Abstract: In an original directed diffusion routing protocol, a sink requests sensing data from a source node by flooding interest messages to the network. Then, the source finds the sink by sending exploratory data messages to all nodes that generate incoming interest messages. This protocol signaling can cause heavy traffic in the network, an interference of the radio signal, collisions, great energy consumption of sensor nodes, etc. According to this research problem, this paper investigates the effect of sending interest and exploratory data messages on the performance of directed diffusion routing protocol. We demonstrate the research problem occurred from employing directed diffusion protocol in mobile wireless environments. For this purpose, we perform a set of experiments by using NS2 (network simulator 2). The radio propagation models; Two-ray ground reflection with and without shadow fading are included to investigate the effect of signaling. The simulation results show that the number of times of sent and received protocol signaling in the case of sending interest and exploratory data messages are larger than the case of sending other protocol signals, especially in the case of shadowing model. Additionally, the number of exploratory data message is largest in one round of the protocol procedure.
Abstract: An expressed sequence tag (EST) analysis provideus portions of expressed genes. We have constructed cDNA library and determined randomly sequences from cDNA library clones of T. molitor injected with acholeplasma lysate. We identified the homologous to a galectin gene. As the result of cloning and characterization of novel, we found that the protein has an open reading frame (ORF) of 495 bp, with 164 amino acid residues and molecular weight of 18.5 kDa. To characterize the role of novel Tm-galectin in immune system, we quantified the mRNA level of galectin at different times after treatment with immune elicitors. The galectin mRNA was up-regulated about 7-folds within 18 hrs. This suggests that Tm-galectin is a novel member of animal lectins, and has a role in the process of pathogen recognition. Our study would be helpful for the study on immune defense system and signaling cascade.
Abstract: The Mobile IP Standard has been developed to support mobility over the Internet. This standard contains several drawbacks as in the cases where packets are routed via sub-optimal paths and significant amount of signaling messages is generated due to the home registration procedure which keeps the network aware of the current location of the mobile nodes. Recently, a dynamic hierarchical mobility management strategy for mobile IP networks (DHMIP) has been proposed to reduce home registrations costs. However, this strategy induces a packet delivery delay and increases the risk of packet loss. In this paper, we propose an enhanced version of the dynamic hierarchical strategy that reduces the packet delivery delay and minimizes the risk of packet loss. Preliminary results obtained from simulations are promising. They show that the enhanced version outperforms the original dynamic hierarchical mobility management strategy version.
Abstract: Integrins are a large family of multidomain α/β cell
signaling receptors. Some integrins contain an additional inserted I
domain, whose earliest expression appears to be with the chordates,
since they are observed in the urochordates Ciona intestinalis (vase
tunicate) and Halocynthia roretzi (sea pineapple), but not in integrins
of earlier diverging species. The domain-s presence is viewed as a
hallmark of integrins of higher metazoans, however in vertebrates,
there are clearly three structurally-different classes: integrins without
I domains, and two groups of integrins with I domains but separable
by the presence or absence of an additional αC helix. For example,
the αI domains in collagen-binding integrins from Osteichthyes
(bony fish) and all higher vertebrates contain the specific αC helix,
whereas the αI domains in non-collagen binding integrins from
vertebrates and the αI domains from earlier diverging urochordate
integrins, i.e. tunicates, do not. Unfortunately, within the early
chordates, there is an evolutionary gap due to extinctions between the
tunicates and cartilaginous fish. This, coupled with a knowledge gap
due to the lack of complete genomic data from surviving species,
means that the origin of collagen-binding αC-containing αI domains
remains unknown. Here, we analyzed two available genomes from
Callorhinchus milii (ghost shark/elephant shark; Chondrichthyes –
cartilaginous fish) and Petromyzon marinus (sea lamprey;
Agnathostomata), and several available Expression Sequence Tags
from two Chondrichthyes species: Raja erinacea (little skate) and
Squalus acanthias (dogfish shark); and Eptatretus burgeri (inshore
hagfish; Agnathostomata), which evolutionary reside between the
urochordates and osteichthyes. In P. marinus, we observed several
fragments coding for the αC-containing αI domain, allowing us to
shed more light on the evolution of the collagen-binding integrins.
