Abstract: This paper examines Japanese life expectancy, and the declining birth rate to investigate the Japanese people’s view of death, and their consciousness of death. To support their perspectives toward death, “Eitai Kuyobo,” and tombs with Japanese animation will be focused as Japanese citizens have created unique tombs designs of their own tombs. With the methodological aspects, Japan’s birth and mortality rates, Japan’s average life expectancy, history of tombs, creation of one’s own tombs and types of marriage will be significant. By examining the Japanese history of tombs, social change and unique tombs, and the increase of mortality rate in Japanese super-aging society, this study contributes the change of people’s view toward tombs, and a view toward life and death. Accordingly, focusing on the change of people’s view toward tombs it is concluded that the change is caused by the increase of mortality rate in Japanese super-aging society.
Abstract: The importance and significance of this research is based upon the fundamental knowledge reported in the scientific literature that physical activity is inversely associated with obesity. In addition, it is recognized there is a global epidemic of sedentariness while at the same time it is known that morbidity and mortality are associated with physical inactivity and as a result of overweight or obesity. Hence this small study in school students is an important area of research in our community. An application submitted in 2005 for the inaugural Public Health Education Research Trust [PHERT] Post Graduate Research Scholarship scheme organized by the Public Health Association of Australia [PHAA] was awarded 3rd place within Australia. The author and title was: D. Hilton, Methods to increase physical activity in school aged children [literature review, a trial using pedometers and a policy paper]. Third place is a good result, however this did not secure funding for the project, as only first place received $5000 funding. Some years later within Australia, a program commenced called the Global Children's Challenge [GCC]. Given details of the 2005 award above were included an application submission prepared for Parkhill Primary School [PPS] which is located in Victoria, Australia was successful. As a result, an excited combined grade 3/ 4 class at the school [27 students] in 2012 became recipients of these free pedometers. Ambassadors for the program were Mrs Catherine Freeman [OAM], Olympic Gold Medalist – Sydney 2000 [400 meters], while another ambassador was Mr Colin Jackson [CBE] who is a Welsh former sprint and hurdling athlete. In terms of PPS and other schools involved in 2012, website details show that the event started on 19th Sep 2012 and students were to wear the pedometer every day for 50 days [at home and at school] aiming for the recommended 15,000 steps/day recording steps taken in a booklet provided. After the finish, an analysis of the average step count for this school showed that the average steps taken / day was 14, 003 [however only a small percentage of students returned the booklets and units] as unfortunately the dates for the program coincided with school holidays so some students either forgot or misplaced the units / booklets. Unfortunately funding for this program ceased in 2013, however the lasting impact of the trial on student’s knowledge and awareness remains and in fact becomes a good grounding for students in how to monitor basic daily physical activity using a method that is easy, fun, low cost and readily accessible.
Abstract: The overarching aim of this study is to develop a soft-computing system for the differential diagnosis of tropical diseases. These conditions are of concern to health bodies, physicians, and the community at large because of their mortality rates, and difficulties in early diagnosis due to the fact that they present with symptoms that overlap, and thus become ‘confusable’. We report on the first phase of our study, which focuses on the development of a fuzzy cognitive map model for early differential diagnosis of tropical diseases. We used malaria as a case disease to show the effectiveness of the FCM technology as an aid to the medical practitioner in the diagnosis of tropical diseases. Our model takes cognizance of manifested symptoms and other non-clinical factors that could contribute to symptoms manifestations. Our model showed 85% accuracy in diagnosis, as against the physicians’ initial hypothesis, which stood at 55% accuracy. It is expected that the next stage of our study will provide a multi-disease, multi-symptom model that also improves efficiency by utilizing a decision support filter that works on an algorithm, which mimics the physician’s diagnosis process.
