Abstract: This article demonstrated development of
controlled release system of an NSAID drug, Diclofenac
sodium employing different ratios of Ethyl cellulose.
Diclofenac sodium and ethyl cellulose in different proportions
were processed by microencapsulation based on phase
separation technique to formulate microcapsules. The
prepared microcapsules were then compressed into tablets to
obtain controlled release oral formulations. In-vitro evaluation
was performed by dissolution test of each preparation was
conducted in 900 ml of phosphate buffer solution of pH 7.2
maintained at 37 ± 0.5 °C and stirred at 50 rpm. At predetermined
time intervals (0, 0.5, 1.0, 1.5, 2, 3, 4, 6, 8, 10, 12,
16, 20 and 24 hrs). The drug concentration in the collected
samples was determined by UV spectrophotometer at 276 nm.
The physical characteristics of diclofenac sodium
microcapsules were according to accepted range. These were
off-white, free flowing and spherical in shape. The release
profile of diclofenac sodium from microcapsules was found to
be directly proportional to the proportion of ethylcellulose and
coat thickness. The in-vitro release pattern showed that with
ratio of 1:1 and 1:2 (drug: polymer), the percentage release of
drug at first hour was 16.91 and 11.52 %, respectively as
compared to 1:3 which is only 6.87 % with in this time. The
release mechanism followed higuchi model for its release
pattern. Tablet Formulation (F2) of present study was found
comparable in release profile the marketed brand Phlogin-SR,
microcapsules showed an extended release beyond 24 h.
Further, a good correlation was found between drug release
and proportion of ethylcellulose in the microcapsules.
Microencapsulation based on coacervation found as good
technique to control release of diclofenac sodium for making
the controlled release formulations.
Abstract: Problem-based learning (PBL) is one of the student
centered approaches and has been considered by a number of higher
educational institutions in many parts of the world as a method of
delivery. This paper presents a creative thinking approach for
implementing Problem-based Learning in Mechanics of Structure
within a Malaysian Polytechnics environment. In the learning
process, students learn how to analyze the problem given among the
students and sharing classroom knowledge into practice. Further,
through this course-s emphasis on problem-based learning, students
acquire creative thinking skills and professional skills as they tackle
complex, interdisciplinary and real-situation problems. Once the
creative ideas are generated, there are useful additional techniques
for tender ideas that will grow into a productive concept or solution.
The combination of creative skills and technical abilities will enable
the students to be ready to “hit-the-ground-running" and produce in
industry when they graduate.
Abstract: Here we have considered non uniform microstrip
leaky-wave antenna implemented on a dielectric waveguide by a
sinusoidal profile of periodic metallic grating. The non distribution of
the attenuation constant α along propagation axis, optimize the
radiating characteristics and performances of such antennas. The
method developped here is based on an integral method where the
formalism of the admittance operator is combined to a BKW
approximation. First, the effect of the modeling in the modal analysis
of complex waves is studied in detail. Then, the BKW model is used
for the dispersion analysis of the antenna of interest. According to
antenna theory, a forced continuity of the leaky-wave magnitude at
discontinuities of the non uniform structure is established. To test the
validity of our dispersion analysis, computed radiation patterns are
presented and compared in the millimeter band.
Abstract: Aim of this paper is to explore the prospect of a new approach of mobile phone banking in Libya. This study evaluates customer knowledge on commercial mobile banking in Libya. To examine the relationship between age, occupation and intention for using mobile banking for commercial purpose, a survey was conducted to gather information from one hundred Libyan bank clients. The results indicate that Libyan customers have accepted the new technology and they are ready to use it. There is no significant joint relationship between age and occupation found in intention to use mobile banking in Libya. On the other hand, the customers’ knowledge about mobile banking has a greater relationship with the intention. This study has implications for demographic researches and consumer behaviour disciplines. It also has profitable implications for banks and managers in Libya, as it will assist in better understanding of the Libyan consumers and their activities, when they develop their market strategies and new service.
Abstract: This paper describes the development of a fully
automated measurement software for antenna radiation pattern
measurements in a Compact Antenna Test Range (CATR). The
CATR has a frequency range from 2-40 GHz and the measurement
hardware includes a Network Analyzer for transmitting and
Receiving the microwave signal and a Positioner controller to control
the motion of the Styrofoam column. The measurement process
includes Calibration of CATR with a Standard Gain Horn (SGH)
antenna followed by Gain versus angle measurement of the Antenna
under test (AUT). The software is designed to control a variety of
microwave transmitter / receiver and two axis Positioner controllers
through the standard General Purpose interface bus (GPIB) interface.