Abstract: Voice Over IP (VoIP) is a technology that could pass
the voice traffic and data packet form over an IP network. Network
can be used for intranet or Internet. Phone calls using VoIP has
advantages in terms of cheaper cost of PSTN phone to more than
half, because the cost is calculated by the cost of the global nature of
the Internet. Session Initiation Protocol (SIP) is a signaling protocol
at the application layer which serves to establish, modify, and
terminate a multimedia session involving one or more users. This SIP
signaling has SIP message in text form that is used for session
management by the SIP components, such as User Agent, Registrar,
Redirect Server, and Proxy Server. To build a SIP communication is
required SIP Express Router (SER) to be able to receive SIP
messages, for handling the basic functions of SIP messages.
Problems occur when the NAT through which affects the voice
communication will be blocked starting from the sound that is not
sent or one side of the sound are sent (half duplex). How that could
be used to penetrate NAT is to use a given mediaproxy random RTP
port to penetrate NAT.
Abstract: This paper represents an investigation on how exploiting multiple transmit antennas by OFDM based wireless LAN subscribers can mitigate physical layer error rate. Then by comparing the Wireless LANs that utilize spatial diversity techniques with the conventional ones it will reveal how PHY and TCP throughputs behaviors are ameliorated. In the next step it will assess the same issues based on a cellular context operation which is mainly introduced as an innovated solution that beside a multi cell operation scenario benefits spatio-temporal signaling schemes as well. Presented simulations will shed light on the improved performance of the wide range and high quality wireless LAN services provided by the proposed approach.
Abstract: Recent communications environment significantly
expands the mobile environment. The popularization of smartphones
with various mobile services has emerged, and smartphone users are
rapidly increasing. Because of these symptoms, existing wired
environment in a variety of mobile traffic entering to mobile network
has threatened the stability of the mobile network. Unlike traditional
wired infrastructure, mobile networks has limited radio resources and
signaling procedures for complex radio resource management. So
these traffic is not a problem in wired networks but mobile networks, it
can be a threat. In this paper, we analyze the security threats in mobile
networks and provide direction to solve it.
Abstract: Mathematical and computational modeling of calcium
signalling in nerve cells has produced considerable insights into how
the cells contracts with other cells under the variation of biophysical
and physiological parameters. The modeling of calcium signaling in
astrocytes has become more sophisticated. The modeling effort has
provided insight to understand the cell contraction. Main objective
of this work is to study the effect of voltage gated (Operated)
calcium channel (VOC) on calcium profile in the form of advection
diffusion equation. A mathematical model is developed in the form
of advection diffusion equation for the calcium profile. The model
incorporates the important physiological parameter like diffusion
coefficient etc. Appropriate boundary conditions have been framed.
Finite volume method is employed to solve the problem. A program
has been developed using in MATLAB 7.5 for the entire problem
and simulated on an AMD-Turion 32-bite machine to compute the
numerical results.
Abstract: Currently, there has been a 3G mobile networks data
traffic explosion due to the large increase in the number of smartphone
users. Unlike a traditional wired infrastructure, 3G mobile networks
have limited wireless resources and signaling procedures for complex
wireless resource management. And mobile network security for
various abnormal and malicious traffic technologies was not ready. So
Malicious or potentially malicious traffic originating from mobile
malware infected smart devices can cause serious problems to the 3G
mobile networks, such as DoS and scanning attack in wired networks.
This paper describes the DoS security threat in the 3G mobile network
and proposes a detection technology.
Abstract: The Internet telephony employs a new type of Internet communication on which a mutual communication is realized by establishing sessions. Session Initiation Protocol (SIP) is used to establish sessions between end-users. For unreliable transmission (UDP), SIP message should be retransmitted when it is lost. The retransmissions increase a load of the SIP signaling network, and sometimes lead to performance degradation when a network is overloaded. The paper proposes an overload control for a SIP signaling network to protect from a performance degradation. Introducing two thresholds in a queue of a SIP proxy server, the SIP proxy server detects a congestion. Once congestion is detected, a SIP signaling network restricts to make new calls. The proposed overload control is evaluated using the network simulator (ns-2). With simulation results, the paper shows the proposed overload control works well.
Abstract: In this paper, we implement a modern serial backplane
platform for telecommunication inter-rack systems. For combination
high reliability and low cost protocol property, we applied high level
data link control (HDLC) protocol with low voltage differential
signaling (LVDS) bus for card to card communicated over backplane.
HDLC protocol is a high performance with several operation modes
and is famous in telecommunication systems. LVDS bus is a high
reliability with high immunity against electromagnetic interference
(EMI) and noise.
