Abstract: Traditional medicine has been part of the Algerian culture for decades. In particular, the city of Tlemcen still retains practices based on phytotherapy to the present day, as this kind of medicine fulfills the needs of its followers among the local population. The toxic plants contain diverse natural substances which supplied a lot of medicine in the pharmaceutical industry. In order to explore new medicinal sources among toxic plants, an ethnobotanical study was carried out on the use of these plants by the population, at Emir Abdelkader Square of the city of Tlemcen, a rather busy place with a high number of traditional health practitioners and herbalists. This is a descriptive and transversal study aimed at estimating the frequency of using toxic plants among the studied population, for a period of 4 months. The information was collected, using self-anonymous questionnaires, and analyzed by the IBM SPSS Statistics software used for statistical analysis. A sample of 200 people, including 120 women and 80 men, were interviewed. The mean age was 41 ± 16 years. Among those questioned, 83.5% used plants; 8% of them used toxic plants and 35% used plants that can be toxic under certain conditions. Some improvements were observed in 88% of the cases where toxic plants were used. 80 medicinal plants, belonging to 36 botanical families, were listed, identified and classified. The most frequent indications for these plants were for respiratory diseases in 64.7% of cases, and for digestive disorders in 51.5% of cases. 11% of these plants are toxic, 26% could be toxic under certain conditions. Among toxics plants, the most common ones are Berberis vulgaris with 5.4%, indicated in the treatment of uterine fibroids and thyroid, Rhamnus alaternus with 4.8% for hepatic jaundice, Nerium oleander with 3% for hemorrhoids, Ruta chalepensis with 1.2%, indicated for digestive disorders and dysmenorrhea, and Viscum album with 1.2%, indicated for respiratory diseases. The most common plants that could be toxic are Mentha pulegium (15.6%), Eucalyptus globulus (11.4%), and Pimpinella anisum (10.2%). This study revealed interesting results on the use of toxic plants, which are likely to serve as a basis for further ethno-pharmacological investigations in order to get new drug sources.
Abstract: Respiratory diseases are the most important problems in the country’s poultry industry, particularly when it comes to broiler flocks. Ornithobacterium rhinotracheale (ORT) is a species that causes poor performance in growth rate, egg production, and mortality. This pathogen causes a respiratory infection including pulmonary alveolar inflammation, and pneumonia of birds throughout the world. Newcastle disease (ND) is a highly contagious disease in poultry, and also, it causes considerable losses to the poultry industry. The aim of this study was to evaluate the simultaneous occurrence of ORT and ND and NDV isolation by inoculation in embryonated eggs and confirmed by RT-PCR in broiler chicken flocks in Fars province. In this study, 318 blood and 85 tissue samples (brain, trachea, liver, and cecal tonsils) were collected from 15 broiler chicken farms. Survey serum antibody titers against ORT by using a commercial enzyme-linked immunosorbent assay (ELISA) kit performed. Evaluation of antibody titer against ND virus is performed by hemagglutination inhibition test. Virus isolation with chick embryo eggs 9-11 and RT-PCR method were carried out. A total of 318 serum samples, 135 samples (42.5%) were positive for antibodies to ORT and titer of HI antibodies against NDV in 122 serum samples (38/4%) were 7-10 (log2) and 61 serum samples (19/2%) had occurrence antibody titer against Newcastle virus and ORT. Results of the present study indicated that 20 tissue samples were positive in embryonated egg and in rapid hemagglutination (HA) test. HI test with specific ND positive serum confirmed that 6 of 20 samples. PCR confirmed that all six samples were positive and PCR products of samples indicated 535-base pair fragments in electrophrosis. Due to the great economic importance of these two diseases in the poultry industry, it is necessary to design and implement a comprehensive plan for prevention and control of these diseases.
Abstract: In recent decades, particulate matter (PM10) have
received much attention due to its potential adverse health impact and
the subsequent need to better control or regulate these pollutants.
The aim of this paper is focused on study risk assessment of PM10
in four different districts (Shebikah, Masfalah, Aziziyah, Awali) in
Makkah, Saudi Arabia during the period from 1 Ramadan 1434 AH -
27 Safar 1435 AH. Samples were collected by using Low Volume
Sampler (LVS Low Volume Sampler) device and filtration method
for estimating the total concentration of PM10.
The study indicated that the mean PM10 concentrations were 254.6
(186.1 - 343.2) μg/m3 in Shebikah, 184.9 (145.6 - 271.4) μg/m3 in
Masfalah, 162.4 (92.4-253.8) μg/m3 in Aziziyah, and 56.0 (44.5 -
119.8) μg/m3 in Awali. These values did not exceed the permissible
limits in PME (340 μg/m3 as daily average). Furthermore, health
assessment is carried out using AirQ2.2.3 model to estimate the
number of hospital admissions due to respiratory diseases. The
cumulative number of cases per 100,000 were 1534 (18-3050 case),
which lower than that recorded in the United States, Malaysia. The
concentration response coefficient was 0.49 (95% CI 0.05 - 0.70) per
10 μg/m3 increase of PM10.
Abstract: Air pollution is still considered as one of the major
environmental and health issues. There is enough research evidence
to show a strong relationship between exposure to air contaminants
and respiratory illnesses among children and adults. In this paper we
used the Copula approach to study a potential relationship between
selected air pollutants (PM10 and NO2) and hospital admissions for
respiratory diseases. Kendall-s tau and Spearman-s rho rank
correlation coefficients are calculated and used in Copula method.
This paper demonstrates that copulas can be used to provide
additional information as a measure of an association when compared
to the standard correlation coefficients. The results find a significant
correlation between the selected air pollutants and hospital
admissions for most of the selected respiratory illnesses.
Abstract: Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.
Abstract: The main objective of our study is to collect data
about the profile of the asthmatic patients in Assam and thereby have
a comprehensive knowledge of the factors influencing the asthmatic
patients of the state and their medication pattern. We developed a
search strategy to find any publication about the community based
survey asthma related and used. These to search the MEDLINE
(1996 to current literature) CINAHL DOAJ pubmed databases using
the key phrases, Asthma, Respiratory disorders, Drug therapy of
Asthma, database decision support system and asthma. The
appropriate literature was printed out from the online source and
library (Journal) source. The study was conducted through a set of
structured and non-structured questionnaires targeted on the
asthmatic patients belonging to the rural and urban areas of Assam,
during the month of Dec 2006 to July 2007, 138 cases were studied
in Gauwathi Medical College & Hospital located in Bhangagarh,
Assam in India. The demographic characteristics a factor in 138
patients with asthma with allergic rhinitis (cases) gives the detail
profile of asthmatic patient-s distribution of Assam as classified on
the basis of age and sex. It is evident from the study that male
populations (66%) are more prone to asthma as compared to the
females (34%).Another striking features that emerged from this
survey is the maximum prevalence of asthma in the age group of 20-
30 years followed by infants belonging to the age group of 7 (0.05%)
0-10years among both male and female populations of Assam. The
high incidence of asthma in the age group of 20-30 years may
probably be due to the allergy arising out of sudden exposure to dust
and pollen which the children face while playing and going to the
school. The rural females in the age group of 30-40 years are more
prone to asthma than urban females in the same age group may be
due to sex differentiation among the tribal population of the state.
Pharmacists should educate the asthmatics how to use inhalers
considering growing menace of asthma in the state. Safer drugs
should be produced in the form of aerosol so that easy administration
by the asthmatic patients and physicians of the state is possible for
curing asthma. The health centers should be more equipped with the
medicines to cure asthma in the state like Assam.