Abstract: Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.
Abstract: Plasmodium vivax malaria differs from P. falciparum malaria in that a person suffering from P. vivax infection can suffer relapses of the disease. This is due the parasite being able to remain dormant in the liver of the patients where it is able to re-infect the patient after a passage of time. During this stage, the patient is classified as being in the dormant class. The model to describe the transmission of P. vivax malaria consists of a human population divided into four classes, the susceptible, the infected, the dormant and the recovered. The effect of a time delay on the transmission of this disease is studied. The time delay is the period in which the P. vivax parasite develops inside the mosquito (vector) before the vector becomes infectious (i.e., pass on the infection). We analyze our model by using standard dynamic modeling method. Two stable equilibrium states, a disease free state E0 and an endemic state E1, are found to be possible. It is found that the E0 state is stable when a newly defined basic reproduction number G is less than one. If G is greater than one the endemic state E1 is stable. The conditions for the endemic equilibrium state E1 to be a stable spiral node are established. For realistic values of the parameters in the model, it is found that solutions in phase space are trajectories spiraling into the endemic state. It is shown that the limit cycle and chaotic behaviors can only be achieved with unrealistic parameter values.
Abstract: This paper presents the source extraction system which can extract only target signals with constraints on source localization in on-line systems. The proposed system is a kind of methods for enhancing a target signal and suppressing other interference signals. But, the performance of proposed system is superior to any other methods and the extraction of target source is comparatively complete. The method has a beamforming concept and uses an improved time-frequency (TF) mask-based BSS algorithm to separate a target signal from multiple noise sources. The target sources are assumed to be in front and test data was recorded in a reverberant room. The experimental results of the proposed method was evaluated by the PESQ score of real-recording sentences and showed a noticeable speech enhancement.
Abstract: Refractive index control of benzocyclobutene (BCB 4024-40) is achieved by facilitating different conditions during the thermal curing of BCB film. Refractive index (RI) change of 1.49% is obtained with curing of BCB film using an oven, while the RI change is 0.1% when the BCB is cured using a hotplate. The two different curing methods exhibit a temperature dependent refractive index change of the BCB photosensitive polymer. By carefully controlling the curing conditions, multiple layers of BCB with different RI can be fabricated, which can then be applied in the fabrication of optical waveguides.
Abstract: Deformable active contours are widely used in
computer vision and image processing applications for image
segmentation, especially in biomedical image analysis. The active
contour or “snake" deforms towards a target object by controlling the
internal, image and constraint forces. However, if the contour
initialized with a lesser number of control points, there is a high
probability of surpassing the sharp corners of the object during
deformation of the contour. In this paper, a new technique is
proposed to construct the initial contour by incorporating prior
knowledge of significant corners of the object detected using the
Harris operator. This new reconstructed contour begins to deform, by
attracting the snake towards the targeted object, without missing the
corners. Experimental results with several synthetic images show the
ability of the new technique to deal with sharp corners with a high
accuracy than traditional methods.
Abstract: In this work a surgical simulator is produced which
enables a training otologist to conduct a virtual, real-time prosthetic
insertion. The simulator provides the Ear, Nose and Throat surgeon
with real-time visual and haptic responses during virtual cochlear
implantation into a 3D model of the human Scala Tympani (ST). The
parametric model is derived from measured data as published in the
literature and accounts for human morphological variance, such as
differences in cochlear shape, enabling patient-specific pre- operative
assessment. Haptic modeling techniques use real physical data and
insertion force measurements, to develop a force model which
mimics the physical behavior of an implant as it collides with the ST
walls during an insertion. Output force profiles are acquired from the
insertion studies conducted in the work, to validate the haptic model.
The simulator provides the user with real-time, quantitative insertion
force information and associated electrode position as user inserts the
virtual implant into the ST model. The information provided by this
study may also be of use to implant manufacturers for design
enhancements as well as for training specialists in optimal force
administration, using the simulator. The paper reports on the methods
for anatomical modeling and haptic algorithm development, with
focus on simulator design, development, optimization and validation.
The techniques may be transferrable to other medical applications
that involve prosthetic device insertions where user vision is
obstructed.
Abstract: Undoubtedly, chassis is one of the most important
parts of a vehicle. Chassis that today are produced for vehicles are
made up of four parts. These parts are jointed together by screwing.
Transverse parts are called cross member.
This study reviews the stress generated by cyclic laboratory loads
in front cross member of Peugeot 405. In this paper the finite element
method is used to simulate the welding process and to determine the
physical response of the spot-welded joints. Analysis is done by the
Abaqus software.
