Abstract: The DNA microarray technology concurrently monitors the expression levels of thousands of genes during significant biological processes and across the related samples. The better understanding of functional genomics is obtained by extracting the patterns hidden in gene expression data. It is handled by clustering which reveals natural structures and identify interesting patterns in the underlying data. In the proposed work clustering gene expression data is done through an Advanced Nelder Mead (ANM) algorithm. Nelder Mead (NM) method is a method designed for optimization process. In Nelder Mead method, the vertices of a triangle are considered as the solutions. Many operations are performed on this triangle to obtain a better result. In the proposed work, the operations like reflection and expansion is eliminated and a new operation called spread-out is introduced. The spread-out operation will increase the global search area and thus provides a better result on optimization. The spread-out operation will give three points and the best among these three points will be used to replace the worst point. The experiment results are analyzed with optimization benchmark test functions and gene expression benchmark datasets. The results show that ANM outperforms NM in both benchmarks.
Abstract: Mammalian genomes contain large number of
retroelements (SINEs, LINEs and LTRs) which could affect
expression of protein coding genes through associated transcription
factor binding sites (TFBS). Activity of the retroelement-associated
TFBS in many genes is confirmed experimentally but their global
functional impact remains unclear. Human SINEs (Alu repeats) and
mouse SINEs (B1 and B2 repeats) are known to be clustered in GCrich
gene rich genome segments consistent with the view that they
can contribute to regulation of gene expression. We have shown
earlier that Alu are involved in formation of cis-regulatory modules
(clusters of TFBS) in human promoters, and other authors reported
that Alu located near promoter CpG islands have an increased
frequency of CpG dinucleotides suggesting that these Alu are
undermethylated. Human Alu and mouse B1/B2 elements have an
internal bipartite promoter for RNA polymerase III containing
conserved sequence motif called B-box which can bind basal
transcription complex TFIIIC. It has been recently shown that TFIIIC
binding to B-box leads to formation of a boundary which limits
spread of repressive chromatin modifications in S. pombe. SINEassociated
B-boxes may have similar function but conservation of
TFIIIC binding sites in SINEs located near mammalian promoters
has not been studied earlier. Here we analysed abundance and
distribution of retroelements (SINEs, LINEs and LTRs) in annotated
sequences of the Database of mammalian transcription start sites
(DBTSS). Fractions of SINEs in human and mouse promoters are
slightly lower than in all genome but >40% of human and mouse
promoters contain Alu or B1/B2 elements within -1000 to +200 bp
interval relative to transcription start site (TSS). Most of these SINEs
is associated with distal segments of promoters (-1000 to -200 bp
relative to TSS) indicating that their insertion at distances >200 bp
upstream of TSS is tolerated during evolution. Distribution of SINEs
in promoters correlates negatively with the distribution of CpG
sequences. Using analysis of abundance of 12-mer motifs from the
B1 and Alu consensus sequences in genome and DBTSS it has been
confirmed that some subsegments of Alu and B1 elements are poorly
conserved which depends in part on the presence of CpG
dinucleotides. One of these CpG-containing subsegments in B1
elements overlaps with SINE-associated B-box and it shows better
conservation in DBTSS compared to genomic sequences. It has been
also studied conservation in DBTSS and genome of the B-box
containing segments of old (AluJ, AluS) and young (AluY) Alu
repeats and found that CpG sequence of the B-box of old Alu is
better conserved in DBTSS than in genome. This indicates that Bbox-
associated CpGs in promoters are better protected from
methylation and mutation than B-box-associated CpGs in genomic
SINEs. These results are consistent with the view that potential
TFIIIC binding motifs in SINEs associated with human and mouse
promoters may be functionally important. These motifs may protect
promoters from repressive histone modifications which spread from
adjacent sequences. This can potentially explain well known
clustering of SINEs in GC-rich gene rich genome compartments and
existence of unmethylated CpG islands.
