoman Scripts has been
developed using handwritten characters. Detection of handwritten
characters written by humans is a difficult process. Segmentation and
feature extraction stages are based on geometrical feature analysis,
followed by the chain code transformation of the main strokes of
each character. The output of segmentation is well-defined segments
that can be fed into any classification approach. The classes of main
strokes are identified through left-right Hidden Markov Model
(HMM).
Abstract: One of the main processes of supply chain
management is supplier selection process which its accurate
implementation can dramatically increase company competitiveness.
In presented article model developed based on the features of
second tiers suppliers and four scenarios are predicted in order to
help the decision maker (DM) in making up his/her mind. In addition
two tiers of suppliers have been considered as a chain of suppliers.
Then the proposed approach is solved by a method combined of
concepts of fuzzy set theory (FST) and linear programming (LP)
which has been nourished by real data extracted from an engineering
design and supplying parts company. At the end results reveal the
high importance of considering second tier suppliers features as
criteria for selecting the best supplier.
Abstract: Thailand is the agriculture country as the weather and geography are suitable for agriculture environment. In 2011, the quantity of exported fresh vegetable was 126,069 tons which valued 117.1 million US dollars. Although the fresh vegetable has a high potential in exporting, there also have a lack of knowledge such as chemical usage, land usage, marketing and also the transportation and logistics. Nakorn Pathom province is the area which the farmer and manufacturer of fresh vegetable located. The objectives of this study are to study the basic information of the local fresh vegetable farmers in Nakorn Pathom province, to study the factor which effects the management of the fresh vegetable supply chain in Nakorn Pathom province and to study the problems and obstacle of the fresh vegetable supply chain in Nakorn Pathom province. This study is limited to the flow of the Nakorn Pathom province fresh vegetable from the farmers to the country which import the vegetable from Thailand. The populations of this study are 100 local farmers in Nakorn Pathom province. The result of this study shows that the key process of the fresh vegetable supply chain is in the supply sourcing process and manufacturing process.
Abstract: Along with forward supply chain organization needs
to consider the impact of reverse logistics due to its economic
advantage, social awareness and strict legislations. In this paper, we
develop a system dynamics framework for a closed-loop supply
chain with fuzzy demand and fuzzy collection rate by incorporating
product exchange policy in forward channel and various recovery
options in reverse channel. The uncertainty issues associated with
acquisition and collection of used product have been quantified using
possibility measures. In the simulation study, we analyze order
variation at both retailer and distributor level and compare bullwhip
effects of different logistics participants over time between the
traditional forward supply chain and the closed-loop supply chain.
Our results suggest that the integration of reverse logistics can reduce
order variation and bullwhip effect of a closed-loop system. Finally,
sensitivity analysis is performed to examine the impact of various
parameters on recovery process and bullwhip effect.