Abstract: There is an urgent need to develop novel
Mycobacterium tuberculosis (Mtb) drugs that are active against drug
resistant bacteria but, more importantly, kill persistent bacteria. Our
study structured based on integrated analysis of metabolic pathways,
small molecule screening and similarity Search in PubChem
Database. Metabolic analysis approaches based on Unified weighted
used for potent target selection. Our results suggest that pantothenate
synthetase (panC) and and 3-methyl-2-oxobutanoate hydroxymethyl
transferase (panB) as a appropriate drug targets. In our study, we
used pantothenate synthetase because of existence inhibitors. We
have reported the discovery of new antitubercular compounds
through ligand based approaches using computational tools.
Abstract: Determination of nano particle size is substantial since
the nano particle size exerts a significant effect on various properties
of nano materials. Accordingly, proposing non-destructive, accurate
and rapid techniques for this aim is of high interest. There are some
conventional techniques to investigate the morphology and grain size
of nano particles such as scanning electron microscopy (SEM),
atomic force microscopy (AFM) and X-ray diffractometry (XRD).
Vibrational spectroscopy is utilized to characterize different
compounds and applied for evaluation of the average particle size
based on relationship between particle size and near infrared spectra
[1,4] , but it has never been applied in quantitative morphological
analysis of nano materials. So far, the potential application of nearinfrared
(NIR) spectroscopy with its ability in rapid analysis of
powdered materials with minimal sample preparation, has been
suggested for particle size determination of powdered
pharmaceuticals. The relationship between particle size and diffuse
reflectance (DR) spectra in near infrared region has been applied to
introduce a method for estimation of particle size. Back propagation
artificial neural network (BP-ANN) as a nonlinear model was applied
to estimate average particle size based on near infrared diffuse
reflectance spectra. Thirty five different nano TiO2 samples with
different particle size were analyzed by DR-FTNIR spectrometry and
the obtained data were processed by BP- ANN.
Abstract: A virtual collaborative classroom was created at East Carolina University, using videoconference technology via regular internet to bring students from 18 different countries, 2 at a time, to the ECU classroom in real time to learn about each other-s culture. Students from two countries are partnered one on one, they meet for 4-5 weeks, and submit a joint paper. Then the same process is repeated for two other countries. Lectures and student discussions are managed with pre-determined topics and questions. Classes are conducted in English and reading assignments are placed on the website. Administratively all partners are independent, students pay fees and get credits at their home institution. Familiarity with technology, knowledge in cultural understanding and attitude change were assessed, only attitude changes are reported in this paper. After taking this course, all students stated their comfort level in working with, and their desire to interact with, culturally different others grew stronger and their xenophobia and isolationist attitudes decreased.
Abstract: Data from 1731 Gentile di Puglia lambs, sired by 65 rams over a 5-year period were analyzed by a mixed model to estimate the variance components for heritability. The considered growth traits were: birth weight (BW), weight at 30 days of age (W30) and average daily gain from birth to 30 days of age (DG). Year of birth, sex of lamb, type of birth (single or twin), dam age at lambing and farm were significant sources of variation for all the considered growth traits. The average lamb weights were 3.85±0.16 kg at birth, 9.57±0.91 kg at 30 days of age and the average daily gain was 191±14 g. Estimates of heritability were 0.33±0.05, 0.41±0.06 and 0.16±0.05 respectively for the same traits. These values suggest there is a good opportunity to improve Gentile di Puglia lambs by selecting animals for growth traits.
Abstract: We have investigated the effect of piezoelectric (PZ)
polarization property in binary as well as in ternary wurtzite nitrides.
It is found that with the presence of PZ polarization property, the
phonon group velocity is modified. The change in phonon group
velocity due to PZ polarization effect directly depends on
piezoelectric tensor value. Using different piezoelectric tensor values
recommended by different workers in the literature, percent change in
group velocities of phonons has been estimated. The Debye
temperatures and frequencies of binary nitrides GaN, AlN and InN
are also calculated using the modified group velocities. For ternary
nitrides AlxGa(1-x)N, InxGa(1-x)N and InxAl(1-x)N, the phonon group
velocities have been calculated as a functions of composition. A
small positive bowing is observed in phonon group velocities of
ternary alloys. Percent variations in phonon group velocities are also
calculated for a straightforward comparison among ternary nitrides.