The Stresses generated in cross member structure are generally
classified into two groups: The stresses remained in form of residual
stresses after welding process and the mechanical stress generated by
cyclic load. Accordingly the total stress must be obtained by
determining residual stress and mechanical stress separately and then
sum them according to the superposition principle.
In order to improve accuracy, material properties including
physical, thermal and mechanical properties were supposed to be
temperature-dependent. Simulation shows that maximum Von Misses
stresses are located at special points. The model results are then
compared to the experimental results which are reported by
producing factory and good agreement is observed.
Abstract: The oil and gas industry has moved towards Load and
Resistance Factor Design through API RP2A - LRFD and the
recently published international standard, ISO-19902, for design of
fixed steel offshore structures. The ISO 19902 is intended to provide
a harmonized design practice that offers a balanced structural fitness
for the purpose, economy and safety. As part of an ongoing work, the
reliability analysis of tubular joints of the jacket structure has been
carried out to calibrate the load and resistance factors for the design
of offshore platforms in Malaysia, as proposed in the ISO.
Probabilistic models have been established for the load effects (wave,
wind and current) and the tubular joints strengths. In this study the
First Order Reliability Method (FORM), coded in MATLAB
Software has been employed to evaluate the reliability index of the
typical joints, designed using API RP2A - WSD and ISO 19902.
Abstract: Color constancy algorithms are generally based on the
simplified assumption about the spectral distribution or the reflection
attributes of the scene surface. However, in reality, these assumptions
are too restrictive. The methodology is proposed to extend existing
algorithm to applying color constancy locally to image patches rather
than globally to the entire images.
In this paper, a method based on low-level image features using
superpixels is proposed. Superpixel segmentation partition an image
into regions that are approximately uniform in size and shape. Instead
of using entire pixel set for estimating the illuminant, only superpixels
with the most valuable information are used. Based on large scale
experiments on real-world scenes, it can be derived that the estimation
is more accurate using superpixels than when using the entire image.
Abstract: In projects like waterpower, transportation and
mining, etc., proving up the rock-mass structure and hidden tectonic
to estimate the geological body-s activity is very important.
Integrating the seismic results, drilling and trenching data,
CSAMT method was carried out at a planning dame site in southwest
China to evaluate the stability of a deformation. 2D and imitated 3D
inversion resistivity results of CSAMT method were analyzed. The
results indicated that CSAMT was an effective method for defining
an outline of deformation body to several hundred meters deep; the
Lung Pan Deformation was stable in natural conditions; but uncertain
after the future reservoir was impounded.
This research presents a good case study of the fine surveying and
research on complex geological structure and hidden tectonic in
engineering project.
Abstract: In this paper, we propose a novel improvement for the generalized Lloyd Algorithm (GLA). Our algorithm makes use of an M-tree index built on the codebook which makes it possible to reduce the number of distance computations when the nearest code words are searched. Our method does not impose the use of any specific distance function, but works with any metric distance, making it more general than many other fast GLA variants. Finally, we present the positive results of our performance experiments.
Abstract: Subdivision is a method to create a smooth surface from a coarse mesh by subdividing the entire mesh. The conventional ways to compute and render surfaces are inconvenient both in terms of memory and computational time as the number of meshes will increase exponentially. An adaptive subdivision is the way to reduce the computational time and memory by subdividing only certain selected areas. In this paper, a new adaptive subdivision method for triangle meshes is introduced. This method defines a new adaptive subdivision rules by considering the properties of each triangle's neighbors and is embedded in a traditional Loop's subdivision. It prevents some undesirable side effects that appear in the conventional adaptive ways. Models that were subdivided by our method are compared with other adaptive subdivision methods
Abstract: This paper is mainly concerned with the application of a novel technique of data interpretation to the characterization and classification of measurements of plasma columns in Tokamak reactors for nuclear fusion applications. The proposed method exploits several concepts derived from soft computing theory. In particular, Artifical Neural Networks have been exploited to classify magnetic variables useful to determine shape and position of the plasma with a reduced computational complexity. The proposed technique is used to analyze simulated databases of plasma equilibria based on ITER geometry configuration. As well as demonstrating the successful recovery of scalar equilibrium parameters, we show that the technique can yield practical advantages compares with earlier methods.