Abstract: Introduction: Prostate cancer is one of the most common causes of morbidity and mortality in men in developed countries. Cancer Stem Cells (CSCs) could be responsible for the progression and relapse of cancer. Therefore, CSCs markers could provide a prognostic strategy for human malignancies. Aldehyde dehydrogenase 1A1 (ALDH1A1) activity has been shown to be associated with tumorigenesis and proposed to represent a functional marker for tumor initiating cells in various tumor types including prostate cancer. Material & Methods: We analyzed the immunohistochemical expression of ALDH1A1 in benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma and assessed their significant correlations in 50 TURP sections. They were microscopically interpreted and the results were correlated with histopathological types and tumor grade. Results: In different prostatic histopathological lesions we found that ALDH1A1 expression was low in BPH (13.3%) and PIN (6.7%) and then its expression increased with prostatic adenocarcinoma (40%), and this was statistically highly significant (P value = 0.02). However, in different grades of prostatic adenocarcinoma we found that the higher the Gleason grade the higher the expression for ALDH1A1 and this was statistically significant (P value = 0.02). We compared the expression of ALDH1A1 in PIN and prostatic adenocarcinoma. ALDH1A1 expression was decreased in PIN and highly expressed in prostatic adenocarcinoma and this was statistically significant (P value = 0.04). Conclusion: Increasing ALDH1A1 expression is correlated with aggressive behavior of the tumor. Immunohistochemical expression of ALDH1A1 might provide a potential approach to study tumorigenesis and progression of primary prostate carcinoma.
Abstract: This research provides a technical account of
estimating Transition Probability using Time-homogeneous Markov
Jump Process applying by South African HIV/AIDS data from the
Statistics South Africa. It employs Maximum Likelihood Estimator
(MLE) model to explore the possible influence of Transition
Probability of mortality cases in which case the data was based on
actual Statistics South Africa. This was conducted via an integrated
demographic and epidemiological model of South African HIV/AIDS
epidemic. The model was fitted to age-specific HIV prevalence data
and recorded death data using MLE model. Though the previous
model results suggest HIV in South Africa has declined and AIDS
mortality rates have declined since 2002 – 2013, in contrast, our
results differ evidently with the generally accepted HIV models
(Spectrum/EPP and ASSA2008) in South Africa. However, there is
the need for supplementary research to be conducted to enhance the
demographic parameters in the model and as well apply it to each of
the nine (9) provinces of South Africa.
Abstract: Dengue is a mosquito-borne viral disease endemic in
many countries in the tropics and sub-tropics. The state of Punjab in
India shows cyclical and seasonal variation in dengue cases. The
Case Fatality Rate of Dengue has ranged from 0.6 to 1.0 in the past
years. The department has initiated review of the cases that have died
due to dengue in order to know the exact cause of the death in a case
of dengue. The study has been undertaken to know the other
associated co-morbidities and factors causing death in a case of
dengue. The study used the predesigned proforma on which the
records (medical and Lab) were recorded and reviewed by the expert
committee of the doctors. This study has revealed that cases of
dengue having co-morbidities have longer stay in hospital. Fluid
overload and co-morbidities have been found as major factors leading
to death, however, in a confirmed case of dengue hepatorenal
shutdown was found to be major cause of mortality. The data
obtained will help in sensitizing the treating physicians in order to
decrease the mortality due to dengue in future.
Abstract: Hypertension is a common condition causing cardio
and cerebrovascular complications. Portugal has one of the highest
mortality rates from stroke and a high prevalence of hypertension.
Systolic Blood Pressure (SBP) is an important risk factor for
cardiovascular events (myocardial infarction and stroke) and
premature mortality, particularly in the elderly population. The
present study aims to estimate the prevalence of hypertension in a
Portuguese population living in a coastal city and to identify some of
its determinants (namely gender, age, the body mass index and
physical activity frequency). A total of 91 adults who attended three pharmacies of a coastal
city in the center of Portugal, between May and August of 2013 were
evaluated. Attendants who reported to have diabetes or taking
antihypertensive drugs in the 2 previous weeks were excluded from
the study. Sociodemographic factors, BMI, habits of exercise and BP
were assessed. Hypertension was defined as blood pressure ≥140/90
mmHg. The majority of the studied population was constituted by women
(75.8%), with a mean age of 54.2±1.6 years old, married or living in
civil union and that had completed secondary school or had higher
education (40%). They presented a mean BMI of 26.2±4.76 Kg/m2.,
and were sedentary. The mean BP was 127.0±17.77mmHg- 74.69 ±
9.53. In this population we found 4.3% of people with hypertension
and 16.1% with normal high blood pressure. Men exhibit a tendency to present higher systolic blood pressure
values than women. Of all the factors considered, SBP values also
tended to be higher with age and higher BMI values.
Despite the fact that the mean values of SBP did not present values
higher than 140 mmHg we must be concerned because the studied
population is undiagnosed for hypertension. Although this is a preliminary study, it might be a prelude to the
upcoming research about the underlying factors responsible for the
occurrence of SBP.