The results are expected to show a change in phonon relaxation rates
and thermal conductivity of III-nitrides when piezoelectric
polarization property is taken into consideration.
Abstract: This paper proposes a new approach to offer a private
cloud service in HPC clusters. In particular, our approach relies on
automatically scheduling users- customized environment request as a
normal job in batch system. After finishing virtualization request jobs,
those guest operating systems will dismiss so that compute nodes will
be released again for computing. We present initial work on the
innovative integration of HPC batch system and virtualization tools
that aims at coexistence such that they suffice for meeting the
minimizing interference required by a traditional HPC cluster. Given
the design of initial infrastructure, the proposed effort has the potential
to positively impact on synergy model. The results from the
experiment concluded that goal for provisioning customized cluster
environment indeed can be fulfilled by using virtual machines, and
efficiency can be improved with proper setup and arrangements.
Abstract: Multi-site damage (MSD) has been a challenge to
aircraft, civil and power plant structures. In real life components are subjected to cracking at many vulnerable locations such as the bolt
holes. However, we do not consider for the presence of multiple cracks. Unlike components with a single crack, these components are
difficult to predict. When two cracks approach one another, their
stress fields influence each other and produce enhancing or shielding effect depending on the position of the cracks. In the present study,
numerical studies on fracture analysis have been conducted by using
the developed code based on the modified virtual crack closure integral (MVCCI) technique and finite element analysis (FEA) software ABAQUS for computing SIF of plates with multiple cracks.
Various parametric studies have been carried out and the results have
been compared with literature where ever available and also with the solution, obtained by using ABAQUS. By conducting extensive
numerical studies expressions for SIF have been obtained for collinear cracks and non-aligned cracks.
Abstract: Information and Communication Technologies (ICT) are increasing in importance everyday, especially since the 90’s (last decade of birth for the Millennials generation). While social interactions involving the Millennials generation have been studied, a lack of investigation remains regarding the use of the ICT by this generation as well as the impact on outcomes in education and professional training. Observing and interviewing students preparing a MSc, we aimed at characterizing the interaction students-ICT during the courses. We found that up to 50% of the students (mainly female) could use ICT during courses at a rate of 0.84 occurrence/minutes for some of them, and they thought this involvement did not disturb learning, even was helpful. As recent researches show that multitasking leads people think they are much better than they actually are, further observations with assessments are needed to conclude whether or not the use ICT by students during the courses is a real strength.
Abstract: In this study, we propose a network architecture for
providing secure access to information resources of enterprise
network from remote locations in a wireless fashion. Our proposed
architecture offers a very promising solution for organizations which
are in need of a secure, flexible and cost-effective remote access
methodology. Security of the proposed architecture is based on
Virtual Private Network technology and a special role based access
control mechanism with location and time constraints. The flexibility
mainly comes from the use of Internet as the communication medium
and cost-effectiveness is due to the possibility of in-house
implementation of the proposed architecture.
Abstract: This paper presents comparative study on recent
integer DCTs and a new method to construct a low sensitive structure
of integer DCT for colored input signals. The method refers to
sensitivity of multiplier coefficients to finite word length as an
indicator of how word length truncation effects on quality of output
signal. The sensitivity is also theoretically evaluated as a function of
auto-correlation and covariance matrix of input signal. The structure of
integer DCT algorithm is optimized by combination of lower sensitive
lifting structure types of IRT. It is evaluated by the sensitivity of
multiplier coefficients to finite word length expression in a function of
covariance matrix of input signal. Effectiveness of the optimum
combination of IRT in integer DCT algorithm is confirmed by quality
improvement comparing with existing case. As a result, the optimum
combination of IRT in each integer DCT algorithm evidently improves
output signal quality and it is still compatible with the existing one.
Abstract: There are three approaches to complete Bayesian
Network (BN) model construction: total expert-centred, total datacentred,
and semi data-centred. These three approaches constitute the
basis of the empirical investigation undertaken and reported in this
paper. The objective is to determine, amongst these three
approaches, which is the optimal approach for the construction of a
BN-based model for the performance assessment of students-
laboratory work in a virtual electronic laboratory environment. BN
models were constructed using all three approaches, with respect to
the focus domain, and compared using a set of optimality criteria. In
addition, the impact of the size and source of the training, on the
performance of total data-centred and semi data-centred models was
investigated. The results of the investigation provide additional
insight for BN model constructors and contribute to literature
providing supportive evidence for the conceptual feasibility and
efficiency of structure and parameter learning from data. In addition,
the results highlight other interesting themes.