Abstract: Data rate, tolerable bit error rate or frame error rate
and range & coverage are the key performance requirement of a
communication link. In this paper performance of MFSK link is
analyzed in terms of bit error rate, number of errors and total number
of data processed. In the communication link model proposed, which
is implemented using MATLAB block set, an improvement in BER
is observed. Different parameters which effects and enables to keep
BER low in M-ary communication system are also identified.
Abstract: Mobile IP has been developed to provide the
continuous information network access to mobile users. In IP-based
mobile networks, location management is an important component of
mobility management. This management enables the system to track
the location of mobile node between consecutive communications. It
includes two important tasks- location update and call delivery.
Location update is associated with signaling load. Frequent updates
lead to degradation in the overall performance of the network and the
underutilization of the resources. It is, therefore, required to devise
the mechanism to minimize the update rate. Mobile IPv6 (MIPv6)
and Hierarchical MIPv6 (HMIPv6) have been the potential
candidates for deployments in mobile IP networks for mobility
management. HMIPv6 through studies has been shown with better
performance as compared to MIPv6. It reduces the signaling
overhead traffic by making registration process local. In this paper,
we present performance analysis of MIPv6 and HMIPv6 using an
analytical model. Location update cost function is formulated based
on fluid flow mobility model. The impact of cell residence time, cell
residence probability and user-s mobility is investigated. Numerical
results are obtained and presented in graphical form. It is shown that
HMIPv6 outperforms MIPv6 for high mobility users only and for low
mobility users; performance of both the schemes is almost equivalent
to each other.
Abstract: EcoDam is an adenine-N6 DNA methyltransferase
that methylates the GATC sites in the Escherichia coli genome.
DNA-adenine methylation is not present in higher eukaryotes
including humans. These observations raise the possibility that dam
inhibitors may be used as anti-microbial agents. Polyphosphate
(Poly(P)) is an important metabolite and signaling molecule in
prokaryotes and eukaryotes. Here, by using gel retardation
experiments to investigate the competition of DNA binding by
EcoDam in the presence of polyphosphate, we found that Poly (P)
strongly interferes with DNA binding by EcoDam, while same
concentration of monophosphate does not. In addition, we
demonstrated that Poly (P) binding inhibits the activity of EcoDam
and our results suggest that Poly (P) led to strong inhibition of the
EcoDam catalytic activity, while monophosphate had only moderate
effect.
Abstract: A new distance-adjusted approach is proposed in
which static square contours are defined around an estimated
symbol in a QAM constellation, which create regions that
correspond to fixed step sizes and weighting factors. As a
result, the equalizer tap adjustment consists of a linearly
weighted sum of adaptation criteria that is scaled by a variable
step size. This approach is the basis of two new algorithms: the
Variable step size Square Contour Algorithm (VSCA) and the
Variable step size Square Contour Decision-Directed
Algorithm (VSDA). The proposed schemes are compared with
existing blind equalization algorithms in the SCA family in
terms of convergence speed, constellation eye opening and
residual ISI suppression. Simulation results for 64-QAM
signaling over empirically derived microwave radio channels
confirm the efficacy of the proposed algorithms. An RTL
implementation of the blind adaptive equalizer based on the
proposed schemes is presented and the system is configured to
operate in VSCA error signal mode, for square QAM signals
up to 64-QAM.
Abstract: Mobile IPv6 (MIPv6) describes how mobile node can change its point of attachment from one access router to another. As a demand for wireless mobile devices increases, many enhancements for macro-mobility (inter-domain) protocols have been proposed, designed and implemented in Mobile IPv6. Hierarchical Mobile IPv6 (HMIPv6) is one of them that is designed to reduce the amount of signaling required and to improve handover speed for mobile connections. This is achieved by introducing a new network entity called Mobility Anchor Point (MAP). This report presents a comparative study of the Hierarchical Mobility IPv6 and Mobile IPv6 protocols and we have narrowed down the scope to micro-mobility (intra-domain). The architecture and operation of each protocol is studied and they are evaluated based on the Quality of Service (QoS) parameter; handover latency. The simulation was carried out by using the Network Simulator-2. The outcome from this simulation has been discussed. From the results, it shows that, HMIPv6 performs best under intra-domain mobility compared to MIPv6. The MIPv6 suffers large handover latency. As enhancement we proposed to HMIPv6 to locate the MAP to be in the middle of the domain with respect to all Access Routers. That gives approximately same distance between MAP and Mobile Node (MN) regardless of the new location of MN, and possible shorter distance. This will reduce the delay since the distance is shorter. As a future work performance analysis is to be carried for the proposed HMIPv6 and compared to HMIPv6.
