Abstract: Targeted drug delivery is a method of delivering
medication to a patient in a manner that increases the concentration
of the medication in some parts of the body relative to others.
Targeted drug delivery seeks to concentrate the medication in the
tissues of interest while reducing the relative concentration of the
medication in the remaining tissues. This improves efficacy of the
while reducing side effects. In the present work, we investigate the
effect of magnetic field, flow rate and particle concentration on the
capturing of magnetic particles transported in a stent implanted
fluidic channel. Iron oxide magnetic nanoparticles (Fe3O4)
nanoparticles were synthesized via co-precipitation method. The
synthesized Fe3O4 nanoparticles were added in the de-ionized (DI)
water to prepare the Fe3O4 magnetic particle suspended fluid. This
fluid is transported in a cylindrical tube of diameter 8 mm with help
of a peristaltic pump at different flow rate (25-40 ml/min). A
ferromagnetic coil of SS 430 has been implanted inside the
cylindrical tube to enhance the capturing of magnetic nanoparticles
under magnetic field. The capturing of magnetic nanoparticles was
observed at different magnetic magnetic field, flow rate and particle
concentration. It is observed that capture efficiency increases from
47-67% at magnetic field 2-5kG, respectively at particle
concentration 0.6mg/ml and at flow rate 30 ml/min. However, the
capture efficiency decreases from 65 to 44% by increasing the flow
rate from 25 to 40 ml/min, respectively. Furthermore, it is observed
that capture efficiency increases from 51 to 67% by increasing the
particle concentration from 0.3 to 0.6 mg/ml, respectively.
Abstract: In this glasshouse study, we developed a new imagebased
non-destructive technique for detecting leaf P status of
different crops such as cotton, tomato and lettuce. The plants were
grown on a nutrient solution containing different P concentrations,
e.g. 0%, 50% and 100% of recommended P concentration (P0 = no P,
L; P1 = 2.5 mL 10 L-1 of P and P2 = 5 mL 10 L-1 of P). After 7 weeks
of treatment, the plants were harvested and data on leaf P contents
were collected using the standard destructive laboratory method and
at the same time leaf images were collected by a handheld crop image
sensor. We calculated leaf area, leaf perimeter and RGB (red, green
and blue) values of these images. These data were further used in
linear discriminant analysis (LDA) to estimate leaf P contents, which
successfully classified these plants on the basis of leaf P contents.
The data indicated that P deficiency in crop plants can be predicted
using leaf image and morphological data. Our proposed nondestructive
imaging method is precise in estimating P requirements of
different crop species.
Abstract: In this study, we investigated numerically heat
transfer by mixed convection coupled to radiation in a square cavity;
the upper horizontal wall is movable. The purpose of this study is to
see the influence of the emissivity ε and the varying of the
Richardson number Ri on the variation of average Nusselt number
Nu. The vertical walls of the cavity are differentially heated, the left
wall is maintained at a uniform temperature higher than the right
wall, and the two horizontal walls are adiabatic. The finite volume
method is used for solving the dimensionless Governing Equations.
Emissivity values used in this study are ranged between 0 and 1, the
Richardson number in the range 0.1 to 10. The Rayleigh number is
fixed to Ra=104 and the Prandtl number is maintained constant
Pr=0.71. Streamlines, isothermal lines and the average Nusselt
number are presented according to the surface emissivity. The results
of this study show that the Richardson number Ri and emissivity ε
affect the average Nusselt number.
Abstract: In this paper, a novel Linear Feedback Shift Register
(LFSR) with Look Ahead Clock Gating (LACG) technique is
presented to reduce the power consumption in modern processors
and System-on-Chip. Clock gating is a predominant technique used
to reduce unwanted switching of clock signals. Several clock gating
techniques to reduce the dynamic power have been developed, of
which LACG is predominant. LACG computes the clock enabling
signals of each flip-flop (FF) one cycle ahead of time, based on the
present cycle data of the flip-flops on which it depends. It overcomes
the timing problems in the existing clock gating methods like datadriven
clock gating and Auto-Gated flip-flops (AGFF) by allotting a
full clock cycle for the determination of the clock enabling signals.