Abstract: Actual load, material characteristics and other
quantities often differ from the design values. This can cause worse
function, shorter life or failure of a civil engineering structure, a
machine, vehicle or another appliance. The paper shows main causes
of the uncertainties and deviations and presents a systematic
approach and efficient tools for their elimination or mitigation of
consequences. Emphasis is put on the design stage, which is most
important for reliability ensuring. Principles of robust design and
important tools are explained, including FMEA, sensitivity analysis
and probabilistic simulation methods. The lifetime prediction of
long-life objects can be improved by long-term monitoring of the
load response and damage accumulation in operation. The condition
evaluation of engineering structures, such as bridges, is often based
on visual inspection and verbal description. Here, methods based on
fuzzy logic can reduce the subjective influences.
Abstract: Artificial Neural Network (ANN) has been
extensively used for classification of heart sounds for its
discriminative training ability and easy implementation. However, it
suffers from overparameterization if the number of nodes is not
chosen properly. In such cases, when the dataset has redundancy
within it, ANN is trained along with this redundant information that
results in poor validation. Also a larger network means more
computational expense resulting more hardware and time related
cost. Therefore, an optimum design of neural network is needed
towards real-time detection of pathological patterns, if any from heart
sound signal. The aims of this work are to (i) select a set of input
features that are effective for identification of heart sound signals and
(ii) make certain optimum selection of nodes in the hidden layer for a
more effective ANN structure. Here, we present an optimization
technique that involves Singular Value Decomposition (SVD) and
QR factorization with column pivoting (QRcp) methodology to
optimize empirically chosen over-parameterized ANN structure.
Input nodes present in ANN structure is optimized by SVD followed
by QRcp while only SVD is required to prune undesirable hidden
nodes. The result is presented for classifying 12 common
pathological cases and normal heart sound.
Abstract: In this paper, we propose a chaotic cipher system consisting of Improved Volterra Filters and the mapping that is created from the actual voice by using Radial Basis Function Network. In order to achieve a practical system, the system supposes to use the digital communication line, such as the Internet, to maintain the parameter matching between the transmitter and receiver sides. Therefore, in order to withstand the attack from outside, it is necessary that complicate the internal state and improve the sensitivity coefficient. In this paper, we validate the robustness of proposed method from three perspectives of "Chaotic properties", "Randomness", "Coefficient sensitivity".
Abstract: In this paper a non-parametric statistical pattern recognition algorithm for the problem of credit scoring will be presented. The proposed algorithm is based on a clustering k- means algorithm and allows for the determination of subclasses of homogenous elements in the data. The algorithm will be tested on two benchmark datasets and its performance compared with other well known pattern recognition algorithm for credit scoring.
Abstract: This paper explores how Critical Systems Thinking and Action Research can be used to improve student performance in Networking. When describing a system from a systems thinking perspective, the following aspects can be identified: the total system performance, the systems environment, the resources, the components and the management of the system. Following the history of system thinking we observe three emerged methodologies namely, hard systems, soft systems, and critical systems. This paper uses Critical Systems Thinking (CST) which describes systems in terms of contradictions and conflict. It demonstrates how CST can be used in an Action Research (AR) project to improve the performance of students. Intervention in terms of student assessment is discussed and the impact of the intervention is discussed.
Abstract: The development of competences and practical
capacities of students is getting an important incidence into the
guidelines of the European Higher Education Area (EHEA). The
methodology applied in this work is based on the education through
directed resolution of practical cases. All cases are related to
professional tasks that the students will have to develop in their
future career. The method is intended to form the necessary
competences of students of the Marine Engineering and Maritime
Transport Degree in the matter of “Physics".
The experience was applied in the course of 2011/2012. Students
were grouped, and a practical task was assigned to them, that should
be developed and solved within the team. The aim was to realize
students learning by three ways: their own knowledge, the
contribution of their teammates and the teacher's direction. The
results of the evaluation were compared with those obtained
previously by the traditional teaching method.
Abstract: In this paper we present an efficient system for
independent speaker speech recognition based on neural network
approach. The proposed architecture comprises two phases: a
preprocessing phase which consists in segmental normalization and
features extraction and a classification phase which uses neural
networks based on nonparametric density estimation namely the
general regression neural network (GRNN). The relative
performances of the proposed model are compared to the similar
recognition systems based on the Multilayer Perceptron (MLP), the
Recurrent Neural Network (RNN) and the well known Discrete
Hidden Markov Model (HMM-VQ) that we have achieved also.
Experimental results obtained with Arabic digits have shown that the
use of nonparametric density estimation with an appropriate
smoothing factor (spread) improves the generalization power of the
neural network. The word error rate (WER) is reduced significantly
over the baseline HMM method. GRNN computation is a successful
alternative to the other neural network and DHMM.