Abstract: Mammalian genomes contain large number of
retroelements (SINEs, LINEs and LTRs) which could affect
expression of protein coding genes through associated transcription
factor binding sites (TFBS). Activity of the retroelement-associated
TFBS in many genes is confirmed experimentally but their global
functional impact remains unclear. Human SINEs (Alu repeats) and
mouse SINEs (B1 and B2 repeats) are known to be clustered in GCrich
gene rich genome segments consistent with the view that they
can contribute to regulation of gene expression. We have shown
earlier that Alu are involved in formation of cis-regulatory modules
(clusters of TFBS) in human promoters, and other authors reported
that Alu located near promoter CpG islands have an increased
frequency of CpG dinucleotides suggesting that these Alu are
undermethylated. Human Alu and mouse B1/B2 elements have an
internal bipartite promoter for RNA polymerase III containing
conserved sequence motif called B-box which can bind basal
transcription complex TFIIIC. It has been recently shown that TFIIIC
binding to B-box leads to formation of a boundary which limits
spread of repressive chromatin modifications in S. pombe. SINEassociated
B-boxes may have similar function but conservation of
TFIIIC binding sites in SINEs located near mammalian promoters
has not been studied earlier. Here we analysed abundance and
distribution of retroelements (SINEs, LINEs and LTRs) in annotated
sequences of the Database of mammalian transcription start sites
(DBTSS). Fractions of SINEs in human and mouse promoters are
slightly lower than in all genome but >40% of human and mouse
promoters contain Alu or B1/B2 elements within -1000 to +200 bp
interval relative to transcription start site (TSS). Most of these SINEs
is associated with distal segments of promoters (-1000 to -200 bp
relative to TSS) indicating that their insertion at distances >200 bp
upstream of TSS is tolerated during evolution. Distribution of SINEs
in promoters correlates negatively with the distribution of CpG
sequences. Using analysis of abundance of 12-mer motifs from the
B1 and Alu consensus sequences in genome and DBTSS it has been
confirmed that some subsegments of Alu and B1 elements are poorly
conserved which depends in part on the presence of CpG
dinucleotides. One of these CpG-containing subsegments in B1
elements overlaps with SINE-associated B-box and it shows better
conservation in DBTSS compared to genomic sequences. It has been
also studied conservation in DBTSS and genome of the B-box
containing segments of old (AluJ, AluS) and young (AluY) Alu
repeats and found that CpG sequence of the B-box of old Alu is
better conserved in DBTSS than in genome. This indicates that Bbox-
associated CpGs in promoters are better protected from
methylation and mutation than B-box-associated CpGs in genomic
SINEs. These results are consistent with the view that potential
TFIIIC binding motifs in SINEs associated with human and mouse
promoters may be functionally important. These motifs may protect
promoters from repressive histone modifications which spread from
adjacent sequences. This can potentially explain well known
clustering of SINEs in GC-rich gene rich genome compartments and
existence of unmethylated CpG islands.
Abstract: The paper presents an on-line recognition machine
(RM) for continuous/isolated, dynamic and static gestures that arise
in Flight Deck Officer (FDO) training. RM is based on generic pattern
recognition framework. Gestures are represented as templates using
summary statistics. The proposed recognition algorithm exploits temporal
and spatial characteristics of gestures via dynamic programming
and Markovian process. The algorithm predicts corresponding index
of incremental input data in the templates in an on-line mode.
Accumulated consistency in the sequence of prediction provides a
similarity measurement (Score) between input data and the templates.
The algorithm provides an intuitive mechanism for automatic detection
of start/end frames of continuous gestures. In the present paper,
we consider isolated gestures. The performance of RM is evaluated
using four datasets - artificial (W TTest), hand motion (Yang) and
FDO (tracker, vision-based ). RM achieves comparable results which
are in agreement with other on-line and off-line algorithms such as
hidden Markov model (HMM) and dynamic time warping (DTW).
