Abstract: Candida spp. are common and aggressive pathogens.
Because of the growing resistance of Candida spp. to current
antifungals, novel targets, found in Candida spp. but not in humans
or other flora, have to be identified. The alternative oxidase (AOX)
is one such possibility. This enzyme is insensitive to cyanide, but is
sensitive to compounds such as salicylhydroxamic acid (SHAM),
disulfiram and n-alkyl gallates. The growth Candida albicans was
inhibited by SHAM (Ki = 9-15 mM) and cyanide (Ki = 2-4 mM),
albeit to differing extents. The rate of O2 uptake was inhibited by
less than 10% by 25 mM SHAM and by about 90% by 250 μM
KCN. Although SHAM substantially inhibited the growth of C.
albicans, it is unlikely that the inhibition of AOX was the cause.
Salicylhydroxamic acid is used therapeutically in the treatment of
urinary tract infections and urolithiasis, but it also has some potential
in the treatment of C. albicans infection.
Abstract: Over the past decade, mobile has experienced a
revolution that will ultimately change the way we communicate.All
these technologies have a common denominator exploitation of
computer information systems, but their operation can be tedious
because of problems with heterogeneous data sources.To overcome
the problems of heterogeneous data sources, we propose to use a
technique of adding an extra layer interfacing applications of
management or supervision at the different data sources.This layer
will be materialized by the implementation of a mediator between
different host applications and information systems frequently used
hierarchical and relational manner such that the heterogeneity is
completely transparent to the VoIP platform.
Abstract: Data stream analysis is the process of computing
various summaries and derived values from large amounts of data
which are continuously generated at a rapid rate. The nature of a
stream does not allow a revisit on each data element. Furthermore,
data processing must be fast to produce timely analysis results. These
requirements impose constraints on the design of the algorithms to
balance correctness against timely responses. Several techniques
have been proposed over the past few years to address these
challenges. These techniques can be categorized as either dataoriented
or task-oriented. The data-oriented approach analyzes a
subset of data or a smaller transformed representation, whereas taskoriented
scheme solves the problem directly via approximation
techniques. We propose a hybrid approach to tackle the data stream
analysis problem. The data stream has been both statistically
transformed to a smaller size and computationally approximated its
characteristics. We adopt a Monte Carlo method in the approximation
step. The data reduction has been performed horizontally and
vertically through our EMR sampling method. The proposed method
is analyzed by a series of experiments. We apply our algorithm on
clustering and classification tasks to evaluate the utility of our
approach.
Abstract: An adaptive Helmholtz resonator was designed and
adapted to hydraulics. The resonator was controlled by open- and
closed-loop controls so that 20 dB attenuation of the peak-to-peak
value of the pulsating pressure was maintained. The closed-loop
control was noted to be better, albeit it was slower because of its low
pressure and temperature variation, which caused variation in the
effective bulk modulus of the hydraulic system. Low-pressure
hydraulics contains air, which affects the stiffness of the hydraulics,
and temperature variation changes the viscosity of the oil. Thus, an
open-loop control loses its efficiency if a condition such as
temperature or the amount of air changes after calibration. The
instability of the low-pressure hydraulic system reduced the
operational frequency range of the Helmholtz resonator when
compared with the results of an analytical model.
Different dampers for hydraulics are presented. Then analytical
models of a hydraulic pipe and a hydraulic pipe with a Helmholtz
resonator are presented. The analytical models are based on the wave
equation of sound pressure. Finally, control methods and the results
of experiments are presented.
Abstract: The limit load carrying capacity of functionally
graded materials (FGM) circular plates subjected to an arbitrary
rotationally symmetric loading has been computed. It is provided that
the plate material behaves rigid perfectly plastic and obeys either the
Square or the Tresca yield criterion. To this end the upper and lower
bound principles of limit analysis are employed to determine the
exact value for the limiting load. The correctness of the result are
verified and finally limiting loads for two examples namely; through
radius and through thickness FGM circular plates with simply
supported edges are calculated, respectively and moreover, the values
of critical loading factor are determined.
Abstract: Newcastle Disease Virus (NDV), an avian
paramyxovirus, is a highly contagious, generalised virus disease of
domestic poultry and wild birds characterized by gastro-intestinal,
respiratory and nervous signs. In this study, it was shown that NDV
strain AF2240 and V4-UPM are cytolytic to Human Promyelocytic
Leukemia, HL60 and Human T-lymphoblastic Leukemia, CEM-SS
cells. Results from MTT cytolytic assay showed that CD50 for NDV
AF2240 against HL60 was 130 HAU and NDV V4-UPM against
HL60 and CEM-SS were 110.6 and 150.9 HAU respectively.