Abstract: Studies in economics domain tried to reveal the correlation between stock markets. Since the globalization era, interdependence between stock markets becomes more obvious. The Dynamic Interaction Network (DIN) algorithm, which was inspired by a Gene Regulatory Network (GRN) extraction method in the bioinformatics field, is applied to reveal important and complex dynamic relationship between stock markets. We use the data of the stock market indices from eight countries around the world in this study. Our results conclude that DIN is able to reveal and model patterns of dynamic interaction from the observed variables (i.e. stock market indices). Furthermore, it is also found that the extracted network models can be utilized to predict movement of the stock market indices with a considerably good accuracy.
Abstract: Voice Over IP (VoIP) is a technology that could pass
the voice traffic and data packet form over an IP network. Network
can be used for intranet or Internet. Phone calls using VoIP has
advantages in terms of cheaper cost of PSTN phone to more than
half, because the cost is calculated by the cost of the global nature of
the Internet. Session Initiation Protocol (SIP) is a signaling protocol
at the application layer which serves to establish, modify, and
terminate a multimedia session involving one or more users. This SIP
signaling has SIP message in text form that is used for session
management by the SIP components, such as User Agent, Registrar,
Redirect Server, and Proxy Server. To build a SIP communication is
required SIP Express Router (SER) to be able to receive SIP
messages, for handling the basic functions of SIP messages.
Problems occur when the NAT through which affects the voice
communication will be blocked starting from the sound that is not
sent or one side of the sound are sent (half duplex). How that could
be used to penetrate NAT is to use a given mediaproxy random RTP
port to penetrate NAT.
Abstract: Recently, most digital systems are designed as GALS (Globally Asynchronous Locally Synchronous) systems. Several architectures have been proposed as bus architectures for a GALS system : shared bus, segmented bus, ring bus, and so on. In this study, we propose a ring segmented bus architecture which is a combination of segmented bus and ring bus architecture with the aim of throughput enhancement. In a segmented bus architecture, segments are connected in series. By connecting the segments at the end of the bus and constructing the ring bus, it becomes possible to allocate a channel of the bus bidirectionally. The bus channel is allocated to the shortest path between segments. We consider a metastable operation caused by asynchronous communication between segments and a burst transfer between segments. According to the result of simulation, it is shown that the GALS system designed by the proposed method has the desired operations.
Abstract: Motion capture devices have been utilized in
producing several contents, such as movies and video games. However,
since motion capture devices are expensive and inconvenient to use,
motions segmented from captured data was recycled and synthesized
to utilize it in another contents, but the motions were generally
segmented by contents producers in manual. Therefore, automatic
motion segmentation is recently getting a lot of attentions. Previous
approaches are divided into on-line and off-line, where on-line
approaches segment motions based on similarities between
neighboring frames and off-line approaches segment motions by
capturing the global characteristics in feature space. In this paper, we
propose a graph-based high-level motion segmentation method. Since
high-level motions consist of several repeated frames within temporal
distances, we consider all similarities among all frames within the
temporal distance. This is achieved by constructing a graph, where
each vertex represents a frame and the edges between the frames are
weighted by their similarity. Then, normalized cuts algorithm is used
to partition the constructed graph into several sub-graphs by globally
finding minimum cuts. In the experiments, the results using the
proposed method showed better performance than PCA-based method
in on-line and GMM-based method in off-line, as the proposed method
globally segment motions from the graph constructed based
similarities between neighboring frames as well as similarities among
all frames within temporal distances.
Abstract: Wireless Sensor Networks consist of inexpensive, low power sensor nodes deployed to monitor the environment and collect
data. Gathering information in an energy efficient manner is a critical aspect to prolong the network lifetime. Clustering algorithms have an advantage of enhancing the network lifetime. Current clustering algorithms usually focus on global re-clustering and local re-clustering separately. This paper, proposed a combination of those two reclustering methods to reduce the energy consumption of the network. Furthermore, the proposed algorithm can apply to homogeneous as well as heterogeneous wireless sensor networks. In addition, the cluster head rotation happens, only when its energy drops below a dynamic threshold value computed by the algorithm. The simulation result shows that the proposed algorithm prolong the network lifetime compared to existing algorithms.