The proposed algorithm has the additional advantage of providing
timely feedback for training purposes.
Abstract: Mycophenolic acid (MPA) is a secondary metabolite
produced by Penicillium brevicompactum, which has antibiotic and
immunosuppressive properties. In this study, the first, mycophenolic
acid was produced in a fermentation process by Penicillium
brevicompactum MUCL 19011 in shake flask using a base medium.
The maximum MPA production, product yield and productivity of
process were 1.379 g/L, 18.6 mg/g glucose and 4.9 mg/L. h,
respectively. Also the glucose consumption, biomass and MPA
production profiles were investigated during batch cultivation.
Obtained results showed that MPA production starts approximately
after 180 hours and reaches to a maximum at 280 h. In the next step,
the effects of some various concentrations of enzymatically
hydrolyzed casein on MPA production were evaluated. Maximum
MPA production, product yield and productivity as 3.63 g/L, 49
mg/g glucose and 12.96 mg/L.h, respectively were obtained with
using 30 g/L enzymatically hydrolyzed casein in culture medium.
These values show an enhanced MPA production, product yield and
process productivity pr as 116.8%, 132.8% and 163.2%, respectively.
Abstract: Schools today face ever-increasing demands in their attempts to ensure that students are well equipped to enter the workforce and navigate a complex world. Research indicates that computer technology can help support learning, implementation of various experiments or learning games, and that it is especially useful in developing the higher-order skills of critical thinking, observation, comprehension, implementation, comparison, analysis and active attention to activities such as research, field work, simulations and scientific inquiry. The ICT in education supports the learning procedure by enabling it to be more flexible and effective, create a rich and attractive training environment and equip the students with knowledge and potential useful for the competitive social environment in which they live. This paper presents the design, the development, and the results of the evaluation analysis of an interactive educational game which using real electric vehicles - toys (material) on a toy race track. When the game starts each student selects a specific vehicle toy. Then students are answering questionnaires in the computer. The vehicles' speed is related to the percentage of right answers in a multiple choice questionnaire (software). Every question has its own significant value depending of the different level of questionnaire. Via the developed software, each right or wrong answers in questionnaire increase or decrease the real time speed of their vehicle toys. Moreover the rate of vehicle's speed increase or decrease depends on the difficulty level of each question. The aim of the work is to attract the student’s interest in a learning process and also to improve their scores. The developed real time game was tested using independent populations of students of age groups: 8-10, 11-14, 15-18 years. Standard educational and statistical analysis tools were used for the evaluation analysis of the game. Results reveal that students using the developed real time control game scored much higher (60%) than students using a traditional simulation game on the same questionnaire. Results further indicate that student's interest in repeating the developed real time control gaming was far higher (70%) than the interest of students using a traditional simulation game.
Abstract: In this paper, self-starting block hybrid method of
order (5,5,5,5)T is proposed for the solution of the special second
order ordinary differential equations with associated initial or
boundary conditions. The continuous hybrid formulations enable us
to differentiate and evaluate at some grids and off – grid points to
obtain four discrete schemes, which were used in block form for
parallel or sequential solutions of the problems. The computational
burden and computer time wastage involved in the usual reduction of
second order problem into system of first order equations are avoided
by this approach. Furthermore, a stability analysis and efficiency of
the block method are tested on stiff ordinary differential equations,
and the results obtained compared favorably with the exact solution.
Abstract: In space during functioning, a satellite will be heated
up due to the behavior of its components such as power electronics.
In order to prevent problems in the satellite, this heat has to be
released in space thanks to the cooling system. This system consists
of a loop heat pipe (LHP), in which a fluid streams through an
evaporator and a condenser. In the evaporator, the fluid captures the
heat from the satellite and evaporates. Then it flows to the condenser
where it releases the heat and it condenses. In this project, the two
mains parts of a cooling system are studied: the evaporator and the
condenser. The study of the diphasic loop was done starting from
digital simulations carried out under Matlab and Femlab.
