Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: In recent years, tuned mass damper (TMD) control systems for civil engineering structures have attracted considerable attention. This paper emphasizes on the application of particle swarm application (PSO) to design and optimize the parameters of the TMD control scheme for achieving the best results in the reduction of the building response under earthquake excitations. The Integral of the Time multiplied Absolute value of the Error (ITAE) based on relative displacement of all floors in the building is taken as a performance index of the optimization criterion. The problem of robustly TMD controller design is formatted as an optimization problem based on the ITAE performance index to be solved using the PSO technique which has a story ability to find the most optimistic results. An 11- story realistic building, located in the city of Rasht, Iran is considered as a test system to demonstrate effectiveness of the proposed method. The results analysis through the time-domain simulation and some performance indices reveals that the designed PSO based TMD controller has an excellent capability in reduction of the seismically excited example building.
Abstract: Chemical industry project management involves
complex decision making situations that require discerning abilities
and methods to make sound decisions. Project managers are faced
with decision environments and problems in projects that are
complex. In this work, case study is Research and Development
(R&D) project selection. R&D is an ongoing process for forward
thinking technology-based chemical industries. R&D project
selection is an important task for organizations with R&D project
management. It is a multi-criteria problem which includes both
tangible and intangible factors. The ability to make sound decisions
is very important to success of R&D projects. Multiple-criteria
decision making (MCDM) approaches are major parts of decision
theory and analysis. This paper presents all of MCDM approaches
for use in R&D project selection. It is hoped that this work will
provide a ready reference on MCDM and this will encourage the
application of the MCDM by chemical engineering management.
Abstract: Natural disasters, including earthquake, kill many people around the world every year. Society rescue actions, which start after the earthquake and are called LAST in abbreviation, include locating, access, stabilization and transportation. In the present article, we have studied the process of local accessibility to the injured and transporting them to health care centers. With regard the heavy traffic load due to earthquake, the destruction of connecting roads and bridges and the heavy debris in alleys and street, which put the lives of the injured and the people buried under the debris in danger, accelerating the rescue actions and facilitating the accessibilities are of great importance, obviously. Tehran, the capital of Iran, is among the crowded cities in the world and is the center of extensive economic, political, cultural and social activities. Tehran has a population of about 9.5 millions and because of the immigration of people from the surrounding cities. Furthermore, considering the fact that Tehran is located on two important and large faults, a 6 Richter magnitude earthquake in this city could lead to the greatest catastrophe during the entire human history. The present study is a kind of review and a major part of the required information for it, has been obtained from libraries all of the rescue vehicles around the world, including rescue helicopters, ambulances, fire fighting vehicles and rescue boats, and their applied technology, and also the robots specifically designed for the rescue system and the advantages and disadvantages of them, have been investigated. The studies show that there is a significant relationship between the rescue team-s arrival time at the incident zone and the number of saved people; so that, if the duration of burial under debris 30 minutes, the probability of survival is %99.3, after a day is %81, after 2days is %19 and after 5days is %7.4. The exiting transport systems all have some defects. If these defects are removed, more people could be saved each hour and the preparedness against natural disasters is increased. In this study, transport system has been designed for the rescue team and the injured; which could carry the rescue team to the incident zone and the injured to the health care centers. In addition, this system is able to fly in the air and move on the earth as well; so that the destruction of roads and the heavy traffic load could not prevent the rescue team from arriving early at the incident zone. The system also has the equipment required firebird for debris removing, optimum transport of the injured and first aid.
Abstract: Electronic Government is one of the special concepts
which has been performed successfully within recent decades.
