Abstract: The study reports about the influence of binding of orthosteric ligands as well as point mutations on the conformational dynamics of β-2-adrenoreceptor. Using molecular dynamics simulation we found that there was a little fraction of active states of the receptor in its apo (ligand free) ensemble corresponded to its constitutive activity. Analysis of MD trajectories indicated that such spontaneous activation of the receptor is accompanied by the motion in intracellular part of its alpha-helices. Thus receptor’s constitutive activity directly results from its conformational dynamics. On the other hand the binding of a full agonist resulted in a significant shift of the initial equilibrium towards its active state. Finally, the binding of the inverse agonist stabilized the receptor in its inactive state. It is likely that the binding of inverse agonists might be a universal way of constitutive activity inhibition in vivo. Our results indicate that ligand binding redistribute pre-existing conformational degrees of freedom (in accordance to the Monod-Wyman-Changeux-Model) of the receptor rather than cause induced fit in it. Therefore, the ensemble of biologically relevant receptor conformations is encoded in its spatial structure, and individual conformations from that ensemble might be used by the cell in conformity with the physiological behavior.
Abstract: Sand cast samples of the as-received 66/34Mg-Al alloy were first homogenized at 4900C and then divided into three groups on which annealing, normalising and artificial ageing were respectively carried out. Thermal ageing of the samples involved treatment at 5000C, soaked for 4 hours and quenched in water at ambient temperature followed by tempering at 2000C for 2 hours. Test specimens were subjected to microstructure and mechanical analyses and the results compared. Precipitation of significant volume of stable Mg17Al12 crystals in the aged specimen’s matrix conferred superior mechanical characteristics compared with the annealed, normalized and as-cast specimens. The ultimate tensile strength was 93.4MPa with micro-hardness of 64.9HRC and impact energy (toughness) of 4.05J. In particular, its Young modulus was 10.4GPa which compared well with that of cortical (trabecule) bone’s modulus that varies from 12-17GPa.
Abstract: Mathematical models of drying are used for the purpose of understanding the drying process in order to determine important parameters for design and operation of the dryer. The jackfruit is a fruit with high consumption in the Northeast and perishability. It is necessary to apply techniques to improve their conservation for longer in order to diffuse it by regions with low consumption. This study aimed to analyze several mathematical models (Page, Lewis, and Midilli) to indicate one that best fits the conditions of convective drying process using performance indicators associated with each model: accuracy (Af) and noise factors (Bf), mean square error (RMSE) and standard error of prediction (% SEP). Jackfruit drying was carried out in convective type tray dryer at a temperature of 50°C for 9 hours. It is observed that the model Midili was more accurate with Af: 1.39, Bf: 1.33, RMSE: 0.01%, and SEP: 5.34. However, the use of the Model Midilli is not appropriate for purposes of control process due to need four tuning parameters. With the performance indicators used in this paper, the Page model showed similar results with only two parameters. It is concluded that the best correlation between the experimental and estimated data is given by the Page’s model.
Abstract: Events discrimination and decision maker in sport field are the subject of many interesting studies in computer vision and artificial intelligence. A large volume of research has been conducted for automatic semantic event detection and summarization of sports videos. Indeed the results of these researches have a very significant contribution, as well to television broadcasts as to the football teams, since the result of sporting event can be reflected on the economic field. In this paper, we propose a novel fuzzy sequential technique which lead to discriminate events and specify the technico-tactics on going the game, nor the fuzzy system or the sequential one, may be able to respond to the asked question, in fact fuzzy process is not sufficient, it does not respect the chronological order according the time of various events, similarly the sequential process needs flexibility about the parameters used in this study, it may affect a membership degree of each parameter on the one hand and respect the sequencing of events for each frame on the other hand. Indeed this technique describes special events such as dribbling, headings, short sprints, rapid acceleration or deceleration, turning, jumping, kicking, ball occupation, and tackling according velocity vectors of the two players and the ball direction.
Abstract: Forest areas are particularly susceptible to fires, which are often manmade. One of the most fire affected forest regions in the world is the Mediterranean. Libya, in the Mediterranean region, has soils that are considered to be arid except in a small area called Aljabal Alakhdar (Green mountain), which is the geographic area covered by this study. Like other forests in the Mediterranean it has suffered extreme degradation. This is mainly due to people removing fire wood, or sometimes converting forested areas to agricultural use, as well as fires which may alter several soil chemical and physical properties. The purpose of this study was to evaluate the effects of fires on the physical properties of soil of Aljabal Alakhdar forest in the north-east of Libya. The physical properties of soil following fire in two geographic areas have been determined, with those subjected to the fire compared to those in adjacent unburned areas in one coastal and one mountain site. Physical properties studied were: soil particle size (soil texture), soil water content, soil porosity and soil particle density. For the first time in Libyan soils, the effect of burning on the magnetic susceptibility properties of soils was also tested. The results showed that the soils in both study sites, irrespective of burning or depth fell into the category of a silt loam texture, low water content, homogeneity of porosity of the soil profiles, relatively high soil particle density values and there is a much greater value of the soil magnetic susceptibility in the top layer from both sites except for the soil water content and magnetic susceptibility, fire has not had a clear effect on the soils’ physical properties.