Addition of new Network Analyzers is supported through a slight
modification of hardware control module. Time-domain gating is
implemented to remove the unwanted signals and get the isolated
response of AUT. The gated response of the AUT is compared with
the calibration data in the frequency domain to obtain the desired
results. The data acquisition and processing is implemented in
Agilent VEE and Matlab. A variety of experimental measurements
with SGH antennas were performed to validate the accuracy of
software. A comparison of results with existing commercial
softwares is presented and the measured results are found to be
within .2 dBm.
Abstract: Flow field around hypersonic vehicles is very
complex and difficult to simulate. The boundary layers are squeezed
between shock layer and body surface. Resolution of boundary layer,
shock wave and turbulent regions where the flow field has high
values is difficult of capture. Detached eddy simulation (DES) is a
modification of a RANS model in which the model switches to a
subgrid scale formulation in regions fine enough for LES
calculations. Regions near solid body boundaries and where the
turbulent length scale is less than the maximum grid dimension are
assigned the RANS mode of solution. As the turbulent length scale
exceeds the grid dimension, the regions are solved using the LES
mode. Therefore the grid resolution is not as demanding as pure LES,
thereby considerably cutting down the cost of the computation. In
this research study hypersonic flow is simulated at Mach 8 and
different angle of attacks to resolve the proper boundary layers and
discontinuities. The flow is also simulated in the long wake regions.
Mesh is little different than RANS simulations and it is made dense
near the boundary layers and in the wake regions to resolve it
properly. Hypersonic blunt cone cylinder body with frustrum at angle
5o and 10 o are simulated and there aerodynamics study is performed
to calculate aerodynamics characteristics of different geometries. The
results and then compared with experimental as well as with some
turbulence model (SA Model). The results achieved with DES
simulation have very good resolution as well as have excellent
agreement with experimental and available data. Unsteady
simulations are performed for DES calculations by using duel time
stepping method or implicit time stepping. The simulations are
performed at Mach number 8 and angle of attack from 0o to 10o for
all these cases. The results and resolutions for DES model found
much better than SA turbulence model.
Abstract: This paper presents an efficient approach to feeder
reconfiguration for power loss reduction and voltage profile
imprvement in unbalanced radial distribution systems (URDS). In
this paper Genetic Algorithm (GA) is used to obtain solution for
reconfiguration of radial distribution systems to minimize the losses.
A forward and backward algorithm is used to calculate load flows in
unbalanced distribution systems. By simulating the survival of the
fittest among the strings, the optimum string is searched by
randomized information exchange between strings by performing
crossover and mutation. Results have shown that proposed algorithm
has advantages over previous algorithms The proposed method is
effectively tested on 19 node and 25 node unbalanced radial
distribution systems.
Abstract: How to maintain the service speeds for the business
to make the biggest profit is a problem worthy of study, which is
discussed in this paper with the use of queuing theory. An M/M/1/N
queuing model with variable input rates, variable service rates and
impatient customers is established, and the following conclusions
are drawn: the stationary distribution of the model, the relationship
between the stationary distribution and the probability that there are n
customers left in the system when a customer leaves (not including
the customer who leaves himself), the busy period of the system,
the average operating cycle, the loss probability for the customers
not entering the system while they arriving at the system, the mean
of the customers who leaves the system being for impatient, the
loss probability for the customers not joining the queue due to the
limited capacity of the system and many other indicators. This paper
also indicates that the following conclusion is not correct: the more
customers the business serve, the more profit they will get. At last,
this paper points out the appropriate service speeds the business
should keep to make the biggest profit.
Abstract: This paper describes the use of artificial neural
networks (ANN) for predicting non-linear layer moduli of flexible
airfield pavements subjected to new generation aircraft (NGA)
loading, based on the deflection profiles obtained from Heavy
Weight Deflectometer (HWD) test data. The HWD test is one of the
most widely used tests for routinely assessing the structural integrity
of airport pavements in a non-destructive manner. The elastic moduli
of the individual pavement layers backcalculated from the HWD
deflection profiles are effective indicators of layer condition and are
used for estimating the pavement remaining life. HWD tests were
periodically conducted at the Federal Aviation Administration-s
(FAA-s) National Airport Pavement Test Facility (NAPTF) to
monitor the effect of Boeing 777 (B777) and Beoing 747 (B747) test
gear trafficking on the structural condition of flexible pavement
sections. In this study, a multi-layer, feed-forward network which
uses an error-backpropagation algorithm was trained to approximate
the HWD backcalculation function. The synthetic database generated
using an advanced non-linear pavement finite-element program was
used to train the ANN to overcome the limitations associated with
conventional pavement moduli backcalculation. The changes in
ANN-based backcalculated pavement moduli with trafficking were
used to compare the relative severity effects of the aircraft landing
gears on the NAPTF test pavements.
