Abstract: The small interfering RNA (siRNA) alters the
regulatory role of mRNA during gene expression by translational
inhibition. Recent studies show that upregulation of mRNA because
serious diseases like cancer. So designing effective siRNA with good
knockdown effects plays an important role in gene silencing. Various
siRNA design tools had been developed earlier. In this work, we are
trying to analyze the existing good scoring second generation siRNA
predicting tools and to optimize the efficiency of siRNA prediction
by designing a computational model using Artificial Neural Network
and whole stacking energy (%G), which may help in gene silencing
and drug design in cancer therapy. Our model is trained and tested
against a large data set of siRNA sequences. Validation of our results
is done by finding correlation coefficient of experimental versus
observed inhibition efficacy of siRNA. We achieved a correlation
coefficient of 0.727 in our previous computational model and we
could improve the correlation coefficient up to 0.753 when the
threshold of whole tacking energy is greater than or equal to -32.5
kcal/mol.
Abstract: A new approach to determine the machine layout in flexible manufacturing cell, and to find the feasible robot configuration of the robot to achieve minimum cycle time is presented in this paper. The location of the input/output location and the optimal robot configuration is obtained for all sequences of work tasks of the robot within a specified period of time. A more realistic approach has been presented to model the problem using the robot joint space. The problem is formulated as a nonlinear optimization problem and solved using Sequential Quadratic Programming algorithm.
Abstract: Equations on curved manifolds display interesting properties in a number of ways. In particular, the symmetries and, therefore, the conservation laws reduce depending on how curved the manifold is. Of particular interest are the wave and Gordon-type equations; we study the symmetry properties and conservation laws of these equations on the Milne and Bianchi type III metrics. Properties of reduction procedures via symmetries, variational structures and conservation laws are more involved than on the well known flat (Minkowski) manifold.
Abstract: One of the common problems encountered in software
engineering is addressing and responding to the changing nature of
requirements. While several approaches have been devised to address
this issue, ranging from instilling resistance to changing requirements
in order to mitigate impact to project schedules, to developing an
agile mindset towards requirements, the approach discussed in this
paper is one of conceptualizing the delta in requirement and
modeling it, in order to plan a response to it. To provide some
context here, change is first formally identified and categorized as
either formal change or informal change. While agile methodology
facilitates informal change, the approach discussed in this paper
seeks to develop the idea of facilitating formal change. To collect,
document meta-requirements that represent the phenomena of change
would be a pro-active measure towards building a realistic cognition
of the requirements entity that can further be harnessed in the
software engineering process.
Abstract: The aim of this study was to develop a storm water quality improvement strategy plan (WQISP) which assists managers and decision makers of local city councils in enhancing their activities to improve regional water quality. City of Gosnells in Western Australia has been considered as a case study. The procedure on developing the WQISP consists of reviewing existing water quality data, identifying water quality issues in the study areas and developing a decision making tool for the officers, managers and decision makers. It was found that land use type is the main factor affecting the water quality. Therefore, activities, sources and pollutants related to different land use types including residential, industrial, agricultural and commercial are given high importance during the study. Semi-structured interviews were carried out with coordinators of different management sections of the regional councils in order to understand the associated management framework and issues. The issues identified from these interviews were used in preparing the decision making tool. Variables associated with the defined “value versus threat" decision making tool are obtained from the intensive literature review. The main recommendations provided for improvement of water quality in local city councils, include non-structural, structural and management controls and potential impacts of climate change.
Abstract: In order to accelerate the similarity search in highdimensional database, we propose a new hierarchical indexing method. It is composed of offline and online phases. Our contribution concerns both phases. In the offline phase, after gathering the whole of the data in clusters and constructing a hierarchical index, the main originality of our contribution consists to develop a method to construct bounding forms of clusters to avoid overlapping. For the online phase, our idea improves considerably performances of similarity search. However, for this second phase, we have also developed an adapted search algorithm. Our method baptized NOHIS (Non-Overlapping Hierarchical Index Structure) use the Principal Direction Divisive Partitioning (PDDP) as algorithm of clustering. The principle of the PDDP is to divide data recursively into two sub-clusters; division is done by using the hyper-plane orthogonal to the principal direction derived from the covariance matrix and passing through the centroid of the cluster to divide. Data of each two sub-clusters obtained are including by a minimum bounding rectangle (MBR). The two MBRs are directed according to the principal direction. Consequently, the nonoverlapping between the two forms is assured. Experiments use databases containing image descriptors. Results show that the proposed method outperforms sequential scan and SRtree in processing k-nearest neighbors.