Abstract: The calcarenites carbonate rocks of the Quaternary ridges, which extend along the northwestern Mediterranean coastal plain of Egypt, represent an excellent model for the transformation of loose sediments to real sedimentary rocks by the different stages of meteoric diagenesis. The depositional and diagenetic fabrics of the rocks, in addition to the strata orientation, highly affect their ultimate compressive strength and other geotechnical properties.
There is a marked increase in the compressive strength (UCS) from the first to the fourth ridge rock samples. The lowest values are related to the loose packing, weakly cemented aragonitic ooid sediments with high porosity, besides the irregularly distributed of cement, which result in decreasing the ability of these rocks to withstand crushing under direct pressure. The high (UCS) values are attributed to the low porosity, the presence of micritic cement, the reduction in grain size and the occurrence of micritization and calcretization processes.
The strata orientation has a notable effect on the measured (UCS). The lowest values have been recorded for the samples cored in the inclined direction; whereas the highest values have been noticed in most samples cored in the vertical and parallel directions to bedding plane. In case of the inclined direction, the bedding planes were oriented close to the plane of maximum shear stress. The lowest and highest anisotropy values have been recorded for the first and the third ridges rock samples, respectively, which may attributed to the relatively homogeneity and well sorted grainstone of the first ridge rock samples, and relatively heterogeneity in grain and pore size distribution and degree of cementation of the third ridge rock samples, besides, the abundance of shell fragments with intraparticle pore spaces, which may produce lines of weakness within the rock.
Abstract: Globalization is putting enormous pressure on the business organizations specially manufacturing one to rethink the supply chain in innovative manners. Inventory consumes major portion of total sale revenue. Effective and efficient inventory management plays a vital role for the successful functioning of any organization. Selection of inventory policy is one of the important purchasing activities. This paper focuses on selection and ranking of alternative inventory policies. A deterministic quantitative model based on Distance Based Approach (DBA) method has been developed for evaluation and ranking of inventory policies. We have employed this concept first time for this type of the selection problem. Four inventory policies economic order quantity (EOQ), just in time (JIT), vendor managed inventory (VMI) and monthly policy are considered. Improper selection could affect a company’s competitiveness in terms of the productivity of its facilities and quality of its products. The ranking of inventory policies is a multi-criteria problem. There is a need to first identify the selection criteria and then processes the information with reference to relative importance of attributes for comparison. Criteria values for each inventory policy can be obtained either analytically or by using a simulation technique or they are linguistic subjective judgments defined by fuzzy sets, like, for example, the values of criteria. A methodology is developed and applied to rank the inventory policies.
Abstract: Our study was designed to determine the metabolic
changes of some biochemical parameters (cholesterol, triglyceride,
Iron, uric acid, Urea and folic acid) and highlight their changes in 57
women of the region Batna, during the first trimester of pregnancy.
This practical work was done with 27 women with missed
miscarriage, compared with 30 control subjects of normal pregnant
women. The assay results revealed a highly significant difference (P
= 0.0006) between the two groups in serum iron (64.00 vs 93.54) and
in the rate of folate (6.70 vs 9.22) (P
Abstract: This article is concerned with the determination of the static interaction of a vertically loaded rigid circular disc embedded at the interface of a horizontal layer sandwiched in between two different transversely isotropic half-spaces called as tri-material full-space. The axes of symmetry of different regions are assumed to be normal to the horizontal interfaces and parallel to the movement direction. With the use of a potential function method, and by implementing Hankel integral transforms in the radial direction, the government partial differential equation for the solely scalar potential function is transformed to an ordinary 4th order differential equation, and the mixed boundary conditions are transformed into a pair of integral equations called dual integral equations, which can be reduced to a Fredholm integral equation of the second kind, which is solved analytically. Then, the displacements and stresses are given in the form of improper line integrals, which is due to inverse Hankel integral transforms. It is shown that the present solutions are in exact agreement with the existing solutions for a homogeneous full-space with transversely isotropic material. To confirm the accuracy of the numerical evaluation of the integrals involved, the numerical results are compared with the solutions exists for the homogeneous full-space. Then, some different cases with different degrees of material anisotropy are compared to portray the effect of degree of anisotropy.