Abstract: Turbulence of the incoming wind field is of paramount
importance to the dynamic response of civil engineering structures. Hence reliable stochastic models of the turbulence should be available from which time series can be generated for dynamic response and
structural safety analysis. In the paper an empirical cross spectral
density function for the along-wind turbulence component over the wind field area is taken as the starting point. The spectrum is spatially
discretized in terms of a Hermitian cross-spectral density matrix for the turbulence state vector which turns out not to be positive
definite. Since the succeeding state space and ARMA modelling of
the turbulence rely on the positive definiteness of the cross-spectral
density matrix, the problem with the non-positive definiteness of such
matrices is at first addressed and suitable treatments regarding it are proposed. From the adjusted positive definite cross-spectral density
matrix a frequency response matrix is constructed which determines the turbulence vector as a linear filtration of Gaussian white noise.
Finally, an accurate state space modelling method is proposed which allows selection of an appropriate model order, and estimation of a state space model for the vector turbulence process incorporating its phase spectrum in one stage, and its results are compared with a conventional ARMA modelling method.
Abstract: Voice Over IP (VoIP) is a technology that could pass
the voice traffic and data packet form over an IP network. Network
can be used for intranet or Internet. Phone calls using VoIP has
advantages in terms of cheaper cost of PSTN phone to more than
half, because the cost is calculated by the cost of the global nature of
the Internet. Session Initiation Protocol (SIP) is a signaling protocol
at the application layer which serves to establish, modify, and
terminate a multimedia session involving one or more users. This SIP
signaling has SIP message in text form that is used for session
management by the SIP components, such as User Agent, Registrar,
Redirect Server, and Proxy Server. To build a SIP communication is
required SIP Express Router (SER) to be able to receive SIP
messages, for handling the basic functions of SIP messages.
Problems occur when the NAT through which affects the voice
communication will be blocked starting from the sound that is not
sent or one side of the sound are sent (half duplex). How that could
be used to penetrate NAT is to use a given mediaproxy random RTP
port to penetrate NAT.
Abstract: Success is a European project that will implement several clean transport offers in three European cities and evaluate the environmental impacts. The goal of these measures is to improve urban mobility or the displacement of residents inside cities. For e.g. park and ride, electric vehicles, hybrid bus and bike sharing etc. A list of 28 criteria and 60 measures has been established for evaluation of these transport projects. The evaluation criteria can be grouped into: Transport, environment, social, economic and fuel consumption. This article proposes a decision support system based that encapsulates a hybrid approach based on fuzzy logic, multicriteria analysis and belief theory for the evaluation of impacts of urban mobility solutions. A web-based tool called DeSSIA (Decision Support System for Impacts Assessment) has been developed that treats complex data. The tool has several functionalities starting from data integration (import of data), evaluation of projects and finishes by graphical display of results. The tool development is based on the concept of MVC (Model, View, and Controller). The MVC is a conception model adapted to the creation of software's which impose separation between data, their treatment and presentation. Effort is laid on the ergonomic aspects of the application. It has codes compatible with the latest norms (XHTML, CSS) and has been validated by W3C (World Wide Web Consortium). The main ergonomic aspect focuses on the usability of the application, ease of learning and adoption. By the usage of technologies such as AJAX (XML and Java Script asynchrones), the application is more rapid and convivial. The positive points of our approach are that it treats heterogeneous data (qualitative, quantitative) from various information sources (human experts, survey, sensors, model etc.).
Abstract: In this paper, a single period inventory model with resalable returns has been analyzed in an imprecise and uncertain mixed environment. Demand has been introduced as a fuzzy random variable. In this model, a single order is placed before the start of the selling season. The customer, for a full refund, may return purchased products within a certain time interval. Returned products are resalable, provided they arrive back before the end of the selling season and are found to be undamaged. Products remaining at the end of the season are salvaged. All demands not met directly are lost. The probabilities that a sold product is returned and that a returned product is resalable, both imprecise in a real situation, have been assumed to be fuzzy in nature.