Abstract: Land surface temperature (LST) is an important
parameter to study in urban climate. The understanding of the
influence of biophysical factors could improve the establishment of
modeling urban thermal landscape. It is well established that climate
hold a great influence on the urban landscape. However, it has been
recognize that climate has a low priority in urban planning process,
due to the complex nature of its influence. This study will focus on
the relatively cloud free Landsat Thematic Mapper image of the study
area, acquired on the 2nd March 2006. Correlation analyses were
conducted to identify the relationship of LST to the biophysical
factors; vegetation indices, impervious surface, and albedo to
investigate the variation of LST. We suggest that the results can be
considered by the stackholders during decision-making process to
create a cooler and comfortable environment in the urban landscape
for city dwellers.
Abstract: The antimicrobial, antiplasmid and cytotoxic activities of marine algae Halimeda opuntia and Sarconema filiforme were investigated. Antimicrobial bioassay against some human pathogenic bacteria and yeast were conducted using disc diffusion method. Halimeda extract exhibited antibacterial activity against six species of microrganisms, with significant inhibition against Staphylococcus aureus. While Sarconema extract was better potent as antifungal against Candida albicans. Comparative antibacterial studies showed that Halimeda extract showed equivalent or better activity as compared with commercial antibiotic when tested against Staphylococcus aureus. Further tests conducted using dilution method showed both extracts as having bacteriostatic mode of action against the tested microorganisms. Methanol extract of two species showed significant cytotoxicity (LC50
Abstract: The identification and classification of weeds are of
major technical and economical importance in the agricultural
industry. To automate these activities, like in shape, color and
texture, weed control system is feasible. The goal of this paper is to
build a real-time, machine vision weed control system that can detect
weed locations. In order to accomplish this objective, a real-time
robotic system is developed to identify and locate outdoor plants
using machine vision technology and pattern recognition. The
algorithm is developed to classify images into broad and narrow class
for real-time selective herbicide application. The developed
algorithm has been tested on weeds at various locations, which have
shown that the algorithm to be very effectiveness in weed
identification. Further the results show a very reliable performance
on weeds under varying field conditions. The analysis of the results
shows over 90 percent classification accuracy over 140 sample
images (broad and narrow) with 70 samples from each category of
weeds.
Abstract: Fatigue life prediction and evaluation are the key
technologies to assure the safety and reliability of automotive rubber
components. The objective of this study is to develop the fatigue
analysis process for vulcanized rubber components, which is
applicable to predict fatigue life at initial product design step. Fatigue
life prediction methodology of vulcanized natural rubber was
proposed by incorporating the finite element analysis and fatigue
damage parameter of maximum strain appearing at the critical location
determined from fatigue test. In order to develop an appropriate
fatigue damage parameter of the rubber material, a series of
displacement controlled fatigue test was conducted using threedimensional
dumbbell specimen with different levels of mean
displacement. It was shown that the maximum strain was a proper
damage parameter, taking the mean displacement effects into account.
Nonlinear finite element analyses of three-dimensional dumbbell
specimens were performed based on a hyper-elastic material model
determined from the uni-axial tension, equi-biaxial tension and planar
test. Fatigue analysis procedure employed in this study could be used
approximately for the fatigue design.