Abstract: A teeming set of doctors that graduated from various
universities within and outside Nigeria with the hope of practicing in
the country, has their hope shattered because of poor financing, lack
of medical equipments and a very weak healthcare systems. Such
hydra headed challenges, allows room for quackery which
increasingly contributes to the cause of mortality in Nigeria. With a
view of reversing the challenges of healthcare delivery and financing
in Nigeria, African Health Market for Equity (AHME), a project
funded by the Bill and Melinda Gates foundation [With contribution
from Department For International Development (DFID)] and
currently implemented in three African Countries (Nigeria, Kenya
and Ghana) over a Five (5) year period supports the healthcare sector
via Medical credit fund (MCF). The study examines the impact of
credit policy and medical credit funding on Nigerian health market.
Ordinary least square analysis, correlation and granger causality tests
were employed to measure the extent to which the Nigerian
healthcare market has been influenced. Medical credit fund
significantly and positively influenced average monthly turnover of
private healthcare providers and Commercial bank’s lending rate had
a weak relationship with access to credit/approved loans (13.46%).
The programme has so far made 13.91% progress, which is very
poor, considering the minimum targeted private health care providers
(437.6) and expected number of loan approvals (180.4) for the two
years. Medical credit policy in Nigeria should be revised to include
private healthcare providers in rural area for more positive impact
and increased returns. Good brand advert and sensitization of the
programme to stakeholders and health pressure group, and an
extension of the programme beyond five years is necessary to better
address the issues raised in the study.
Abstract: Tuberculosis (TB) remains a leading cause of
infectious mortality. It is primarily transmitted by the respiratory
route, individuals with active disease may infect others through
airborne particles which releases when they cough, talk, or sing and
subsequently inhale by others. In order to study the effect of the
Bacilli Calmette-Guerin (BCG) vaccine after vaccination of TB
patient, a Vaccinated Susceptible Infected and Recovered (VSIR)
mathematical model is being developed to achieve the desired
objectives. The mathematical model, so developed, shall be used to
quantify the effect of BCG Vaccine to protect the immigrant young
adult person. Moreover, equations are to be established for the
disease endemic and free equilibrium states and subsequently utilized
in disease stability analysis. The stability analysis will give a
complete picture of disease annihilation from the total population if
the total removal rate from the infectious group should be greater
than total number of dormant infections produced throughout
infectious period.
Abstract: In the years followed independence, an economic
crisis and some conflicts led to the displacement of many people
inside Georgia. The growing poverty, unemployment, low income
and its unequal distribution limited access to basic social service have
had a clear direct impact on Georgian population dynamics and its
age-sex structure. Factors influencing the changing population age
structure and urbanization include mortality, fertility, migration and
expansion of urban. In this paper presents the main factors of
changing the distribution by urban and rural areas. How different are
the urban and rural age and sex structures? Does Georgia have the
same age-sex structure among their urban and rural populations since
1950s?
Abstract: Obesity and osteoporosis are the two diseases whose
increasing prevalence and high impact on the global morbidity and
mortality, during the two recent decades, have gained a status of
major health threats worldwide. Obesity purports to affect the bone
metabolism through complex mechanisms. Debated data on the
connection between the bone mineral density and fracture prevalence
in the obese patients are widely presented in literature. There is
evidence that the correlation of weight and fracture risk is sitespecific.