Abstract: The African Great Lakes Region refers to the zone
around lakes Victoria, Tanganyika, Albert, Edward, Kivu, and
Malawi. The main source of electricity in this region is hydropower
whose systems are generally characterized by relatively weak,
isolated power schemes, poor maintenance and technical deficiencies
with limited electricity infrastructures. Most of the hydro sources are
rain fed, and as such there is normally a deficiency of water during
the dry seasons and extended droughts. In such calamities fossil fuels
sources, in particular petroleum products and natural gas, are
normally used to rescue the situation but apart from them being nonrenewable,
they also release huge amount of green house gases to our
environment which in turn accelerates the global warming that has at
present reached an amazing stage. Wind power is ample, renewable,
widely distributed, clean, and free energy source that does not
consume or pollute water. Wind generated electricity is one of the
most practical and commercially viable option for grid quality and
utility scale electricity production. However, the main shortcoming
associated with electric wind power generation is fluctuation in its
output both in space and time. Before making a decision to establish
a wind park at a site, the wind speed features there should therefore
be known thoroughly as well as local demand or transmission
capacity. The main objective of this paper is to utilise monthly
average wind speed data collected from one prospective site within
the African Great Lakes Region to demonstrate that the available
wind power there is high enough to generate electricity. The mean
monthly values were calculated from records gathered on hourly
basis for a period of 5 years (2001 to 2005) from a site in Tanzania.
The documentations that were collected at a height of 2 m were
projected to a height of 50 m which is the standard hub height of
wind turbines. The overall monthly average wind speed was found to
be 12.11 m/s whereas June to November was established to be the
windy season as the wind speed during the session is above the
overall monthly wind speed. The available wind power density
corresponding to the overall mean monthly wind speed was evaluated
to be 1072 W/m2, a potential that is worthwhile harvesting for the
purpose of electric generation.
Abstract: The direct synthesis process of dimethyl ether (DME)
from syngas in slurry reactors is considered to be promising because
of its advantages in caloric transfer. In this paper, the influences of
operating conditions (temperature, pressure and weight hourly space
velocity) on the conversion of CO, selectivity of DME and methanol
were studied in a stirred autoclave over Cu-Zn-Al-Zr slurry catalyst,
which is far more suitable to liquid phase dimethyl ether synthesis
process than bifunctional catalyst commercially. A Langmuir-
Hinshelwood mechanism type global kinetics model for liquid phase
DME direct synthesis based on methanol synthesis models and a
methanol dehydration model has been investigated by fitting our
experimental data. The model parameters were estimated with
MATLAB program based on general Genetic Algorithms and
Levenberg-Marquardt method, which is suitably fitting experimental
data and its reliability was verified by statistical test and residual
error analysis.
Abstract: The international society focuses on the environment
protection and natural energy sources control for the global
cooperation against weather change and sustainable growth. The study
presents the overview of the water shortage status and the necessity of wastewater reuse facility in military facilities and for the possibility of
the introduction, compares the economics by means of cost-benefit
analysis. The military features such as the number of users of military barracks and the water use were surveyed by the design principles by
facility types, the application method of wastewater reuse facility was selected, the feed water, its application and the volume of reuse volume were defined and the expectation was estimated, confirming
the possibility of introducing a wastewater reuse possibility by means of cost-benefit analysis.
Abstract: The prediction of meteorological parameters at a
meteorological station is an interesting and open problem. A firstorder
linear dynamic model GM(1,1) is the main component of the
grey system theory. The grey model requires only a few previous data
points in order to make a real-time forecast. In this paper, we
consider the daily average ambient temperature as a time series and
the grey model GM(1,1) applied to local prediction (short-term
prediction) of the temperature. In the same case study we use a fuzzy
predictive model for global prediction. We conclude the paper with a
comparison between local and global prediction schemes.