Further to reduce the power consumption in LACG technique, FFs
can be grouped so that they share a common clock enabling signal.
Simulation results show that the novel grouped LFSR with LACG
achieves 15.03% power savings than conventional LFSR with LACG
and 44.87% than data-driven clock gating.
Abstract: Introduction: The process to build a better safety
culture, methods of error analysis, and preventive measures, starts
with an understanding of the effects when human factors engineering
refer to remote microscopic diagnosis in surgery and specially in
organ transplantation for the remote evaluation of the grafts. It has
been estimated that even in well-organized transplant systems an
average of 8% to 14% of the grafts (G) that arrive at the recipient
hospitals may be considered as diseased, injured, damaged or
improper for transplantation. Digital microscopy adds information on
a microscopic level about the grafts in Organ Transplant (OT), and
may lead to a change in their management. Such a method will
reduce the possibility that a diseased G, will arrive at the recipient
hospital for implantation. Aim: Ergonomics of Digital Microscopy
(DM) based on virtual slides, on Telemedicine Systems (TS) for
Tele-Pathological (TPE) evaluation of the grafts (G) in organ
transplantation (OT). Material and Methods: By experimental
simulation, the ergonomics of DM for microscopic TPE of Renal
Graft (RG), Liver Graft (LG) and Pancreatic Graft (PG) tissues is
analyzed. In fact, this corresponded to the ergonomics of digital
microscopy for TPE in OT by applying Virtual Slide (VS) system for
graft tissue image capture, for remote diagnoses of possible
microscopic inflammatory and/or neoplastic lesions. Experimentation
included: a. Development of an OTE-TS similar Experimental
Telemedicine System (Exp.-TS), b. Simulation of the integration of
TS with the VS based microscopic TPE of RG, LG and PG applying
DM. Simulation of the DM based TPE was performed by 2
specialists on a total of 238 human Renal Graft (RG), 172 Liver Graft
(LG) and 108 Pancreatic Graft (PG) tissues digital microscopic
images for inflammatory and neoplastic lesions on four electronic
spaces of the four used TS. Results: Statistical analysis of specialist‘s
answers about the ability to diagnose accurately the diseased RG, LG
and PG tissues on the electronic space among four TS (A,B,C,D)
showed that DM on TS for TPE in OT is elaborated perfectly on the
ES of a Desktop, followed by the ES of the applied Exp.-TS. Tablet
and Mobile-Phone ES seem significantly risky for the application of
DM in OT (p
Abstract: Background: To improve the delivery of paediatric
healthcare in low resource settings, Community Health Workers
(CHW) have been provided with a paper-based set of protocols
known as Community Case Management (CCM). Yet research has
shown that CHW adherence to CCM guidelines is poor, ultimately
impacting health service delivery. Digitising the CCM guidelines via
mobile technology is argued in extant literature to improve CHW
adherence. However, little research exist which outlines how (a) this
process can be digitised and (b) adherence could be improved as a
result. Aim: To explore how an electronic mobile version of CCM
(eCCM) can overcome issues associated with the paper-based CCM
protocol (inadequate adherence to guidelines) vis-à-vis service
blueprinting. This service blueprint will outline how (a) the CCM
process can be digitised using mobile Clinical Decision Support
Systems software to support clinical decision-making and (b)
adherence can be improved as a result. Method: Development of a
single service blueprint for a standalone application which visually
depicts the service processes (eCCM) when supporting the CHWs,
using an application known as Supporting LIFE (SL eCCM app) as
an exemplar. Results: A service blueprint is developed which
illustrates how the SL eCCM app can be utilised by CHWs to assist
with the delivery of healthcare services to children. Leveraging
smartphone technologies can (a) provide CHWs with just-in-time
data to assist with their decision making at the point-of-care and (b)
improve CHW adherence to CCM guidelines. Conclusions: The
development of the eCCM opens up opportunities for the CHWs to
leverage the inherent benefit of mobile devices to assist them with
health service delivery in rural settings. To ensure that benefits are
achieved, it is imperative to comprehend the functionality and form
of the eCCM service process. By creating such a service blueprint for
an eCCM approach, CHWs are provided with a clear picture
regarding the role of the eCCM solution, often resulting in buy-in
from the end-users.