Electronic government is a digital, wall-free government with a
virtual organization for presenting of online governmental services
and further cooperation in different political/social activities. In order
to have a successful implementation of electronic government
strategy and benefiting from its complete potential and benefits and
generally for establishment and applying of electronic government, it
is necessary to have different infrastructures as the basics of
electronic government with lack of which it is impossible to benefit
from mentioned services. For this purpose, in this paper we have
managed to recognize relevant obstacles for establishment of
electronic government in Iran. All required data for recognition of
obstacles were collected from statistical society of involved
specialists of Ministry of Communications & Information
Technology of Iran and Information Technology Organization of
Tehran Municipality through questionnaire. Then by considering of
five-point Likert scope and μ =3 as the index of relevant factors of
proposed model, we could specify current obstacles against
electronic government in Iran along with some guidelines and
proposal in this regard. According to the results, mentioned obstacles
for applying of electronic government in Iran are as follows:
Technical & technological problems, Legal, judicial & safety
problems, Economic problems and Humanistic Problems.
Abstract: This paper presents a novel algorithm of stereo
correspondence with rank transform. In this algorithm we used the
genetic algorithm to achieve the accurate disparity map. Genetic
algorithms are efficient search methods based on principles of
population genetic, i.e. mating, chromosome crossover, gene
mutation, and natural selection. Finally morphology is employed to
remove the errors and discontinuities.
Abstract: Reducing the risk of information leaks is one of
the most important functions of identity management systems. To
achieve this purpose, Dey et al. have already proposed an account
management method for a federated login system using a blind
signature scheme. In order to ensure account anonymity for the
authentication provider, referred to as an IDP (identity provider),
a blind signature scheme is utilized to generate an authentication
token on an authentication service and the token is sent to an IDP.
However, there is a problem with the proposed system. Malicious
users can establish multiple accounts on an IDP by requesting such
accounts. As a measure to solve this problem, in this paper, the
authors propose an account checking method that is performed before
account generation.
Abstract: None of the processing models in the software
development has explained the software systems performance
evaluation and modeling; likewise, there exist uncertainty in the
information systems because of the natural essence of requirements,
and this may cause other challenges in the processing of software
development. By definition an extended version of UML (Fuzzy-
UML), the functional requirements of the software defined
uncertainly would be supported. In this study, the behavioral
description of uncertain information systems by the aid of fuzzy-state
diagram is crucial; moreover, the introduction of behavioral diagrams
role in F-UML is investigated in software performance modeling
process. To get the aim, a fuzzy sub-profile is used.
Abstract: This paper presents an exact analytical model for
optimizing stability of thin-walled, composite, functionally graded
pipes conveying fluid. The critical flow velocity at which divergence
occurs is maximized for a specified total structural mass in order to
ensure the economic feasibility of the attained optimum designs. The
composition of the material of construction is optimized by defining
the spatial distribution of volume fractions of the material
constituents using piecewise variations along the pipe length. The
major aim is to tailor the material distribution in the axial direction so
as to avoid the occurrence of divergence instability without the
penalty of increasing structural mass. Three types of boundary
conditions have been examined; namely, Hinged-Hinged, Clamped-
Hinged and Clamped-Clamped pipelines. The resulting optimization
problem has been formulated as a nonlinear mathematical
programming problem solved by invoking the MatLab optimization
toolbox routines, which implement constrained function
minimization routine named “fmincon" interacting with the
associated eigenvalue problem routines. In fact, the proposed
mathematical models have succeeded in maximizing the critical flow
velocity without mass penalty and producing efficient and economic
designs having enhanced stability characteristics as compared with
the baseline designs.
Abstract: As part of national epidemiological survey on bovine
viral diarrhea virus (BVDV), a total of 274 dejecta samples were
collected from 14 cattle farms in 8 areas of Xinjiang Uygur
Autonomous Region in northwestern China. Total RNA was extracted
from each sample, and 5--untranslated region (UTR) of BVDV
genome was amplified by using two-step reverse
transcriptase-polymerase chain reaction (RT-PCR). The PCR products
were subsequently sequenced to study the genetic variations of BVDV
in these areas. Among the 274 samples, 33 samples were found
virus-positive. According to sequence analysis of the PCR products,
the 33 samples could be arranged into 16 groups. All the sequences,
however, were highly conserved with BVDV Osloss strains. The virus
possessed theses sequences belonged to BVDV-1b subtype by
phylogenetic analysis. Based on these data, we established a typing
tree for BVDV in these areas. Our results suggested that BVDV-1b
was a predominant subgenotype in northwestern China and no
correlation between the genetic and geographical distances could be
observed above the farm level.