Besides, both strains were found to inhibit the proliferation of cells in
a dose dependent manner. The mode of cell death either by apoptosis
or necrosis was further analyzed using acridine orange and propidium
iodide (AO/PI) staining. Our results showed that both NDV strains
induced primarily apoptosis in treated cells at CD50 concentration. In
conclusion, both NDV strains caused cytolytic effects primarily via
apoptosis in leukemia cells.
Abstract: Among all geo-hydrological relationships, rainfallrunoff
relationship is of utmost importance in any hydrological
investigation and water resource planning. Spatial variation, lag time
involved in obtaining areal estimates for the basin as a whole can
affect the parameterization in design stage as well as in planning
stage. In conventional hydrological processing of data, spatial aspect
is either ignored or interpolated at sub-basin level. Temporal
variation when analysed for different stages can provide clues for its
spatial effectiveness. The interplay of space-time variation at pixel
level can provide better understanding of basin parameters.
Sustenance of design structures for different return periods and their
spatial auto-correlations should be studied at different geographical
scales for better management and planning of water resources.
In order to understand the relative effect of spatio-temporal
variation in hydrological data network, a detailed geo-hydrological
analysis of Betwa river catchment falling in Lower Yamuna Basin is
presented in this paper. Moreover, the exact estimates about the
availability of water in the Betwa river catchment, especially in the
wake of recent Betwa-Ken linkage project, need thorough scientific
investigation for better planning. Therefore, an attempt in this
direction is made here to analyse the existing hydrological and
meteorological data with the help of SPSS, GIS and MS-EXCEL
software. A comparison of spatial and temporal correlations at subcatchment
level in case of upper Betwa reaches has been made to
demonstrate the representativeness of rain gauges. First, flows at
different locations are used to derive correlation and regression
coefficients. Then, long-term normal water yield estimates based on
pixel-wise regression coefficients of rainfall-runoff relationship have
been mapped. The areal values obtained from these maps can
definitely improve upon estimates based on point-based
extrapolations or areal interpolations.
Abstract: Equations with differentials relating to the inverse of an unknown function rather than to the unknown function itself are solved exactly for some special cases and numerically for the general case. Invertibility combined with differentiability over connected domains forces solutions always to be monotone. Numerical function inversion is key to all solution algorithms which either are of a forward type or a fixed point type considering whole approximate solution functions in each iteration. The given considerations are restricted to ordinary differential equations with inverted functions (ODEIs) of first order. Forward type computations, if applicable, admit consistency of order one and, under an additional accuracy condition, convergence of order one.
Abstract: A water surface slope limiting scheme is tested and
compared with the water depth slope limiter for the solution of one
dimensional shallow water equations with bottom slope source term.
Numerical schemes based on the total variation diminishing Runge-
Kutta discontinuous Galerkin finite element method with slope
limiter schemes based on water surface slope and water depth are
used to solve one-dimensional shallow water equations. For each
slope limiter, three different Riemann solvers based on HLL, LF, and
Roe flux functions are used. The proposed water surface based slope
limiter scheme is easy to implement and shows better conservation
property compared to the slope limiter based on water depth. Of the
three flux functions, the Roe approximation provides the best results
while the LF function proves to be least suitable when used with
either slope limiter scheme.
Abstract: In most of the popular implementation of Parallel GAs
the whole population is divided into a set of subpopulations, each
subpopulation executes GA independently and some individuals are
migrated at fixed intervals on a ring topology. In these studies,
the migrations usually occur 'synchronously' among subpopulations.
Therefore, CPUs are not used efficiently and the communication
do not occur efficiently either. A few studies tried asynchronous
migration but it is hard to implement and setting proper parameter
values is difficult.
The aim of our research is to develop a migration method which is
easy to implement, which is easy to set parameter values, and which
reduces communication traffic. In this paper, we propose a traffic
reduction method for the Asynchronous Parallel Distributed GA by
migration of elites only. This is a Server-Client model. Every client
executes GA on a subpopulation and sends an elite information to the
server. The server manages the elite information of each client and
the migrations occur according to the evolution of sub-population in
a client. This facilitates the reduction in communication traffic.
To evaluate our proposed model, we apply it to many function optimization
problems. We confirm that our proposed method performs
as well as current methods, the communication traffic is less, and
setting of the parameters are much easier.