Abstract: Studies were carried out to determine the in vitro
susceptibility of the typhoid pathogens to combined action of Euphorbia hirta, Euphorbia heterophylla and Phyllanthus niruri. Clinical isolates of the typhoid bacilli were subjected to susceptibility testing using agar diffusion technique and the minimum inhibitory
concentration (MIC) determined with tube dilution technique. These
isolates, when challenged with doses of the extracts from the three
medicinal plants showed zones of inhibition as wide as 26±0.2mm, 22±0.1mm and 18±0.0mm respectively. The minimum inhibitory concentration (MIC) revealed organisms inhibited at varying
concentrations of extracts: E. hirta (S. typhi 0.250mg/ml, S. paratyphi A 0.125mg/ml, S. paratyphi B 0.185mg/ml and S. paratyphi C 0.225mg/ml), E. heterophylla (S. typhi 0.280mg/ml, S. paratyphi A
0.150mg/ml, S. paratyphi B 0.200mg/ml and S. paratyphi C 0.250mg/ml) and P. niruri (S. typhi 0.150mg/ml, S. paratyphi A 0.100mg/ml, S. paratyphi B 0.115mg/ml and S. paratyphi C 0.125mg/ml). The results of the synergy between the three plants in
the ration of 1:1:1 showed very low MICs for the test pathogens as follows S. typhi 0.025mg/ml, S. paratyphi A 0.080mg/ml, S. paratyphi B 0.015mg/ml and S. paratyphi C 0.10mg/ml with the
diameter zone of inhibition (DZI) ranging from 35±0.2mm,
28±0.4mm, 20±0.1mm and 32±0.3mm respectively. The secondary
metabolites were identified using simple methods and HPLC. Organic components such as anthroquinones, different alkaloids,
tannins, 6-ethoxy-1,2,3,4-tetrahydro-2,2,4-trimethyl and steroids were identified. The prevalence of Salmonellae, a deadly infectious disease, is still very high in parts of Nigeria. The synergistic action of these three plants is very high. It is concluded that pharmaceutical companies should take advantage of these findings to develop new
anti-typhoid drugs from these plants.
Abstract: The Inter feeder Power Flow Regulator (IFPFR)
proposed in this paper consists of several voltage source inverters
with common dc bus; each inverter is connected in series with one of
different independent distribution feeders in the power system. This
paper is concerned with how to transfer power between the feeders for
load sharing purpose. The power controller of each inverter injects
the power (for sending feeder) or absorbs the power (for receiving
feeder) via injecting suitable voltage; this voltage injection is
simulated by voltage drop across series virtual impedance, the
impedance value is selected to achieve the concept of power exchange
between the feeders without perturbing the load voltage magnitude of
each feeder. In this paper a new control scheme for load sharing using
IFPFR is proposed.
Abstract: Following the loss of NASA's Space Shuttle
Columbia in 2003, it was determined that problems in the agency's
organization created an environment that led to the accident. One
component of the proposed solution resulted in the formation of the
NASA Engineering Network (NEN), a suite of information retrieval
and knowledge-sharing tools. This paper describes the
implementation of communities of practice, which are formed along
engineering disciplines. Communities of practice enable engineers to
leverage their knowledge and best practices to collaborate and take
information learning back to their jobs and embed it into the
procedures of the agency. This case study offers insight into using
traditional engineering disciplines for virtual collaboration, including
lessons learned during the creation and establishment of NASA-s
communities.
Abstract: Characteristics and sonocatalytic activity of zeolite
Y catalysts loaded with TiO2 using impregnation and ion exchange
methods for the degradation of amaranth dye were investigated.