Abstract: This paper is to develop a fuzzy net present value (FNPV) method by taking vague cash flow and imprecise required rate of return into account for evaluating the value of the Build-Operate-Transfer (BOT) sport facilities. In order to clearly manifest a more realistic capital budgeting model based on the classical net present value (NPV) method, some uncertain financial elements in NPV formula will be fuzzified as triangular fuzzy numbers. Through the conscientious manipulation of fuzzy set theory, we will find that the proposed FNPV model is a more explicit extension of classical (crisp) model and could be more practicable for the financial managers to capture the essence of capital budgeting of sport facilities than non-fuzzy model.
Abstract: The paper provides an in-depth tutorial of mathematical
construction of maximal length sequences (m-sequences) via primitive
polynomials and how to map the same when implemented in
shift registers. It is equally important to check whether a polynomial
is primitive or not so as to get proper m-sequences. A fast method to
identify primitive polynomials over binary fields is proposed where
the complexity is considerably less in comparison with the standard
procedures for the same purpose.
Abstract: Decomposition processes take place in landfill
generate leachates that can be categorized mainly of acetogenic and
methanogenic in nature. BOD:COD ratio computed in this study for a
landfill site over a 3 years duration revealed as a good indicator to
identify acetogenic leachate from methanogenic leachate. Correlation
relationships to predict pollutant level taking into consideration of
climatic condition are derived.
Abstract: The ITE Project is a project that has 1800 km length
and across the Turkey's land through east to west. The project of
pipeline enters geographically from Iran to Doğubayazit (Turkey) in
the east, exits to Greece from Ipsala province of Turkey in the west.
This project is the one of the international projects in such scale that
provides the natural gas of Iran and Caspian Sea through the
European continent. In this investigation, some information will be
given about the methods used to verify the direction of the pipeline
and the technical properties of the results obtained. The cost of
project itself entirely depends on the direction of the pipeline which
would be as short as possible and the specifications of the land cover.
Production standards of 1/2000 scaled digital orthophoto and vectoral
maps as a results of the use of map production materials and methods
(such as high resolution satellite images, and digital aerial images
captured from digital aerial cameras), will also be given in this report.
According to Turkish national map production standards, TM
((Transversal Mercator, 3 degree) projection is used for large scale
map and UTM (Universal Transversal Mercator, 6 degree) is used for
small scale map production standards. Some information is also given
about the projection used in the ITE natural gas pipeline project.
Abstract: This paper describes the development of an electronic
instrument that looks like a flute, which is able to sense the basic musical notes being executed by a specific user. The principal function of the instrument is to teach how to play a flute. This device
will generate a significant academic impact, in a field of virtual reality interactive that combine art and technology. With this example is expected to contribute in research and implementation of teaching devices around the world.
Abstract: This paper provides an in-depth study of Wireless
Sensor Network (WSN) application to monitor and control the
swiftlet habitat. A set of system design is designed and developed
that includes the hardware design of the nodes, Graphical User
Interface (GUI) software, sensor network, and interconnectivity for
remote data access and management. System architecture is proposed
to address the requirements for habitat monitoring. Such applicationdriven
design provides and identify important areas of further work
in data sampling, communications and networking. For this
monitoring system, a sensor node (MTS400), IRIS and Micaz radio
transceivers, and a USB interfaced gateway base station of Crossbow
(Xbow) Technology WSN are employed. The GUI of this monitoring
system is written using a Laboratory Virtual Instrumentation
Engineering Workbench (LabVIEW) along with Xbow Technology
drivers provided by National Instrument. As a result, this monitoring
system is capable of collecting data and presents it in both tables and
waveform charts for further analysis. This system is also able to send
notification message by email provided Internet connectivity is
available whenever changes on habitat at remote sites (swiftlet farms)
occur. Other functions that have been implemented in this system
are the database system for record and management purposes; remote
access through the internet using LogMeIn software. Finally, this
research draws a conclusion that a WSN for monitoring swiftlet
habitat can be effectively used to monitor and manage swiftlet
farming industry in Sarawak.