Abstract: This paper presents the IP traffic analysis. The traffic
was collected from the network of Suranaree University of
Technology using the software based on the Simple Network
Management Protocol (SNMP). In particular, we analyze the
distribution of the aggregated traffic during the hours of peak load
and light load. The traffic profiles including the parameters described
the traffic distributions were derived. From the statistical analysis
applying three different methods, including the Kolmogorov Smirnov
test, Anderson Darling test, and Chi-Squared test, we found that the
IP traffic distribution is a non-normal distribution and the
distributions during the peak load and the light load are different. The
experimental study and analysis show high uncertainty of the IP
traffic.
Abstract: The Zung self-depression scale and Beck Anxiety Inventory were used both to study the depression and anxiety levels of Armenian Crohn’s disease patients, and to reveal the relation between emotional status and placebo effect of these patients. On the other hand, the blood cell analyses and gut bacteria investigations were used to assess the placebo effect on ESR, and haemoglobin-s and leukocyte-s levels as well as gut commensal E. coli quantities of these patients. Despite of registered high levels of depression and anxiety, the high placebo effect on psychoemotional status for investigated patients during the investigations was described. On the other hand, no positive effect of placebo on measurements of ESP and hemoglobin-s levels of Crohn’s disease patients was revealed. The importance of use of psychotherapies for optimal outcomes during treatments of Crohn’s disease is discussed.
Abstract: The objective of this study was to investigate the effects of dietary supplementation with raw or heat-treated sunflower oil seed with two levels of 7.5% or 15% on unsaturated fatty acids in milk fat and performances of high-yielding lactating cows. Twenty early lactating Holstein cows were used in a complete randomized design. Treatments included: 1) CON, control (without sunflower oil seed). 2) LS-UT, 7.5% raw sunflower oil seed. 3) LS-HT, 7.5% heat-treated sunflower oil seed. 4) HS-UT, 15% raw sunflower oil seed. 5) HS-HT, 15% heat-treated sunflower oil seed. Experimental period lasted for 4 wk, with first 2 wk used for adaptation to the diets. Supplementation with 7.5% raw sunflower seed (LS-UT) tended to decrease milk yield, with 28.37 kg/d compared with the control (34.75 kg/d). Milk fat percentage was increased with the HS-UT treatment that obtained 3.71% compared with CON that was 3.39% and without significant different. Milk protein percent was decreased high level sunflower oil seed treatments (15%) with 3.18% whereas CON treatment is caused 3.40% protein. The cows fed added low sunflower heat-treated (LS-HT) produced milk with the highest content of total unsaturated fatty acid with 32.59 g/100g of milk fat compared with the HS-UT with 23.59 g/100g of milk fat. Content of C18 unsaturated fatty acids in milk fat increased from 21.68 g/100g of fat in the HS-UT to 22.50, 23.98, 27.39 and 30.30 g/100g of fat from the cow fed HS-HT, CON, LS-UT and LS-HT treatments, respectively. C18:2 isomers of fatty acid in milk were greater by LSHT supplementation with significant effect (P < 0.05). Total of C18 unsaturated fatty acids content was significantly higher in milk of animal fed added low heat-treated sunflower (7.5%) than those fed with high sunflower. In all, results of this study showed that diet cow's supplementation with sunflower oil seed tended to reduce milk production of lactating cows but can improve C18 UFA (Unsaturated Fatty Acid) content in milk fat. 7.5% level of sunflower oil seed that heated seemed to be the optimal source to increase UFA production.
Abstract: The research purpose was to evaluate the effect of
Active Imagination Technique (AIT) for bruxism treatment. This
project was approved by the Ethics Committee on Human Research
(CAAE: 05619512.9.0000.0109). Twenty-one volunteers using
interocclusal splint completed the study. Initially they filled in a
questionnaire about their condition, composed of objective questions
on signs and symptoms. Following they were underwent asingle
session of AIT. After 15 days, the volunteers met again the same
initial questionnaire. The results were compared and showed that the
vast majority had pain symptoms, difficulty opening the mouth, pain
when chewing, reduced, some of the participants abandoned the
interocclusal splint during the evaluate period. It is concluded that the
technique can be used in bruxism treatment. Results seem to be
promising and demonstrates the need of highlighting Active
Imagination Technique since it points a possibility of bruxism cure
and that is unprecedented.
Abstract: The motion planning procedure described in this paper has been developed in order to eliminate or reduce the residual vibrations of electromechanical positioning systems, without augmenting the motion time (usually imposed by production requirements), nor introducing overtime for vibration damping. The proposed technique is based on a suitable choice of the motion law assigned to the servomotor that drives the mechanism. The reference profile is defined by a Bezier curve, whose shape can be easily changed by modifying some numerical parameters. By means of an optimization technique these parameters can be modified without altering the continuity conditions imposed on the displacement and on its time derivatives at the initial and final time instants.
