Abstract: The biomarker for colorectal cancer (CRC) is CEACAM-6 antigen (C6AG). Therefore, this study aims to develop a novel, simple and low-cost CEACAM-6 antigen immumosensor (C6AG-IMS), based on electrical impedance measurement, for precise determination of C6AG. A low-cost screen-printed graphite electrode was constructed and used as the sensor, with CEACAM-6 antibody (C6AB) immobilized on it. The procedures of sensor fabrication and antibody immobilization are simple and low-cost. Measurement of the electrical impedance at a definite frequency ranges (0.43 – 1.26 MHz) showed that the C6AG-IMS has an excellent linear (r2>0.9) response range (8.125 – 65 pg/mL), covering the normal physiological and pathological ranges of blood C6AG levels. Also, the C6AG-IMS has excellent reliability and validity, with the intraclass correlation coefficient being 0.97. In conclusion, a novel, simple, low-cost and reliable C6AG-IMS was designed and developed, being able to accurately determine blood C6AG levels in the range of pathological and normal physiological regions. The C6AG-IMS can provide a point-of-care and immediate screening results to the user at home.
Abstract: The concurrent era is characterised by strengthened interactions among financial markets and increased capital mobility globally. In this frames we examine the effects the international financial integration process has on the European bond markets. We perform a comparative study of the interactions of the European and international bond markets and exploit Cointegration analysis results on the elimination of stochastic trends and the decomposition of the underlying long run equilibria and short run causal relations. Our investigation provides evidence on the relation between the European integration process and that of globalisation, viewed through the bond markets- sector. Additionally the structural formulation applied, offers significant implications of the findings. All in all our analysis offers a number of answers on crucial queries towards the European bond markets integration process.
Abstract: Sickness absence represents a major economic and
social issue. Analysis of sick leave data is a recurrent challenge to analysts because of the complexity of the data structure which is
often time dependent, highly skewed and clumped at zero. Ignoring these features to make statistical inference is likely to be inefficient
and misguided. Traditional approaches do not address these problems. In this study, we discuss model methodologies in terms of statistical techniques for addressing the difficulties with sick leave data. We also introduce and demonstrate a new method by performing a longitudinal assessment of long-term absenteeism using
a large registration dataset as a working example available from the Helsinki Health Study for municipal employees from Finland during the period of 1990-1999. We present a comparative study on model
selection and a critical analysis of the temporal trends, the occurrence
and degree of long-term sickness absences among municipal employees. The strengths of this working example include the large
sample size over a long follow-up period providing strong evidence in supporting of the new model. Our main goal is to propose a way to
select an appropriate model and to introduce a new methodology for analysing sickness absence data as well as to demonstrate model
applicability to complicated longitudinal data.
Abstract: Text categorization (the assignment of texts in natural language into predefined categories) is an important and extensively studied problem in Machine Learning. Currently, popular techniques developed to deal with this task include many preprocessing and learning algorithms, many of which in turn require tuning nontrivial internal parameters. Although partial studies are available, many authors fail to report values of the parameters they use in their experiments, or reasons why these values were used instead of others. The goal of this work then is to create a more thorough comparison of preprocessing parameters and their mutual influence, and report interesting observations and results.
Abstract: This paper describes a computer-aided design for
design of the concave globoidal cam with cylindrical rollers and
swinging follower. Four models with different modeling methods are
made from the same input data. The input data are angular input and
output displacements of the cam and the follower and some other
geometrical parameters of the globoidal cam mechanism. The best
cam model is the cam which has no interference with the rollers
when their motions are simulated in assembly conditions. The
angular output displacement of the follower for the best cam is also
compared with that of in the input data to check errors. In this study,
Pro/ENGINEER® Wildfire 2.0 is used for modeling the cam,
simulating motions and checking interference and errors of the
system.