Abstract: Non-viral gene carriers composed of biodegradable
polymers or lipids have been considered as a safer alternative for gene
carriers over viral vectors. We have developed multi-functional
nano-micelles for both drug and gene delivery application.
Polyethyleneimine (PEI) was modified by grafting stearic acid (SA)
and formulated to polymeric micelles (PEI-SA) with positive surface
charge for gene and drug delivery. Our results showed that PEI-SA
micelles provided high siRNA binding efficiency. In addition, siRNA
delivered by PEI-SA carriers also demonstrated significantly high
cellular uptake even in the presence of serum proteins. The
post-transcriptional gene silencing efficiency was greatly improved by
the polyplex formulated by 10k PEI-SA/siRNA. The amphiphilic
structure of PEI-SA micelles provided advantages for multifunctional
tasks; where the hydrophilic shell modified with cationic charges can
electrostatically interact with DNA or siRNA, and the hydrophobic
core can serve as payloads for hydrophobic drugs, making it a
promising multifunctional vehicle for both genetic and chemotherapy
application.
Abstract: In this paper, the effect of atmospheric turbulence on
bit error probability in free-space optical CDMA scheme with
Sequence Inverse Keyed (SIK) optical correlator receiver is analyzed.
Here Intensity Modulation scheme is considered for transmission.
The turbulence induced fading is described by the newly introduced
gamma-gamma pdf[1] as a tractable mathematical model for
atmospheric turbulence. Results are evaluated with Gold and Kasami
code & it is shown that Gold sequence can be used for more
efficient transmission than Kasami sequence in an atmospheric
turbulence channel.
Abstract: Human identification at a distance has recently gained
growing interest from computer vision researchers. Gait recognition
aims essentially to address this problem by identifying people based
on the way they walk [1]. Gait recognition has 3 steps. The first step
is preprocessing, the second step is feature extraction and the third
one is classification. This paper focuses on the classification step that
is essential to increase the CCR (Correct Classification Rate).
Multilayer Perceptron (MLP) is used in this work. Neural Networks
imitate the human brain to perform intelligent tasks [3].They can
represent complicated relationships between input and output and
acquire knowledge about these relationships directly from the data
[2]. In this paper we apply MLP NN for 11 views in our database and
compare the CCR values for these views. Experiments are performed
with the NLPR databases, and the effectiveness of the proposed
method for gait recognition is demonstrated.
Abstract: A Comparison and evaluation of the different
condition monitoring (CM) techniques was applied experimentally
on RC e.g. Dynamic cylinder pressure and crankshaft Instantaneous
Angular Speed (IAS), for the detection and diagnosis of valve faults
in a two - stage reciprocating compressor for a programme of
condition monitoring which can successfully detect and diagnose a
fault in machine. Leakage in the valve plate was introduced
experimentally into a two-stage reciprocating compressor. The effect
of the faults on compressor performance was monitored and the
differences with the normal, healthy performance noted as a fault
signature been used for the detection and diagnosis of faults.
The paper concludes with what is considered to be a unique
approach to condition monitoring. First, each of the two most useful
techniques is used to produce a Truth Table which details the
circumstances in which each method can be used to detect and
diagnose a fault. The two Truth Tables are then combined into a
single Decision Table to provide a unique and reliable method of
detection and diagnosis of each of the individual faults introduced
into the compressor. This gives accurate diagnosis of compressor
faults.