Abstract: Gene expression profiling is rapidly evolving into a
powerful technique for investigating tumor malignancies. The
researchers are overwhelmed with the microarray-based platforms
and methods that confer them the freedom to conduct large-scale
gene expression profiling measurements. Simultaneously,
investigations into cross-platform integration methods have started
gaining momentum due to their underlying potential to help
comprehend a myriad of broad biological issues in tumor diagnosis,
prognosis, and therapy. However, comparing results from different
platforms remains to be a challenging task as various inherent
technical differences exist between the microarray platforms. In this
paper, we explain a simple ratio-transformation method, which can
provide some common ground for cDNA and Affymetrix platform
towards cross-platform integration. The method is based on the
characteristic data attributes of Affymetrix- and cDNA- platform. In
the work, we considered seven childhood leukemia patients and their
gene expression levels in either platform. With a dataset of 822
differentially expressed genes from both these platforms, we carried
out a specific ratio-treatment to Affymetrix data, which subsequently
showed an improvement in the relationship with the cDNA data.
Abstract: Life is beautiful. But, it is decided by genes, environment and the individual and shattered by the natural and / or the invited problems. Most of the global rural helpless masses are struggling for their survival since; they are neglected in all aspects of life including health. Amidst a countless number of miserable diseases in man, diabetes is becoming a dreaded killer and ramifying the entire globe in a jet speed. Diabetes control continues as a Herculean task to the scientific community and the modern society in the 21st century also. T2DM is not pertaining to any age and it can develop even during the childhood. This multifactorial disease abruptly changes the activities of certain vital biomarkers in the present rural T2DM cases. A remarkable variation in the levels of biomarkers like AST, ALT, GGT, ALP, LDH, HbA1C, C- peptide, fasting sugar, post-prandial sugar, sodium, potassium, BUN, creatinine and insulin show the rampant nature of T2DM in this physically active rural agrarian community.
Abstract: The evaluation and measurement of human body
dimensions are achieved by physical anthropometry. This research
was conducted in view of the importance of anthropometric indices
of the face in forensic medicine, surgery, and medical imaging. The
main goal of this research is to optimization of facial feature point by
establishing a mathematical relationship among facial features and
used optimize feature points for age classification. Since selected
facial feature points are located to the area of mouth, nose, eyes and
eyebrow on facial images, all desire facial feature points are extracted
accurately. According this proposes method; sixteen Euclidean
distances are calculated from the eighteen selected facial feature
points vertically as well as horizontally. The mathematical
relationships among horizontal and vertical distances are established.
Moreover, it is also discovered that distances of the facial feature
follows a constant ratio due to age progression. The distances
between the specified features points increase with respect the age
progression of a human from his or her childhood but the ratio of the
distances does not change (d = 1 .618 ) . Finally, according to the
proposed mathematical relationship four independent feature
distances related to eight feature points are selected from sixteen
distances and eighteen feature point-s respectively. These four feature
distances are used for classification of age using Support Vector
Machine (SVM)-Sequential Minimal Optimization (SMO) algorithm
and shown around 96 % accuracy. Experiment result shows the
proposed system is effective and accurate for age classification.
Abstract: The overall penumbra is usually defined as the
distance, p20–80, separating the 20% and 80% of the dose on the beam axis at the depth of interest. This overall penumbra accounts
also for the fact that some photons emitted by the distal parts of the source are only partially attenuated by the collimator. Medulloblastoma is the most common type of childhood brain tumor
and often spreads to the spine. Current guidelines call for surgery to remove as much of the tumor as possible, followed by radiation of the brain and spinal cord, and finally treatment with chemotherapy.
The purpose of this paper was to present results on an Uniformity of dose distribution in radiation fields surrounding the spine using film
dosimetry and comparison with 3D treatment planning software.
Abstract: A series of microarray experiments produces observations
of differential expression for thousands of genes across multiple
conditions.
Principal component analysis(PCA) has been widely used in
multivariate data analysis to reduce the dimensionality of the data in
order to simplify subsequent analysis and allow for summarization of
the data in a parsimonious manner. PCA, which can be implemented
via a singular value decomposition(SVD), is useful for analysis of
microarray data.
For application of PCA using SVD we use the DNA microarray
data for the small round blue cell tumors(SRBCT) of childhood
by Khan et al.(2001). To decide the number of components which
account for sufficient amount of information we draw scree plot.
Biplot, a graphic display associated with PCA, reveals important
features that exhibit relationship between variables and also the
relationship of variables with observations.
Abstract: Data Mining aims at discovering knowledge out of
data and presenting it in a form that is easily comprehensible to
humans. One of the useful applications in Egypt is the Cancer
management, especially the management of Acute Lymphoblastic
Leukemia or ALL, which is the most common type of cancer in
children.