Abstract: In this paper, the optimum weight and cost of a laminated composite plate is seeked, while it undergoes the heaviest load prior to a complete failure. Various failure criteria are defined for such structures in the literature. In this work, the Tsai-Hill theory is used as the failure criterion. The theory of analysis was based on the Classical Lamination Theory (CLT). A newly type of Genetic Algorithm (GA) as an optimization technique with a direct use of real variables was employed. Yet, since the optimization via GAs is a long process, and the major time is consumed through the analysis, Radial Basis Function Neural Networks (RBFNN) was employed in predicting the output from the analysis. Thus, the process of optimization will be carried out through a hybrid neuro-GA environment, and the procedure will be carried out until a predicted optimum solution is achieved.
Abstract: The globe Sustainability has become the subject of international attention, the key reason is that global climate change. Climate and disasters around the abnormal frequency multiplier, the global temperature of the catastrophe and disaster continue to occur throughout the world, as well as countries around the world. Currently there are many important international conferences and policy, it is a "global environmental sustainability " and "living human health " as the goal of development, including the APEC 2007 meeting to "climate Clean Energy" as the theme Sydney Declaration, 2008 World Economic Forum's "Carbon - promote Cool Earth energy efficiency improvement project", the EU proposed "Green Idea" program, the Japanese annual policy, "low-carbon society, sustainable eco-city environment (Eco City) "And from 2009 to 2010 to promote the "Eco-Point" to promote green energy and carbon reduction products .And the 2010 World Climate Change Conference (COP16 United Nations Climate Change Conference Copenhagen), the world has been the subject of Negative conservative "Environmental Protection ", "save energy consumption, " into a positive response to the "Sustainable " and" LOHAS", while Taiwan has actively put forward eco-cities, green building, green building materials and other related environmental response Measures, especially green building construction environment that is the basis of factors, the most widely used application level, and direct contact with human health and the key to sustainable planet. "Sustainable development "is a necessary condition for continuation of the Earth, "healthy and comfortable" is a necessary condition for the continuation of life, and improve the "quality" is a necessary condition for economic development, balance between the three is "to enhance the efficiency of ", According to the World Business Council for Sustainable Development (WBCSD) for the "environmental efficiency "(Eco-Efficiency) proposed: " the achievement of environmental efficiency, the price to be competitive in the provision of goods or services to meet people's needs, improve living Quality at the same time, the goods or services throughout the life cycle. Its impact on the environment and natural resource utilization and gradually reduced to the extent the Earth can load. "whichever is the economy "Economic" and " Ecologic". The research into the methodology to obtain the Taiwan Green Building Material Labeling product as the scope of the study, by investigating and weight analysis to explore green building environmental load (Ln) factor and the Green Building Quality (Qn) factor to Establish green building environmental efficiency assessment model (GBM Eco-Efficiency). And building materials for healthy green label products for priority assessment object, the object is set in the material evidence for the direct response to the environmental load from the floor class-based, explicit feedback correction to the Green Building environmental efficiency assessment model, "efficiency " as a starting point to achieve balance between human "health "and Earth "sustainable development of win-win strategy. The study is expected to reach 1.To establish green building materials and the quality of environmental impact assessment system, 2. To establish value of GBM Eco-Efficiency model, 3. To establish the GBM Eco-Efficiency model for application of green building material feedback mechanisms.
Abstract: The accelerated growth in aircraft industries desire
effectual schemes, programs, innovative designs of advanced systems
and facilities to accomplish the augmenting need for home-free air
transportation. In this paper, a contemporary conceptual design of a
cambered airfoil has been proposed in order to providing augmented
effective lift force relative to the airplane, and to eliminating
drawbacks and limitations of an airfoil in a commercial airplane by
using a kind of smart materials. This invention of an unsymmetrical
airfoil structure utilizes the amplified air momentum around the
airfoil and increased camber length to providing improved aircraft
performance and assist to enhancing the reliability of the aircraft
components. Moreover, this conjectured design helps to reducing
airplane weight and total drag.
Abstract: The Navier–Stokes equations for unsteady, incompressible, viscous fluids in the axisymmetric coordinate system are solved using a control volume method. The volume-of-fluid (VOF) technique is used to track the free-surface of the liquid. Model predictions are in good agreement with experimental measurements. It is found that the dynamic processes after impact are sensitive to the initial droplet velocity and the liquid pool depth. The time evolution of the crown height and diameter are obtained by numerical simulation. The critical We number for splashing (Wecr) is studied for Oh (Ohnesorge) numbers in the range of 0.01~0.1; the results compares well with those of the experiments.