Abstract: Lateral torsional buckling is a global buckling mode
which should be considered in design of slender structural members
under flexure about their strong axis. It is possible to compute the
load which causes lateral torsional buckling of a beam by finite
element analysis, however, closed form equations are needed in
engineering practice for calculation ease which can be obtained by
using energy method. In lateral torsional buckling applications of
energy method, a proper function for the critical lateral torsional
buckling mode should be chosen which can be thought as the
variation of twisting angle along the buckled beam. Accuracy of the
results depends on how close is the chosen function to the exact
mode. Since critical lateral torsional buckling mode of the cantilever
I-beams varies due to material properties, section properties and
loading case, the hardest step is to determine a proper mode function
in application of energy method. This paper presents an approximate function for critical lateral
torsional buckling mode of doubly symmetric cantilever I-beams.
Coefficient matrices are calculated for concentrated load at free end,
uniformly distributed load and constant moment along the beam
cases. Critical lateral torsional buckling modes obtained by presented
function and exact solutions are compared. It is found that the modes
obtained by presented function coincide with differential equation
solutions for considered loading cases.
Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: The steady flow of a second order fluid through
constricted tube with slip velocity at wall is modeled and analyzed
theoretically. The governing equations are simplified by implying no
slip in radial direction. Based on Karman Pohlhausen procedure
polynomial solution for axial velocity profile is presented.
Expressions for pressure gradient, shear stress, separation and
reattachment points, and radial velocity are also calculated. The
effect of slip and no slip velocity on magnitude velocity, shear stress,
and pressure gradient are discussed and depicted graphically. It is
noted that when Reynolds number increases magnitude velocity of
the fluid decreases in both slip and no slip conditions. It is also found
that the wall shear stress, separation, and reattachment points are
strongly affected by Reynolds number.
Abstract: Obturator Foramen is a specific structure in Pelvic
bone images and recognition of it is a new concept in medical image
processing. Moreover, segmentation of bone structures such as
Obturator Foramen plays an essential role for clinical research in
orthopedics. In this paper, we present a novel method to analyze the
similarity between the substructures of the imaged region and a hand
drawn template as a preprocessing step for computation of Pelvic
bone rotation on hip radiographs. This method consists of integrated
usage of Marker-controlled Watershed segmentation and Zernike
moment feature descriptor and it is used to detect Obturator Foramen
accurately. Marker-controlled Watershed segmentation is applied to
separate Obturator Foramen from the background effectively. Then,
Zernike moment feature descriptor is used to provide matching
between binary template image and the segmented binary image for
final extraction of Obturator Foramens. Finally, Pelvic bone rotation
rate calculation for each hip radiograph is performed automatically to
select and eliminate hip radiographs for further studies which depend
on Pelvic bone angle measurements. The proposed method is tested
on randomly selected 100 hip radiographs. The experimental results
demonstrated that the proposed method is able to segment Obturator
Foramen with 96% accuracy.
Abstract: Mixed-use development is one of the most important
trends in new island house transformation along southeast coastal area
in China. Unique island geographical environment and profound
fishing village culture coexist for a long time in this. With artistic
creation for the purpose of the "live-work" houses are in a large
number of emergence, however, still lack of systematic strategy.
Based on space effect from marine resources to regional human
settlements, this article teases out the evolution regularity of island
settlement context and architectural form, then, puts forward the
formation mechanism and construction model of art island houses.
Thereby, to further explore space design method and site creation
strategy of mixed-use development.
Abstract: An early diagnosis of bone metastasis is very
important for making a right decision on a subsequent therapy. One
of the most important steps to be taken initially, for developing a new
radiopharmaceutical is the measurement of organ radiation exposure
dose. In this study, the dosimetric studies of a novel agent for
SPECT-imaging of the bone metastasis, 111In-(4-
{[(bis(phosphonomethyl))carbamoyl]methyl}7,10bis(carboxymethyl)
-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (111In-BPAMD)
complex, have been carried out to estimate the dose in human organs
based on the data derived from mice. The radiolabeled complex was
prepared with high radiochemical purity in the optimal conditions.