Abstract: the research was conducted using the self report of
shoplifters who apprehended in the supermarket while stealing. 943
shoplifters in three years were interviewed right after the stealing act
and before calling the police. The aim of the study is to know the
shoplifting characteristics in Saudi Arabia, including the trait of
shoplifters and the situation of the supermarkets where the stealing
takes place. The analysis based on the written information about each
thief as the documentary research method. Descriptive statistics as
well as some inferential statistics were employed. The result shows
that there are differences between genders, age groups, occupations,
time of the day, days of the week, months, way of stealing, individual
or group of thieves and other supermarket situations in the type of
items stolen, total price and the count of items. The result and the
recommendation will serve as a guide for retailers where, when and
who to look at to prevent shoplifting.
Abstract: A novel thermo-sensitive superabsorbent hydrogel
with salt- and pH-responsiveness properties was obtained by grafting
of mixtures of acrylic acid (AA) and N-isopropylacrylamide
(NIPAM) monomers onto kappa-carrageenan, kC, using ammonium
persulfate (APS) as a free radical initiator in the presence of
methylene bisacrylamide (MBA) as a crosslinker. Infrared
spectroscopy was carried out to confirm the chemical structure of the
hydrogel. Moreover, morphology of the samples was examined by
scanning electron microscopy (SEM). The effect of MBA
concentration and AA/NIPAM weight ratio on the water absorbency
capacity has been investigated. The swelling variations of hydrogels
were explained according to swelling theory based on the hydrogel
chemical structure. The hydrogels exhibited salt-sensitivity and
cation exchange properties. The temperature- and pH-reversibility
properties of the hydrogels make the intelligent polymers as good
candidates for considering as potential carriers for bioactive agents,
e.g. drugs.
Abstract: An advanced Monte Carlo simulation method, called Subset Simulation (SS) for the time-dependent reliability prediction for underground pipelines has been presented in this paper. The SS can provide better resolution for low failure probability level with efficient investigating of rare failure events which are commonly encountered in pipeline engineering applications. In SS method, random samples leading to progressive failure are generated efficiently and used for computing probabilistic performance by statistical variables. SS gains its efficiency as small probability event as a product of a sequence of intermediate events with larger conditional probabilities. The efficiency of SS has been demonstrated by numerical studies and attention in this work is devoted to scrutinise the robustness of the SS application in pipe reliability assessment. It is hoped that the development work can promote the use of SS tools for uncertainty propagation in the decision-making process of underground pipelines network reliability prediction.
Abstract: In the present study, fracture behavior of woven
fabric-reinforced glass/epoxy composite laminates under mode III
crack growth was experimentally investigated and numerically
modeled. Two methods were used for the calculation of the strain
energy release rate: the experimental compliance calibration (CC)
method and the Virtual Crack Closure Technique (VCCT). To
achieve this aim ECT (Edge Crack Torsion) was used to evaluate
fracture toughness in mode III loading (out of plane-shear) at
different crack lengths. Load–displacement and associated energy
release rates were obtained for various case of interest. To
calculate fracture toughness JIII, two criteria were considered
including non-linearity and maximum points in load-displacement
curve and it is observed that JIII increases with the crack length
increase. Both the experimental compliance method and the virtual
crack closure technique proved applicable for the interpretation of the
fracture mechanics data of woven glass/epoxy laminates in mode III.
Abstract: In Peer-to-Peer service networks, where peers offer any kind of publicly available services or applications, intuitive navigation through all services in the network becomes more difficult as the number of services increases. In this article, a concept is discussed that enables users to intuitively browse and use large scale P2P service networks. The concept extends the idea of creating virtual 3D-environments solely based on Peer-to-Peer technologies. Aside from browsing, users shall have the possibility to emphasize services of interest using their own semantic criteria. The appearance of the virtual world shall intuitively reflect network properties that may be of interest for the user. Additionally, the concept comprises options for load- and traffic-balancing. In this article, the requirements concerning the underlying infrastructure and the graphical user interface are defined. First impressions of the appearance of future systems are presented and the next steps towards a prototypical implementation are discussed.
Abstract: Empty Fruit Bunches (EFB) and Palm Oil Mill
Effluent (POME) are two main wastes from oil palm industries which
contain rich lignocellulose. Degradation of EFB and POME by
microorganisms will produce hydrolytic enzyme which will degrade
cellulose and hemicellulose during composting process. However,
normal composting takes about four to six months to reach maturity.