Abstract: Dredging activities inevitably cause sediment
dispersion. In certain locations, where there are important ecological
areas such as mangroves or coral reefs, carefully planning the
dredging can significantly reduce negative impacts. This article
utilizes the dredging at Phuket port, Thailand, as a case study to
demonstrate how computer simulations can be helpful to protect
existing coral reefs. A software package named MIKE21 was
applied. Necessary information required by the simulations was
gathered. After calibrating and verifying the model, various dredging
scenario were simulated to predict spoil movement. The simulation
results were used as guidance to setting up an environmental
measure. Finally, the recommendation to dredge during flood tide
with silt curtains installed was made.
Abstract: In this paper a numerical technique is used to predict
the metal temperature of a gas turbine vane. The Rising combustor
exit temperatures in gas turbine engines necessitate active cooling for
the downstream turbine section to avoid thermal failure. This study is
performed the solution of external flow, internal convection, and
conduction within the metal vane. Also the trade-off between the
cooling performances in four different hole shapes and configurations
is performed. At first one of the commonly used cooling hole
geometry is investigated; cylindrical holes and then two other
configurations are simulated. The average temperature magnitude in
mid-plan section of each configuration is obtained and finally the
lower temperature value is selected such as best arrangement.
Abstract: In this paper an analytical solution is presented for fully developed flow in a parallel plates channel under the action of Lorentz force, by use of Homotopy Perturbation Method (HPM). The analytical results are compared with exact solution and an excellent agreement has been observed between them for both Couette and Poiseuille flows. Moreover, the effects of key parameters have been studied on the dimensionless velocity profile.
Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.
Abstract: Groundwater is one of the most important water resources in Fars province. Based on this study, 95 percent of the total annual water consumption in Fars is used for agriculture, whereas the percentages for domestic and industrial uses are 4 and 1 percent, respectively. Population growth, urban and industrial growth, and agricultural development in Fars have created a condition of water stress. In this province, farmers and other users are pumping groundwater faster than its natural replenishment rate, causing a continuous drop in groundwater tables and depletion of this resource. In this research variation of groundwater level , their effects and ways to help control groundwater levels in some plains of Fars were evaluated .Excessive exploitation of groundwater in Darab, Jahrom, Estahban, Arsanjan, Khir and Niriz plains of Fars caused the groundwater levels fall too fast or to unacceptable levels. The average drawdown of the water table in Arsanjan, Khir. Estahban and Niriz plain plains were 12,8, 9 and 6 meters during 16,11,11 and 13 years ago respectively. This not only reduces available water resources and well yields but also can saline water intrusion, reductions in river flow and in wetland areas , drying springs, and ground subsidence, considerable increase in pumping costs and a significant decline in crop yields as a result of the increasing salinity. Finally based on situation and condition of the aquifer some suggestions are recommended.
Abstract: While service quality is acceptably most valued in the tourism industry, the issue of safety and security plays a key role in sustaining the industry success. Such an issue has been part of Thailand-s tourism development and promotion for several years. Evidently, the Tourist Police Department was set up for this purpose. Its main responsibility is to deal with international tourists- safety and confidence in travelling within Thai territory. However, to strengthen the tourism safety of the country, it is important to better understand international tourists- safety concerns about Thailand. This article seeks to compare international tourists- safety needs and Thai tourist polices- perception towards the tourists- safety concern to determine what measure should be taken to assure the tourist of Thailand-s secure environment. Through the employment of quantitative and qualitative methodological approaches, the tourism safety need of international tourists from Europe, North America and Asia was excavated, how Thai tourist polices and local polices perceived the international tourist-s safety concern was investigated, and opinion and experiences about how the police deal with international tourists- problems in eight touristic areas were also explored. A comparative result reveals a certain degrees of differences in international tourists- safety needs and Thai polices- perception towards their needs. The tourism safety prevention and protection measure and practice are also suggested.