Biodistribution studies of the complex was investigated in the male
Syrian mice at the selected times after injection (2, 4, 24 and 48 h).
The human absorbed dose estimation of the complex was made based
on data derived from the mice by the radiation absorbed dose
assessment resource (RADAR) method. 111In-BPAMD complex was prepared with high radiochemical
purity >95% (ITLC) and specific activities of 2.85 TBq/mmol. Total
body effective absorbed dose for 111In-BPAMD was 0.205
mSv/MBq. This value is comparable to the other 111In clinically used
complexes. The results show that the dose with respect to the critical
organs is satisfactory within the acceptable range for diagnostic
nuclear medicine procedures. Generally, 111In-BPAMD has
interesting characteristics and it can be considered as a viable agent
for SPECT-imaging of the bone metastasis in the near future.
Abstract: Cesium molybdates with general formula
CsMIII(MoO4)2, where MIII = Bi, Dy, Pr, Er, exhibit rich
polymorphism, and crystallize in a layered structure. These properties
cause intensive studies on cesium molybdates. CsBi(MoO4)2 was synthesized by microwave method by using
cerium sulphate, bismuth oxide and molybdenum (VI) oxide in an
appropriate molar ratio. Characterizations were done by x-ray
diffraction (XRD), fourier transform infrared (FTIR) spectroscopy,
scanning electron microscopy/energy dispersive analyze (SEM/EDS),
thermo gravimetric/differantial thermal analysis (TG/DTA).
Abstract: The paper aims at investigating the effect of number
of story on different structural components of reinforced concrete
building due to gravity and lateral loading. For the study, three
building models having same building plan of three, six and nine
stories are analyzed and designed using software package. All the
buildings are residential and are located in Dhaka city of Bangladesh.
Lateral load including wind and earthquake loading are applied to the
building along both longitudinal and transverse direction as per
Bangladesh National Building Code (BNBC, 2006). Equivalent static
force method is followed for the applied seismic loading. The present
study investigates as well as compares mainly total steel requirement
in different structural components for those buildings. It has been
found that total longitudinal steel requirement for beams at each floor
is 48.57% for three storied building, 61.36% for six storied building
when the total percentage is taken as 100% in case of nine storied
building. For an exterior column, the steel ratio is 2.1%, 3.06%,
4.55% for three, six and nine storied building respectively for the first
three floors. In addition, it has been noted that total weight of
longitudinal reinforcement of an interior column is 14.02 % for threestoried
building and 43.12% for six storied building when the total
reinforcement is considered 100% for nine storied building for the
first three floors.
Abstract: The current study focuses on the seismic design of
offshore pipelines against active faults. After an extensive literature
review of the provisions of the seismic norms worldwide and of the
available analytical methods, the study simulates numerically
(through finite-element modeling and strain-based criteria) the
distress of offshore pipelines subjected to PGDs induced by active
normal and reverse seismic faults at the seabed. Factors, such as the
geometrical properties of the fault, the mechanical properties of the
ruptured soil formations, and the pipeline characteristics, are
examined. After some interesting conclusions regarding the seismic
vulnerability of offshore pipelines, potential cost-effective mitigation
measures are proposed taking into account constructability issues.
Abstract: Annihilations, phase shifts, scattering lengths and
elastic cross sections of low energy positrons scattering from
magnesium atoms were studied using the least-squares variational
method (LSVM). The possibility of positron binding to the
magnesium atoms is investigated. A trial wave function is suggested
to represent e+-Mg elastic scattering and scattering parameters were
derived to estimate the binding energy and annihilation rates. The
trial function is taken to depend on several adjustable parameters, and
is improved iteratively by increasing the number of terms. The
present results have the same behavior as reported semi-empirical,
theoretical and experimental results. Especially, the estimated
positive scattering length supports the possibility of positronmagnesium
bound state system that was confirmed in previous
experimental and theoretical work.