Abstract: The persistent nature of perfluorochemicals (PFCs) has attracted global concern in recent years. Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are the most commonly found PFC compounds, and thus their fate and transport play key roles in PFC distribution in the natural environment. The kinetic behavior of PFOS or PFOA on boehmite consists of a fast adsorption process followed by a slow adsorption process which may be attributed to the slow transport of PFOS or PFOA into the boehmite pore surface. The adsorption isotherms estimated the maximum adsorption capacities of PFOS and PFOA on boehmite as 0.877 μg/m2 and 0.633 μg/m2, with the difference primarily due to their different functional groups. The increase of solution pH led to a moderate decrease of PFOS and PFOA adsorption, owing to the increase of ligand exchange reactions and the decrease of electrostatic interactions. The presence of NaCl in solution demonstrated negative effects for PFOS and PFOA adsorption on boehmite surfaces, with potential mechanisms being electrical double layer compression, competitive adsorption of chloride.
Abstract: Based on different experiences in the historic centers
of Spain, we propose an global strategy for the regeneration of the
pre-tertiary fabrics and its application to the specific case of San
Mateo neighborhood, in Jerez de la Frontera (Andalusia), through a
diagnosis that focus particularly on the punishments the last-decade
economic situation (building boom and crisis) and shows the tragic
transition from economic center to an imminent disappearance with
an image similar to the ruins of war, due to the loss of their
traditional roles. From it we will learn their historically-tested
mechanisms of environment adaptation, which distill the vernacular
architecture essence and that we will apply to our strategy of action
based on a dotacional-and-free-space rhizome which rediscovers its
hidden character. The architectural fact will be crystallized in one of
the example-pieces proposed: The Artistic Revitalization Center.
Abstract: The development of wireless communication technologies has changed our living style in global level. After the international success of mobile telephony standards, the location and time independent voice connection has become a default method in daily telecommunications. As for today, highly advanced multimedia messaging plays a key role in value added service handling. Along with evolving data services, the need for more complex applications can be seen, including the mobile usage of broadcast technologies. Here performance of a system design for terrestrial multimedia content is examined with emphasis on mobile reception. This review paper has accommodated the understanding of physical layer role and the flavour of terrestrial channel effects on the terrestrial multimedia transmission using OFDM keeping DVB-H as benchmark standard.
Abstract: This paper presents an algorithm of particle swarm
optimization with reduction for global optimization problems. Particle
swarm optimization is an algorithm which refers to the collective
motion such as birds or fishes, and a multi-point search algorithm
which finds a best solution using multiple particles. Particle
swarm optimization is so flexible that it can adapt to a number
of optimization problems. When an objective function has a lot of
local minimums complicatedly, the particle may fall into a local
minimum. For avoiding the local minimum, a number of particles are
initially prepared and their positions are updated by particle swarm
optimization. Particles sequentially reduce to reach a predetermined
number of them grounded in evaluation value and particle swarm
optimization continues until the termination condition is met. In order
to show the effectiveness of the proposed algorithm, we examine the
minimum by using test functions compared to existing algorithms.
Furthermore the influence of best value on the initial number of
particles for our algorithm is discussed.
Abstract: In recent years, new product development became more and more competitive and globalized, and the designing phase is critical for the product success. The concept of modularity can provide the necessary foundation for organizations to design products that can respond rapidly to market needs. The paper describes data structures and algorithms of intelligent Web-based system for modular design taking into account modules compatibility relationship and given design requirements. The system intelligence is realized by developed algorithms for choice of modules reflecting all system restrictions and requirements. The proposed data structure and algorithms are illustrated by case study of personal computer configuration. The applicability of the proposed approach is tested through a prototype of Web-based system.
Abstract: In the highly competitive and rapidly changing global
marketplace, independent organizations and enterprises often come
together and form a temporary alignment of virtual enterprise in a
supply chain to better provide products or service. As firms adopt the
systems approach implicit in supply chain management, they must
manage the quality from both internal process control and external
control of supplier quality and customer requirements. How to
incorporate quality management of upstream and downstream supply
chain partners into their own quality management system has recently
received a great deal of attention from both academic and practice.