Hence, application of fungi into compost can shorten the period of
composting. This study identifies the effect of xylanase and cellulase
produced by Aspergillus niger and Trichoderma virens on
composting process using EFB and POME. The degradation of EFB
and POME indicates the lignocellulolytic capacity of Aspergillus
niger and Trichoderma virens with more than 7% decrease in
hemicellulose and more than 25% decrease in cellulose for both
inoculated compost. Inoculation of Aspergillus niger and
Trichoderma virens also increased the enzyme activities during the
composting period compared to the control compost by 21% for both
xylanase and cellulase. Rapid rise in the activities of cellulase and
xylanase was observed by Aspergillus niger with the highest
activities of 14.41 FPU/mg and 3.89 IU/mg, respectively. Increased
activities of cellulase and xylanase also occurred in inoculation of
Trichoderma virens with the highest activities obtained at 13.21
FPU/mg and 4.43 IU/mg, respectively. Therefore, it is evident that
the inoculation of fungi can increase the enzyme activities hence
effectively degrading the EFB and POME.
Abstract: A Wireless sensor network (WSN) consists of a set of battery-powered nodes, which collaborate to perform sensing tasks in a given environment. Each node in WSN should be capable to act for long periods of time with scrimpy or no external management. One requirement for this independent is: in the presence of adverse positions, the sensor nodes must be capable to configure themselves. Hence, the nodes for determine the existence of unusual events in their surroundings should make use of position awareness mechanisms. This work approaches the problem by considering the possible unusual events as diseases, thus making it possible to diagnose them through their symptoms, namely, their side effects. Considering these awareness mechanisms as a foundation for highlevel monitoring services, this paper also shows how these mechanisms are included in the primal plan of an intrusion detection system.
Abstract: A large number of chemical, bio-chemical and pollution-control processes use heterogeneous fixed-bed reactors. The use of finite hollow cylindrical catalyst pellets can enhance conversion levels in such reactors. The absence of the pellet core can significantly lower the diffusional resistance associated with the solid phase. This leads to a better utilization of the catalytic material, which is reflected in the higher values for the effectiveness factor, leading ultimately to an enhanced conversion level in the reactor. It is however important to develop a rigorous heterogeneous model for the reactor incorporating the two-dimensional feature of the solid phase owing to the presence of the finite hollow cylindrical catalyst pellet. Presently, heterogeneous models reported in the literature invariably employ one-dimension solid phase models meant for spherical catalyst pellets. The objective of the paper is to present a rigorous model of the fixed-bed reactors containing finite hollow cylindrical catalyst pellets. The reaction kinetics considered here is the widely used Michaelis–Menten kinetics for the liquid-phase bio-chemical reactions. The reaction parameters used here are for the enzymatic degradation of urea. Results indicate that increasing the height to diameter ratio helps to improve the conversion level. On the other hand, decreasing the thickness is apparently not as effective. This could however be explained in terms of the higher void fraction of the bed that causes a smaller amount of the solid phase to be packed in the fixed-bed bio-chemical reactor.
Abstract: Nowadays it is a trend for electronic circuit designers to
integrate all system components on a single-chip. This paper proposed
the design of a single-chip proportional to absolute temperature
(PTAT) sensor including a voltage reference circuit using CEDEC
0.18m CMOS Technology. It is a challenge to design asingle-chip
wide range linear response temperature sensor for many applications.
The channel widths between the compensation transistor and the
reference transistor are critical to design the PTAT temperature sensor
circuit. The designed temperature sensor shows excellent linearity
between -100°C to 200° and the sensitivity is about 0.05mV/°C.
The chip is designed to operate with a single voltage source of 1.6V.
Abstract: IVE toolkit has been created for facilitating research,education and development in the field of virtual storytelling and computer games. Primarily, the toolkit is intended for modelling action selection mechanisms of virtual humans, investigating level-of-detail AI techniques for large virtual environments, and for exploring joint behaviour and role-passing technique (Sec. V). Additionally, the toolkit can be used as an AI middleware without any changes. The main facility of IVE is that it serves for prototyping both the AI and virtual worlds themselves. The purpose of this paper is to describe IVE's features in general and to present our current work - including an educational game - on this platform.