Abstract: In this article, we used the residual correction method
to deal with transient thermoelastic problems with a hollow spherical
region when the continuum medium possesses spherically isotropic
thermoelastic properties. Based on linear thermoelastic theory, the
equations of hyperbolic heat conduction and thermoelastic motion
were combined to establish the thermoelastic dynamic model with
consideration of the deformation acceleration effect and non-Fourier
effect under the condition of transient thermal shock. The approximate
solutions of temperature and displacement distributions are obtained
using the residual correction method based on the maximum principle
in combination with the finite difference method, making it easier and
faster to obtain upper and lower approximations of exact solutions.
The proposed method is found to be an effective numerical method
with satisfactory accuracy. Moreover, the result shows that the effect
of transient thermal shock induced by deformation acceleration is
enhanced by non-Fourier heat conduction with increased peak stress.
The influence on the stress increases with the thermal relaxation time.
Abstract: Countryside has been generally recognized and
regarded as a characteristic symbol which presents in human memory
for a long time. As a result of the change of times, because of it is
failure to meet the growing needs of the growing life and mental
decline, the vast rural area began to decline. But their history feature
image which accumulated by the ancient tradition provides people
with the origins of existence on the spiritual level, such as "identity"
and "belonging", makes people closer to the others in the spiritual and
psychological aspects of a common experience about the past, thus the
sense of a lack of culture caused by the losing of memory symbols is
weakened. So, in the modernization process, how to repair its vitality
and transform and planning it in a sustainable way has become a hot
topics in architectural and urban planning. This paper aims to break
the constraints of disciplines, from the perspective of interdiscipline,
using the research methods of systems science to analyze and discuss
the theories and methods of rural form factors, which based on the
viewpoint of memory in psychology. So we can find a right way to
transform the Rural to give full play to the role of the countryside in
the actual use and the shape of history spirits.
Abstract: Adequate and reliable estimates of aquifer parameters
are of utmost importance for proper management of vital
groundwater resources. At present scenario, the ground water is
polluted because of industrial waste disposed over the land and the
contaminants are transported in the aquifer from one area to another
area, which is depending on the characteristics of the aquifer and
contaminants. To know the contaminant transport, the accurate
estimation of aquifer properties is highly needed. Conventionally,
these properties are estimated through pumping tests carried out on
water wells. The occurrence and movement of ground water in the
aquifer are characteristically defined by the aquifer parameters. The
pumping (aquifer) test is the standard technique for estimating
various hydraulic properties of aquifer systems, viz., transmissivity
(T), hydraulic conductivity (K), storage coefficient (S) etc., for which
the graphical method is widely used. The study area for conducting
pumping test is Pydibheemavaram Industrial area near the coastal
belt of Srikulam, AP, India. The main objective of the present work is
to estimate the aquifer properties for developing contaminant
transport model for the study area.
Abstract: Background: To compare the thinning patterns of the
ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal
nerve fiber layer (pRNFL) as measured using Cirrus high-definition
optical coherence tomography (HD-OCT) in patients with visual field
(VF) defects that respect the vertical meridian. Methods: Twenty eyes of eleven patients with VF defects that
respect the vertical meridian were enrolled retrospectively. The
thicknesses of the macular GCIPL and pRNFL were measured using
Cirrus HD-OCT. The 5% and 1% thinning area index (TAI) was
calculated as the proportion of abnormally thin sectors at the 5% and
1% probability level within the area corresponding to the affected VF.
The 5% and 1% TAI were compared between the GCIPL and pRNFL
measurements. Results: The color-coded GCIPL deviation map showed a
characteristic vertical thinning pattern of the GCIPL, which is also
seen in the VF of patients with brain lesions. The 5% and 1% TAI
were significantly higher in the GCIPL measurements than in the
pRNFL measurements (all P < 0.01). Conclusions: Macular GCIPL analysis clearly visualized a
characteristic topographic pattern of retinal ganglion cell (RGC) loss
in patients with VF defects that respect the vertical meridian, unlike
pRNFL measurements. Macular GCIPL measurements provide more
valuable information than pRNFL measurements for detecting the
loss of RGCs in patients with retrograde degeneration of the optic
nerve fibers.