Abstract: NFκB activation plays a crucial role in anti-apoptotic responses in response to the apoptotic signaling during tumor necrosis factor (TNFa) stimulation in Multiple Myeloma (MM). Although several drugs have been found effective for the treatment of MM by mainly inhibiting NFκB pathway, there are no any quantitative or qualitative results of comparison assessment on inhibition effect between different single drugs or drug combinations. Computational modeling is becoming increasingly indispensable for applied biological research mainly because it can provide strong quantitative predicting power. In this study, a novel computational pathway modeling approach is employed to comparably assess the inhibition effects of specific single drugs and drug combinations on the NFκB pathway in MM, especially the prediction of synergistic drug combinations.
Abstract: Support Vector Machine (SVM) is a statistical
learning tool developed to a more complex concept of
structural risk minimization (SRM). In this paper, SVM is
applied to signal detection in communication systems in the
presence of channel noise in various environments in the form
of Rayleigh fading, additive white Gaussian background noise
(AWGN), and interference noise generalized as additive color
Gaussian noise (ACGN). The structure and performance of
SVM in terms of the bit error rate (BER) metric is derived and
simulated for these advanced stochastic noise models and the
computational complexity of the implementation, in terms of
average computational time per bit, is also presented. The
performance of SVM is then compared to conventional binary
signaling optimal model-based detector driven by binary
phase shift keying (BPSK) modulation. We show that the
SVM performance is superior to that of conventional matched
filter-, innovation filter-, and Wiener filter-driven detectors,
even in the presence of random Doppler carrier deviation,
especially for low SNR (signal-to-noise ratio) ranges. For
large SNR, the performance of the SVM was similar to that of
the classical detectors. However, the convergence between
SVM and maximum likelihood detection occurred at a higher
SNR as the noise environment became more hostile.
Abstract: Timing driven physical design, synthesis, and
optimization tools need efficient closed-form delay models for
estimating the delay associated with each net in an integrated circuit
(IC) design. The total number of nets in a modern IC design has
increased dramatically and exceeded millions. Therefore efficient
modeling of interconnection is needed for high speed IC-s. This
paper presents closed–form expressions for RC and RLC
interconnection trees in current mode signaling, which can be
implemented in VLSI design tool. These analytical model
expressions can be used for accurate calculation of delay after the
design clock tree has been laid out and the design is fully routed.
Evaluation of these analytical models is several orders of magnitude
faster than simulation using SPICE.
Abstract: Type 2 diabetes mellitus (T2DM) is a complex
metabolic disorder that characterized by the presence of high glucose
in blood that cause from insulin resistance and insufficiency due to
deterioration β-cell Langerhans functions. T2DM is commonly
caused by the combination of inherited genetic variations as well as
our own lifestyle. Metallothionein (MT) is a known cysteine-rich
protein responsible in helping zinc homeostasis which is important in
insulin signaling and secretion as well as protection our body from
reactive oxygen species (ROS). MT scavenged ROS and free
radicals in our body happen to be one of the reasons of T2DM and its
complications. The objective of this study was to investigate the
association of MT1A and MT2A polymorphisms between T2DM and
control subjects among Malay populations. This study involved 150
T2DM and 120 Healthy individuals of Malay ethnic with mixed
genders. The genomic DNA was extracted from buccal cells and
amplified for MT1A and MT2A loci; the 347bp and 238bp banding
patterns were respectively produced by mean of the Polymerase
Chain Reaction (PCR). The PCR products were digested with Mlucl
and Tsp451 restriction enzymes respectively and producing
fragments lengths of (158/189/347bp) and (103/135/238bp)
respectively. The ANOVA test was conducted and it shown that there
was a significant difference between diabetic and control subjects for
age, BMI, WHR, SBP, FPG, HBA1C, LDL, TG, TC and family
history with (P0.05). The genotype
frequency for AA, AG and GG of MT1A polymorphisms was 72.7%,
22.7% and 4.7% in cases and 15%, 55% and 30% in control
respectively. As for MT2A, genotype frequency of GG, GC and CC
was 42.7%, 27.3% and 30% in case and 5%, 40% and 55% for
control respectively. Both polymorphisms show significant difference
between two investigated groups with (P=0.000). The Post hoc test
was conducted and shows a significant difference between the
genotypes within each polymorphism (P=0. 000). The MT1A and
MT2A polymorphisms were believed to be the reliable molecular
markers to distinguish the T2DM subjects from healthy individuals in
Malay populations.