This study is aimed at determining the connection between
the bone mineral density (BMD) and trabecular bone score (TBS)
parameters in Ukrainian women suffering from obesity. We
examined 1025 40-89-year-old women, divided them into the groups
according to their body mass index: Group A included 360 women
with obesity whose BMI was ≥30 kg/m2, and Group B – 665 women
with no obesity and BMI of
Abstract: In the immunologic sense, clinical infection is a state
of failure of the immune system to combat the pathogenic weapon of
the bacteria invading the host. A motile gram negative vibroid
organism associated with marked mono and poly nuclear cell
responses was traced during the examination of a clinical material
from an infected common carp Cyprinus carpio. On primary plate
culture, growth was shown to be pure, dense population of an
Aeromonas-like colony morphotype. The pure isolate was found to
be; Aerobic, facultatively anaerobic, non-halophilic, grew at 0C, and
37C, oxidase positive utilizes glucose through fermentative pathway,
resist 0/129 and novobiocin, produces alanine and lysine
decarboxylases but non-producing ornithine dehydrolases. Tests for
the in vitro determinants of pathogenicity has shown to be; Betahaemolytic
onto blood agar, gelatinase, casienase and amylase
producer. Three in vivo determinants of pathogenicity were tested as,
the lethal dose fifty, the pathogenesis and pathogenicity. It was
evident that 0.1 milliliter of the causal bacterial cell suspension of a
density 1 x 107 CFU/ml injected intramuscularly into an average of
100gms fish toke five days incubation period, then at the day six
morbidity and mortality were initiated. LD50 was recorded at the day
12 post-infection. Use of an LD50 doses to study the pathogenicity,
reveals mononuclear and polynuclear cell responses, on examining
the stained direct films of the clinical materials from the
experimentally infected fish. Re-isolation tests confirm that the reisolant
is same. The course of the infection in natural case was shown
manifestation of; skin ulceration, haemorrhage and descaling. On
evisceration, the internal organs were shown; congestion in the
intestines, spleen and, air sacs. The induced infection showed a
milder form of these manifestations. The grading of the virulence of
this organism was virulent causing chronic course of infections as
indicated from the pathogenesis and pathogenicity studies. Thus the
infectious bacteria were consistent with Aeromonas hydrophila, and
the infection was chronic.
Abstract: During the post-Civil War era, the city of Nashville,
Tennessee, had the highest mortality rate in the United States. The
elevated death and disease rates among former slaves were
attributable to lack of quality healthcare. To address the paucity of
healthcare services, Meharry Medical College, an institution with the
mission of educating minority professionals and serving the
underserved population, was established in 1876.
Purpose: The social ecological framework and partial least squares
(PLS) path modeling were used to quantify the impact of
socioeconomic status and adverse health outcome on primary care
professionals serving the disadvantaged community. Thus, the study
results could demonstrate the accomplishment of the College’s
mission of training primary care professionals to serve in underserved
areas.
Methods: Various statistical methods were used to analyze alumni
data from 1975 – 2013. K-means cluster analysis was utilized to
identify individual medical and dental graduates in the cluster groups
of the practice communities (Disadvantaged or Non-disadvantaged
Communities). Discriminant analysis was implemented to verify the
classification accuracy of cluster analysis. The independent t-test was
performed to detect the significant mean differences of respective
clustering and criterion variables. Chi-square test was used to test if
the proportions of primary care and non-primary care specialists are
consistent with those of medical and dental graduates practicing in
the designated community clusters. Finally, the PLS path model was
constructed to explore the construct validity of analytic model by
providing the magnitude effects of socioeconomic status and adverse
health outcome on primary care professionals serving the
disadvantaged community.
Results: Approximately 83% (3,192/3,864) of Meharry Medical
College’s medical and dental graduates from 1975 to 2013 were
practicing in disadvantaged communities. Independent t-test confirmed the content validity of the cluster analysis model. Also, the
PLS path modeling demonstrated that alumni served as primary care
professionals in communities with significantly lower socioeconomic
status and higher adverse health outcome (p < .001). The PLS path
modeling exhibited the meaningful interrelation between primary
care professionals practicing communities and surrounding
environments (socioeconomic statues and adverse health outcome),
which yielded model reliability, validity, and applicability.
Conclusion: This study applied social ecological theory and
analytic modeling approaches to assess the attainment of Meharry
Medical College’s mission of training primary care professionals to
serve in underserved areas, particularly in communities with low
socioeconomic status and high rates of adverse health outcomes. In
summary, the majority of medical and dental graduates from Meharry
Medical College provided primary care services to disadvantaged
communities with low socioeconomic status and high adverse health
outcome, which demonstrated that Meharry Medical College has
fulfilled its mission. The high reliability, validity, and applicability of
this model imply that it could be replicated for comparable
universities and colleges elsewhere.
Abstract: In Brazil, neonatal mortality rate is considered
incompatible with the country development conditions, and has been
a Public Health concern. Reduction in infant mortality rates has also
been part of the Millennium Development Goals, a commitment
made by countries, members of the Organization of United Nations
(OUN), including Brazil. Fetal mortality rate is considered a highly
sensitive indicator of health care quality. Suitable actions, such as
good quality and access to health services may contribute positively
towards reduction in these fetal and neonatal rates. With appropriate
antenatal follow-up and health care during gestation and delivery,
some death causes could be reduced or even prevented by means of
early diagnosis and intervention, as well as changes in risk factors
and interventions. Objectives: To study the quality of maternal and
infant health care based on fetal and neonatal mortality, as well as the
possible actions to prevent those deaths in Botucatu (Brazil).