Abstract: In large Internet backbones, Service Providers
typically have to explicitly manage the traffic flows in order to
optimize the use of network resources. This process is often referred
to as Traffic Engineering (TE). Common objectives of traffic
engineering include balance traffic distribution across the network
and avoiding congestion hot spots. Raj P H and SVK Raja designed
the Bayesian network approach to identify congestion hors pots in
MPLS. In this approach for every node in the network the
Conditional Probability Distribution (CPD) is specified. Based on
the CPD the congestion hot spots are identified. Then the traffic can
be distributed so that no link in the network is either over utilized or
under utilized. Although the Bayesian network approach has been
implemented in operational networks, it has a number of well known
scaling issues.
This paper proposes a new approach, which we call the Pragati
(means Progress) Node Popularity (PNP) approach to identify the
congestion hot spots with the network topology alone. In the new
Pragati Node Popularity approach, IP routing runs natively over the
physical topology rather than depending on the CPD of each node as
in Bayesian network. We first illustrate our approach with a simple
network, then present a formal analysis of the Pragati Node
Popularity approach. Our PNP approach shows that for any given
network of Bayesian approach, it exactly identifies the same result
with minimum efforts. We further extend the result to a more
generic one: for any network topology and even though the network
is loopy. A theoretical insight of our result is that the optimal routing
is always shortest path routing with respect to some considerations of
hot spots in the networks.
Abstract: This paper presented a MATLAB-based system named Smart Access Network Testing, Analyzing and Database (SANTAD), purposely for in-service transmission surveillance and self restoration against fiber fault in fiber-to-the-home (FTTH) access network. The developed program will be installed with optical line terminal (OLT) at central office (CO) to monitor the status and detect any fiber fault that occurs in FTTH downwardly from CO towards residential customer locations. SANTAD is interfaced with optical time domain reflectometer (OTDR) to accumulate every network testing result to be displayed on a single computer screen for further analysis. This program will identify and present the parameters of each optical fiber line such as the line's status either in working or nonworking condition, magnitude of decreasing at each point, failure location, and other details as shown in the OTDR's screen. The failure status will be delivered to field engineers for promptly actions, meanwhile the failure line will be diverted to protection line to ensure the traffic flow continuously. This approach has a bright prospect to improve the survivability and reliability as well as increase the efficiency and monitoring capabilities in FTTH.
Abstract: Environment today is featured with aging population,
increasing prevalence of chronic disease and complex of medical
treatment. Safe use of pharmaceutics relied very much on the efforts
made by both the health- related organizations and as well as the
government agencies. As far as the specialization concern in providing
health services to the patients, the government actively issued and
implemented the divisions of medical treatment and pharmaceutical to
improve the quality of care and to reduce medication errors and ensure
public health. Pharmaceutical sub-sector policy has been implemented
for 13 years. This study attempts to explore the factors that affect the
patients- behavior intention of refilling a prescription from a NHIB
pharmacy. Samples were those patients refilling their prescriptions
with the case NHIB pharmacies. A self-administered questionnaire
was used to collect respondents- information while the patients or
family members visit the pharmacy for the refilling. 1,200
questionnaires were dispatched in 37 pharmacies that randomly
selected from Pingtung City, Dongkang, Chaozhou, Hengchun areas.
732 responses were gained with 604 valid samples for further analyses.
Results of data analyses indicated that respondents- attitude,
subjective norm, perceived behavior control and behavior intentions
toward refilling behavior varied from some demographic variables to
another. This research also suggested adding actual behavior, either by
a self-report or observed, into the research.
Abstract: In this empirical research, how marketing managers evaluate their firms- performances and decide to make innovation is examined. They use some standards which are past performance of the firm, target performance of the firm, competitor performance, and average performance of the industry to compare and evaluate the firms- performances. It is hypothesized that marketing managers and owners of the firm compare the firms- current performance with these four standards at the same time to decide when to make innovation relating to any aspects of the firm, either management style or products. Relationship between the comparison of the firm-s performance with these standards and innovation are searched in the same regression model. The results of the regression analysis are discussed and some recommendations are made for future studies and applicants.
Abstract: This paper presents an application of level sets for the segmentation of abdominal and thoracic aortic aneurysms in CTA
datasets. An important challenge in reliably detecting aortic is the
need to overcome problems associated with intensity
inhomogeneities. Level sets are part of an important class of methods
that utilize partial differential equations (PDEs) and have been extensively applied in image segmentation. A kernel function in the
level set formulation aids the suppression of noise in the extracted
regions of interest and then guides the motion of the evolving contour
for the detection of weak boundaries. The speed of curve evolution
has been significantly improved with a resulting decrease in segmentation time compared with previous implementations of level
sets, and are shown to be more effective than other approaches in
coping with intensity inhomogeneities. We have applied the Courant
Friedrichs Levy (CFL) condition as stability criterion for our algorithm.