Abstract: To coop with urbanization issues and the economic need for expansion, the city of Jakarta is planning to reclaim more land in the Jakarta Bay. However, the reclamation activities of some islands have barely started and already the developers are facing difficulties in finding sufficient quantities of sand as fill material. When addressing the problem of sand scarcity in the case of Jakarta where, an excess of waste production, an inadequate solid waste management system and a lack of dumping ground pose a major problem, it is hard not to think of the use of waste as alternative fill material. This paper analyses the possibilities of using waste in the land reclamation projects, considering the governmental, social, environmental and economic context of the city. The results identify types of waste that could be used, ways of using those types of waste and implementation conditions for the city of Jakarta.
Abstract: Operating a device at high power and high frequency
is a major problem because wall losses greatly reduce the efficiency
of the device. In the present communication, authors analytically
analyzed the dependence of ohmic/RF efficiency, the fraction of
output power with respect to the total power generated, of gyrotron
cavity structure on the conductivity of copper for the second
harmonic TE0,6 mode. This study shows a rapid fall in the RF
efficiency as the quality (conductivity) of copper degrades. Starting
with an RF efficiency near 40% at the conductivity of ideal copper
(5.8 x 107 S/m), the RF efficiency decreases (upto 8%) as the copper
quality degrades. Assuming conductivity half that of ideal copper the
RF efficiency as a function of diffractive quality factor, Qdiff, has
been studied. Here the RF efficiency decreases rapidly with
increasing diffractive Q. Ohmic wall losses as a function of
frequency for 460 GHz gyrotron cavity excited in TE0,6 mode has
also been analyzed. For 460 GHz cavity, the extracted power is
reduced to 32% of the generated power due to ohmic losses in the
walls of the cavity.
Abstract: Magnesium wastes are produced by many industrial activities. This waste problem is becoming a future problem for the world. Magnesium borates have many advantages such as; high corrosion resistance, heat resistance, high coefficient of elasticity and can also be used in the production of material against radiation. Addition, magnesium borates have great potential in sectors
including ceramic and detergents industry and superconducting materials.
In this study, using the starting materials of waste magnesium and H3BO3 the hydrothermal method was applied at a moderate
temperature of 70oC. Several mole ratios of waste magnesium to H3BO3 are selected as; 1:2, 1:4, 1:6, 1:8, 1:10. Reaction time was determined as 1 hour. After the synthesis, X-Ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FT-IR) techniques are applied to products. As a result the forms of mcallisterite “Mg2(B6O7(OH)6)2.9(H2O)”, admontite “MgO(B2O3)3.7(H2O)” and magnesium boron hydrate (MgO(B2O3)3.6(H2O)” are obtained.
Abstract: Urban planning, in particular on protected landscape
areas, demands an increasing role of public participation within the
frame of the efficiency of sustainable planning process. The
development of urban planning actions in Protected Landscape areas,
as Sintra-Cascais Natural Park, should perform a methodological
process that is structured over distinct sequential stages, providing
the development of a continuous, interactive, integrated and
participative planning. From the start of Malveira da Serra and Janes
Plan process, several public participation actions were promoted, in
order to involve the local agents, stakeholders and the population in
the decision of specific local key issues and define the appropriate
priorities within the goals and strategies previously settled. As a
result, public participation encouraged an innovative process that
guarantees the efficiency of sustainable urban planning and promotes
a sustainable new way of living in community.
Abstract: ZnO nanostructure were synthesized via microwave
method using zinc acetate as starting material, guanidinium as
structure directing agents, and water as solvent.. This work
investigates the photodegradation of azo dyes using the ZnO Flowerlike
in aqueous solutions. As synthesized ZnO samples were
characterized using X-Ray powder diffraction (XRD), scanning
electron microscopy (SEM), and FTIR spectroscopy.In this work
photodecolorization of congored azo dye under UV irradiation by
nano ZnO was studied.