Abstract: Vehicle suspension design must fulfill
some conflicting criteria. Among those is ride comfort
which is attained by minimizing the acceleration
transmitted to the sprung mass, via suspension spring
and damper. Also good handling of a vehicle is a
desirable property which requires stiff suspension and
therefore is in contrast with a vehicle with good ride.
Among the other desirable features of a suspension is
the minimization of the maximum travel of suspension.
This travel which is called suspension working space in
vehicle dynamics literature is also a design constraint
and it favors good ride. In this research a full car 8
degrees of freedom model has been developed and the
three above mentioned criteria, namely: ride, handling
and working space has been adopted as objective
functions. The Multi Objective Programming (MOP)
discipline has been used to find the Pareto Front and
some reasoning used to chose a design point between
these non dominated points of Pareto Front.
Abstract: The traditional Failure Mode and Effects Analysis
(FMEA) uses Risk Priority Number (RPN) to evaluate the risk level
of a component or process. The RPN index is determined by
calculating the product of severity, occurrence and detection indexes.
The most critically debated disadvantage of this approach is that
various sets of these three indexes may produce an identical value of
RPN. This research paper seeks to address the drawbacks in
traditional FMEA and to propose a new approach to overcome these
shortcomings. The Risk Priority Code (RPC) is used to prioritize
failure modes, when two or more failure modes have the same RPN.
A new method is proposed to prioritize failure modes, when there is a
disagreement in ranking scale for severity, occurrence and detection.
An Analysis of Variance (ANOVA) is used to compare means of
RPN values. SPSS (Statistical Package for the Social Sciences)
statistical analysis package is used to analyze the data. The results
presented are based on two case studies. It is found that the proposed
new methodology/approach resolves the limitations of traditional
FMEA approach.
Abstract: The dynamical contouring error is a critical element for the accuracy of machine tools. The contouring error is defined as the difference between the processing actual path and commanded path, which is implemented by following the command curves from feeding driving system in machine tools. The contouring error is resulted from various factors, such as the external loads, friction, inertia moment, feed rate, speed control, servo control, and etc. Thus, the study proposes a 2D compensating system for the contouring accuracy of machine tools. Optical method is adopted by using stable frequency laser diode and the high precision position sensor detector (PSD) to performno-contact measurement. Results show the related accuracy of position sensor detector (PSD) of 2D contouring accuracy compensating system was ±1.5 μm for a calculated range of ±3 mm, and improvement accuracy is over 80% at high-speed feed rate.
Abstract: In this paper, an estimation accuracy of multiple moving
talker tracking using a microphone array is improved. The tracking
can be achieved by the adaptive method in which two algorithms are integrated, namely, the PAST (Projection Approximation Subspace
Tracking) algorithm and the IPLS (Interior Point Least Square) algorithm. When either talker begins to speak again after a silent
period, an appropriate feasible region for an evaluation function of
the IPLS algorithm might not be set. Then, the tracking fails due to the incorrect updating. Therefore, if an increment of the number of
active talkers is detected, the feasible region must be reset. Then, a low cost realization is required for the high speed tracking and a high
accuracy realization is desired for the precise tracking. In this paper,
the directions roughly estimated using the delayed-sum-array method
are used for the resetting. Several results of experiments performed in
an actual room environment show the effectiveness of the proposed method.
Abstract: Historical monuments as architectural heritage are,
economically and culturally, considered one of the key aspects for
modern communities. Cultural heritage represents a country-s
national identity and pride and maintains and enriches that country-s
culture. Therefore, conservation of the monuments remained from
our ancestors requires everybody-s serious and unremitting effort.
Conservation, renewal, restoration, and technical study of cultural
and historical matters are issues which have a special status among
various forms of art and science in the present century and this is due
to two reasons: firstly, progress of humankind in this century has
created a factor called environmental pollution which not only has
caused new destructive processes of cultural/historical monuments
but also has accelerated the previous destructive processes by several
times, and secondly, the rapid advance of various sciences, especially
chemistry, has lead to the contribution of new methods and materials
to this significant issue.