Abstract: Skin color based tracking techniques often assume a
static skin color model obtained either from an offline set of library
images or the first few frames of a video stream. These models
can show a weak performance in presence of changing lighting or
imaging conditions. We propose an adaptive skin color model based
on the Gaussian mixture model to handle the changing conditions.
Initial estimation of the number and weights of skin color clusters
are obtained using a modified form of the general Expectation
maximization algorithm, The model adapts to changes in imaging
conditions and refines the model parameters dynamically using spatial
and temporal constraints. Experimental results show that the method
can be used in effectively tracking of hand and face regions.
Abstract: Sports Sciences has been historically supported by the positivism idea of science, especially by the mechanistic/reductionist and becomes a field that views experimentation and measurement as the mayor research domains. The disposition to simplify nature and the world by parts has fragmented and reduced the idea of bodyathletes as machine. In this paper we intent to re-think this perception lined by Complexity Theory. We come with the idea of athletes as a reflexive and active being (corporeity-body). Therefore, the construction of a training that considers the cultural, biological, psychological elements regarding the experience of the human corporal movements in a circumspect and responsible way could bring better chances of accomplishment. In the end, we hope to help coaches understand the intrinsic complexity of the body they are training, how better deal with it, and, in the field of a deep globalization among the different types of knowledge, to respect and accepted the peculiarities of knowledge that comprise this area.
Abstract: One part of the total employee’s reward is apart from basic wages or salary, employee’s benefits and intangible remuneration also so called contingent (variable) pay. Contingent pay is connected to performance, contribution, cap competency or skills of individual employees, and to team’s or company-wide performance or to combination of few of the mentioned possibilities. Sometimes among the contingent pay is also incorporated the remuneration based on length of employment, when the financial reward is not connected to performance or skills, but to length of continuous employment either on one working position or in one level of remuneration scale. Main aim of this article is to define, based on available information, contingent pay, describe individual forms, its advantages and disadvantages and possibilities to utilization in practice; but also bring information not only about its extent and level of utilization of contingent pay by companies in one of the Czech Republic’s regions, but also mention their practical experience with this type of remuneration.
Abstract: Public awareness towards green energy are on the rise and this can be prove by many product being manufactured or prerequired to be made as energy saving devices mainly to save consumer from spending more on utility billing. These schemes are popular nowadays and many homemade appliances are turned into energy saving gadget which attracts the attention of consumers. Knowing the public demands and pattern towards purchasing home appliances thus the idea of “energy saving suction hood (ESSH)" is proposed. The ESSH can be used in many places that require smoke ventilation or even to reduce the room temperature as many conventional suction hoods (CSH) do, but this device works automatically by the usage of sensors that detects the smoke/temperature and automatically spins the exhaust fan. As it turns, the mechanical rotation rotates the AC generator which is coupled together with the fan and then charges the battery. The innovation of this product is, it does not rely on the utility supply as it is also hook up with a solar panel which also charges the battery, Secondly, it generates energy as the exhaust fan mechanically rotates. Thirdly, an energy loop back feature is introduced to this system which will supply for the ventilator fan. Another major innovation is towards interfacing this device with an in house production of generator. This generator is produced by proper design on stator as well as rotor to reduce the losses. A comparison is made between the ESSH and the CSH and result shows that the ESSH saves 172.8kWh/year of utility supply which is used by CSH. This amount of energy can save RM 3.14 from monthly utility bill and a total of RM 37.67 per year. In fact this product can generate 175 Watt of power from generator(75W) and solar panel(100W) that can be used either to supply other household appliances and/or to loop back to supply the fans motor. The innovation of this system is essential for future production of other equipment by using the loopback power method and turning most equipment into a standalone system.
Abstract: This paper presents various classifiers results from a system that can automatically recognize four different static human body postures in video sequences. The considered postures are standing, sitting, squatting, and lying. The three classifiers considered are a naïve one and two based on the belief theory. The belief theory-based classifiers use either a classic or restricted plausibility criterion to make a decision after data fusion. The data come from the people 2D segmentation and from their face localization. Measurements consist in distances relative to a reference posture. The efficiency and the limits of the different classifiers on the recognition system are highlighted thanks to the analysis of a great number of results. This system allows real-time processing.