The Ion-exchange method was used to encapsulate the TiO2 into
the internal pores of the zeolite while the incorporation of TiO2
mostly on the external surface of zeolite was carried out using the
impregnation method. Different characterization techniques were
used to elucidate the physicochemical properties of the produced
catalysts. The framework of zeolite Y remained virtually
unchanged after the encapsulation of TiO2 while the crystallinity of
zeolite decreased significantly after the incorporation of 15 wt% of
TiO2. The sonocatalytic activity was enhanced by TiO2
incorporation with maximum degradation efficiencies of 50% and
68% for the encapsulated titanium and titanium loaded onto the
zeolite, respectively after 120min of reaction. Catalysts
characteristics and sonocatalytic behaviors were significantly
affected by the preparation method and the location of TiO2
introduced with zeolite structure. Behaviors in the sonocatalytic
process were successfully correlated with the characteristics of the
catalysts used.
Abstract: In this study, active tendons with Proportional Integral
Derivation type controllers were applied to a SDOF and a MDOF
building model. Physical models of buildings were constituted with
virtual springs, dampers and rigid masses. After that, equations of
motion of all degrees of freedoms were obtained. Matlab Simulink
was utilized to obtain the block diagrams for these equations of
motion. Parameters for controller actions were found by using a trial
method. After earthquake acceleration data were applied to the
systems, building characteristics such as displacements, velocities,
accelerations and transfer functions were analyzed for all degrees of
freedoms. Comparisons on displacement vs. time, velocity vs. time,
acceleration vs. time and transfer function (Db) vs. frequency (Hz)
were made for uncontrolled and controlled buildings. The results
show that the method seems feasible.
Abstract: This article discusses the customs and traditions in
Turkestan in the late XIXth and early XXth centuries. Having a long
history, Turkestan is well-known as the birthplace of many nations
and nationalities. The name of Turkestan is also given to it for a
reason - the land of the Turkic peoples who inhabited Central Asia
and united under together. Currently, nations and nationalities of the
Turkestan region formed their own sovereign states, and every year
they prove their country names in the world community. Political,
economic importance of Turkestan, which became the gold wire
between Asia and Europe was always very high. So systematically
various aggressive actions were made by several great powers. As a
result of expansionary policy of colonization of the Russian Empire -
the Turkestan has appeared.
Abstract: Fuel and oxidant gas delivery plate, or fuel cell
plate, is a key component of a Proton Exchange Membrane (PEM)
fuel cell. To manufacture low-cost and high performance fuel cell
plates, advanced computer modeling and finite element structure
analysis are used as virtual prototyping tools for the optimization
of the plates at the early design stage. The present study examines
thermal stress analysis of the fuel cell plates that are produced
using a patented, low-cost fuel cell plate production technique
based on screen-printing. Design optimization is applied to
minimize the maximum stress within the plate, subject to strain
constraint with both geometry and material parameters as design
variables. The study reveals the characteristics of the printed
plates, and provides guidelines for the structure and material design
of the fuel cell plate.
Abstract: This paper proposed a stiffness analysis method for a
3-PRS mechanism for welding thick aluminum plate using FSW
technology. In the molding process, elastic deformation of lead-screws
and links are taken into account. This method is based on the virtual
work principle. Through a survey of the commonly used stiffness
performance indices, the minimum and maximum eigenvalues of the
stiffness matrix are used to evaluate the stiffness of the 3-PRS
mechanism. Furthermore, A FEA model has been constructed to verify
the method. Finally, we redefined the workspace using the stiffness
analysis method.
Abstract: In this work, we improve a previously developed
segmentation scheme aimed at extracting edge information from
speckled images using a maximum likelihood edge detector. The
scheme was based on finding a threshold for the probability density
function of a new kernel defined as the arithmetic mean-to-geometric
mean ratio field over a circular neighborhood set and, in a general
context, is founded on a likelihood random field model (LRFM). The
segmentation algorithm was applied to discriminated speckle areas
obtained using simple elliptic discriminant functions based on
measures of the signal-to-noise ratio with fractional order moments.
A rigorous stochastic analysis was used to derive an exact expression
for the cumulative density function of the probability density
function of the random field. Based on this, an accurate probability
of error was derived and the performance of the scheme was
analysed. The improved segmentation scheme performed well for
both simulated and real images and showed superior results to those
previously obtained using the original LRFM scheme and standard
edge detection methods. In particular, the false alarm probability was
markedly lower than that of the original LRFM method with
oversegmentation artifacts virtually eliminated. The importance of
this work lies in the development of a stochastic-based segmentation,
allowing an accurate quantification of the probability of false
detection. Non visual quantification and misclassification in medical
ultrasound speckled images is relatively new and is of interest to
clinicians.