This paper discusses the process of designing a prototype that can
help in the management of childhood ALL, which has a great
significance in the health care field. Besides, it has a social impact
on decreasing the rate of infection in children in Egypt. It also
provides valubale information about the distribution and
segmentation of ALL in Egypt, which may be linked to the possible
risk factors.
Undirected Knowledge Discovery is used since, in the case of this
research project, there is no target field as the data provided is
mainly subjective. This is done in order to quantify the subjective
variables. Therefore, the computer will be asked to identify
significant patterns in the provided medical data about ALL. This
may be achieved through collecting the data necessary for the
system, determimng the data mining technique to be used for the
system, and choosing the most suitable implementation tool for the
domain.
The research makes use of a data mining tool, Clementine, so as to
apply Decision Trees technique. We feed it with data extracted from
real-life cases taken from specialized Cancer Institutes. Relevant
medical cases details such as patient medical history and diagnosis
are analyzed, classified, and clustered in order to improve the disease
management.
Abstract: The research objective aims to search information about storytelling and fable associated with fireflies in Amphawa community, in order to design and create a story book which is appropriate for the interests of children in early childhood. This book should help building the development of learning about the natural environment, imagination, and creativity among children, which then, brings about the promotion of the development, conservation and dissemination of cultural values and uniqueness of the Amphawa community. The population used in this study were 30 students in early childhood aged between 6-8 years-old, grade 1-3 from the Demonstration School of Suan Sunandha Rajabhat University. The method used for this study was purposive sampling and the research conducted by the query and analysis of data from both the document and the narrative field tales and fable associated with the fireflies of Amphawa community. Then, using the results to synthesize and create a conceptual design in a form of 8 visual images which were later applied to 1 illustrated children’s book and presented to the experts to evaluate and test this media.
Abstract: Failure in mastery of motor skills proficiency during
childhood has been seen as a detrimental factor for children to be
physically active. Lack of motor skills proficiency tends to reduce
children’s competency and confidence level to participate in physical
activity. As a consequence of less participation in physical activity,
children will turn to be overweight and obese. It has been suggested
that children who master motor skill proficiency will be more
involved in physical activity thus preventing them from being
overweight. Obesity has become a serious childhood health issues
worldwide. Previous studies have found that children who were
overweight and obese were generally less active however these
studies focused on one gender. This study aims to compare motor
skill proficiency of underweight, normal-weight, overweight and
obese young boys as well as to determine the relationship between
motor skills proficiency and body composition. 112 boys aged
between 8 to 10 years old participated in this study. Participants were
assigned to four groups; underweight, normal-weight, overweight and
obese using BMI-age percentile chart for children. Bruininks-
Oseretsky Test Second Edition-Short Form was administered to
assess their motor skill proficiency. Meanwhile, body composition
was determined by the skinfold thickness measurement. Result
indicated that underweight and normal children were superior in
motor skills proficiency compared to overweight and obese children
(p < 0.05). A significant strong inverse correlation between motor
skills proficiency and body composition (r = -0.849) is noted. The
findings of this study could be explained by non-contributory mass
that carried by overweight and obese children leads to biomechanical
movement inefficiency which will become detrimental to motor skills
proficiency. It can be concluded that motor skills proficiency is
inversely correlated with body composition.
Abstract: The people are differed by their capabilities, skills and mental agilities. The evolution of human from childhood when they are completely dependent up to adultness the time they gradually set the dependency free is too complicated, by considering they have all started from almost one point but some become cleverer and some less. The main control command of a cybernetic hand should be posted by remaining healthy organs of disabled Person. These commands can be from several channels, which their recording and detecting are different and need complicated study. In this research, we suppose that, this stage has been done or in the other words, the command has been already sent and detected. So the main goal is to control a long hand, upper elbow hand missing, by an interest angle define by disabled. It means that, the system input is the position desired by disables and the output is the elbow-joint angle variation. Therefore the goal is a suitable control design based on neural network theory in order to meet the given mapping.
Abstract: Mathematical models can be used to describe the
transmission of disease. Dengue disease is the most significant
mosquito-borne viral disease of human. It now a leading cause of
childhood deaths and hospitalizations in many countries. Variations
in environmental conditions, especially seasonal climatic parameters,
effect to the transmission of dengue viruses the dengue viruses and
their principal mosquito vector, Aedes aegypti. A transmission model
for dengue disease is discussed in this paper. We assume that the
human and vector populations are constant. We showed that the local
stability is completely determined by the threshold parameter, 0 B . If
0 B is less than one, the disease free equilibrium state is stable. If
0 B is more than one, a unique endemic equilibrium state exists and
is stable. The numerical results are shown for the different values of
the transmission probability from vector to human populations.