Abstract: The effect of small non-parallelism of the base flow
on the stability of slightly curved mixing layers is analyzed in the
present paper. Assuming that the instability wavelength is much
smaller than the length scale of the variation of the base flow we
derive an amplitude evolution equation using the method of multiple
scales. The proposed asymptotic model provides connection between
parallel flow approximations and takes into account slow
longitudinal variation of the base flow.
Abstract: We present a method for the selection of students
in interdisciplinary studies based on the hybrid averaging
operator. We assume that the available information given in
the problem is uncertain so it is necessary to use interval
numbers. Therefore, we suggest a new type of hybrid
aggregation called uncertain induced generalized hybrid
averaging (UIGHA) operator. It is an aggregation operator
that considers the weighted average (WA) and the ordered
weighted averaging (OWA) operator in the same formulation.
Therefore, we are able to consider the degree of optimism of
the decision maker and grades of importance in the same
approach. By using interval numbers, we are able to represent
the information considering the best and worst possible results
so the decision maker gets a more complete view of the
decision problem. We develop an illustrative example of the
proposed scheme in the selection of students in
interdisciplinary studies. We see that with the use of the
UIGHA operator we get a more complete representation of the
selection problem. Then, the decision maker is able to
consider a wide range of alternatives depending on his
interests. We also show other potential applications that could
be used by using the UIGHA operator in educational problems
about selection of different types of resources such as
students, professors, etc.
Abstract: The basic objective of this paper is to measure and
compare the profitability of investments made by the small and
marginal farmers of the state of West Bengal in floriculture shifting
from the traditional cultivation of paddy. A comparison of IRR is
made to establish the fact that cultivation of flowers yield higher
returns farmers whose land size is so small that viability of paddy
cultivation is raising a question mark. A detailed study of the price
behavior of the flower crop has been carried out in which the factors
leading to the volatility of the price and the dispersion of the range
have also been discussed. Finally the incremental incomes of the
farmers have been calculated with the help of imputed income from
paddy cultivation and the reported income from the selected flowers.
The study shows that the farmers stand gainers if they opt for flower
cultivation.
Abstract: This paper reported an experimental research of
steady-state heat transfer behaviour of a gas flowing through a fixed
bed under the different operating conditions. Studies had been carried
out in a fixed-bed packed methanol synthesis catalyst percolated by air
at appropriate flow rate. Both radial and axial direction temperature
distribution had been investigated under the different operating
conditions. The effects of operating conditions including the reactor
inlet air temperature, the heating pipe temperature and the air flow rate
on temperature distribution was investigated and the experimental
results showed that a higher inlet air temperature was conducive to
uniform temperature distribution in the fixed bed. A large temperature
drop existed at the radial direction, and the temperature drop increased
with the heating pipe temperature increasing under the experimental
conditions; the temperature profile of the vicinity of the heating pipe
was strongly affected by the heating pipe temperature. A higher air
flow rate can improve the heat transfer in the fixed bed. Based on the
thermal distribution, heat transfer models of the fixed bed could be
established, and the characteristics of the temperature distribution in
the fixed bed could be finely described, that had an important practical
significance.
Abstract: Patients with diabetes are susceptible to chronic foot
wounds which may be difficult to manage and slow to heal.
Diagnosis and treatment currently rely on the subjective judgement of
experienced professionals. An objective method of tissue assessment
is required. In this paper, a data fusion approach was taken to wound
tissue classification. The supervised Maximum Likelihood and
unsupervised Multi-Modal Expectation Maximisation algorithms
were used to classify tissues within simulated wound models by
weighting the contributions of both colour and 3D depth information.
It was found that, at low weightings, depth information could show
significant improvements in classification accuracy when compared
to classification by colour alone, particularly when using the
maximum likelihood method. However, larger weightings were
found to have an entirely negative effect on accuracy.
Abstract: Worm propagation profiles have significantly changed
since 2003-2004: sudden world outbreaks like Blaster or Slammer
have progressively disappeared and slower but stealthier worms
appeared since, most of them for botnets dissemination. Decreased
worm virulence results in more difficult detection.
In this paper, we describe a stealth worm propagation model
which has been extensively simulated and analysed on a huge virtual
network. The main features of this model is its ability to infect any
Internet-like network in a few seconds, whatever may be its size while
greatly limiting the reinfection attempt overhead of already infected
hosts. The main simulation results shows that the combinatorial
topology of routing may have a huge impact on the worm propagation
and thus some servers play a more essential and significant role than
others. The real-time capability to identify them may be essential to
greatly hinder worm propagation.