Methods: Classification of prevention according to the International
Classification of Diseases and the modified Wigglesworth´s
classification. In order to evaluate adequacy, indicators of quality of
antenatal and delivery care were established by the authors. Results:
Considering fetal deaths, 56.7% of them occurred before delivery,
which reveals possible shortcomings in antenatal care, and 38.2% of
them were a result of intra- labor changes, which could be prevented
or reduced by adequate obstetric management. These findings were
different from those in the group of early neonatal deaths which were
also studied. Adequacy of health services showed that antenatal and
childbirth care was appropriate for 24% and 33.3% of pregnant
women, respectively, which corroborates the results of prevention.
These results revealed that shortcomings in obstetric and antenatal
care could be the causes of deaths in the study. Early and late
neonatal deaths have similar characteristics: 76% could be prevented
or reduced mainly by adequate newborn care (52.9%) and adequate
health care for gestational women (11.7%). When adequacy of care
was evaluated, childbirth and newborn care was adequate in 25.8%
and antenatal care was adequate in 16.1%. In conclusion, direct
relationship was found between adequacy and quality of care
rendered to pregnant women and newborns, and fetal and infant
mortality. Moreover, our findings highlight that deaths could be
prevented by an adequate obstetric and neonatal management.
Abstract: Leukaemia is a blood cancer disease that contributes
to the increment of mortality rate in Malaysia each year. There are
two main categories for leukaemia, which are acute and chronic
leukaemia. The production and development of acute leukaemia cells
occurs rapidly and uncontrollable. Therefore, if the identification of
acute leukaemia cells could be done fast and effectively, proper
treatment and medicine could be delivered. Due to the requirement of
prompt and accurate diagnosis of leukaemia, the current study has
proposed unsupervised pixel segmentation based on clustering
algorithm in order to obtain a fully segmented abnormal white blood
cell (blast) in acute leukaemia image. In order to obtain the
segmented blast, the current study proposed three clustering
algorithms which are k-means, fuzzy c-means and moving k-means
algorithms have been applied on the saturation component image.
Then, median filter and seeded region growing area extraction
algorithms have been applied, to smooth the region of segmented
blast and to remove the large unwanted regions from the image,
respectively. Comparisons among the three clustering algorithms are
made in order to measure the performance of each clustering
algorithm on segmenting the blast area. Based on the good sensitivity
value that has been obtained, the results indicate that moving kmeans
clustering algorithm has successfully produced the fully
segmented blast region in acute leukaemia image. Hence, indicating
that the resultant images could be helpful to haematologists for
further analysis of acute leukaemia.
Abstract: Liver disorders are one of the major problems of the
world. Despite its frequent occurrence, high morbidity and high
mortality, its medical management is currently inadequate. This study
was designed to evaluate the hepatoprotective effect of saponin
extract of the root of Garcinia kola on the integrity of the liver of
paracetamol induced wistar albino rats. Twenty five (25) male adult
wistar albino rats were divided into five (5) groups. Group I was the
Control group that received distilled water only, group II was the
negative control that received 2 g/kg of paracetamol on the 13th day,
and group III, IV and V were pre-treated with 100, 200 and
400mg/kg of the saponin extract before inducing the liver damage on
the 13th day with 2 g/kg of paracetamol. Twenty four (24) h after
administration, the rats were sacrificed and blood samples were
collected. The serum Alanine Transaminase (ALT), Aspartate
Transaminase (AST), Alkaline Phosphatase (ALP) activities,
Bilirubin and conjugated bilirubin, glucose and protein
concentrations were evaluated. The liver was fixed immediately in
Formalin and was processed and stained in Haematoxylin and Eosin
(H&E). Administration of saponin extract from the root of Garcinia
kola significantly decreased paracetamol induced elevated enzymes
in the test group. Also histological observations showed that saponin
extract of the root of Garcinia kola exhibited a significant liver
protection against the toxicant as evident by the cells trying to return
to normal. Saponin extract from the root of Garcinia kola indicated a
protection of structural integrity of the hepatocytic cell membrane
and regeneration of the damaged liver.