Abstract: As internet continues to expand its usage with an
enormous number of applications, cyber-threats have significantly
increased accordingly. Thus, accurate detection of malicious traffic in
a timely manner is a critical concern in today’s Internet for security.
One approach for intrusion detection is to use Machine Learning (ML)
techniques. Several methods based on ML algorithms have been
introduced over the past years, but they are largely limited in terms of
detection accuracy and/or time and space complexity to run. In this
work, we present a novel method for intrusion detection that
incorporates a set of supervised learning algorithms. The proposed
technique provides high accuracy and outperforms existing techniques
that simply utilizes a single learning method. In addition, our
technique relies on partial flow information (rather than full
information) for detection, and thus, it is light-weight and desirable for
online operations with the property of early identification. With the
mid-Atlantic CCDC intrusion dataset publicly available, we show that
our proposed technique yields a high degree of detection rate over 99%
with a very low false alarm rate (0.4%).
Abstract: This paper presents the results of an experimental
study on the effects of elevated temperature on compressive and
flexural strength of Normal Strength Concrete (NSC), High Strength
Concrete (HSC) and High Performance Concrete (HPC). In addition,
the specimen mass and volume were measured before and after
heating in order to determine the loss of mass and volume during the
test. In terms of non-destructive measurement, ultrasonic pulse
velocity test was proposed as a promising initial inspection method
for fire damaged concrete structure. 100 Cube specimens for three
grades of concrete were prepared and heated at a rate of 3°C/min up
to different temperatures (150, 250, 400, 600, and 900°C). The results
show a loss of compressive and flexural strength for all the concretes
heated to temperature exceeding 400°C. The results also revealed that
mass and density of the specimen significantly reduced with an
increase in temperature.
Abstract: The pipe taper thread measurement and uncertainty
normally used the four-wire probe according to the JIS B 0262.
Besides, according to the EA-10/10 standard, the pipe thread could be
measured using the three-wire probe. This research proposed to use
the three-wire probe measuring the pitch diameter of the pipe taper
thread. The measuring accessory component was designed and made,
then, assembled to one side of the ULM 828 CiM machine.
Therefore, this machine could be used to measure and calibrate both
the pipe thread and the pipe taper thread. The equations and the
expanded uncertainty for pitch diameter measurement were
formulated. After the experiment, the results showed that the pipe
taper thread had the pitch diameter equal to 19.165mm and the
expanded uncertainty equal to 1.88µm. Then, the experiment results
were compared to the results from the National Institute of Metrology
Thailand. The equivalence ratio from the comparison showed that
both results were related. Thus, the proposed method of using the
three-wire probe measured the pitch diameter of the pipe taper thread
was acceptable.
Abstract: Industries using conventional fossil fuels have an
interest in better understanding the mechanism of particulate
formation during combustion since such is responsible for emission
of undesired inorganic elements that directly impact the atmospheric
pollution level. Fine and ultrafine particulates have tendency to
escape the flue gas cleaning devices to the atmosphere. They also
preferentially collect on surfaces in power systems resulting in
ascending in corrosion inclination, descending in the heat transfer
thermal unit, and severe impact on human health. This adverseness
manifests particularly in the regions of world where coal is the
dominated source of energy for consumption.
This study highlights the behavior of calcium transformation as
mineral grains verses organically associated inorganic components
during pulverized coal combustion. The influence of existing type of
calcium on the coarse, fine and ultrafine mode formation mechanisms
is also presented. The impact of two sub-bituminous coals on particle
size and calcium composition evolution during combustion is to be
assessed. Three mixed blends named Blends 1, 2, and 3 are selected
according to the ration of coal A to coal B by weight. Calcium
percentage in original coal increases as going from Blend 1 to 3.
A mathematical model and a new approach of describing
constituent distribution are proposed. Analysis of experiments of
calcium distribution in ash is also modeled using Poisson distribution.
A novel parameter, called elemental index λ, is introduced as a
measuring factor of element distribution.
Results show that calcium in ash that originally in coal as mineral
grains has index of 17, whereas organically associated calcium
transformed to fly ash shown to be best described when elemental
index λ is 7.
As an alkaline-earth element, calcium is considered the
fundamental element responsible for boiler deficiency since it is the
major player in the mechanism of ash slagging process. The
mechanism of particle size distribution and mineral species of ash
particles are presented using CCSEM and size-segregated ash
characteristics. Conclusions are drawn from the analysis of
pulverized coal ash generated from a utility-scale boiler.