Abstract: The occurrence and removal of trace organic
contaminants in the aquatic environment has become a focus of
environmental concern. For the selective removal of carbamazepine
from loaded waters molecularly imprinted polymers (MIPs) were
synthesized with carbamazepine as template. Parameters varied were
the type of monomer, crosslinker, and porogen, the ratio of starting
materials, and the synthesis temperature. Best results were obtained
with a template to crosslinker ratio of 1:20, toluene as porogen, and
methacrylic acid (MAA) as monomer. MIPs were then capable to
recover carbamazepine by 93% from a 10-5 M landfill leachate
solution containing also caffeine and salicylic acid. By comparison,
carbamazepine recoveries of 75% were achieved using a nonimprinted
polymer (NIP) synthesized under the same conditions, but
without template. In landfill leachate containing solutions
carbamazepine was adsorbed by 93-96% compared with an uptake of
73% by activated carbon. The best solvent for desorption was
acetonitrile, with which the amount of solvent necessary and dilution
with water was tested. Selected MIPs were tested for their reusability
and showed good results for at least five cycles. Adsorption
isotherms were prepared with carbamazepine solutions in the
concentration range of 0.01 M to 5*10-6 M. The heterogeneity index
showed a more homogenous binding site distribution.
Abstract: This paper addresses the fundamental requirements for
starting an online business. It covers the process of ideation,
conceptualization, formulation, and implementation of new venture
ideas on the Web. Using Facebook as an illustrative example, we learn
how to turn an idea into a successful electronic business and to execute
a business plan with IT skills, management expertise, a good
entrepreneurial attitude, and an understanding of Internet culture. The
personality traits and characteristics of a successful e-commerce
entrepreneur are discussed with reference to Facebook-s founder,
Mark Zuckerberg. Facebook is a social and e-commerce success. It
provides a trusted environment of which participants can conduct
business with social experience. People are able to discuss products
before, during the after the sale within the Facebook environment. The
paper also highlights the challenges and opportunities for e-commerce
entrepreneurial startups to go public and of entering the China market.
Abstract: In this treatise we will study the capability of static
compensator for reactive power to stabilize sheen voltage with motor
loading on power networks system. We also explain the structure and main function of STATCOM and the method to control it using STATCOM transformer current to simultaneously predict after
telling about the necessity of FACTS tools to compensate in power networks. Then we study topology and controlling system to stabilize
voltage during start of inductive motor. The outcome of stimulat by MATLAB software supports presented controlling idea and
system in the treatise.
Abstract: Stipples are desired for pattern fillings and
transparency effects. In contrast, some graphics standards, including
OpenGL ES 1.1 and 2.0, omitted this feature. We represent details of
providing line stipples and polygon stipples, through combining
texture mapping and alpha blending functions. We start from the
OpenGL-specified stipple-related API functions. The details of
mathematical transformations are explained to get the correct texture
coordinates. Then, the overall algorithm is represented, and its
implementation results are followed. We accomplished both of line
and polygon stipples, and verified its result with conformance test
routines.
Abstract: In this study, the effect of mechanical activation on the synthesis of Fe3Al/Al2O3 nanocomposite has been investigated by using mechanochemical method. For this purpose, Aluminum powder and hematite as precursors, with stoichiometric ratio, have been utilized and other effective parameters in milling process were kept constant. Phase formation analysis, crystallite size measurement and lattice strain were studied by X-ray diffraction (XRD) by using Williamson-Hall method as well as microstructure and morphology were explored by Scanning electron microscopy (SEM). Also, Energy-dispersive X-ray spectroscopy (EDX) analysis was used in order to probe the particle distribution. The results showed that after 30-hour milling, the reaction was started, combustibly done and completed.