This paper investigate the collaborative feature and the entities-
relationship in a supply chain, and presents an ontology of
collaborative supply chain from an approach of aligning
service-oriented framework with service-dominant logic. This
perspective facilitates the segregation of material flow management
from manufacturing capability management, which provides a
foundation for the coordination and integration of the business process
to measure, analyze, and continually improve the quality of products,
services, and process. Further, this approach characterizes the different
interests of supply chain partners, providing an innovative approach to
analyze the collaborative features of supply chain. Furthermore, this
ontology is the foundation to develop quality management system
which internalizes the quality management in upstream and
downstream supply chain partners and manages the quality in supply
chain systematically.
Abstract: This paper aims to present a framework for the
organizational knowledge management, which seeks to deploy a
standardized structure for the integrated management of knowledge is
a common language based on domains, processes and global
indicators inspired by the COBIT framework 5 (ISACA, 2012),
which supports the integration of three technologies, enterprise
information architecture (EIA), the business process modeling (BPM)
and service-oriented architecture (SOA). The Gomak Framework is a
management platform that seeks to integrate the information
technology infrastructure, the structure of applications, information
infrastructure, and business logic and business model to support a
sound strategy of organizational knowledge management, low
process-based approach and concurrent engineering. Concurrent
engineering (CE) is a systematic approach to integrated product
development that respond to customer expectations, involving all
perspectives in parallel, from the beginning of the product life cycle.
(European Space Agency, 2000).
Abstract: This paper presents a new Hybrid Fuzzy (HF) PID type controller based on Genetic Algorithms (GA-s) for solution of the Automatic generation Control (AGC) problem in a deregulated electricity environment. In order for a fuzzy rule based control system to perform well, the fuzzy sets must be carefully designed. A major problem plaguing the effective use of this method is the difficulty of accurately constructing the membership functions, because it is a computationally expensive combinatorial optimization problem. On the other hand, GAs is a technique that emulates biological evolutionary theories to solve complex optimization problems by using directed random searches to derive a set of optimal solutions. For this reason, the membership functions are tuned automatically using a modified GA-s based on the hill climbing method. The motivation for using the modified GA-s is to reduce fuzzy system effort and take large parametric uncertainties into account. The global optimum value is guaranteed using the proposed method and the speed of the algorithm-s convergence is extremely improved, too. This newly developed control strategy combines the advantage of GA-s and fuzzy system control techniques and leads to a flexible controller with simple stricture that is easy to implement. The proposed GA based HF (GAHF) controller is tested on a threearea deregulated power system under different operating conditions and contract variations. The results of the proposed GAHF controller are compared with those of Multi Stage Fuzzy (MSF) controller, robust mixed H2/H∞ and classical PID controllers through some performance indices to illustrate its robust performance for a wide range of system parameters and load changes.
Abstract: As is needless to say; a majority of accidents, which occur, are due to drunk driving. As such, there is no effective mechanism to prevent this. Here we have designed an integrated system for the same purpose. Alcohol content in the driver-s body is detected by means of an infrared breath analyzer placed at the steering wheel. An infrared cell directs infrared energy through the sample and any unabsorbed energy at the other side is detected. The higher the concentration of ethanol, the more infrared absorption occurs (in much the same way that a sunglass lens absorbs visible light, alcohol absorbs infrared light). Thus the alcohol level of the driver is continuously monitored and calibrated on a scale. When it exceeds a particular limit the fuel supply is cutoff. If the device is removed also, the fuel supply will be automatically cut off or an alarm is sounded depending upon the requirement. This does not happen abruptly and special indicators are fixed at the back to avoid inconvenience to other drivers using the highway signals. Frame work for integration of sensors and control module in a scalable multi-agent system is provided .A SMS which contains the current GPS location of the vehicle is sent via a GSM module to the police control room to alert the police. The system is foolproof and the driver cannot tamper with it easily. Thus it provides an effective and cost effective solution for the problem of drunk driving in vehicles.