Abstract: The efficiency of wood vinegar mixed with each
individual of three plants extract such as: citronella grass
(Cymbopogon nardus), neem seed (Azadirachta indica A. Juss), and
yam bean seed (Pachyrhizus erosus Urb.) were tested against the
second instar larvae of housefly (Musca domestica L.). Steam
distillation was used for extraction of the citronella grass while neem
and yam bean were simple extracted by fermentation with ethyl
alcohol. Toxicity test was evaluated in laboratory based on two
methods of larvicidal bioassay: topical application method (contact
poison) and feeding method (stomach poison). Larval mortality was
observed daily and larval survivability was recorded until the
survived larvae developed to pupae and adults. The study resulted
that treatment of wood vinegar mixed with citronella grass showed
the highest larval mortality by topical application method (50.0%)
and by feeding method (80.0%). However, treatment of mixed wood
vinegar and neem seed showed the longest pupal duration to 25 day
and 32 days for topical application method and feeding method
respectively. Additional, larval duration on treated M. domestica
larvae was extended to 13 days for topical application method and 11
days for feeding method. Thus, the feeding method gave higher
efficiency compared with the topical application method.
Abstract: Background: Bleeding during first half of pregnancy
mostly originates from placenta, some abort, others are at risk of
complications. Objective: Study was done to know perinatal outcome
with bleeding up to 20 weeks in singleton pregnancy. Material
Methods: Subjects were 1020, equal controls managed over 2 years,
435 had viable pregnancy at admission, 135 excluded, 300 followed
for perinatal outcome, 99 (19.52% up to 10 weeks), 201 (39.18% of
11-20 weeks). Results: Hypertensive disorders occurred in 24% cases
of bleeding within 10 weeks, 22% 11-20 weeks 14.79% controls,
placenta previa 4% in 10 weeks, 0.9% 11-20 weeks, 0.97% controls,
prelabor rupture of membranes in 16%, 7.45% controls. 20% up to 10
weeks, 35% 11-20 weeks, 18% controls had fetal growth restriction,
34.34% up to 10 weeks 30.35% of 11-20 weeks 17.17% controls had
preterm births, perinatal mortality rate in study was 118.62, in
controls 68.16 (Uneventful pregnancy in 13.52% study, 46.11%
controls). Conclusion: Once bleeding occurs, one third continue
pregnancy, maternal neonatal outcome gets affected with variations
in cases of bleeding within first 10 weeks & 11-20 weeks.
Abstract: Muscid flies are known to be vectors of disease agents and species that annoy humans and domesticated animals. An example of these flies is Musca domestica (house fly) whose adult and immature stages occur in a variety of filthy organic substances including household garbage and animal manures. They contribute to microbial contamination of foods. It is therefore imperative to control these flies as a result of their role in Public health. The second and third instars of Musca domestica (Linn) were infected with varying cell loads of Bacillus subtilis in vitro for a period of 48 hours to evaluate its larvicidal activities. Mortality of the larvae increased with incubation period after treatment with the varying cell loads. Investigation revealed that the second instars larvae were more susceptible to treatment than the third instars treatments. Values obtained from the third instar group were significantly different (P
Abstract: Malaria constitutes one of the major health problems
in Nigeria. One of the reasons attributed for the upsurge was the
development of resistance of Plasmodium falciparum and the
emergence of multi-resistant strains of the parasite to anti-malaria
drugs. A continued search for other effective, safe and cheap plantbased
anti-malaria agents thus becomes imperative in the face of
these difficulties. The objective of this study is therefore to evaluate
the in vivo anti-malarial efficacy of ethanolic extracts of
Chromolaena odorata and Androgaphis paniculata leaves. The two
plants were evaluated for their anti-malaria efficacy in vivo in a 4-day
curative test assay against Plasmodium berghei strain in mice. The
group treated with 500mg/ml dose of ethanolic extract of A.
paniculata plant showed parasite suppression with increase in Packed
Cell Volume (PCV) value except day 3 which showed a slight
decrease in PCV value. During the 4-day curative test, an increase in
the PCV values, weight measurement and zero count of Plasmodium
berghei parasite values was recorded after day 3 of drug
administration. These results obtained in group treated with A.
paniculata extract showed anti-malarial efficacy with higher
mortality rate in parasitaemia count when compared with
Chromolaena odorata group. These results justify the use of
ethanolic extracts of A. paniculata plant as medicinal herb used in
folklore medicine in the treatment of malaria.