Abstract: The influence of organic amendments and inorganic fertilizers on cabbage head was investigated to determine their effect on storage behavior and organoleptic quality. Field cabbage was raised by combining fourteen different treatments comprising of organic amendments and inorganic fertilizers at different levels. The result showed that nutrient schedule of the crop significantly influenced the physiological loss in weight (PLW) and organoleptic quality of cabbage head and judicious selection of nutrient combination can extend the storage life and reduce the post harvest detoriaration of head. The nutrient schedule comprising of higher level of FYM (16 t ha-1) along with 75% of recommended inorganic fertilizers in conjugation with seedling inoculation of biofertilizer emerged as potential nutrient source for improving storage life, marketability and maintaining nutritional and organoleptic quality under ambient storage condition.
Abstract: Utmost care of human related issues are essentially required for sustainable growth of micro, small and medium enterprises (MSMEs) of India, as these MSMEs are contributing enormously to socio-economic development of country. In this research, aspects related to human factors and functioning of MSMEs of India were studied. The investigation, based on a survey of 84 MSMEs of India cited that the enterprises are mostly employing unskilled labor whose wages are less with poor training. In spite of reported minor accidents, attention towards safety is poorly paid. To meet-out the production target, MSMEs generally employ over-time and payment towards this overtime is sometimes missing. Hence, honest and humanitarian attention for better human resources is needed to improve the performance and competitiveness of MSMEs of India.
Abstract: The primary objective of this paper is to elimination of the problem of sensitivity to parameter variation of induction motor drive. The proposed sensorless strategy is based on an algorithm permitting a better simultaneous estimation of the rotor speed and the stator resistance including an adaptive mechanism based on the lyaponov theory. To study the reliability and the robustness of the sensorless technique to abnormal operations, some simulation tests have been performed under several cases.
The proposed sensorless vector control scheme showed a good performance behavior in the transient and steady states, with an excellent disturbance rejection of the load torque.
Abstract: Many researchers have suggested the use of zero inflated Poisson (ZIP) and zero inflated negative binomial (ZINB) models in modeling overdispersed medical count data with extra variations caused by extra zeros and unobserved heterogeneity. The studies indicate that ZIP and ZINB always provide better fit than using the normal Poisson and negative binomial models in modeling overdispersed medical count data. In this study, we proposed the use of Zero Inflated Inverse Trinomial (ZIIT), Zero Inflated Poisson Inverse Gaussian (ZIPIG) and zero inflated strict arcsine models in modeling overdispered medical count data. These proposed models are not widely used by many researchers especially in the medical field. The results show that these three suggested models can serve as alternative models in modeling overdispersed medical count data. This is supported by the application of these suggested models to a real life medical data set. Inverse trinomial, Poisson inverse Gaussian and strict arcsine are discrete distributions with cubic variance function of mean. Therefore, ZIIT, ZIPIG and ZISA are able to accommodate data with excess zeros and very heavy tailed. They are recommended to be used in modeling overdispersed medical count data when ZIP and ZINB are inadequate.
Abstract: The closed form study deals with elastic stress analysis of annular bi-material discs with variable thickness subjected to the mechanical and thermomechanical loads. Those discs have many applications in the aerospace industry, such as gas turbines and gears. Those discs normally work under thermal and mechanical loads. Their life cycle can increase when stress components are minimized. Each material property is assumed to be isotropic. The results show that material combinations and thickness of profiles play an important role in determining the responses of bi-material discs and an optimal design of those structures. Stress distribution is investigated and results are shown as graphs.
Abstract: Knowledge plays an important role to the success of any organization. Software development organizations are highly knowledge-intensive organizations especially in their requirement elicitation process (REP). There are several problems regarding communicating and using the knowledge in REP such as misunderstanding, being out of scope, conflicting information and changes of requirements. All of these problems occurred in transmitting the requirements knowledge during REP. Several researches have been done in REP in order to solve the problem towards requirements. Knowledge Audit (KA) approaches were proposed in order to solve managing knowledge in human resources, financial and manufacturing. There is lack of study applying the KA in requirements elicitation process. Therefore, this paper proposes a KA model for REP in supporting to acquire good requirements.
Abstract: Research leads to the development of science and technology and hence it leads to the betterment of humankind also. Journals and Conferences provide a platform to receive large number of research papers for publications and presentations before the expert and peer-level scientific community. In order to assure quality of such papers, they are also sent to reviewers for their comments. In order to maintain good ethical standards, the research papers are sent to reviewers in such a way authors and reviewers do not know each other’s identity. This technique is called Double-blind Review Process. It is called Single-blind Review Process, if identity of any one party, generally authors’, is disclosed to the other. This paper presents the techniques by which identity of author as well as reviewer could be found even through Double-blind Review process. It is proposed that the characteristics and techniques presented here will help journals and conferences in assuring intentional or un-intentional disclosure of identity revealing information by the either party.